Abstract：
:Immunoglobulins (Ig) and some complement components (C) were quantified in sera from patients with gastric carcinoma before surgery and at regular intervals during a 5-year follow-up. The preoperative concentrations of C1-INH and C4 were higher (P < 0.0005 and P < 0.005) and IgG lower (P < 0.0005) in 50 patients with recurrence than in 46 5-year survivors. The prognostic significant of C1-INH was superior to that of the extent of disease (F-values 37.1 and 26.1). The preoperative immune data classified 76% of the patients correctly as to recurrence and no recurrence. Also, the preoperative C1-INH concentration had a highly significant effect on time to recurrence of cancer (P = 0.0007), adjusting for age and disease extent. After surgery the mean IgG concentrations were within normal range and without difference between the two groups. On the other hand, the concentrations of C1-INH and C4 in the individual patients in both groups remained the same from before to after surgery and throughout the observation period (P = 0.34). Apparently, the serum levels of C1-INH and C4 do not reflect the bearing of cancer. We therefore suggest that these variables represent an independent immune state that is appropriate to the host. A comparison of our variables with those of healthy individuals seems to support this idea. This immune state has a significant influence on whether a resected gastric cancer will recur, and also on how soon recurrence may be manifest.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Janssen CW Jr,Lie RT,Bassøe CF,Maartmann-Moe H,Matre Rdoi
10.1038/bjc.1992.376subject
Has Abstractpub_date
1992-11-01 00:00:00pages
870-4issue
5eissn
0007-0920issn
1532-1827journal_volume
66pub_type
杂志文章abstract：:We have studied whether N-methylformamide can affect the expression pattern of adhesion molecules and the attachment behaviour of M14 human melanoma cells. The role of N-methylformamide on experimental and spontaneous pulmonary metastases from M14 cells in nude mice was also investigated. We demonstrate that N-methylf...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.35
更新日期：1998-01-01 00:00:00
abstract：:2-Amino-3,4-dihydro-6-methyl-4-oxo-5-(4-pyridylthio)-quinazoline dihydrochloride (nolatrexed dihydrochloride, Thymitaq, AG337), a specific inhibitor of thymidylate synthase, was developed using protein structure-based drug design. Intravenously administered nolatrexed is active clinically. As oral bioavailability is h...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1038/sj.bjc.6690146
更新日期：1999-02-01 00:00:00
abstract：BACKGROUND:Patients with borderline resectable pancreatic cancer (BRPC) have poor prognosis with upfront surgery. METHODS:This was a single-arm Phase 2 trial for clinical and biomarker analysis. The primary endpoint is 1-year progression-free survival (PFS) rate. Patients received 8 cycles of neoadjuvant modified (m) ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-0867-x
更新日期：2020-08-01 00:00:00
abstract：:Detailed data and statistics per each morphological site of various digestive neoplasms were obtained for the period 1976-87 from the Vaud Cancer Registry datafile, a population-based cancer registration scheme covering about 530,000 inhabitants from the French-speaking part of Switzerland. Tabulations presented inclu...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1991.132
更新日期：1991-04-01 00:00:00
abstract：:Basal cell carcinomas (BCCs) are very frequent cutaneous cancers, often located on the face. Cure rates with surgery and radiotherapy are high, but these treatments have never been compared prospectively. A randomized trial was initiated in 1982 to compare surgery and radiotherapy in the treatment of primary BCC of th...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/bjc.1997.343
更新日期：1997-01-01 00:00:00
abstract：:Adriamycin and cyclophosphamide are active agents in human and experimental tumours. Using the L1210 murine leukaemia, their effectiveness alone and in combination was studied. The combination is highly synergistic in this tumour, resulting in a greater than 50% survival rate when the agents used alone at optimal dose...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1975.150
更新日期：1975-08-01 00:00:00
abstract：:In rapidly frozen livers from chickens affected with myeloblastosis and Marek's disease and from unaffected control birds there exists a strong correlation between catalase activity and catalase Electron Paramagnetic Resonance (EPR) signal intensities. The diseased chickens had activities and signals reduced to as lit...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1984.189
更新日期：1984-09-01 00:00:00
abstract：INTRODUCTION:We investigated the association between socioeconomic position, stage at diagnosis, and length of period between referral and diagnosis in a nationwide cohort of lung cancer patients. METHODS:Through the Danish Lung Cancer Register, we identified 18,103 persons diagnosed with lung cancer (small cell and n...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.342
更新日期：2011-09-27 00:00:00
abstract：:The management of older patients with aggressive non-Hodgkin's lymphoma presents a challenge to the physician. Age is a poor prognostic indicator, due to reduced ability to tolerate and maintain dose-intensive chemotherapy. Generally, older patients demonstrate a lower response rate, reduced survival and increased tox...
