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Relationship between the immune microenvironment of different locations in a primary tumour and clinical outcomes of oesophageal squamous cell carcinoma.

Abstract：

BACKGROUND:Tumour microenvironments can differ according to intratumoural locations. We investigated the immune status at different locations in primary tumours and its clinical significance in oesophageal squamous cell carcinoma (ESCC). METHODS:The number of CD8+ tumour-infiltrating immune cells (TIICs) and PD-1+ TIICs, and PD-L1 expression on tumour cells (PD-L1TC) were immunohistochemically examined in the surface (Surf), centre (Cent) and invasive front (Inv) of tumours surgically resected from 192 patients with ESCC. RESULTS:The PD-L1+ rate was lower in Inv than in Cent (12.0% vs. 18.2%, P = 0.012), although the numbers of CD8+ TIICs and PD-1+ TIICs were comparable among intratumoural locations. High numbers of CD8+ and PD-1+ TIICs and positive PD-L1TC were related to better overall survival (OS) only in Surf and Cent (CD8: P = 0.012 in Surf, 0.018 in Cent, and 0.165 in Inv; PD-1: P = 0.028 in Surf, 0.021 in Cent, and 0.208 in Inv; and PD-L1: 0.044 in Surf, 0.026 in Cent, and 0.718 in Inv). Positive PD-L1TC in Surf and/or Cent but not in Inv demonstrated a strong tendency toward better OS (P = 0.053). CONCLUSIONS:Immune microenvironments according to the intratumoural location have different effects on the survival of patients with ESCC.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Hatogai K,Fujii S,Kitano S,Kojima T,Daiko H,Yoshino T,Ohtsu A,Takiguchi Y,Doi T,Ochiai A

doi

10.1038/s41416-019-0622-3

subject

Has Abstract

pub_date

2020-02-01 00:00:00

pages

413-420

issue

3

eissn

0007-0920

issn

1532-1827

pii

10.1038/s41416-019-0622-3

journal_volume

122

pub_type

杂志文章

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