当前位置： SCI文献检索 > BRITISH JOURNAL OF CANCER期刊下所有文献 > Lowering of innate resistance of the lungs to the growth of blood-borne cancer cells in states of topical and systemic stress.

Lowering of innate resistance of the lungs to the growth of blood-borne cancer cells in states of topical and systemic stress.

Abstract：

:The survival and clonogenic growth (measured in terms of colony forming efficiency (CFE) of intravenously injected (i.v.) Walker (W256) tumour cells in the lungs of rats was greatly enhanced by states of topical and systemic stress induced by the intraperitoneal (i.p.) injection of rats with a single dose of 10(-5)-10(-3) mmol g-1 body weight of adrenaline and other beta-adrenergic agonists, inflammatory agents (including local x-irradiation), convulsive seizures, "tumbling" or physical restraint. Lowering of innate resistance of the host to growth of seeded tumour cells induced by states of topical and systemic stress, and by the addition of an excess of lethally irradiated (LI) tumour cells to i.v. injected intact tumour cells, were all potentiated by treatment of rats with aminophylline, an inhibitor of cyclic AMP phosphodiesterase. Enhancement of tumour growth by systemic stress was inhibited by bilateral total or medullary adrenalectomy and is attributed to the release and actions of endogenous adreno-medullary hormones. Alpha-adrenergic and most non-adrenergic agents administered in maximum tolerated doses did not significantly affect host resistance to tumour growth in the lungs. These findings, correlated with measurements of cyclic AMP in the lungs of normal and stressed rats, suggest that changes in the resistance of the host to tumour growth involve changes in cyclic nucleotide metabolism in the target tissues (tumour bed); possible mechanisms of action of cyclic nucleotides in this respect are discussed.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Van Den Brenk HA,Stone MG,Kelly H,Sharpington C

doi

10.1038/bjc.1976.7

subject

Has Abstract

pub_date

1976-01-01 00:00:00

pages

60-78

issue

1

eissn

0007-0920

issn

1532-1827

journal_volume

33

pub_type

杂志文章

相关文献

BRITISH JOURNAL OF CANCER文献大全
  • Therapy of human ovarian cancer xenografts with intraperitoneal liposome encapsulated muramyl-tripeptide phosphoethanolamine (MTP-PE) and recombinant GM-CSF.

    abstract：:Three intraperitoneal human ovarian cancer xenografts (OS, HU, and LA) were used to assess the antitumour activity of intraperitoneal therapy with liposome encapsulated MTP-PE. MTP-PE led to significant prolongation of survival in all three xenograft models, but with varying efficacy. In one tumour model (OS), 80% of ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1991.92

    authors： Malik ST,Martin D,Hart I,Balkwill F

    更新日期：1991-03-01 00:00:00

  • Immunosuppressive effects of radiation on human dendritic cells: reduced IL-12 production on activation and impairment of naive T-cell priming.

    abstract：:Dendritic cells (DC) are professional antigen-presenting cells (APC) of the immune system, uniquely able to prime naive T-cell responses. They are the focus of a range of novel strategies for the immunotherapy of cancer, a proportion of which include treating DC with ionising radiation to high dose. The effects of rad...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6602518

    authors： Merrick A,Errington F,Milward K,O'Donnell D,Harrington K,Bateman A,Pandha H,Vile R,Morrison E,Selby P,Melcher A

    更新日期：2005-04-25 00:00:00

  • Prognostic role of clinical, pathological and biological characteristics in patients with locally advanced breast cancer.

    abstract：:Forty-two patients with clinical stage IIIA or IIIB breast cancer were treated with neoadjuvant chemotherapy followed by mastectomy and radiotherapy. The median follow-up was 32 months (range 10-72 months) and the median time to progression was 17 months (range 10-30 months). A multivariate analysis showed that a long...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1998.99

    authors： Honkoop AH,van Diest PJ,de Jong JS,Linn SC,Giaccone G,Hoekman K,Wagstaff J,Pinedo HM

    更新日期：1998-02-01 00:00:00

  • Phase II study of rhizoxin in squamous cell head and neck cancer. The EORTC Early Clinical Trials Group.

