Abstract：
:Nuclear polyploidization in the livers of CF-1 mice, exposed to dieldrin (0, 1, 5 and 10 ppm in the diet), was studied up to the median time of liver tumour development (ranging from 15 to 27 months) in the respective treatment groups. In untreated controls nuclear polyploidization is characterized by a linear increase of octaploid nuclei with age. Approximately 4 months before tumour development a reduction in the tetraploid to diploid ratio is observed. Dieldrin treatment was found to enhance nuclear polyploidization in the initial phases of treatment, as expressed by a dose-dependent increase in octaploid nuclei. In 'steady-state' situations all age dependent changes in the level of polyploidization found in controls were also found in dieldrin treated mice. However, these changes occurred at an increasingly earlier age with higher dieldrin treatment levels. The decrease in the tetraploid:diploid ratio always takes place a few months before tumour development. This change in the ploidy level may thus be related to the subsequent liver tumour formation. The liver tumours themselves appear to originate from a diploid stem line, and were found to increase their degree of polyploidization during growth, eventually developing aneuploid nuclei. A comparison of nuclear polyploidization and liver tumour formation in CF-1 mouse liver for the given dietary dieldrin concentrations showed that liver tumour formation was associated with a constant level of polyploidization. Since polyploidization is an age-dependent process, these findings suggest that liver tumour formation is imminent at a constant biological age and that dieldrin may advance the biological age of CF-1 mouse liver.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
van Ravenzwaay B,Kunz Wdoi
10.1038/bjc.1988.160subject
Has Abstractpub_date
1988-07-01 00:00:00pages
52-6issue
1eissn
0007-0920issn
1532-1827journal_volume
58pub_type
杂志文章abstract：:A substantial excess risk of lymphomas and nonmelanoma skin cancer has been demonstrated following organ transplantation. Large sample size and long follow-up time may, however, allow more accurate risk estimates and detailed understanding of long-term cancer risk. The objective of the study was to assess the risk of ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601219
更新日期：2003-10-06 00:00:00
abstract：PURPOSE:To determine the feasibility of induction chemotherapy and chemo-IMRT in head and neck squamous cell cancers at risk of bilateral nodal spread (midline tumours) and to evaluate whether bilateral superficial lobe parotid-sparing IMRT can reduce the incidence of ⩾G2 subjective xerostomia. METHODS:Patients with m...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2014.553
更新日期：2015-01-06 00:00:00
abstract：:There are two main histological groups of testicular germ cell tumours, which may have different risk factors. Some authors have analysed potential risk factors by histological group but few consistent differences have been identified. In this paper we examine risk factors for pure seminoma and other tumours using dat...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690611
更新日期：1999-08-01 00:00:00
abstract：:The family history of cancer in children treated for a solid malignant tumour in the Paediatric Oncology Department at Institute Gustave-Roussy, has been investigated. In order to determine the role of germline p53 mutations in genetic predisposition to childhood cancer, germline p53 mutations were sought in individua...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2000.1167
更新日期：2000-06-01 00:00:00
abstract：:In 1985 a second randomisation was initiated for women in the treatment arm of the Scottish Tamoxifen Trial either to stop tamoxifen at 5 years or to continue indefinitely. A preliminary analysis of outcome in 342 patients at a median follow-up of 6 years suggests that a worthwhile gain in disease control from continu...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1038/bjc.1996.356
更新日期：1996-07-01 00:00:00
abstract：BACKGROUND:The percentage of tumour stroma (TSP) has recently been reported to be a novel independent predictor of outcome in patients with a variety of common solid organ tumours. The aim of this study was to examine the relationship between TSP, clinicopathological characteristics and outcome in patients with invasiv...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2014.279
更新日期：2014-07-08 00:00:00
abstract：BACKGROUND:Period analysis is increasingly used to compute long-term cancer survival, as it provides better prediction of survival of newly diagnosed patients than traditional cohort analysis. However, the patient population to which period survival estimates best pertain to and which should be described in a study is ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.14
更新日期：2013-02-19 00:00:00
abstract：:Spontaneous and radiation-induced genetic instability of peripheral blood mononuclear cells derived from unselected breast cancer (BC) patients (n=50) was examined using the single-cell gel electrophoresis (Comet) assay and a modified G2 micronucleus (MN) test. Cells from apparently healthy donors (n=16) and from canc...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603005
更新日期：2006-04-24 00:00:00
abstract：:Cellular adhesion molecules have been implicated in tumour progression and metastasis. This study examines for the first time the serum concentrations of circulating VCAM-1 and E-selectin in a consecutive series of 110 cancer patients seen in a general medical oncology clinic, and confirms and extends previous studies...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1993.298
更新日期：1993-07-01 00:00:00
abstract：BACKGROUND:Efficacy and safety are the two considerations when characterising the effects of a new therapy. We sought to apply an innovative method of assessing the benefit-risk balance using data from a completed randomised controlled trial that compared erlotinib vs placebo added to gemcitabine in patients with advan...
