Anti-Her-2/neu antibody induces apoptosis in Her-2/neu overexpressing breast cancer cells independently from p53 status.

abstract：BACKGROUND:The target substrates of DNA mismatch recognising factors MutSalpha (MSH2+MSH6) and MutSbeta (MSH2+MSH3) have already been widely researched. However, the extent of their functional redundancy and clinical substance remains unclear. Mismatch repair (MMR)-deficient tumours are strongly associated with microsa...

journal_title：British journal of cancer

authors： Kantelinen J,Kansikas M,Korhonen MK,Ollila S,Heinimann K,Kariola R,Nyström M

更新日期：2010-03-16 00:00:00

abstract：:The Rac-specific guanine nucleotide exchange factor, Tiam1, plays a major role in oncogenicity, tumour invasion and metastasis but its usefulness as a prognostic marker in human cancer has not been tested yet. In the present study, Tiam1 expression was analysed in benign secretory epithelium, pre-neoplastic high-grade...

journal_title：British journal of cancer

authors： Engers R,Mueller M,Walter A,Collard JG,Willers R,Gabbert HE

更新日期：2006-10-23 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) gene mutations and increased copy numbers are considered as predictors of response to EGFR tyrosine kinase inhibitors (EGFR-TKI) in non-small-cell lung cancer (NSCLC). Lung cancer diagnosis is often based on cytology alone. However, almost all published data on EGFR gene analyse...

journal_title：British journal of cancer

authors： Savic S,Tapia C,Grilli B,Rufle A,Bihl MP,de Vito Barascud A,Herzog M,Terracciano L,Baty F,Bubendorf L

更新日期：2008-01-15 00:00:00

abstract：BACKGROUND:Multiple myeloma is a plasma cell disorder that is characterised by clonal proliferation of malignant plasma cells in the bone marrow, monoclonal paraprotein in the blood or urine and associated organ dysfunction. It accounts for approximately 1% of cancers and 13% of haematological cancers. Myeloma arises f...

journal_title：British journal of cancer

authors： Jones CI,Zabolotskaya MV,King AJ,Stewart HJ,Horne GA,Chevassut TJ,Newbury SF

更新日期：2012-12-04 00:00:00

abstract：:The purpose of this study was to evaluate the occurrence of lymphatic drainage to non-axillary sentinel nodes and to determine the implications of this phenomenon. A total of 549 breast cancer patients underwent lymphoscintigraphy after intratumoural injection of (99m)Tc-nanocolloid. The sentinel node was intraoperati...

journal_title：British journal of cancer

authors： Tanis PJ,Nieweg OE,Valdés Olmos RA,Peterse JL,Rutgers EJ,Hoefnagel CA,Kroon BB

更新日期：2002-09-23 00:00:00

abstract：:Over the period 1966-1995, based on 11,662 patients, the incidence of squamous cell carcinoma of the skin increased three to four times in Norway mainly as a result of an increased number of localized tumours. In men, cancer of the auricle was the second most common site; in women the incidence was low. ...

journal_title：British journal of cancer

authors： Iversen T,Tretli S

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND:The percentage of tumour stroma (TSP) has recently been reported to be a novel independent predictor of outcome in patients with a variety of common solid organ tumours. The aim of this study was to examine the relationship between TSP, clinicopathological characteristics and outcome in patients with invasiv...

journal_title：British journal of cancer

authors： Gujam FJ,Edwards J,Mohammed ZM,Going JJ,McMillan DC

更新日期：2014-07-08 00:00:00

abstract：:A series of 176 archival cervical intraepithelial neoplasia (CIN) was analysed for the presence, viral load and integration status of 'high-risk' types of human papillomavirus (HR-HPV). The samples were assayed using newly developed methods based on real-time PCR. Two methods for the extraction of DNA from the paraffi...

journal_title：British journal of cancer

authors： Andersson S,Safari H,Mints M,Lewensohn-Fuchs I,Gyllensten U,Johansson B

更新日期：2005-06-20 00:00:00

abstract：:Delays in cancer diagnosis and treatment due to the COVID-19 pandemic is a widespread source of concern, but the scale of the challenge for different tumour sites is not known. Routinely collected NHS England Cancer Waiting Time data were analysed to compare activity for breast cancer in the first 6 months of 2020 com...

journal_title：British journal of cancer

authors： Gathani T,Clayton G,MacInnes E,Horgan K

更新日期：2020-11-30 00:00:00

abstract：BACKGROUND:HOX transcript antisense RNA (HOTAIR), which is expressed from the homebox C gene (HOXC) locus, is capable of reprogramming chromatin organisation and promoting cancer cell metastasis and can simultaneously bind the polycomb repressive complex 2, which enhances H3K27 trimethylation, and the LSD1-CoREST-REST ...

journal_title：British journal of cancer

authors： Li X,Wu Z,Mei Q,Li X,Guo M,Fu X,Han W

更新日期：2013-10-15 00:00:00

abstract：BACKGROUND:A major molecular pathway of genetic instability in cancer is DNA mismatch repair deficiency. High-level microsatellite instability (MSI-H) is currently the best predictor of responsiveness towards immune checkpoint blockade. Data about the prevalence of high-level microsatellite instability in cholangiocarc...