journal_title：British journal of cancer
pub_type： 杂志文章,随机对照试验
doi：10.1038/sj.bjc.6602975
更新日期：2006-03-27 00:00:00
abstract：BACKGROUND:We aimed to assess the efficacy of second-line fluoropyrimidine-based chemotherapy in patients with advanced biliary tract cancer (BTC) after failure of gemcitabine plus cisplatin (GEMCIS). METHODS:We retrospectively examined patients with histologically documented advanced BTC who received first-line GEMCI...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2016.446
更新日期：2017-02-28 00:00:00
abstract：:Experimental studies indicated that long-chain polyunsaturated fatty acids may increase sensitivity of mammary tumours to several cytotoxic drugs. To evaluate this hypothesis in breast cancer, we have prospectively studied the association between levels of fatty acids stored in breast adipose tissue and the response o...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690281
更新日期：1999-04-01 00:00:00
abstract：BACKGROUND:Myelosuppression has been observed with several multikinase angiogenesis inhibitors in clinical studies, although the frequency and severity varies among the different agents. Inhibitors targeting vascular endothelial growth factor receptor (VEGFR) often inhibit other kinases, which may contribute to their a...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605366
更新日期：2009-11-17 00:00:00
abstract：:Increased fibre intake has been shown to reduce serum oestrogen concentrations. We hypothesized that fibre exerts this effect by decreasing the time available for reabsorption of oestrogens in the colon. We tested this in volunteers by measuring changes in serum oestrogen levels in response to manipulation of intestin...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/bjc.1997.397
更新日期：1997-01-01 00:00:00
abstract：:We analysed 26 metastases from 25 patients with sporadic cutaneous malignant melanoma for alterations in the CDKN2 gene by a combined polymerase chain reaction/single-strand conformation polymorphism (PCR/SSCP)/nucleotide sequencing approach. Eleven alterations (one in exon 1, five in exon 2 and five in the 3' non-cod...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.59
更新日期：1996-02-01 00:00:00
abstract：:Recently, apoptosis has been implicated as one of the end points of cells exposed to chemotherapeutic agents. The p53 and Bcl-2 family of proteins are involved in chemotherapy-induced apoptosis, but in a cell type-dependent manner. We sought to determine the roles played by the p53 and Bcl-2 family of proteins in 5-fl...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.617
更新日期：1998-10-01 00:00:00
abstract：:O6-benzylguanine (O6-BG) and 3-aminobenzamide (3-AB) inhibit the DNA repair proteins O6-alkylguanine-DNA alkyltransferase (AGT) and poly(ADP-ribose) polymerase (PARP) respectively. The effect of O6-BG and/or 3-AB on temozolomide and 1,3-bis(2-chloroethyl)-nitrosourea (BCNU) cytotoxicity, was assessed in seven human tu...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.485
更新日期：1996-10-01 00:00:00
abstract：:In vivo growth characteristics of myeloid leukaemia induced by whole-body irradiation of CBA/H male mice were examined in the strain of origin by procedures expected to enhance or depress immunological responses. Syngeneic growth in vivo (survival time and frequency of takes) was not modified by attempted active immun...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1982.68
更新日期：1982-03-01 00:00:00
abstract：:The mechanism of down-regulation of c-myc RNA associated with androgen-induced suppression of the transformed phenotype in the human prostate carcinoma cell line LNCaP was investigated. The synthetic androgen mibolerone (7 alpha-17 alpha-Dimethyl-19-nortestosterone) reversibly inhibits the proliferation of LNCaP cells...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.76
更新日期：1992-03-01 00:00:00
abstract：BACKGROUND:We previously reported that chaetocin has potent and selective anti-myeloma activity attributable to reactive oxygen species (ROS) induction imposed by inhibition of the redox enzyme thioredoxin reductase; we now detail its effects in solid tumours. METHODS:Cellular assays, transcriptional profiling and the...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.522
更新日期：2012-01-17 00:00:00
