当前位置： SCI文献检索 > BRITISH JOURNAL OF CANCER期刊下所有文献 > Induction of endothelial cell apoptosis by the antivascular agent 5,6-Dimethylxanthenone-4-acetic acid.

Induction of endothelial cell apoptosis by the antivascular agent 5,6-Dimethylxanthenone-4-acetic acid.

Abstract：

:5,6-Dimethylxanthenone-4-acetic acid, synthesised in this laboratory, reduces tumour blood flow, both in mice and in patients on Phase I trial. We used TUNEL (TdT-mediated dUTP nick end labelling) assays to investigate whether apoptosis induction was involved in its antivascular effect. 5,6-Dimethylxanthenone-4-acetic acid induced dose-dependent apoptosis in vitro in HECPP murine endothelial cells in the absence of up-regulation of mRNA for tumour necrosis factor. Selective apoptosis of endothelial cells was detected in vivo in sections of Colon 38 tumours in mice within 30 min of administration of 5,6-Dimethylxanthenone-4-acetic acid (25 mg x kg(-1)). TUNEL staining intensified with time and after 3 h, necrosis of adjacent tumour tissue was observed. Apoptosis of central vessels in splenic white pulp was also detected in tumour-bearing mice but not in mice without tumours. Apoptosis was not observed in liver tissue. No apoptosis was observed with the inactive analogue 8-methylxanthenone-4-acetic acid. Positive TUNEL staining of tumour vascular endothelium was evident in one patient in a Phase I clinical trial, from a breast tumour biopsy taken 3 and 24 h after infusion of 5,6-Dimethylxanthenone-4-acetic acid (3.1 mg x m(-2)). Tumour necrosis and the production of tumour tumour necrosis factor were not observed. No apoptotic staining was seen in tumour biopsies taken from two other patients (doses of 3.7 and 4.9 mg x m(-2)). We conclude that 5,6-Dimethylxanthenone-4-acetic acid can induce vascular endothelial cell apoptosis in some murine and human tumours. The action is rapid and appears to be independent of tumour necrosis factor induction.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Ching LM,Cao Z,Kieda C,Zwain S,Jameson MB,Baguley BC

doi

10.1038/sj.bjc.6600368

subject

Has Abstract

pub_date

2002-06-17 00:00:00

pages

1937-42

issue

12

eissn

0007-0920

issn

1532-1827

journal_volume

86

pub_type

临床试验,杂志文章

相关文献

BRITISH JOURNAL OF CANCER文献大全
  • Renal cancer and pneumothorax risk in Birt-Hogg-Dubé syndrome; an analysis of 115 FLCN mutation carriers from 35 BHD families.

    abstract：BACKGROUND:Birt-Hogg-Dubé (BHD) syndrome is an autosomal dominant condition caused by germline FLCN mutations, and characterised by fibrofolliculomas, pneumothorax and renal cancer. The renal cancer risk, cancer phenotype and pneumothorax risk of BHD have not yet been fully clarified. The main focus of this study was t...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2011.463

    authors： Houweling AC,Gijezen LM,Jonker MA,van Doorn MB,Oldenburg RA,van Spaendonck-Zwarts KY,Leter EM,van Os TA,van Grieken NC,Jaspars EH,de Jong MM,Bongers EM,Johannesma PC,Postmus PE,van Moorselaar RJ,van Waesberghe JH,Starink

    更新日期：2011-12-06 00:00:00

  • Chemical modification and immunogenicity of membrane fractions from mouse tumour cells.

    abstract：:A crude membrane fraction isolated from mouse tumour cells was treated with various chemicals. The effects on the immunogenicity of the membrane sample were tested in syngeneic mice for tumour protection, using a challenge dose of 10(5) viable tumour cells. Best protection was obtained after immunization of mice with ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1978.236

    authors： Staab HJ,Anderer FA

    更新日期：1978-10-01 00:00:00

  • A comparative analysis of management and prognosis in stage I and II fallopian tube carcinoma and epithelial ovarian cancer.

    abstract：:Staging and surgical as well as post-operative treatment of primary Fallopian tube carcinoma (FTC) followed the lines established for primary ovarian cancer (OC). In a nationwide retrospective analysis we were able to find a distinct difference between these two tumours. A total of 262 patients, 68 with FTC and 194 wi...

