Chemotherapy of advanced breast cancer: a controlled randomized trial of cyclophosphamide versus a four-drug combination.

abstract：:Four-hundred-forty-five husbands of women with invasive cervical carcinoma, 165 of women with in situ cervical cancer, and 717 of control women (age range 19-82 years) were interviewed and a sample of exfoliated cells from the penis obtained in seven case-control studies conducted by the International Agency for Resea...

journal_title：British journal of cancer

authors： Franceschi S,Castellsagué X,Dal Maso L,Smith JS,Plummer M,Ngelangel C,Chichareon S,Eluf-Neto J,Shah KV,Snijders PJ,Meijer CJ,Bosch FX,Muñoz N

更新日期：2002-03-04 00:00:00

abstract：:We evaluated whether social deprivation affected decision-making for breast cancer surgery. Of 3419 patients, 53.6% had mastectomy and this was predicted by deprivation, age, tumour size and hospital, all of which retained significance on multivariate analysis, except deprivation. Pathological characteristics and surg...

journal_title：British journal of cancer

authors： Henley NC,Hole DJ,Kesson E,Burns HJ,George WD,Cooke TG

更新日期：2005-02-28 00:00:00

abstract：:The prostate cancer cell lines PC3 and LNCaP have been shown to lack expression of the tumour suppressor gene MMAC1/PTEN, in contrast to the immortalized non-tumorigenic epithelial lines PNT1a and PNT2. We have measured the effects of reintroduction of wild type (wt) and mutant MMAC1 genes on to these genetic backgrou...

journal_title：British journal of cancer

authors： Sharrard RM,Maitland NJ

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND:FOXA1 expression is a good prognostic marker for endocrine therapy in hormone-positive breast cancer. We retrospectively examined breast cancer patients with luminal human epidermal growth factor receptor 2 (HER2)-negative tumours, as defined by immunohistochemistry, who received neo-adjuvant chemotherapy (N...

journal_title：British journal of cancer

authors： Horimoto Y,Arakawa A,Harada-Shoji N,Sonoue H,Yoshida Y,Himuro T,Igari F,Tokuda E,Mamat O,Tanabe M,Hino O,Saito M

更新日期：2015-01-20 00:00:00

abstract：:Several uncertainties surround optimal management of colorectal cancer. We investigated treatment patterns and factors influencing treatment receipt and mortality in routine clinical practice. We included 15 249 individuals, recorded by the National Cancer Registry (Ireland), with primary invasive colon or rectal tumo...

journal_title：British journal of cancer

authors： Carsin AE,Sharp L,Cronin-Fenton DP,Céilleachair AO,Comber H

更新日期：2008-07-22 00:00:00

abstract：:Progression of colorectal cancer may follow either of two main genetic routes: the chromosome- or microsatellite-instability pathways. Association between the patients' prognosis and microsatellite instability has been questioned. Improved survival has previously been found in patients with expression of HLA-DR antige...

journal_title：British journal of cancer

authors： Løvig T,Andersen SN,Thorstensen L,Diep CB,Meling GI,Lothe RA,Rognum TO

更新日期：2002-09-23 00:00:00

abstract：:We have studied loss of heterozygosity at the BRCA1 and BRCA2 loci in 992 normal cell clones derived from topographically defined areas of normal tissue in four samples from BRCA1/BRCA2 mutation carriers. The frequency of loss of heterozygosity in the clones was low (1.01%), but it was found in all four samples, wheth...

journal_title：British journal of cancer

authors： Clarke CL,Sandle J,Jones AA,Sofronis A,Patani NR,Lakhani SR

更新日期：2006-08-21 00:00:00

abstract：:The malignant epithelial cells of nasopharyngeal carcinoma (NPC) and cells of lines derived form the lymphoid cells which infiltrate this tumour have been investigated cytogenetically. Chromosome spreads of lymphoblastoid cells of lines established from 7 different NPC biopsy specimens were examined after banding stai...

journal_title：British journal of cancer

authors： Finerty S,Jarvis JE,Epstein MA,Trumper PA,Ball G,Giovanella BC

更新日期：1978-02-01 00:00:00

abstract：:The combination effect of docetaxel and capecitabine on tumour response rate and survival was demonstrated recently in metastatic breast cancer patients. This combination was based on an experimental hypothesis that taxane can increase tumour sensitivity to the effect of capecitabine through the upregulation of thymid...

journal_title：British journal of cancer

authors： Toi M,Bando H,Horiguchi S,Takada M,Kataoka A,Ueno T,Saji S,Muta M,Funata N,Ohno S

更新日期：2004-06-14 00:00:00

abstract：:The conventional diffusion chamber (CDC) as described by Benestad (1970) had been modified to assay the colony forming capacity of RFM bone marrow and spleen cells in agar diffusion chambers (ADCs). The colonies are morphologically identical to those formed by the CFUc in agar culture in vitro and have an incidence of...