    abstract：:To test the anti-tumour activity of rhizoxin in recurrent and/or metastatic squamous cell head and neck cancer, we performed a phase II study. Eligibility required histologically proven squamous cell head and neck cancer. Patients could only have received one prior chemotherapy. Patients were entered if WHO PS was < o...

    journal_title：British journal of cancer

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1038/bjc.1996.69

    authors： Verweij J,Wanders J,Gil T,Schöffski P,Catimel G,te Velde A,de Mulder PH

    更新日期：1996-02-01 00:00:00

  • The oncogenic potential of a combination of hyperthermia and chemotherapy agents.

    abstract：:The modulating effect of 43 degrees C hyperthermia on the induction of oncogenic transformation by the antineoplastic agents, actinomycin D, mitomycin C, and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) was examined using the C3H 10T1/2 cell line. For any given level of cytotoxicity, cells exposed to the three chemothe...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1988.9

    authors： Komatsu K,Miller RC,Hall EJ

    更新日期：1988-01-01 00:00:00

  • The cell-autonomous mechanisms underlying the activity of metformin as an anticancer drug.

    abstract：:The biguanide drug metformin profoundly affects cell metabolism, causing an impairment of the cell energy balance and triggering a plethora of pleiotropic effects that vary depending on the cellular or environmental context. Interestingly, a decade ago, it was observed that metformin-treated diabetic patients have a s...

    journal_title：British journal of cancer

    pub_type： 杂志文章,评审

    doi：10.1038/bjc.2016.385

    authors： Sacco F,Calderone A,Castagnoli L,Cesareni G

    更新日期：2016-12-06 00:00:00

  • Persistence to 5-year hormonal breast cancer therapy: a French national population-based study.

    abstract：BACKGROUND:Non-persistence to oral hormonal therapy (HT) in breast cancer (BC) is an emerging health issue, and estimations vary according to the population selected and/or the statistical method applied. This study aimed to estimate non-persistence over 5 years to HT in an unselected sample of women with BC using a Fr...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2016.276

    authors： Bosco-Lévy P,Jové J,Robinson P,Moore N,Fourrier-Réglat A,Bezin J

    更新日期：2016-10-11 00:00:00

  • Overexpression of the rhoC gene correlates with progression of ductal adenocarcinoma of the pancreas.

    abstract：:It has been reported that the rho genes, which consist of a ras-related small GTPase protein family, regulate cytoskeletal structures and have the potential to transform cultured cells. To investigate the biological relevance of the rho genes in pancreatic carcinogenesis, we examined expressions of the rhoA, B and C g...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1998.23

    authors： Suwa H,Ohshio G,Imamura T,Watanabe G,Arii S,Imamura M,Narumiya S,Hiai H,Fukumoto M

    更新日期：1998-01-01 00:00:00

  • Correlation of in vitro infiltration with glioma histological type in organotypic brain slices.

    abstract：:Diffuse invasion of the brain, an intrinsic property of gliomas, renders these tumours incurable, and is a principal determinant of their spatial and temporal growth. Knowledge of the invasive potential of gliomas is highly desired in order to understand their behaviour in vivo. Comprehensive ex vivo invasion studies ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6602048

    authors： Palfi S,Swanson KR,De Boüard S,Chrétien F,Oliveira R,Gherardi RK,Kros JM,Peschanski M,Christov C

    更新日期：2004-08-16 00:00:00

  • Nutrient stress alters the glycosylation status of LGR5 resulting in reduced protein stability and membrane localisation in colorectal tumour cells: implications for targeting cancer stem cells.

    abstract：BACKGROUND:LGR5 is an important marker of intestinal stem cells and performs its vital functions at the cell membrane. Despite the importance of LGR5 to both normal and cancer stem cell biology, it is not known how microenvironmental stress affects the expression and subcellular distribution of the protein. METHODS:Nu...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2015.4

    authors： Morgan RG,Molnár E,Jones RF,Collard TJ,Lane JD,Greenhough A,Paraskeva C,Williams AC

    更新日期：2015-02-17 00:00:00

  • NF-kappaB inhibition impairs the radioresponse of hypoxic EMT-6 tumour cells through downregulation of inducible nitric oxide synthase.

