Oestrogen-receptor status and sites of metastasis in breast cancer.

abstract：BACKGROUND:The aim of this work was to improve the knowledge of the role of histamine in breast cancer by assessing the therapeutic efficacy of histamine and histamine H4 receptor (H4R) ligands in a triple-negative breast cancer (TNBC) model developed in immunocompetent hosts. By using publicly available genomic data, ...

journal_title：British journal of cancer

authors： Nicoud MB,Sterle HA,Massari NA,Táquez Delgado MA,Formoso K,Herrero Ducloux MV,Martinel Lamas D,Cremaschi GA,Medina VA

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Around 60% of women ≥ 80 years old, in the UK do not have surgery for their breast cancer (vs<10% of younger age groups). The extent to which this difference can be accounted for by co-morbidity has not been established. METHODS:A Cancer Registry/Hospital Episode Statistics-linked data set identified women ...

journal_title：British journal of cancer

authors： Lavelle K,Downing A,Thomas J,Lawrence G,Forman D,Oliver SE

更新日期：2012-09-25 00:00:00

abstract：:We evaluated whether social deprivation affected decision-making for breast cancer surgery. Of 3419 patients, 53.6% had mastectomy and this was predicted by deprivation, age, tumour size and hospital, all of which retained significance on multivariate analysis, except deprivation. Pathological characteristics and surg...

journal_title：British journal of cancer

authors： Henley NC,Hole DJ,Kesson E,Burns HJ,George WD,Cooke TG

更新日期：2005-02-28 00:00:00

abstract：:Oral capecitabine is a highly active, well-tolerated and convenient treatment for breast and colorectal cancer. This trial assessed the efficacy and safety of single-agent capecitabine in patients with previously treated ovarian cancer. A total of 29 patients with platinum-pretreated relapsed ovarian cancer were enrol...

journal_title：British journal of cancer

authors： Vasey PA,McMahon L,Paul J,Reed N,Kaye SB

更新日期：2003-11-17 00:00:00

abstract：:Palliative chemotherapy for inoperable/metastatic oesophageal cancer has limited activity. This study assesses the feasibility and activity of gemcitabine and cisplatin in this group of patients. In total, 42 patients with locally advanced/metastatic squamous or adenocarcinoma of the oesophagus were treated with gemci...

journal_title：British journal of cancer

authors： Millar J,Scullin P,Morrison A,McClory B,Wall L,Cameron D,Philips H,Price A,Dunlop D,Eatock M

更新日期：2005-11-14 00:00:00

abstract：:To test the hypothesis that high levels of endogenous oestrogens increase the risk for developing breast cancer, concentrations of oestrone, oestradiol and oestriol were measured in 24 h urine samples from 1000 women participants in a prospective study of breast cancer on the island of Guernsey. Sixty-nine subjects we...

journal_title：British journal of cancer

authors： Key TJ,Wang DY,Brown JB,Hermon C,Allen DS,Moore JW,Bulbrook RD,Fentiman IS,Pike MC

更新日期：1996-06-01 00:00:00

abstract：:A human tamoxifen-resistant mammary carcinoma, MaCa 3366/TAM, originating from a sensitive parental xenograft 3366 was successfully established by treatment of tumour-bearing nude mice with 1-50 mg kg(-1) tamoxifen for 3 years during routine passaging. Both tumours did not differ significantly in OR- and PR-positivity...

journal_title：British journal of cancer

authors： Naundorf H,Becker M,Lykkesfeldt AE,Elbe B,Neumann C,Büttner B,Fichtner I

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND:The recognition that cancer is not a single entity, rather that different cancers have different causes and trajectories, has been a key development in the scientific understanding of cancer. However, little is known about the British public's awareness of differences between cancers. This study examined dif...

journal_title：British journal of cancer

authors： Whitaker KL,Simon AE,Beeken RJ,Wardle J

更新日期：2012-06-05 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) is the third most common cancer worldwide. Accurately identifying stage II CRC patients at risk for recurrence is an unmet clinical need. KCNQ1 was previously identified as a tumour suppressor gene and loss of expression was associated with poor survival in patients with CRC liver met...

journal_title：British journal of cancer

authors： den Uil SH,Coupé VM,Linnekamp JF,van den Broek E,Goos JA,Delis-van Diemen PM,Belt EJ,van Grieken NC,Scott PM,Vermeulen L,Medema JP,Bril H,Stockmann HB,Cormier RT,Meijer GA,Fijneman RJ

更新日期：2016-12-06 00:00:00

abstract：:Within a population-based cohort study, 40,708 men aged 45-79 years followed from 1998 to 2004. After adjusting for potential confounders, we observed a strong inverse linear association between total daily physical activity (PA) and death from cancer (n=1153). For each increment of 4 metabolic equivalent (MET)-h day(...

journal_title：British journal of cancer

authors： Orsini N,Mantzoros CS,Wolk A

更新日期：2008-06-03 00:00:00

abstract：BACKGROUND:Few studies have investigated the relationship between physician and patient-assessed performance status (PS) in blood cancers. METHODS:Retrospective analysis among 1418 patients with haematologic malignancies seen at Dana-Farber Cancer Institute between 2007 and 2014. We analysed physician-patient agreemen...

