Does deprivation affect breast cancer management?

abstract：:A number of growth factors have been implicated in the control of the proliferation of breast cancer cells and some have been reported to mediate the proliferative effects of oestradiol. MCF-7 cells were treated with growth factors in the presence and absence of oestradiol. Oestradiol increased the response of cells t...

journal_title：British journal of cancer

authors： Stewart AJ,Westley BR,May FE

更新日期：1992-10-01 00:00:00

abstract：BACKGROUND:Metabolomics has shown promise in gastric cancer (GC) detection. This research sought to identify whether GC has a unique urinary metabolomic profile compared with benign gastric disease (BN) and healthy (HE) patients. METHODS:Urine from 43 GC, 40 BN, and 40 matched HE patients was analysed using (1)H nucle...

journal_title：British journal of cancer

authors： Chan AW,Mercier P,Schiller D,Bailey R,Robbins S,Eurich DT,Sawyer MB,Broadhurst D

更新日期：2016-01-12 00:00:00

abstract：:The incidence of nodal metastasis in early gastric carcinoma (EGC) is 10-20%. However, the optimal nodal dissection for early gastric carcinoma has not been established. A retrospective study was conducted in 392 consecutive patients who underwent potentially curative distal gastrectomy for EGC between 1962 and 1990. ...

journal_title：British journal of cancer

authors： Miwa K,Miyazaki I,Sahara H,Fujimura T,Yonemura Y,Noguchi M,Falla R

更新日期：1995-12-01 00:00:00

abstract：:In rats a maximal tolerated dose of carboplatin (60 mg kg-1, i.v.) caused severe anaemia, leucopenia and thrombocytopenia. These indices of haematological toxicity were also observed with a maximal tolerated dose of cis-platin (6.5 mg kg-1, i.v.), but reductions in blood cell counts were less than those observed with ...

journal_title：British journal of cancer

authors： Siddik ZH,Boxall FE,Harrap KR

更新日期：1987-04-01 00:00:00

abstract：:In addition to the direct targeting effects on HER2-positive cells, trastuzumab may have a therapeutic role modulating the activity of the cellular immune system in patients with breast cancer. To investigate this further, the balance of T-regulatory (T(reg)), Th17, natural killer (NK) and NK T (NKT) cells before, dur...

journal_title：British journal of cancer

authors： Horlock C,Stott B,Dyson PJ,Morishita M,Coombes RC,Savage P,Stebbing J

更新日期：2009-04-07 00:00:00

abstract：:In this study, we have investigated the expression of inhibin subunits and activin receptors (ActRs) in normal and malignant ovarian cells. Each product of the inhibin subunits (alpha, betaa, betab) and activin receptors (ActRs) amplified by reverse transcription polymerase chain reaction were detected as a single ban...

journal_title：British journal of cancer

authors： Ito I,Minegishi T,Fukuda J,Shinozaki H,Auersperg N,Leung PC

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:Colonoscopic surveillance provides the best practical means for preventing colorectal cancer (CRC) in inflammatory bowel disease (IBD) patients. Strong evidence for improved survival from surveillance programmes is sparse. METHOD:The aim of this study was to compare tumour stage and survival of IBD patients...

journal_title：British journal of cancer

authors： Lutgens MW,Oldenburg B,Siersema PD,van Bodegraven AA,Dijkstra G,Hommes DW,de Jong DJ,Stokkers PC,van der Woude CJ,Vleggaar FP

更新日期：2009-11-17 00:00:00

abstract：BACKGROUND:The human epidermal growth factor receptor (EGFR) is an important therapeutic target in oncology, and three different types of EGFR inhibitors have been approved for the treatment of cancer patients. However, there has been no clear association between the expression levels of EGFR protein in the tumours det...

journal_title：British journal of cancer

authors： Modjtahedi H,Khelwatty SA,Kirk RS,Seddon AM,Essapen S,Del Vecchio CA,Wong AJ,Eccles S

更新日期：2012-02-28 00:00:00

abstract：:Using bivariate flow cytofluorometry, we have determined the nuclear DNA distribution and the expression of the p21 protein (coded by the Ha-ras oncogene) in the bone marrow (BM) cells of five solid tumour patients having histologically normal BM and in those of 57 patients with plasma cell dyscrasia (28 with monoclon...

journal_title：British journal of cancer

authors： Danova M,Riccardi A,Ucci G,Luoni R,Giordano M,Mazzini G

更新日期：1990-11-01 00:00:00

abstract：:Oestrogen (RE) and progesterone (RP) cytosolic receptors have been studied in 59 clinically inflammatory tumours of the human breast. The results were compared to those obtained in a series of 496 operable tumours. A single saturating dose of oestradiol for RE and R 5020 for RP was used and the cut-off between negativ...

journal_title：British journal of cancer

authors： Delarue JC,May-Levin F,Mouriesse H,Contesso G,Sancho-Garnier H

更新日期：1981-12-01 00:00:00

abstract：:HMGI and HMGY are splicing variants of the HMGI(Y) gene and together with HMGI-C, belong to a family of DNA binding proteins involved in maintaining active chromatin conformation and in the regulation of gene transcription. The expression of the HMGI(Y) gene is maximal during embryonic development, declines in adult d...