    abstract：:Hypoxic EMT-6 tumour cells displayed a high level of inducible nitric oxide synthase (iNOS) and an increased radiosensitivity after a 16 h exposure to lipopolysaccharide, a known activator of nuclear factor-kappaB (NF-kappaB). Both iNOS activation and radioresponse were impaired by the NF-kappaB inhibitors phenylarsin...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6600678

    authors： De Ridder M,Van den Berge DL,Verovski VN,Monsaert C,Wauters N,Storme GA

    更新日期：2003-01-13 00:00:00

  • Study of the antitumour effects and the modulation of immune response by histamine in breast cancer.

    abstract：BACKGROUND:The aim of this work was to improve the knowledge of the role of histamine in breast cancer by assessing the therapeutic efficacy of histamine and histamine H4 receptor (H4R) ligands in a triple-negative breast cancer (TNBC) model developed in immunocompetent hosts. By using publicly available genomic data, ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/s41416-019-0636-x

    authors： Nicoud MB,Sterle HA,Massari NA,Táquez Delgado MA,Formoso K,Herrero Ducloux MV,Martinel Lamas D,Cremaschi GA,Medina VA

    更新日期：2020-02-01 00:00:00

  • Inhibition of OATP1B1 by tyrosine kinase inhibitors: in vitro-in vivo correlations.

    abstract：BACKGROUND:Several tyrosine kinase inhibitors (TKIs) can decrease docetaxel clearance in patients by an unknown mechanism. We hypothesised that these interactions are mediated by the hepatic uptake transporter OATP1B1. METHODS:The influence of 16 approved TKIs on transport was studied in vitro using HEK293 cells expre...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2013.811

    authors： Hu S,Mathijssen RH,de Bruijn P,Baker SD,Sparreboom A

    更新日期：2014-02-18 00:00:00

  • Anti-Her-2/neu antibody induces apoptosis in Her-2/neu overexpressing breast cancer cells independently from p53 status.

    abstract：:Anti-Her-2/neu antibody is known to induce apoptosis in HER-2/neu overexpressing breast cancer cells. However, exact regulatory mechanisms mediating and controlling this phenomenon are still unknown. In the present study, we have investigated the effect of anti-Her-2/neu antibody on apoptosis of HER-2/neu overexpressi...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1054/bjoc.2001.2197

    authors： Brodowicz T,Kandioler D,Tomek S,Ludwig C,Rudas M,Kunstfeld R,Koestler W,Hejna M,Budinsky A,Wiltschke C,Zielinski CC

    更新日期：2001-11-30 00:00:00

  • Immunohistochemical expression of SKALP/elafin in squamous cell carcinoma of the oesophagus.

    abstract：:In this study, the immunohistochemical expression of a new inducible elastase inhibitor, SKALP (skin-derived anti-leucoproteinase)/elafin, in the tissue of squamous cell carcinoma and uninvolved oesophageal mucosa was studied using a polyclonal rabbit anti-serum against SKALP/elafin. The results were compared with the...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1997.511

    authors： Yamamoto S,Egami H,Kurizaki T,Ohmachi H,Hayashi N,Okino T,Shibata Y,Schalkwijk J,Ogawa M

    更新日期：1997-01-01 00:00:00

  • Effects of inoculation site and Matrigel on growth and metastasis of human breast cancer cells.

    abstract：:The co-injection of extracellular matrix components, such as Matrigel, with human tumour cells into nude mice has been reported to facilitate tumour formation and growth, but it is unknown whether such components exert similar effects on tumour progression and metastasis. Metastatic behaviour is known to be enhanced w...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1994.284

    authors： Bao L,Matsumura Y,Baban D,Sun Y,Tarin D

    更新日期：1994-08-01 00:00:00

  • ERCC1 is a prognostic biomarker in locally advanced head and neck cancer: results from a randomised, phase II trial.

    abstract：BACKGROUND:Cisplatin-radiotherapy is a preferred standard for locally advanced, head and neck squamous cell carcinoma (HNSCC). However, the cisplatin-attributable survival benefit is small and toxicity substantial. A biomarker of cisplatin resistance could guide treatment selection and spare morbidity. The ERCC1-XPF nu...

    journal_title：British journal of cancer

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/bjc.2013.576

    authors： Bauman JE,Austin MC,Schmidt R,Kurland BF,Vaezi A,Hayes DN,Mendez E,Parvathaneni U,Chai X,Sampath S,Martins RG

