Epigenetic gene deregulation in cancer.

abstract：BACKGROUND:The Nottinghamshire Lymphoma Registry contains the details of all the patients diagnosed with lymphoma (since 1 January 1973) within a defined geographical area with a population of 1.1 million. It was therefore possible to study the outcome of treatment for Hodgkin's disease for three 10-year cohorts (1973-...

journal_title：British journal of cancer

authors： Bessell EM,Bouliotis G,Armstrong S,Baddeley J,Haynes AP,O'Connor S,Nicholls-Elliott H,Bradley M

更新日期：2012-07-24 00:00:00

abstract：:To design hybrid tumour necrosis factor-alpha (TNF-alpha) applicable to systemic anti-tumour therapeutic use, we assessed the relationships among the molecular size of hybrid TNF-alpha, in vitro bioactivity and in vivo anti-tumour potency. Natural human TNF-alpha was covalently modified with polyethylene glycol (PEG) ...

journal_title：British journal of cancer

authors： Tsutsumi Y,Tsunoda S,Kamada H,Kihira T,Nakagawa S,Kaneda Y,Kanamori T,Mayumi T

更新日期：1996-10-01 00:00:00

abstract：:TNF-related apoptosis-inducing ligand (TRAIL, also known as Apo-2L) is a promising novel anticancer agent that selectively induces apoptosis in tumour cells and the activity of which can be enhanced by combined treatment with chemo- or radiotherapy. For therapeutic purposes, the use of full-length TRAIL may be favoura...

journal_title：British journal of cancer

authors： Abou El Hassan MA,Mastenbroek DC,Gerritsen WR,Giaccone G,Kruyt FA

更新日期：2004-07-05 00:00:00

abstract：BACKGROUND:Lapatinib, a dual EGFR and HER2 inhibitor has shown disappointing results in clinical trials of metastatic oesophago-gastric adenocarcinomas (OGAs), and in vitro studies suggest that MET, IGFR, and HER3 confer resistance. This trial applied Lapatinib in the curative neoadjuvant setting and investigated the f...

journal_title：British journal of cancer

authors： De Silva N,Schulz L,Paterson A,Qain W,Secrier M,Godfrey E,Cheow H,O'Donovan M,Lao-Sirieix P,Jobanputra M,Hochhauser D,Fitzgerald R,Ford H

更新日期：2015-11-03 00:00:00

abstract：:A recent study showed an association between a single base substitution, T-->C, in the promotor region of the CYP17 gene, the risk of breast cancer and age at menarche in Asian, African-American and Latino women from California and Hawaii. The C allele was associated with increased risk of breast cancer, significantly...

journal_title：British journal of cancer

authors： Dunning AM,Healey CS,Pharoah PD,Foster NA,Lipscombe JM,Redman KL,Easton DF,Day NE,Ponder BA

更新日期：1998-06-01 00:00:00

abstract：:Angiopoietin-1 is a promoter of physiological vasculogenesis and angiogenesis because it induces vascular branching and smooth muscle recruitment to newly formed blood vessels. However, angiopoietin-1 expression in tumours appears to be uncommon, and angiopoietin-1 overexpression in cancer cells has been reported to l...

journal_title：British journal of cancer

authors： Tian S,Hayes AJ,Metheny-Barlow LJ,Li LY

更新日期：2002-02-12 00:00:00

abstract：BACKGROUND:Platinum-based doublet chemotherapy is the standard first-line treatment for advanced non-small cell lung cancer (NSCLC), but earlier studies have suggested that non-platinum combinations are equally effective and better tolerated. We conducted a national, randomised study to compare a non-platinum with a pl...

journal_title：British journal of cancer

authors： Fløtten Ø,Grønberg BH,Bremnes R,Amundsen T,Sundstrøm S,Rolke H,Hornslien K,Wentzel-Larsen T,Aasebø U,von Plessen C

更新日期：2012-07-24 00:00:00

abstract：:This study reports on the frequency and disease association pattern of a number of gene rearrangements in a large panel of lymphoid tumours (n = 94). We detected the t(11;14) translocation, involving rearrangement of the BCL-1 locus, in 60% of mantle cell lymphomas. The BCL-2 gene, located at band 18q21, was rearrange...

journal_title：British journal of cancer

authors： Butler M,Corbally N,Dervan PA,Carney DN

更新日期：1997-01-01 00:00:00

abstract：:Loss of cell cycle control through the structural or functional aberration of checkpoint genes and their products is a potentially important process in carcinogenesis. In this study, a panel of well-characterised established human bladder cancer cell lines was screened by the polymerase chain reaction for homozygous l...

journal_title：British journal of cancer

authors： Southgate J,Proffitt J,Roberts P,Smith B,Selby P

更新日期：1995-11-01 00:00:00

abstract：:Twenty patients with non-Hodgkin's lymphoma were treated with a combination of cyclophosphamide (750 mg m(-2), day 1), epidoxorubicin (60 mg m(-2), day 1), vincristine (1.4 mg m(-2), day 1) and prednisone (100 mg m(-2), days 1-5) every 14 days. Shortening of intervals was associated with the prophylactic employment of...