journal_title：British journal of cancer

authors： Giannini G,Kim CJ,Di Marcotullio L,Manfioletti G,Cardinali B,Cerignoli F,Ristori E,Zani M,Frati L,Screpanti I,Guilino A

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND:Exploring variation in patients' experiences of involvement in treatment decision making can identify groups needing extra support, such as additional consultation time, when considering treatment options. METHODS:We analysed data from the 2010 English National Cancer Patient Experience Survey, a national s...

journal_title：British journal of cancer

authors： El Turabi A,Abel GA,Roland M,Lyratzopoulos G

更新日期：2013-08-06 00:00:00

abstract：:The family history of cancer in children treated for a solid malignant tumour in the Paediatric Oncology Department at Institute Gustave-Roussy, has been investigated. In order to determine the role of germline p53 mutations in genetic predisposition to childhood cancer, germline p53 mutations were sought in individua...

journal_title：British journal of cancer

authors： Chompret A,Brugières L,Ronsin M,Gardes M,Dessarps-Freichey F,Abel A,Hua D,Ligot L,Dondon MG,Bressac-de Paillerets B,Frébourg T,Lemerle J,Bonaïti-Pellié C,Feunteun J

更新日期：2000-06-01 00:00:00

abstract：:The photodynamic effects of sulphonated aluminium phthalocyanine (SALPC) have been compared on cultured AR4-2J cells of a pancreatic carcinoma cell line and on exocrine cells of the normal phenotype freshly isolated from the rat pancreas; a multi-channel perifusion system was used for this kinetic study in vitro. Wher...

journal_title：British journal of cancer

authors： Matthews EK,Cui ZJ

更新日期：1990-05-01 00:00:00

abstract：:Vascular endothelial growth factor-A (VEGF-A) has been demonstrated to play an important role in tumour angiogenesis and to influence prognosis in many cancers. However its prognostic value in head and neck squamous cell carcinomas (HNSCCs) remains controversial. Therefore, we investigated the clinical relevance of VE...

journal_title：British journal of cancer

authors： Onesto C,Hannoun-Lévi JM,Chamorey E,Formento JL,Ramaioli A,Pagès G

更新日期：2006-05-22 00:00:00

abstract：:Carzelesin is a cyclopropylpyrroloindole analogue which acts as a DNA-sequence-specific alkylating agent. In this phase I study, Carzelesin was given as a 4-weekly 10 min i.v. infusion to 51 patients with advanced solid tumours. Patients received a median of two courses (range 1-5) at one of nine dose levels: 24, 48, ...

journal_title：British journal of cancer

authors： Awada A,Punt CJ,Piccart MJ,Van Tellingen O,Van Manen L,Kerger J,Groot Y,Wanders J,Verweij J,Wagener DJ

更新日期：1999-03-01 00:00:00

abstract：:Specimens from 45 patients with previously-untreated non-small cell lung cancer (NSCLC) were tested for in vitro chemosensitivity to ten drugs utilising the DiSC assay, which measures cell kill in the total (largely non-dividing) tumour cell population. Thirty-five assays were successful and 25 patients with advanced ...

journal_title：British journal of cancer

authors： Wilbur DW,Camacho ES,Hilliard DA,Dill PL,Weisenthal LM

更新日期：1992-01-01 00:00:00

abstract：:Bacteriochlorin a (BCA) is a second-generation photosensitizer that is effective in tumour destruction upon illumination with light of a wavelength of 760 nm. Tissue penetration by light at this wavelength is greater compared with wavelengths at which commonly used photosensitizers are illuminated, making it possible ...

journal_title：British journal of cancer

authors： Rovers JP,Schuitmaker JJ,Vahrmeijer AL,van Dierendonck JH,Terpstra OT

更新日期：1998-06-01 00:00:00

abstract：BACKGROUND:Record-based studies have generally reported association of higher childhood leukaemia incidence with higher socioeconomic status (SES), but recent findings are less consistent. METHODS:We examined records from the National Registry of Childhood Tumours for evidence of this association in England and Wales ...

journal_title：British journal of cancer

authors： Kroll ME,Stiller CA,Murphy MF,Carpenter LM

更新日期：2011-11-22 00:00:00

abstract：:The aim of our analysis was to assess retrospectively the effect on local relapse, overall survival (OS) and disease-free survival (DFS) of a limited or an extended lymphadenectomy in radically resected gastric cancer patients. This study was performed in order to identify a subgroup of patients possibly not benefitin...

journal_title：British journal of cancer

authors： Scartozzi M,Galizia E,Graziano F,Catalano V,Berardi R,Baldelli AM,Testa E,Mari D,Silva RR,Cascinu S

更新日期：2005-03-28 00:00:00

abstract：:This cross-sectional survey aimed to evaluate the prevalence of burnout and estimated psychiatric disorders among haemato-oncology healthcare professionals in Italy. The aspects of work that respondents perceive as stressful and satisfying have also been examined. The assessments were made using the Maslach Burnout In...