journal_title：British journal of cancer

authors： Liu MA,Hshieh T,Condron N,Wadleigh M,Abel GA,Driver JA

更新日期：2016-09-27 00:00:00

abstract：BACKGROUND:Tissue micro-arrays (TMAs) are increasingly used to generate data of the molecular phenotype of tumours in clinical epidemiology studies, such as studies of disease prognosis. However, TMA data are particularly prone to missingness. A variety of methods to deal with missing data are available. However, the v...

journal_title：British journal of cancer

authors： Ali AM,Dawson SJ,Blows FM,Provenzano E,Ellis IO,Baglietto L,Huntsman D,Caldas C,Pharoah PD

更新日期：2011-02-15 00:00:00

abstract：:Tumour angiogenesis is essential for progression of solid tumours and constitutes an interesting target for therapy. However, impaired tumour blood supply may also be an important obstacle for treatment by radiotherapy and chemotherapy. Estramustine has been shown to increase tumour blood flow and potentiate the effec...

journal_title：British journal of cancer

authors： Johansson M,Bergenheim AT,Widmark A,Henriksson R

更新日期：1999-04-01 00:00:00

abstract：:We examined the levels of expression of the multidrug resistance-associated protein (MRP) gene quantified by Northern blot analysis in comparison with those of the MDR1 gene determined by reverse transcription-polymerase chain reaction (RT-PCR) in 104 non-small-cell lung cancer (NSCLC) specimens [59 adenocarcinoma (Ad...

journal_title：British journal of cancer

authors： Ota E,Abe Y,Oshika Y,Ozeki Y,Iwasaki M,Inoue H,Yamazaki H,Ueyama Y,Takagi K,Ogata T

更新日期：1995-09-01 00:00:00

abstract：:Based on observations that for certain cancers, mortality varies according to sun exposure, vitamin D has been proposed to influence on disease progression. This study aims to investigate whether serum levels of 25(OH)D are associated with prognosis in patients with prostate cancer. In total, 160 patients with a serum...

journal_title：British journal of cancer

authors： Tretli S,Hernes E,Berg JP,Hestvik UE,Robsahm TE

更新日期：2009-02-10 00:00:00

abstract：BACKGROUND:Congenital anomalies have been found more often in children with cancer than in those without. Rib abnormalities (RAs) have been associated with childhood cancer; however, studies have differed in the type of RAs and cancers implicated. METHODS:Rib abnormalities were assessed predominantly by X-ray in a hos...

journal_title：British journal of cancer

authors： Zierhut H,Murati M,Holm T,Hoggard E,Spector LG

更新日期：2011-10-25 00:00:00

abstract：:The sera of 80 newly diagnosed lung-cancer patients have been examined for immune complexes and autoantibodies. Control subjects consisted of 20 bronchitic patients and 150 normal blood donors. Immune-complex measurements used 4 established and sensitive techniques (Raji cell assay, fluid and solid-phase C1q assays an...

journal_title：British journal of cancer

authors： Guy K,Di Mario U,Irvine WJ,Hunter AM,Hadley A,Horne NW

更新日期：1981-03-01 00:00:00

abstract：BACKGROUND:Cisplatin-radiotherapy is a preferred standard for locally advanced, head and neck squamous cell carcinoma (HNSCC). However, the cisplatin-attributable survival benefit is small and toxicity substantial. A biomarker of cisplatin resistance could guide treatment selection and spare morbidity. The ERCC1-XPF nu...

journal_title：British journal of cancer

authors： Bauman JE,Austin MC,Schmidt R,Kurland BF,Vaezi A,Hayes DN,Mendez E,Parvathaneni U,Chai X,Sampath S,Martins RG

更新日期：2013-10-15 00:00:00

abstract：:Urethane was found to be uniformly distributed in all the major organs of foetal, young and adult ICR/Jcl mice and then to disappear rapidly as measured by the incorporation of urethane-carbonyl-14C, thus permitting the accurate comparison of tumour susceptibility of cells in various organs of mice at different ages. ...

journal_title：British journal of cancer

authors： Nomura T

更新日期：1976-05-01 00:00:00

abstract：:We report observations on the spread by metastasis and infiltration of a transplantable tumour in rats treated by 60Co gamma-irradiation of the primary, irradiation plus parenteral cyclophosphamide, or parenteral cyclophosphamide alone. The proportion of animals with overt disseminated disease and the extent of spread...

journal_title：British journal of cancer

authors： Moore JV,Dixon B

更新日期：1977-08-01 00:00:00

abstract：:Detailed data and statistics per each morphological site of various digestive neoplasms were obtained for the period 1976-87 from the Vaud Cancer Registry datafile, a population-based cancer registration scheme covering about 530,000 inhabitants from the French-speaking part of Switzerland. Tabulations presented inclu...