journal_title：British journal of cancer
pub_type： 杂志文章,随机对照试验
doi：10.1038/bjc.2015.55
更新日期：2015-03-17 00:00:00
abstract：:5,6-Dimethylxanthenone-4-acetic acid, synthesised in this laboratory, reduces tumour blood flow, both in mice and in patients on Phase I trial. We used TUNEL (TdT-mediated dUTP nick end labelling) assays to investigate whether apoptosis induction was involved in its antivascular effect. 5,6-Dimethylxanthenone-4-acetic...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/sj.bjc.6600368
更新日期：2002-06-17 00:00:00
abstract：:Both misonidazole (MISO) and hyperthermia are known to enhance the radiation response of hypoxic cells, and to be selectively cytotoxic against cells in a hypoxic and acidic environment. The ability of these conditions to modify the effect of irradiation and their individual relationship was studied in a C3H mammary c...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1980.2
更新日期：1980-01-01 00:00:00
abstract：BACKGROUND:Melatonin reduces the development of breast cancer interfering with oestrogen-signalling pathways, and also inhibits aromatase activity and expression. Our objective was to study the promoters through which melatonin modifies aromatase expression, evaluate the ability of melatonin to regulate cyclooxygenases...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605336
更新日期：2009-11-03 00:00:00
abstract：BACKGROUND:Expression of epithelial cell adhesion molecule (EpCAM) is deregulated in epithelial malignancies. Beside its role in cell adhesion, EpCAM acts as signalling molecule with tumour-promoting functions. Thus, EpCAM is part of the molecular network of oncogenic receptors and considered an interesting therapeutic...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2014.366
更新日期：2014-08-26 00:00:00
abstract：:A new cancer-associated antigen CA130, recognised by two monoclonal antibodies (moABs) 130-22 and 145-9, was often found to be present at high levels in the sera of patients with ovarian cancer. There was a strong correlation between CA130 and CA125 values. The epitopes recognised by moABs 130-22 and 145-9 were proved...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1993.46
更新日期：1993-02-01 00:00:00
abstract：:The serum CA125 level was determined by a one-step immunoradiometric assay method in patients with lung cancer. Increased serum CA125 levels were observed in 37.8% of patients with squamous cell cancer, in 30.0% of those with adenocarcinoma and in 60.0% of those with small call cancer. Most patients with increased ser...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1990.355
更新日期：1990-10-01 00:00:00
abstract：:Cellular senescence is an established tumour-suppressive mechanism that prevents the proliferation of premalignant cells. However, several lines of evidence show that senescent cells, which often persist in vivo, can also promote tumour progression in addition to other age-related pathologies via the senescence-associ...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/bjc.2016.115
更新日期：2016-05-24 00:00:00
abstract：:Mutation of c-K-ras oncogene is an important step in progression of colon cancer. We used a hammerhead ribozyme (KrasRz) against mutated K-ras gene transcripts (codon 12, GTT) to inactivate mutant K-ras function in the colon cancer cell line SW480, harbouring a mutant K-ras gene. The beta-actin promoter-driven KrasRz ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2000.1363
更新日期：2000-09-01 00:00:00
abstract：:This study explored the relationships of serum insulin-like growth factors, IGF-I and IGF-II, and their binding proteins (IGFBP)-2 and IGFBP-3, with key clinicopathological parameters in 92 patients with colorectal cancer (cases). Comparisons were made with 57 individuals who had a normal colonoscopy (controls). Seria...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2000.1462
更新日期：2000-11-01 00:00:00
abstract：:We have studied loss of heterozygosity at the BRCA1 and BRCA2 loci in 992 normal cell clones derived from topographically defined areas of normal tissue in four samples from BRCA1/BRCA2 mutation carriers. The frequency of loss of heterozygosity in the clones was low (1.01%), but it was found in all four samples, wheth...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603298