journal_title：British journal of cancer

authors： Bressi C,Manenti S,Porcellana M,Cevales D,Farina L,Felicioni I,Meloni G,Milone G,Miccolis IR,Pavanetto M,Pescador L,Poddigue M,Scotti L,Zambon A,Corrao G,Lambertenghi-Deliliers G,Invernizzi G

更新日期：2008-03-25 00:00:00

abstract：:Nuclear polyploidization in the livers of CF-1 mice, exposed to dieldrin (0, 1, 5 and 10 ppm in the diet), was studied up to the median time of liver tumour development (ranging from 15 to 27 months) in the respective treatment groups. In untreated controls nuclear polyploidization is characterized by a linear increas...

journal_title：British journal of cancer

authors： van Ravenzwaay B,Kunz W

更新日期：1988-07-01 00:00:00

abstract：BACKGROUND:Lymph node metastasis is one of the most important adverse prognostic factors for pancreatic cancer. The aim of this study was to identify novel lymphatic metastasis-associated markers and therapeutic targets for pancreatic cancer. METHODS:DNA microarray study was carried out to identify genes differentiall...

journal_title：British journal of cancer

authors： Lee JY,Lee KT,Lee JK,Lee KH,Jang KT,Heo JS,Choi SH,Kim Y,Rhee JC

更新日期：2011-03-15 00:00:00

abstract：:Although patients with superficial bladder cancer (Ta, T1) have a generally good prognosis, those patients who develop muscle-invasive tumours or metastatic disease at recurrence do poorly clinically. In the current study 69 patients undergoing complete transurethral resection for superficial transitional cell cancer ...

journal_title：British journal of cancer

authors： Serth J,Kuczyk MA,Bokemeyer C,Hervatin C,Nafe R,Tan HK,Jonas U

更新日期：1995-01-01 00:00:00

abstract：:Smoke condensate from two types of cigarette, dissolved in two solvents, has been applied regularly to the backs of mice at each of seven different dose levels. Treatment was continued 3 times weekly for up to 110 weeks, by which time 509 of the 1428 treated mice had developed skin tumours. The dependence of tumour in...

journal_title：British journal of cancer

authors： Davies RF,Lee PN,Rothwell K

更新日期：1974-08-01 00:00:00

abstract：BACKGROUND:Activating mutations of Fms-like tyrosine kinase 3 (FLT3) constitute a major driver in the pathogenesis of acute myeloid leukaemia (AML). Hence, pharmacological inhibitors of FLT3 are of therapeutic interest for AML. METHODS:The effects of inhibition of FLT3 activity by a novel potent FLT3 inhibitor, BPR1J-...

journal_title：British journal of cancer

authors： Lin WH,Jiaang WT,Chen CW,Yen KJ,Hsieh SY,Yen SC,Chen CP,Chang KY,Chang CY,Chang TY,Huang YL,Yeh TK,Chao YS,Chen CT,Hsu JT

更新日期：2012-01-31 00:00:00

abstract：:The use of more lipophilic derivatives of 5-aminolevulinic acid (ALA) is expected to have better diffusing properties, and after conversion into the parent ALA, to reach a higher protoporphyrin IX (PPIX) formation rate, thus improving the efficacy of topical photodynamic therapy (PDT). Here we have analysed the behavi...

journal_title：British journal of cancer

authors： Casas A,Fukuda H,Di Venosa G,Batlle A

更新日期：2001-07-20 00:00:00

abstract：:Immunohistochemical localization of chondroitin sulphate and dermatan sulphate proteoglycans (PGs) was observed in 70 tumour tissues, using monoclonal antibodies 9A-2 and 3B-3 raised against core molecules obtained from chondroitin sulphate PG by chondroitinase ABC-treatment. They recognize a stub of delta Di-4S and d...

journal_title：British journal of cancer

authors： Fukatsu T,Sobue M,Nagasaka T,Ohiwa N,Fukata S,Nakashima N,Takeuchi J

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:The prognosis of squamous cell carcinoma of the oral tongue is poor and it would be beneficial to find prognostic markers to better adjust treatment. Bmi-1 controls cell cycle and self-renewal of tissue stem cells, transcription factor c-myc affects cell proliferation and apoptosis, and Snail regulates epith...

journal_title：British journal of cancer

authors： Häyry V,Mäkinen LK,Atula T,Sariola H,Mäkitie A,Leivo I,Keski-Säntti H,Lundin J,Haglund C,Hagström J

更新日期：2010-03-02 00:00:00

abstract：:Use of aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs) may reduce the risk of gastric or oesophageal adenocarcinomas. We examined the association between self-reported use of aspirin or non-aspirin NSAIDs in the earlier 12 months and gastric non-cardia (N=182), gastric cardia (N=178), and oesophageal a...

journal_title：British journal of cancer

authors： Abnet CC,Freedman ND,Kamangar F,Leitzmann MF,Hollenbeck AR,Schatzkin A

更新日期：2009-02-10 00:00:00