journal_title：British journal of cancer

authors： Pronzato P,Lionetto R,Botto F,Pensa F,Tognoni A

更新日期：1998-09-01 00:00:00

abstract：:Women with gross cystic breast disease may have an increased risk of breast cancer. In this study the ability of breast cyst fluid (BCF), obtained from British or Hungarian women, to modulate oestrone sulphate (E1S) formation or hydrolysis, has been examined. For this, oestrogen receptor-positive (ER+) MCF-7 or MDA-MB...

journal_title：British journal of cancer

authors： Purohit A,Budai B,Wang DY,Willemsen EL,de Winkel A,Parish D,Ghilchik MW,Szamel I,Reed MJ

更新日期：2000-01-01 00:00:00

abstract：:The 62 kDa protein product of the c-myc oncogene (p62 c-myc) is thought to be involved in the control of normal cellular proliferation and differentiation. We have measured oncoprotein levels using a flow cytometric assay in 141 operable breast cancers and have correlated levels with prognostic variables, patient surv...

journal_title：British journal of cancer

authors： Locker AP,Dowle CS,Ellis IO,Elston CW,Blamey RW,Sikora K,Evan G,Robins RA

更新日期：1989-11-01 00:00:00

abstract：:In the UK, 10% of patients diagnosed with rectal cancer have inoperable disease at presentation. This study ascertained whether the resectability rate of inoperable locally advanced rectal cancer was improved by administration of intravenous irinotecan, 5-fluorouracil (5-FU) and pelvic radiotherapy. During phase I of ...

journal_title：British journal of cancer

authors： Iles S,Gollins S,Susnerwala S,Haylock B,Myint S,Biswas A,Swindell R,Levine E

更新日期：2008-04-08 00:00:00

abstract：:In 1977 a number of patients with soft-tissue sarcomas and previous exposure to phenoxyacetic acids were described. Following from these observations a matched case-control study was made. Exposure to chlorophenols was also included in this study. The results showed that exposure to phenoxyacetic acids or chlorophenol...

journal_title：British journal of cancer

authors： Hardell L,Sandström A

更新日期：1979-06-01 00:00:00

abstract：:To investigate the association between medullary carcinoma of the thyroid (MCT) and carcinoembryonic antigen (CEA), we assayed 78 sera from patients with thyroid diseases for CEA, employing the radioimmunoassay of double antibody technique. All 13 sera from patients with MCT had high levels of CEA, ranging from 14 to ...

journal_title：British journal of cancer

authors： Ishikawa N,Hamada S

更新日期：1976-08-01 00:00:00

abstract：:In a case-control study, we investigated 169 women aged 15-49 years with malignant melanoma notified to the Oxford and South Western cancer registries during the years 1971-1976, together with 507 matched controls. Data about medical, reproductive, drug and smoking histories were obtained both by reviewing general pra...

journal_title：British journal of cancer

authors： Adam SA,Sheaves JK,Wright NH,Mosser G,Harris RW,Vessey MP

更新日期：1981-07-01 00:00:00

abstract：:Short-term cultures from one synovial chondroma and three cases of synovial chondromatosis, a lesion for which no previous karyotypic information exists, were cytogenetically analysed. Whereas the chondroma displayed the relatively simple karyotype 46,XY,add(12)(q13),der(17)t(12;17)(q13;q21), more complex changes were...

journal_title：British journal of cancer

authors： Mertens F,Jonsson K,Willén H,Rydholm A,Kreicbergs A,Eriksson L,Olsson-Sandin G,Mitelman F,Mandahl N

更新日期：1996-07-01 00:00:00

abstract：:We have studied the cytotoxic effects of recombinant tumour necrosis factor and recombinant gamma interferon on primary cultures of leukaemia cells. The agents were added alone or in a combination to cells from 17 patients. Eleven had acute myeloblastic leukaemia (6 at presentation, 5 at relapse), 4 had acute lymphobl...

journal_title：British journal of cancer

authors： Price G,Brenner MK,Prentice HG,Hoffbrand AV,Newland AC

更新日期：1987-03-01 00:00:00

abstract：BACKGROUND:Glomerular filtration rate (GFR) is used in the calculation of carboplatin dose. Glomerular filtration rate is measured using a radioisotope method (radionuclide GFR (rGFR)), however, estimation equations are available (estimated GFR (eGFR)). Our aim was to assess the accuracy of three eGFR equations and the...

journal_title：British journal of cancer

authors： Craig AJ,Samol J,Heenan SD,Irwin AG,Britten A

更新日期：2012-10-09 00:00:00

abstract：:It has been postulated that paternal gonadal exposure would increase the sex ratio by inducing X-chromosomal dominant lethals but that maternal gonadal exposure would decrease the sex ratio by inducing recessive sex-linked lethals. We therefore evaluated the sex ratio (male-to-female ratio) of children born to survivo...