abstract：:Imaging has an essential role in the planning and delivery of radiotherapy. Recent advances in imaging have led to the development of advanced radiotherapy techniques-including image-guided radiotherapy, intensity-modulated radiotherapy, stereotactic body radiotherapy and proton beam therapy. The optimal use of imagin...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/s41416-019-0412-y
更新日期：2019-04-01 00:00:00
abstract：:In this study, the immunohistochemical expression of a new inducible elastase inhibitor, SKALP (skin-derived anti-leucoproteinase)/elafin, in the tissue of squamous cell carcinoma and uninvolved oesophageal mucosa was studied using a polyclonal rabbit anti-serum against SKALP/elafin. The results were compared with the...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1997.511
更新日期：1997-01-01 00:00:00
abstract：BACKGROUND:Epstein-Barr virus-positive post-transplant lymphoproliferative disease (PTLD) is a potentially lethal complication of iatrogenic immunosupression after transplantation. Predicting the development of PTLD allowing early and effective intervention is therefore of importance. Polymorphisms within cytokine gene...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605278
更新日期：2009-09-15 00:00:00
abstract：:Helicobacter has been suggested to play a possible role in hepatitis, gallstones, and hepatobiliary tumours. We assessed whether seropositivity to 15 H. pylori proteins was associated with subsequent incidence of 74 biliary tract and 105 liver cancer cases vs. 357 matched controls in the Prostate, Lung, Colorectal, an...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-0961-0
更新日期：2020-09-01 00:00:00
abstract：:Cultured H35 hepatoma cells release a cytotoxic factor in response to irradiation with X-rays. When the conditioned medium from irradiated cells is given to nonirradiated cells, growth is inhibited and followed by cell death, possibly apoptosis, Analysis of the conditioned medium reveals a dramatic change in the ornit...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600700
更新日期：2003-02-10 00:00:00
abstract：BACKGROUND:MEK is activated in ∼40% colorectal cancer (CRC) and 20-30% non-small cell lung cancer (NSCLC). Selumetinib is a selective inhibitor of MEK1/2, which is currently in clinical development. METHODS:We evaluated the effects of selumetinib in vitro and in vivo in CRC and NSCLC cell lines to identify cancer cell...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2012.129
更新日期：2012-05-08 00:00:00
abstract：:Cells of a patient with Turcot's syndrome and of her parents were evaluated for the presence of molecular alterations in the p53 and the Ki-ras gene. Deletions on chromosome 17p, overexpression and point mutations of the p53 gene as well as mutations of the Ki-ras gene were detected in primary and metastatic tumour bu...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1993.379
更新日期：1993-09-01 00:00:00
abstract：:We examined the relationship between p53 levels before and after irradiation, radiation-induced cell cycle delays, apoptotic cell death and radiosensitivity in a panel of eight human tumour cell lines. The cell lines differed widely in their clonogenic survival after radiation, (surviving fraction at 2 Gy: SF2=0.18-0....
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.101
更新日期：1996-03-01 00:00:00
abstract：BACKGROUND:Cervical cancer screening coverage remains insufficient in most countries. Our objective was to assess whether in-home vaginal self-sampling with a dry swab for high-risk human papillomavirus (HR-HPV) testing is effective and cost-effective in increasing participation in cervical cancer screening. METHODS:I...
journal_title：British journal of cancer
pub_type： 杂志文章,随机对照试验
doi：10.1038/bjc.2014.510
更新日期：2014-11-25 00:00:00
abstract：:Matrix metalloproteinases (MMPs) have been implicated as important factors in gliomas since they may both facilitate invasion into the surrounding brain and participate in neovascularization. We have tested the hypothesis that deregulated expression of gelatinase-A or B, or an activator of gelatinase-A, MT1-MMP, may c...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/sj.bjc.6690291
更新日期：1999-04-01 00:00:00
abstract：BACKGROUND:In 2006, the National Health Service Bowel Cancer Screening Programme in England (NHSBCSP) began offering routine population-based biennial faecal occult blood testing (FOBt) at ages 60-69. There is, however, limited information on how characteristics of individuals affect participation and outcomes of scree...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2015.69
更新日期：2015-04-28 00:00:00
