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Changes in the ornithine cycle following ionising radiation cause a cytotoxic conditioning of the culture medium of H35 hepatoma cells.

Abstract：

:Cultured H35 hepatoma cells release a cytotoxic factor in response to irradiation with X-rays. When the conditioned medium from irradiated cells is given to nonirradiated cells, growth is inhibited and followed by cell death, possibly apoptosis, Analysis of the conditioned medium reveals a dramatic change in the ornithine (urea) cycle components after the irradiation. A strong decrease in medium arginine is accompanied with parallel increases in ornithine, citrulline and ammonia. The high level of ammonia appears to be largely responsible for the observed cytotoxicity. The development of hyperammonia by irradiated cells and the related toxicity depend on the radiation dose and the number of cells seeded thereafter for the medium conditioning. Development of cytotoxicity by irradiated cells is completely prevented with the arginase inhibitor L-norvaline, in arginine-deficient medium or when citrulline replaces arginine. These preventive measures result in subtoxic ammonia levels.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

van Rijn J,van den Berg J,Teerlink T,Kruyt FA,Schor DS,Renardel de Lavalette AC,van den Berg TK,Jakobs C,Slotman BJ

doi

10.1038/sj.bjc.6600700

subject

Has Abstract

pub_date

2003-02-10 00:00:00

pages

447-54

issue

3

eissn

0007-0920

issn

1532-1827

pii

6600700

journal_volume

88

pub_type

杂志文章

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