journal_title：British journal of cancer

authors： Gordon MY

更新日期：1974-11-01 00:00:00

abstract：:A cell-free plasmid reactivation assay was used to determine the fidelity of DNA double-strand break (DSB) repair in a panel of eight DSB repair-proficient human tumour cell lines. Nuclear protein extracts derived from radiosensitive tumour cells were less capable of correctly rejoining EcoRI-induced DSBs than were si...

journal_title：British journal of cancer

authors： Britten RA,Liu D,Kuny S,Allalunis-Turner MJ

更新日期：1997-01-01 00:00:00

abstract：:In mice given a single dose of diethylnitrosamine, a hepatonecrotic dose of carbon tetrachloride, 5 weeks after dosing with DEN and repeated 6 times at 4-weekly intervals, augmented the tumour yield in the livers. A single hepatonecrotic dose of CCl4 24 h before a single dose of DEN also increased the number of tumour...

journal_title：British journal of cancer

authors： Poound AW,McGuire LJ

更新日期：1978-04-01 00:00:00

abstract：BACKGROUND:We previously showed that activation of the nuclear factor of activated T cells (NFAT)1/Fas ligand (FasL) pathway induces glioma cell death. Lithium (Li) is an inhibitor of glycogen synthase kinase (GSK)-3 that activates NFAT1/FasL signalling. Temozolomide (TMZ) inhibits GSK-3 and activates Fas in tumour pro...

journal_title：British journal of cancer

authors： Han S,Meng L,Jiang Y,Cheng W,Tie X,Xia J,Wu A

更新日期：2017-05-09 00:00:00

abstract：BACKGROUND:Soft tissue sarcomas are heterogeneous and a major complication in their management is that the existing classification scheme is not definitive and is still evolving. Leiomyosarcomas, a major histologic category of soft tissue sarcomas, are malignant tumours displaying smooth muscle differentiation. Althoug...

journal_title：British journal of cancer

authors： Lee YF,Roe T,Mangham DC,Fisher C,Grimer RJ,Judson I

更新日期：2016-10-11 00:00:00

abstract：:Cells from V79 multicell spheroids must be exposed to approximately 50 times more etoposide than exponentially growing monolayers in order to produce the same amount of cell killing. A part of this difference in sensitivity is readily explained by the decrease in growth fraction of large spheroids, and by the protecti...

journal_title：British journal of cancer

authors： Olive PL,Banáth JP,Evans HH

更新日期：1993-03-01 00:00:00

abstract：:The last 15 years has seen an explosion of interest in the cancer stem cell (CSC). Although it was initially believed that only a rare population of stem cells are able to undergo self-renewing divisions and differentiate to form all populations within a malignancy, a recent work has shown that these cells may not be ...

journal_title：British journal of cancer

authors： Bomken S,Fiser K,Heidenreich O,Vormoor J

更新日期：2010-08-10 00:00:00

abstract：:This study evaluates the overall survival and disease free survival of melanoma patients that were treated with an autologous melanoma cell vaccine, administered as a post-operative adjuvant. Included are 43 patients with totally resected metastatic melanoma (28-AJCC stage III, 15-AJCC stage IV), with a median follow ...

journal_title：British journal of cancer

authors： Lotem M,Peretz T,Drize O,Gimmon Z,Ad El D,Weitzen R,Goldberg H,Ben David I,Prus D,Hamburger T,Shiloni E

更新日期：2002-05-20 00:00:00

abstract：:Antibody drug conjugates (ADCs) employ the exquisite specificity of tumour-specific monoclonal antibodies (mAb) for the targeted delivery of highly potent cytotoxic drugs to the tumour site. The chemistry of the linker, which connects the drug to the mAb, determines how and when the drug is released from the mAb. This...

journal_title：British journal of cancer

authors： Staudacher AH,Brown MP

更新日期：2017-12-05 00:00:00

abstract：:Short-term cultures from one synovial chondroma and three cases of synovial chondromatosis, a lesion for which no previous karyotypic information exists, were cytogenetically analysed. Whereas the chondroma displayed the relatively simple karyotype 46,XY,add(12)(q13),der(17)t(12;17)(q13;q21), more complex changes were...

journal_title：British journal of cancer

authors： Mertens F,Jonsson K,Willén H,Rydholm A,Kreicbergs A,Eriksson L,Olsson-Sandin G,Mitelman F,Mandahl N

更新日期：1996-07-01 00:00:00

abstract：:A total of 165 adult patients with Hodgkin's disease (HD) were questioned following treatment to examine their perceptions of actual and desired involvement and provision of information in the treatment decision-making process. Irrespective of the degree to which patients felt they had been involved in the decision-ma...

journal_title：British journal of cancer

authors： Turner S,Maher EJ,Young T,Young J,Vaughan Hudson G

更新日期：1996-01-01 00:00:00

abstract：:Cells of a patient with Turcot's syndrome and of her parents were evaluated for the presence of molecular alterations in the p53 and the Ki-ras gene. Deletions on chromosome 17p, overexpression and point mutations of the p53 gene as well as mutations of the Ki-ras gene were detected in primary and metastatic tumour bu...