    journal_title：British journal of cancer

    pub_type： 杂志文章,多中心研究

    doi：10.1038/bjc.1994.105

    authors： Rosen AC,Sevelda P,Klein M,Graf AH,Lahousen M,Reiner A,Auerbach L,Vavra N,Rosen HR

    更新日期：1994-03-01 00:00:00

  • TMPRSS4: an emerging potential therapeutic target in cancer.

    abstract：:Altered expression and activity of proteases is a key event in cancer, particularly in relation to invasion, modification of the extracellular matrix and metastasis. The transmembrane protease, serine 4 (TMPRSS4) is closely related to other cancer-associated proteases, such as hepsin, TMPRSS2 and matriptase. We review...

    journal_title：British journal of cancer

    pub_type： 杂志文章,评审

    doi：10.1038/bjc.2014.403

    authors： de Aberasturi AL,Calvo A

    更新日期：2015-01-06 00:00:00

  • Evaluation of pharmacodynamic biomarkers in a Phase 1a trial of dulanermin (rhApo2L/TRAIL) in patients with advanced tumours.

    abstract：BACKGROUND:Dulanermin (rhApo2L/TRAIL) induces apoptosis by binding to death receptors DR4 and DR5, leading to caspase activation and subsequent cell death. A Phase1a trial evaluated the safety and tolerability of dulanermin in patients with advanced tumours. One aim was to develop and validate pharmacodynamic biomarker...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2011.456

    authors： Pan Y,Xu R,Peach M,Huang CP,Branstetter D,Novotny W,Herbst RS,Eckhardt SG,Holland PM

    更新日期：2011-12-06 00:00:00

  • Effects of opioids on immunologic parameters that are relevant to anti-tumour immune potential in patients with cancer: a systematic literature review.

    abstract：BACKGROUND:The immune system has a central role in controlling cancer, and factors that influence protective antitumour immunity could therefore have a significant impact on the course of malignant disease. Opioids are essential for the management of cancer pain, and preclinical studies indicate that opioids have the p...

    journal_title：British journal of cancer

    pub_type： 杂志文章,评审

    doi：10.1038/bjc.2014.384

    authors： Boland JW,McWilliams K,Ahmedzai SH,Pockley AG

    更新日期：2014-08-26 00:00:00

  • Dietary induction of NQO1 increases the antitumour activity of mitomycin C in human colon tumours in vivo.

    abstract：:The bioreductive antitumour agent, mitomycin C (MMC), requires activation by reductive enzymes like NAD(P)H:quinone oxidoreductase 1 (NQO1). We used a novel approach to increase MMC efficacy by selectively inducing NQO1 in tumour cells in vivo. CD-1 nude mice were implanted with HCT116 cells, and fed control diet or d...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6602171

    authors： Begleiter A,Leith MK,Thliveris JA,Digby T

    更新日期：2004-10-18 00:00:00

  • A phase I pharmacokinetic and pharmacodynamic study of BGC9331 and carboplatin in relapsed gynaecological malignancies.

    abstract：:BGC9331 is a rationally designed, specific nonpolyglutamatable thymidylate synthase (TS) inhibitor that is active in gynaecological malignancies. In the light of the sensitivity of human ovarian tumour cell lines to BGC9331 and non-cross resistance to platinum drugs, we studied the combination BGC9331/carboplatin (BCA...

    journal_title：British journal of cancer

    pub_type： 临床试验,杂志文章

    doi：10.1038/sj.bjc.6602811

    authors： Benepal T,Jackman A,Pyle L,Bate S,Hardcastle A,Aherne W,Mitchell F,Simmons L,Ruddle R,Raynaud F,Gore M

    更新日期：2005-10-17 00:00:00

  • Transarterial chemo-embolisation of hepatocellular carcinoma: impact of liver function and vascular invasion.

    abstract：BACKGROUND:Transarterial chemo-embolisation (TACE) is recommended for patients with BCLC intermediate stage hepatocellular carcinoma (stage B), particularly in patients with good underlying liver function and minimal symptoms. The hepatoma arterial embolisation prognostic (HAP) score combines measures of liver function...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2016.423

    authors： Waked I,Berhane S,Toyoda H,Chan SL,Stern N,Palmer D,Tada T,Yeo W,Mo F,Bettinger D,Kirstein MM,Iñarrairaegui M,Gomaa A,Vogel A,Meyer T,Sangro B,Lai P,Kumada T,Johnson PJ