更新日期：2006-08-21 00:00:00
abstract：:Bcl-2 expression in colorectal carcinomas was studied in a series of 224 patients and the relation to p53 expression, stage and survival assessed. Bcl-2 expression was down-regulated compared with normal mucosa in 67% (151) of the cases. In 144 cases staining was positive for p53 (MAB DO7), and 41 of these 144 p53-pos...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.310
更新日期：1998-06-01 00:00:00
abstract：BACKGROUND:After radical prostatectomy (RP) for prostate cancer (PC), p53 alterations predict biochemical relapse (BCR), however, recent evidence suggests that metastatic relapse (MR) not BCR is a surrogate for PC specific mortality (PCSM). This updated analysis of a previously published study investigated the associat...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-019-0549-8
更新日期：2019-10-01 00:00:00
abstract：:In a case-control study, we investigated 169 women aged 15-49 years with malignant melanoma notified to the Oxford and South Western cancer registries during the years 1971-1976, together with 507 matched controls. Data about medical, reproductive, drug and smoking histories were obtained both by reviewing general pra...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1981.145
更新日期：1981-07-01 00:00:00
abstract：:Adenosine deaminase (EC 3.5.4.4, ADA) has been assayed in lymphocytes, granulocytes and erythrocytes from 45 patients with haematological malignancies. Activities were uniformly low in lymphocytes from patients with chronic lymphocytic leukaemia. Variable, but abnormal activities were frequently found in multiple myel...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1976.45
更新日期：1976-03-01 00:00:00
abstract：BACKGROUND:Non-invasive biomarkers of disease progression in mice with cancer are lacking making it challenging to implement appropriate humane end points. We investigated whether body temperature, food and water consumption could be used to predict tumour burden. METHODS:Thirty-six male, wild-type C57Bl/6 mice were i...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.818
更新日期：2014-02-18 00:00:00
abstract：:Metastasis of colorectal carcinomas rarely occurs in cirrhotic livers. Our study investigated the influence of activated Kupffer cells from cirrhotic rat livers on hepatic colonization and FasR-mediated apoptosis of colon cancer cells. A rat colon cancer cell line, RCN-9, was used to inoculate rat livers. Treatment wi...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2000.1737
更新日期：2001-05-04 00:00:00
abstract：BACKGROUND:Recently, many studies have suggested a possible adjuvant role of aspirin in colorectal cancer, reporting a positive prognostic effect with its use in patients with established disease. The aim of this study was to investigate the anticancer effect of aspirin use during preoperative chemoradiation for rectal...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2015.336
更新日期：2015-10-20 00:00:00
abstract：:Several techniques are under development to diagnose oesophageal adenocarcinoma at an earlier stage. We have demonstrated the potential of Raman spectroscopy, an optical diagnostic technique, for the identification and classification of malignant changes. However, there is no clear recognition of the biochemical chang...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603102
更新日期：2006-05-22 00:00:00
abstract：:In a previous report we suggested that the estimation of prothymosin alpha (PTA) levels in primary breast tumours might be used to identify breast cancer patients at high risk for distant metastasis (Dominguez F et al (1993) Eur J Cancer 29A: 893-897). Here the role of tumour PTA levels as predictor was investigated w...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.1999.0968
更新日期：2000-02-01 00:00:00
abstract：:The primary aim of this study was to investigate if the expression of the DNA damage identifying protein DNA-PKcs known to be involved in DNA repair after treatment with ionising radiation can be used as a predictive marker for radiotherapy (RT) response in cervical cancer. Formalin-fixed primary tumour biopsies from ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603153
更新日期：2006-06-05 00:00:00