    更新日期：2013-10-15 00:00:00

  • Overall obesity, abdominal adiposity, diabetes and cigarette smoking in relation to the risk of pancreatic cancer in two Swedish population-based cohorts.

    abstract：:We examined the associations of body mass index (BMI), waist circumference, a history of diabetes, and cigarette smoking with risk of pancreatic cancer among 37,147 women and 45,906 men followed up during 560,666 person-years in the Swedish Mammography Cohort and the Cohort of Swedish Men; 136 incident cases of pancre...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6602868

    authors： Larsson SC,Permert J,Håkansson N,Näslund I,Bergkvist L,Wolk A

    更新日期：2005-11-28 00:00:00

  • Eight years of experience with vismodegib for advanced and multiple basal cell carcinoma patients in the Netherlands: a retrospective cohort study.

    abstract：BACKGROUND:Vismodegib has been used for the treatment of locally advanced basal cell carcinoma (laBCC) and metastatic BCC (mBCC) since 2011. Most efficacy and safety data are provided by clinical trials. This study evaluates the effectiveness of vismodegib for the treatment of laBCC, mBCC and basal cell nevus syndrome ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/s41416-020-01220-w

    authors： Verkouteren BJA,Wakkee M,Reyners AKL,Nelemans P,Aarts MJB,Rácz E,Terra JB,Devriese LA,Alers RJ,Kapiteijn E,van Doorn R,Bekkenk MW,Reinders MGHC,Mosterd K

    更新日期：2021-01-19 00:00:00

  • Indomethacin induces apoptosis via a MRP1-dependent mechanism in doxorubicin-resistant small-cell lung cancer cells overexpressing MRP1.

    abstract：:Small-cell lung cancers (SCLCs) initially respond to chemotherapy, but are often resistant at recurrence. The non-steroidal anti-inflammatory drug indomethacin is an inhibitor of multidrug resistance protein 1 (MRP1) function. The doxorubicin-resistant MRP1-overexpressing human SCLC cell line GLC(4)-Adr was highly sen...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6604010

    authors： de Groot DJ,van der Deen M,Le TK,Regeling A,de Jong S,de Vries EG

    更新日期：2007-10-22 00:00:00

  • Ewing sarcoma dissemination and response to T-cell therapy in mice assessed by whole-body magnetic resonance imaging.

    abstract：BACKGROUND:Novel treatment strategies in Ewing sarcoma include targeted cellular therapies. Preclinical in vivo models are needed that reflect their activity against systemic (micro)metastatic disease. METHODS:Whole-body magnetic resonance imaging (WB-MRI) was used to monitor the engraftment and dissemination of human...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2013.356

    authors： Liebsch L,Kailayangiri S,Beck L,Altvater B,Koch R,Dierkes C,Hotfilder M,Nagelmann N,Faber C,Kooijman H,Ring J,Vieth V,Rossig C

    更新日期：2013-08-06 00:00:00

  • Analysis of the cytochrome c-dependent apoptosis apparatus in cells from human pancreatic carcinoma.

    abstract：:Defects in the apoptotic system are likely to play a role in tumorigenesis. Pancreatic carcinoma cells are extremely resistant to apoptosis induction by chemotherapy suggesting that the apoptosis machinery is faulty. We investigated the integrity of the cytochrome c-dependent apoptotic apparatus in 10 human pancreatic...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6600171

    authors： Gerhard MC,Schmid RM,Häcker G

    更新日期：2002-03-18 00:00:00

  • An examination of the initial cancer consultation of medical and radiation oncologists using the Cancode interaction analysis system.

    abstract：:This study provides an analysis of the structure of the initial cancer consultation, the consultation styles of medical and radiation oncologists, and their effect on patient outcomes. One hundred and fifty-five cancer patients attending their first consultation with either a medical or radiation oncologist were audio...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6604348

    authors： Dimoska A,Butow PN,Dent E,Arnold B,Brown RF,Tattersall MH

    更新日期：2008-05-06 00:00:00

  • Survival and contralateral breast cancer in CHEK2 1100delC breast cancer patients: impact of adjuvant chemotherapy.