    更新日期：2017-02-14 00:00:00

  • MDM2 gene amplification and expression in non-small-cell lung cancer: immunohistochemical expression of its protein is a favourable prognostic marker in patients without p53 protein accumulation.

    abstract：:MDM2 is an oncoprotein that inhibits p53 tumour-suppressor protein. Amplification of the MDM2 gene and overexpression of its protein have been observed in some human malignancies, and these abnormalities have a role in tumorigenesis through inactivation of p53 function. To determine the clinicopathological and prognos...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1997.221

    authors： Higashiyama M,Doi O,Kodama K,Yokouchi H,Kasugai T,Ishiguro S,Takami K,Nakayama T,Nishisho I

    更新日期：1997-01-01 00:00:00

  • Personalising docetaxel and G-CSF schedules in cancer patients by a clinically validated computational model.

    abstract：BACKGROUND:This study was aimed to develop a new method for personalising chemotherapeutic and granulocyte colony-stimulating factor (G-CSF) combined schedules, and use it for suggesting efficacious chemotherapy with reduced neutropenia. METHODS:Clinical data from 38 docetaxel (Doc)-treated metastatic breast cancer pa...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2012.316

    authors： Vainas O,Ariad S,Amir O,Mermershtain W,Vainstein V,Kleiman M,Inbar O,Ben-Av R,Mukherjee A,Chan S,Agur Z

    更新日期：2012-08-21 00:00:00

  • Reduction by anti-inflammatory corticosteroids of clonogenic growth of allogeneic tumour cells in normal and irradiated tissues of the rat.

    abstract：:Anti-inflammatory corticosteroids administered to rats in high dosages before intravenous injection of allogeneic tumour cells caused 5-10 fold reductions in "take" and clonogenic growth of the cells in lung and kidney and decreased growth and spread of the cells transplanted to leg muscle. Steroid therapy also reduce...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1974.84

    authors： Van Den Brenk HA,Kelly H,Orton C

    更新日期：1974-05-01 00:00:00

  • Immunotherapy for acute myelogenous leukaemia.

    abstract：:One hundred and seven untreated patients with acute myelogenous leukaemia (AML) were admitted to St Bartholomew's Hospital between 10 October 1970 and 31 January 1973. Before receiving drugs to induce remission they were allocated alternatively into 2 groups to decide their remission treatment-a group to receive chemo...

    journal_title：British journal of cancer

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1038/bjc.1973.162

    authors： Powles RL,Crowther D,Bateman CJ,Beard ME,McElwain TJ,Russell J,Lister TA,Whitehouse JM,Wrigley PF,Pike M,Alexander P,Fairley GH

    更新日期：1973-11-01 00:00:00

  • High expression of kinesin light chain-2, a novel target of miR-125b, is associated with poor clinical outcome of elderly non-small-cell lung cancer patients.

    abstract：BACKGROUND:MiR-125b has critical role in non-small-cell lung cancer (NSCLC) cell migration, and its target genes have not been elucidated. Kinesin-1 light chain (KLC)-2 was predicted as one of miR-125b's targets by bioinformatics analysis. This study is to identify the function of KLC2 and its interaction with miR-125b...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2015.3

    authors： Wang M,Zhu X,Sha Z,Li N,Li D,Chen L

    更新日期：2015-03-03 00:00:00

  • The impact of regulatory T cells on carcinogen-induced sarcogenesis.

    abstract：:Burnet proposed in the 1950's that the immune system is engaged in identifying and destroying abnormal cancerous cells. This process, termed immune surveillance, has been at the centre of intense debate for decades. Results using immunodeficient mice lend support to the immune surveillance hypothesis. We surmised that...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6603824

    authors： Betts G,Twohig J,Van den Broek M,Sierro S,Godkin A,Gallimore A

    更新日期：2007-06-18 00:00:00

  • Prognostic and predictive value of plasma testosterone levels in patients receiving first-line chemotherapy for metastatic castrate-resistant prostate cancer.