journal_title：British journal of cancer

authors： Winther JF,Boice JD Jr,Thomsen BL,Schull WJ,Stovall M,Olsen JH

更新日期：2003-02-10 00:00:00

abstract：:A partially purified fraction of the water soluble photosensitive dye sulphonated aluminium phthalocyanine (AlSPc) was encapsulated in liposomes which were then linked to a targeting monoclonal antibody 791T/36 using a heterobifunctional linking agent. The photocytotoxic effects of the liposomes were determined on two...

journal_title：British journal of cancer

authors： Morgan J,Gray AG,Huehns ER

更新日期：1989-03-01 00:00:00

abstract：:We have previously shown that epidermal growth factor (EGF) enhances the in vitro and in vivo sensitivity of human ovarian carcinoma 2008 cells to cisplatin. EGF was found to enhance selectively the in vivo toxicity of cisplatin to 2008 cell xenografts without altering the toxicity of cisplatin to non-malignant target...

journal_title：British journal of cancer

authors： Kröning R,Jones JA,Hom DK,Chuang CC,Sanga R,Los G,Howell SB,Christen RD

更新日期：1995-09-01 00:00:00

abstract：:In a phase I study of weekly administered cisplatin combined with oral etoposide, we observed a partial response in 4 out of 11 patients with metastatic colorectal cancer. Subsequently, we performed a phase II study to investigate the activity of this combination as first-line treatment in this disease. Fourteen patie...

journal_title：British journal of cancer

authors： Planting AS,van der Burg ME,van den Bent MJ,de Boer-Dennert M,Stoter G,Verweij J

更新日期：1996-05-01 00:00:00

abstract：:Lung cancer is the primary cause of cancer mortality in developed countries. First diagnosis only when disease has already reached the metastatic phase is the main reason for failure in treatment. To this regard, although low-dose spiral computed tomography (CT) has proven to be effective in the early detection of lun...

journal_title：British journal of cancer

authors： Pastorino U

更新日期：2010-06-08 00:00:00

abstract：:To test the hypothesis that high levels of endogenous oestrogens increase the risk for developing breast cancer, concentrations of oestrone, oestradiol and oestriol were measured in 24 h urine samples from 1000 women participants in a prospective study of breast cancer on the island of Guernsey. Sixty-nine subjects we...

journal_title：British journal of cancer

authors： Key TJ,Wang DY,Brown JB,Hermon C,Allen DS,Moore JW,Bulbrook RD,Fentiman IS,Pike MC

更新日期：1996-06-01 00:00:00

abstract：:Spontaneous and radiation-induced genetic instability of peripheral blood mononuclear cells derived from unselected breast cancer (BC) patients (n=50) was examined using the single-cell gel electrophoresis (Comet) assay and a modified G2 micronucleus (MN) test. Cells from apparently healthy donors (n=16) and from canc...

journal_title：British journal of cancer

authors： Djuzenova CS,Mühl B,Fehn M,Oppitz U,Müller B,Flentje M

更新日期：2006-04-24 00:00:00

abstract：:Previous studies have shown that multidrug resistance (MDR) in the doxorubicin-selected lung tumour cell lines COR-L23/R, GLC4/ADR and MOR/R is associated with overexpression of the MRP gene. In this study we report that resistance to daunorubicin, vincristine and rhodamine 123 can be partially reversed in these cell ...

journal_title：British journal of cancer

authors： Versantvoort CH,Broxterman HJ,Bagrij T,Scheper RJ,Twentyman PR

更新日期：1995-07-01 00:00:00

abstract：:Prostate-specific antigen (PSA) is a serine protease secreted at low levels by normal luminal epithelial cells of the prostate and in significantly higher levels by prostate cancer cells. Therefore, PSA is a potential target for various immunotherapeutical approaches against prostate cancer. DNA vaccination has been i...

journal_title：British journal of cancer

authors： Pavlenko M,Roos AK,Lundqvist A,Palmborg A,Miller AM,Ozenci V,Bergman B,Egevad L,Hellström M,Kiessling R,Masucci G,Wersäll P,Nilsson S,Pisa P

更新日期：2004-08-16 00:00:00

abstract：:The cancer vaccine 105AD7 is an anti-idiotypic monoclonal antibody that mimics the tumour-associated antigen 791T/gp72 (CD55, Decay Accelerating Factor) on colorectal cancer cells. Phase I studies in patients with advanced disease confirmed that 105AD7 is non-toxic, and that T cell responses could be generated. A pros...

journal_title：British journal of cancer

authors： Maxwell-Armstrong CA,Durrant LG,Buckley TJ,Scholefield JH,Robins RA,Fielding K,Monson JR,Guillou P,Calvert H,Carmichael J,Hardcastle JD

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND:Early detection of non-small-cell lung cancer (NSCLC) and accurate prognostic risk assessment could improve patient outcome. We examined the significance of urinary N(1), N(12)-diacetylspermine (DiAcSpm) in the detection and prognostic stratification of NSCLC patients. METHODS:A DiAcSpm/cutoff ratio (DASr) ...

journal_title：British journal of cancer

authors： Takahashi Y,Sakaguchi K,Horio H,Hiramatsu K,Moriya S,Takahashi K,Kawakita M

更新日期：2015-11-17 00:00:00