    abstract：BACKGROUND:We assessed the sensitivity to adjuvant chemotherapy in cell cycle checkpoint kinase 2 (CHEK2) vs non-CHEK2 breast cancer patients by comparing the contralateral breast cancer incidence and distant disease-free and breast cancer-specific survival between both groups, stratified for adjuvant chemotherapy. ME...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2014.306

    authors： Kriege M,Hollestelle A,Jager A,Huijts PE,Berns EM,Sieuwerts AM,Meijer-van Gelder ME,Collée JM,Devilee P,Hooning MJ,Martens JW,Seynaeve C

    更新日期：2014-08-26 00:00:00

  • Differential expression of translation-associated genes in benign and malignant human breast tumours.

    abstract：:The human gene sequences encoding the translation-associated functions of alpha-subunit of elongation factor 1 (EF-1 alpha) and the ubiquitin carboxyl extension protein (HUBCEP80) have been isolated by differential cDNA screening, and found to have significantly higher levels of expression in fibroadenomas (benign) co...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1992.12

    authors： Adams SM,Sharp MG,Walker RA,Brammar WJ,Varley JM

    更新日期：1992-01-01 00:00:00

  • Integrin α3 is overexpressed in glioma stem-like cells and promotes invasion.

    abstract：BACKGROUND:Glioma stem-like cell (GSC) properties are responsible for gliomagenesis and recurrence. GSCs are invasive but its mechanism remains to be elucidated. Here, we attempted to identify the molecules that promote invasion in GSCs. METHODS:Neurospheres and CD133⁺ cells were collected from glioblastoma (GBM) spec...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2013.218

    authors： Nakada M,Nambu E,Furuyama N,Yoshida Y,Takino T,Hayashi Y,Sato H,Sai Y,Tsuji T,Miyamoto KI,Hirao A,Hamada JI

    更新日期：2013-06-25 00:00:00

  • Assessing the benefit-risk of new treatments using generalised pairwise comparisons: the case of erlotinib in pancreatic cancer.

    abstract：BACKGROUND:Efficacy and safety are the two considerations when characterising the effects of a new therapy. We sought to apply an innovative method of assessing the benefit-risk balance using data from a completed randomised controlled trial that compared erlotinib vs placebo added to gemcitabine in patients with advan...

    journal_title：British journal of cancer

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/bjc.2015.55

    authors： Péron J,Roy P,Ding K,Parulekar WR,Roche L,Buyse M

    更新日期：2015-03-17 00:00:00

  • Combination chemotherapy in advanced gastrointestinal cancers: ex vivo sensitivity to gemcitabine and mitomycin C.

    abstract：:Advanced or metastatic disease is common in both oesophagogastric and colorectal cancers, with poor 5-year survival despite palliative chemotherapy. We have investigated the sensitivity of gastrointestinal tumours to gemcitabine in combination with mitomycin C (GeM), using a modified ex vivo ATP-based tumour chemosens...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6601403

    authors： Whitehouse PA,Mercer SJ,Knight LA,Di Nicolantonio F,O'Callaghan A,Cree IA,Portsmouth Upper GI and Colorectal Cancer Multidisciplinary Teams.

    更新日期：2003-12-15 00:00:00

  • TMPRSS4: an emerging potential therapeutic target in cancer.

    abstract：:Altered expression and activity of proteases is a key event in cancer, particularly in relation to invasion, modification of the extracellular matrix and metastasis. The transmembrane protease, serine 4 (TMPRSS4) is closely related to other cancer-associated proteases, such as hepsin, TMPRSS2 and matriptase. We review...

    journal_title：British journal of cancer

    pub_type： 杂志文章,评审

    doi：10.1038/bjc.2014.403

    authors： de Aberasturi AL,Calvo A

    更新日期：2015-01-06 00:00:00

  • Lipoprotein lipase is frequently overexpressed or translocated in cervical squamous cell carcinoma and promotes invasiveness through the non-catalytic C terminus.

    abstract：BACKGROUND:We studied the biological significance of genes involved in a novel t(8;12)(p21.3;p13.31) reciprocal translocation identified in cervical squamous cell carcinoma (SCC) cells. METHODS:The rearranged genes were identified by breakpoint mapping, long-range PCR and sequencing. We investigated gene expression in...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2012.301

    authors： Carter SA,Foster NA,Scarpini CG,Chattopadhyay A,Pett MR,Roberts I,Coleman N

    更新日期：2012-08-07 00:00:00