    abstract：BACKGROUND:Biomarkers for metastatic castration-resistant prostatic cancer (mCRPC) are an unmet medical need. METHODS:The prognostic and predictive value for survival and response to salvage hormonal therapy (SHT) of baseline testosterone level (TL) was analysed in a cohort of 101 mCRPC patients participating in 9 non...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2014.189

    authors： de Liaño AG,Reig O,Mellado B,Martin C,Rull EU,Maroto JP

    更新日期：2014-04-29 00:00:00

  • Mapping the HLA-A24-restricted T-cell epitope peptide from a tumour-associated antigen HER2 / neu: possible immunotherapy for colorectal carcinomas.

    abstract：:HER2 / neu is a potential antigen candidate for immunotherapy because of its correlation to a poor prognosis and high expressions in many kinds of epithelial tumours. Especially in the colorectal carcinomas, the higher expression of HER2 / neu is recognized in metastatic regions as well as in primary sites. Several CT...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1054/bjoc.2000.1547

    authors： Tanaka H,Tsunoda T,Nukaya I,Sette A,Matsuda K,Umano Y,Yamaue H,Takesako K,Tanimura H

    更新日期：2001-01-05 00:00:00

  • Hormone replacement therapy, body mass, and the risk of colorectal cancer among postmenopausal women from Germany.

    abstract：:Previous studies have reported inconsistent results regarding the modifying effect of hormone replacement therapy (HRT) on the association of body mass index (BMI) and the risk of colorectal cancer (CRC) among postmenopausal women. We assessed the use of HRT and BMI in 208 postmenopausal women with histologically conf...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6604066

    authors： Hoffmeister M,Raum E,Winter J,Chang-Claude J,Brenner H

    更新日期：2007-12-03 00:00:00

  • The effects of aminoglutethimide and hydrocortisone, alone and combined, on androgen levels in post-orchiectomy prostatic cancer patients.

    abstract：:Aminoglutethimide has been used in combination with hydrocortisone in patients with advanced prostatic cancer with the rationale that it causes a 'medical adrenalectomy'. Both objective and subjective responses have been recorded. We have examined the effect of AG and HC alone and in combination on plasma androgen lev...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1988.40

    authors： Dowsett M,Shearer RJ,Ponder BA,Malone P,Jeffcoate SL

    更新日期：1988-02-01 00:00:00

  • A prospective study of urinary oestrogen excretion and breast cancer risk.

    abstract：:To test the hypothesis that high levels of endogenous oestrogens increase the risk for developing breast cancer, concentrations of oestrone, oestradiol and oestriol were measured in 24 h urine samples from 1000 women participants in a prospective study of breast cancer on the island of Guernsey. Sixty-nine subjects we...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1996.304

    authors： Key TJ,Wang DY,Brown JB,Hermon C,Allen DS,Moore JW,Bulbrook RD,Fentiman IS,Pike MC

    更新日期：1996-06-01 00:00:00

  • Immunosuppression by platinum diamines.

    abstract：:Platinum diamine dichloride and tetrachloride inhibit the formation of antibody-forming cells in the mouse spleen after injection of sheep red cells. The dichloride is the more effective agent. It acts best when given 2 days after the antigen, which suggests that cells are more sensitive to its action when they are ra...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1971.27

    authors： Berenbaum MC

    更新日期：1971-03-01 00:00:00

  • Multicentre phase II trial of trastuzumab and capecitabine in patients with HER2 overexpressing metastatic pancreatic cancer.

    abstract：BACKGROUND:New therapeutic options for metastatic pancreatic cancer are urgently needed. In pancreatic cancer, overexpression of the epidermal growth factor receptor 2 (HER2) has been reported in up to 45%. This multicentre phase II study investigated the efficacy and toxicity of the HER2 antibody trastuzumab combined ...

    journal_title：British journal of cancer

    pub_type： 杂志文章,多中心研究

    doi：10.1038/bjc.2012.18

    authors： Harder J,Ihorst G,Heinemann V,Hofheinz R,Moehler M,Buechler P,Kloeppel G,Röcken C,Bitzer M,Boeck S,Endlicher E,Reinacher-Schick A,Schmoor C,Geissler M

    更新日期：2012-03-13 00:00:00

  • Lessons to Europe from China for cancer treatment during the COVID-19 pandemic.