journal_title：British journal of cancer

authors： Levi F,La Vecchia C,Franceschi S,Te VC

更新日期：1991-04-01 00:00:00

abstract：BACKGROUND:Systemic inflammation measured by the neutrophil-to-lymphocyte ratio (NLR), leucocyte-to-lymphocyte ratio (LLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR) and CRP/albumin ratio (CRP/Alb) was shown to impact the survival prognosis in patients with extracranial solid cancer. METHO...

journal_title：British journal of cancer

authors： Starzer AM,Steindl A,Mair MJ,Deischinger C,Simonovska A,Widhalm G,Gatterbauer B,Dieckmann K,Heller G,Preusser M,Berghoff AS

更新日期：2021-01-21 00:00:00

abstract：:Novel synthetic antagonists of retinoic acid receptors (RARs) have been developed. To avoid interference by serum retinoids when testing these compounds, we established serum-free grown sub-lines (>3 years) of the prostate carcinoma lines LNCaP, PC3 and DU145. A high affinity pan-RAR antagonist (AGN194310, K(d) for bi...

journal_title：British journal of cancer

authors： Hammond LA,Van Krinks CH,Durham J,Tomkins SE,Burnett RD,Jones EL,Chandraratna RA,Brown G

更新日期：2001-08-03 00:00:00

abstract：BACKGROUND:Activated anaplastic lymphoma kinase (ALK) gene fusions are recurrent events in a small fraction of colorectal cancers (CRCs), although these events have not yet been exploited as in other malignancies. METHODS:We detected ALK protein expression by immunohistochemistry and gene rearrangements by fluorescenc...

journal_title：British journal of cancer

authors： Amatu A,Somaschini A,Cerea G,Bosotti R,Valtorta E,Buonandi P,Marrapese G,Veronese S,Luo D,Hornby Z,Multani P,Murphy D,Shoemaker R,Lauricella C,Giannetta L,Maiolani M,Vanzulli A,Ardini E,Galvani A,Isacchi A,Sartore

更新日期：2015-12-22 00:00:00

abstract：BACKGROUND:Our previous laboratory and clinical data suggested that one mechanism underlying the development of platinum resistance in ovarian cancer is the acquisition of DNA methylation. We therefore tested the hypothesis that the DNA hypomethylating agent 5-aza-2'-deoxycytodine (decitabine) can reverse resistance to...

journal_title：British journal of cancer

authors： Glasspool RM,Brown R,Gore ME,Rustin GJ,McNeish IA,Wilson RH,Pledge S,Paul J,Mackean M,Hall GD,Gabra H,Halford SE,Walker J,Appleton K,Ullah R,Kaye S,Scottish Gynaecological Trials Group.

更新日期：2014-04-15 00:00:00

abstract：BACKGROUND:To evaluate the prognostic value of lymph node density (LND) in patients with lymph node-positive cervical cancer. METHODS:A total of 88 consecutive patients were included in our study. Patients were treated with cisplatin-based concomitant chemoradiotherapy after surgical staging was performed at the Medic...

journal_title：British journal of cancer

authors： Polterauer S,Hefler L,Seebacher V,Rahhal J,Tempfer C,Horvat R,Reinthaller A,Grimm C

更新日期：2010-08-24 00:00:00

abstract：:The activity of ZD 1839 on brain metastases (BM) from Non-Small-Cell Lung Cancer (NSCLC) is unknown. We report four cases of BM responding to ZD 1839 theraphy. ...

journal_title：British journal of cancer

authors： Cappuzzo F,Calandri C,Bartolini S,Crinò L

更新日期：2003-07-21 00:00:00

abstract：:The effect of 6 putative prognostic factors on survival was studied in patients with Stages III and IV malignant teratoma of the testis. Differences between survival curves were tested for statistical significance. A diameter greater than 5 cm in the largest tumour mass, and greater than 8 pulmonary metastases were ad...

journal_title：British journal of cancer

authors： Germa-Lluch JR,Begent RH,Bagshawe KD

更新日期：1980-12-01 00:00:00

abstract：:Cell line studies demonstrate that the PI3K/Akt pathway is upregulated in hormone-refractory prostate cancer (HRPC) and can result in phosphorylation of the androgen receptor (AR). The current study therefore aims to establish if this has relevance to the development of clinical HRPC. Immunohistochemistry was employed...

journal_title：British journal of cancer

authors： McCall P,Gemmell LK,Mukherjee R,Bartlett JM,Edwards J

更新日期：2008-03-25 00:00:00

abstract：:Serum protein induced by vitamin K absence or antagonist II (PIVKAII), hepatoma-specific band of serum gamma-glutamyl transferase (GGTII), and alpha-fetoprotein (AFP) levels were determined in 120 patients with hepatocellular carcinoma (HCC) and 90 patients with cirrhosis. The mean serum concentration of PIVKAII in HC...

journal_title：British journal of cancer

authors： Cui R,He J,Zhang F,Wang B,Ding H,Shen H,Li Y,Chen X

更新日期：2003-06-16 00:00:00