journal_title：British journal of cancer

authors： Goeppert B,Roessler S,Renner M,Singer S,Mehrabi A,Vogel MN,Pathil A,Czink E,Köhler B,Springfeld C,Pfeiffenberger J,Rupp C,Weiss KH,Schirmacher P,von Knebel Doeberitz M,Kloor M

更新日期：2019-01-01 00:00:00

abstract：:A urinary gonadotrophin peptide (UGP) was isolated and purified from semi-purified human chorionic gonadotrophin (hCG), prepared from pregnancy urine. The peptide showed hCG-B subunit activity and no hCG-alpha subunit activity as demonstrated by binding studies with the relevant antibodies. It had a molecular weight s...

journal_title：British journal of cancer

authors： Kardana A,Taylor ME,Southall PJ,Boxer GM,Rowan AJ,Bagshawe KD

更新日期：1988-09-01 00:00:00

abstract：:The oestrogen receptor (RE) status of the primary tumour has been assessed in 466 of a consecutive series of 550 patients with primary operable breast cancer. All patients were followed up (without treatment) until the development of recurrence or metastases. Distant metastases have so far occurred in 124 patients and...

journal_title：British journal of cancer

authors： Campbell FC,Blamey RW,Elston CW,Nicholson RI,Griffiths K,Haybittle JL

更新日期：1981-09-01 00:00:00

abstract：:There is increasing evidence that essential fatty acids (EFA) may have a role to play in the aetiology of some types of cancer although their precise mode of action is unknown. Differences in the metabolism of EFA between patients with benign or malignant prostatic disease may help to elucidate their role in the latte...

journal_title：British journal of cancer

authors： Chaudry A,McClinton S,Moffat LE,Wahle KW

更新日期：1991-12-01 00:00:00

abstract：:NIH3T3 cells transfected with c-H-ras and/or c-myc genes were examined for differences in drug sensitivity. The five transfectants used were N8, NIH3T3-nm-1, pT22-3-nm-2, pP1-4 and pT22-3. They were transfected with pKOneo alone, pKOneo and c-myc, pKOneo and c-myc plus activated c-H-ras, normal c-H-ras and activated c...

journal_title：British journal of cancer

authors： Niimi S,Nakagawa K,Yokota J,Tsunokawa Y,Nishio K,Terashima Y,Shibuya M,Terada M,Saijo N

更新日期：1991-02-01 00:00:00

abstract：:Piwi proteins and their interaction with piRNAs have rapidly emerged as important contributors to gene regulation, indicating their crucial function in germline and stem cell development. However, data on the Hiwi 1 (Hiwi) gene, one of the four human Piwi homologues, are still scarce. Therefore, we investigated the Hi...

journal_title：British journal of cancer

authors： Grochola LF,Greither T,Taubert H,Möller P,Knippschild U,Udelnow A,Henne-Bruns D,Würl P

更新日期：2008-10-07 00:00:00

abstract：BACKGROUND:Epithelial-to-mesenchymal transition (EMT) enhances motility, stemness, chemoresistance and metastasis. Little is known about how various pathways coordinate to elicit EMT's different functional aspects in non-small cell lung cancer (NSCLC). Thymidylate synthase (TS) has been previously correlated with EMT t...

journal_title：British journal of cancer

authors： Siddiqui MA,Gollavilli PN,Ramesh V,Parma B,Schwab A,Vazakidou ME,Natesan R,Saatci O,Rapa I,Bironzo P,Schuhwerk H,Asangani IA,Sahin O,Volante M,Ceppi P

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:The accuracy of prostate-specific antigen (PSA) testing in prostate cancer detection is constrained by low sensitivity and specificity. Dysregulated expression of minichromosome maintenance (Mcm) 2-7 proteins is an early event in epithelial multistep carcinogenesis and thus MCM proteins represent powerful ca...

journal_title：British journal of cancer

authors： Dudderidge TJ,Kelly JD,Wollenschlaeger A,Okoturo O,Prevost T,Robson W,Leung HY,Williams GH,Stoeber K

更新日期：2010-08-24 00:00:00

abstract：:The Type 1 family of growth factor receptors includes epidermal growth factor receptor (EGFR), c-erbB-2, c-erbB-3 and c-erbB-4. Overexpression of the first two members is associated with poorer prognosis in patients with breast carcinoma. In this study we examined the expression of c-erbB-4 protein using the monoclona...

journal_title：British journal of cancer

authors： Kew TY,Bell JA,Pinder SE,Denley H,Srinivasan R,Gullick WJ,Nicholson RI,Blamey RW,Ellis IO

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:First Spanish trial of Ewing sarcoma (ES) including adults and children with the aim to test the efficacy of Gemcitabine and Docetaxel (G/D) in newly diagnosed high-risk (HR) patients. METHODS:This was a prospective, multicentric, non-randomised, open study for patients ⩽40 years with newly diagnosed ES. HR...