    abstract：:During the COVID-19 era, Chinese hospitals have developed a system that enables vulnerable cancer patients to continue to receive high-quality medical care, optimising their survival whilst protecting them. This includes use of digital quick codes, fever clinics and optimal scheduling. We wish to share our experiences...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/s41416-020-0856-0

    authors： Peng L,Yang JS,Stebbing J

    更新日期：2020-07-01 00:00:00

  • Control of cell proliferation in human glioma by glucocorticoids.

    abstract：:Survival and proliferation of cell cultures from human anaplastic astrocytomas were shown to be enhanced by glucocorticoids with an optimal concentration of approximately 2.5 x 10(-5)M (10 micrograms/ml). The stimulation of proliferation was only observed in a clonal growth assay and was reversed as the size of indivi...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1980.161

    authors： Freshney RI,Sherry A,Hassanzadah M,Freshney M,Crilly P,Morgan D

    更新日期：1980-06-01 00:00:00

  • Inhibition of polypyrimidine tract-binding protein 3 induces apoptosis and cell cycle arrest, and enhances the cytotoxicity of 5- fluorouracil in gastric cancer cells.

    abstract：BACKGROUND:Human polypyrimidine tract binding protein 3 (PTBP3) was first discovered in 1999 and has been well characterised as a differentiation regulator. However, its role in human cancer has rarely been reported. Our previous study revealed increased PTBP3 protein level in gastric cancer tissues. Downregulation of ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2017.32

    authors： Liang X,Shi H,Yang L,Qiu C,Lin S,Qi Y,Li J,Zhao A,Liu J

    更新日期：2017-03-28 00:00:00

  • Auditing the diagnosis of cancer in primary care: the experience in Scotland.

    abstract：INTRODUCTION:This paper reports on an ongoing primary care audit of cancer referrals undertaken in Scotland in 2006-2007 and 2007-2008. METHODS:General practitioners (GPs) in Scotland were asked to review all new cancer diagnoses within their practice during the preceding year. RESULTS:4181 patients were identified i...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6605397

    authors： Baughan P,O'Neill B,Fletcher E

    更新日期：2009-12-03 00:00:00

  • Clinical value of R-spondins in triple-negative and metaplastic breast cancers.

    abstract：BACKGROUND:RSPO ligands, activators of the Wnt/β-catenin pathway, are overexpressed in different cancers. The objective of this study was to investigate the role of RSPOs in breast cancer (BC). METHODS:Expression of RSPO and markers of various cancer pathways were measured in breast tumours and cell lines by qRT-PCR. ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2017.131

    authors： Coussy F,Lallemand F,Vacher S,Schnitzler A,Chemlali W,Caly M,Nicolas A,Richon S,Meseure D,El Botty R,De-Plater L,Fuhrmann L,Dubois T,Roman-Roman S,Dangles-Marie V,Marangoni E,Bièche I

    更新日期：2017-06-06 00:00:00

  • Cyclooxygenase-2 overexpression abrogates the antiproliferative effects of TGF-beta.

    abstract：:The influence of cyclooxygenase-2 (COX-2) overexpression on the development of tumours has been well documented. The underlying mechanism however has still not been completely elucidated. An escape of proliferating cells from the regulatory influence of TGF-beta for example in the intestine has been discussed as well ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6604048

    authors： Enders GA

    更新日期：2007-11-19 00:00:00

  • Evaluation of single-agent therapy in human colorectal tumour xenografts.

    abstract：:The response of 6 human colorectal tumour xenografts to 7 cytotoxic agents have been established. Tumour responses have been quantified by growth inhibition, and the time taken for 3H-thymidine fractional incorporation (TFI) to recover to the control value after treatment. The chemosensitivity of each tumour line to a...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1978.122

    authors： Houghton PJ,Houghton JA

    更新日期：1978-05-01 00:00:00

  • High-dose methotrexate in the treatment of malignant mesothelioma of the pleura. A phase II study.

    abstract：:From 1984 to 1989, 63 patients with diffuse, malignant mesothelioma of the pleura were treated with 4-8 courses of high-dose methotrexate (HDMTX, 3 g total dose) and citrovorum factor rescue. There were 61 male and two female patients of median age 60 years. CT scan was performed before and after treatment and used fo...

    journal_title：British journal of cancer

    pub_type： 临床试验,杂志文章

    doi：10.1038/bjc.1992.200

    authors： Solheim OP,Saeter G,Finnanger AM,Stenwig AE

    更新日期：1992-06-01 00:00:00