journal_title：British journal of cancer

authors： Rochlitz CF,Heide I,de Kant E,Neubauer A,Schmidt CA,Neuhaus P,Huhn D,Herrmann R

更新日期：1993-09-01 00:00:00

abstract：:In the years before human immunodeficiency virus (HIV) infection, the incidence of Kaposi's sarcoma varied markedly across the African continent, and it was a disease primarily affecting men. In contrast, the evidence reviewed here shows that the causal virus-Kaposi's sarcoma associated herpesvirus (KSHV)-is prevalent...

journal_title：British journal of cancer

authors： Dedicoat M,Newton R

更新日期：2003-01-13 00:00:00

abstract：BACKGROUND:The severity of cancers is often measured in number of deaths. However, number of years of life lost (YLL) may be a more appropriate indicator of impact on society. Here we have calculated the YLL of adult cancers in Norway for the year 2012, as well as for the previous 15-year period. METHODS:Data on age c...

journal_title：British journal of cancer

authors： Brustugun OT,Møller B,Helland A

更新日期：2014-08-26 00:00:00

abstract：:The histological breakdown of a consecutive series of 264 surgically resected malignant lesions of the breast was studied. Oestrogen and epidermal growth factor receptor status was quantified and presented along with size and lymph node status of the non-ductal lesions. Those non-ductal tumours containing EGF receptor...

journal_title：British journal of cancer

authors： Sainsbury JR,Nicholson S,Angus B,Farndon JR,Malcolm AJ,Harris AL

更新日期：1988-10-01 00:00:00

abstract：:The effects of polymorphisms in genes coding for key folate metabolism enzymes such as thymidylate synthetase (TS) on colorectal neoplasia risk are likely to be influenced by gene-gene and gene-nutrient interactions. We investigated the combined effects of three polymorphisms in the TS gene region, TSER, TS 3R G>C, an...

journal_title：British journal of cancer

authors： Hubner RA,Liu JF,Sellick GS,Logan RF,Houlston RS,Muir KR

更新日期：2007-11-19 00:00:00

abstract：BACKGROUND:A dose-dense strategy has been considered to improve results of adjuvant chemotherapy for breast cancer. This randomised phase II trial investigated the feasibility of this approach with sequential anthracyclines and taxanes-based chemotherapy. METHODS:Patients with high-risk node-positive breast cancer wer...

journal_title：British journal of cancer

authors： Brain E,Levy C,Serin D,Roché H,Spielmann M,Delva R,Veyret C,Mauriac L,Rios M,Martin AL,Jimenez M,Asselain B,Gauthier M,Bonnetain F,Fumoleau P

更新日期：2011-11-08 00:00:00

abstract：:Eleven patients with measurable subcutaneous or pulmonary metastases were selected for a study of the effectiveness of the radiosensitizer misonidazole (MIS). Evaluable data were obtained in 6 patients and radiosensitization demonstrated in 5. Patients were irradiated either before or after MIS, and each patient acted...

journal_title：British journal of cancer

authors： Ash DV,Peckham MJ,Steel GG

更新日期：1979-12-01 00:00:00

abstract：BACKGROUND:Non-epithelial gonadal tumours largely comprise sex cord-stromal tumours (SCSTs) and germ cell tumours (GCTs). Specific somatic mutations in DICER1, a microRNA maturation pathway gene, have been identified in these tumours. We conducted a study that aimed to confirm, refine and extend the previous observatio...

journal_title：British journal of cancer

authors： Witkowski L,Mattina J,Schönberger S,Murray MJ,Choong CS,Huntsman DG,Reis-Filho JS,McCluggage WG,Nicholson JC,Coleman N,Calaminus G,Schneider DT,Arseneau J,Stewart CJ,Foulkes WD

更新日期：2013-11-12 00:00:00

abstract：BACKGROUND:Osteosarcoma (OS) is the most common primary bone tumour in children and adolescents. Patients who respond poorly to chemotherapy have a higher risk of metastatic disease and 5-year survival rates of only 10-20%. Therefore, identifying molecular targets that are specific for OS, or more specifically, metasta...

journal_title：British journal of cancer

authors： Endo-Munoz L,Cumming A,Sommerville S,Dickinson I,Saunders NA

更新日期：2010-06-29 00:00:00

abstract：:A regional cancer network has been set up in the Rhône-Alpes region in France. The aim of the project is to improve the quality of care and to rationalize prescriptions in the network. In this network, we assessed the impact of the implementation of a clinical practice guidelines project by assessing the conformity of...

journal_title：British journal of cancer

authors： Ray-Coquard I,Philip T,de Laroche G,Froger X,Suchaud JP,Voloch A,Mathieu-Daudé H,Fervers B,Farsi F,Browman GP,Chauvin F

更新日期：2002-02-01 00:00:00