journal_title：British journal of cancer

authors： Mora J,Castañeda A,Perez-Jaume S,Lopez-Pousa A,Maradiegue E,Valverde C,Martin-Broto J,Garcia Del Muro X,Cruz O,Cruz J,Martinez-Trufero J,Maurel J,Vaz MA,de Alava E,de Torres C

更新日期：2017-09-05 00:00:00

abstract：:Caffeine has for many years been known to be involved in the sensitization of DNA to damage. One potential mechanism recently put forward is an override of the G2/M block induced by irradiation, which would leave the cells less time for DNA repair prior to mitosis. However, different cell types display a variety of re...

journal_title：British journal of cancer

authors： Deplanque G,Vincent F,Mah-Becherel MC,Cazenave JP,Bergerat JP,Klein-Soyer C

更新日期：2000-08-01 00:00:00

abstract：:The aim of the study is to assess the value of carbonic anhydrase isozyme IX (CA IX) expression as a predictor of disease-free survival (DFS) and disease-specific survival (DSS) in rectal cancer treated by preoperative radio- or chemoradiotherapy or surgery only. Archival tumour samples from 166 patients were analysed...

journal_title：British journal of cancer

authors： Korkeila E,Talvinen K,Jaakkola PM,Minn H,Syrjänen K,Sundström J,Pyrhönen S

更新日期：2009-03-24 00:00:00

abstract：:A mini-review of the literature concerning epigenetic gene regulation in cancer. ...

journal_title：British journal of cancer

authors： Malik K,Brown KW

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND:The human epidermal growth factor receptor (EGFR) is an important therapeutic target in oncology, and three different types of EGFR inhibitors have been approved for the treatment of cancer patients. However, there has been no clear association between the expression levels of EGFR protein in the tumours det...

journal_title：British journal of cancer

authors： Modjtahedi H,Khelwatty SA,Kirk RS,Seddon AM,Essapen S,Del Vecchio CA,Wong AJ,Eccles S

更新日期：2012-02-28 00:00:00

abstract：:In order to elucidate the clinical significance of the erbB family, epidermal growth factor receptor (EGF-R), c-erbB-2, c-erbB-3 and c-erbB-4 in hepatocellular carcinoma (HCC), we investigated the expression of these proteins by means of immunohistochemistry for HCC as well as adjacent noncancerous lesions. EGF-R was ...

journal_title：British journal of cancer

authors： Ito Y,Takeda T,Sakon M,Tsujimoto M,Higashiyama S,Noda K,Miyoshi E,Monden M,Matsuura N

更新日期：2001-05-18 00:00:00

abstract：BACKGROUND:Gestational trophoblastic diseases (GTDs) are related to trophoblasts, and human chorionic gonadotropin (hCG) is secreted by GTDs as well as normal placentas. However, the asparagine-linked sugar chains on hCG contain abnormal biantennary structures in invasive mole and choriocarcinoma, but not normal pregna...

journal_title：British journal of cancer

authors： Niimi K,Yamamoto E,Fujiwara S,Shinjo K,Kotani T,Umezu T,Kajiyama H,Shibata K,Ino K,Kikkawa F

更新日期：2012-12-04 00:00:00

abstract：:Imaging has an essential role in the planning and delivery of radiotherapy. Recent advances in imaging have led to the development of advanced radiotherapy techniques-including image-guided radiotherapy, intensity-modulated radiotherapy, stereotactic body radiotherapy and proton beam therapy. The optimal use of imagin...

journal_title：British journal of cancer

authors： Beaton L,Bandula S,Gaze MN,Sharma RA

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Gram-negative bacteria mediated gemcitabine resistance in pre-clinical models. We determined if intratumoural lipopolysaccharide (LPS) detection by immunohistochemistry is associated with outcome in advanced pancreatic ductal adenocarcinoma (PDAC) treated with gemcitabine and non-gemcitabine containing 1st-l...

journal_title：British journal of cancer

authors： Guenther M,Haas M,Heinemann V,Kruger S,Westphalen CB,von Bergwelt-Baildon M,Mayerle J,Werner J,Kirchner T,Boeck S,Ormanns S

更新日期：2020-10-01 00:00:00

abstract：:Up to 60% of gastro-oesophageal junction (GEJ) adenocarcinomas show nuclear beta-catenin expression, pointing to activated T-cell factor (TCF)/beta-catenin-driven gene transcription. We demonstrate in five human GEJ adenocarcinoma cell lines that nuclear beta-catenin expression indeed correlates with enhanced TCF-medi...

journal_title：British journal of cancer

authors： Koppert LB,van der Velden AW,van de Wetering M,Abbou M,van den Ouweland AM,Tilanus HW,Wijnhoven BP,Dinjens WN

更新日期：2004-02-23 00:00:00

abstract：:Although most colorectal cancer develops based on the adenoma-adenocarcinoma sequence, morphologically, colorectal cancer is not a homogeneous disease entity. Generally, there are two distinct morphological types: polypoid and ulcerative colorectal tumours. Previous studies have demonstrated that K-ras codon 12 mutati...

journal_title：British journal of cancer

authors： Chiang JM,Chou YH,Chen TC,Ng KF,Lin JL

更新日期：2002-04-08 00:00:00