Melatonin inhibits aromatase promoter expression by regulating cyclooxygenases expression and activity in breast cancer cells.

abstract：BACKGROUND:For patients with locally advanced rectal cancer (LARC), it is unclear whether neoadjuvant chemoradiotherapy-induced pathologic complete response (pCR) individuals would further benefit from adjuvant chemotherapy (ACT). METHODS:The pCR individuals who received different ACT cycles were paired by propensity ...

journal_title：British journal of cancer

authors： He F,Ju HQ,Ding Y,Jiang Z,Li Z,Huang B,Wang X,Zhao Y,Li Y,Qi B,Luo W,Zhang Z,Pei Q,Chen H,Liu S,Pang X,Zheng J,Wang J,Ajani JA,Wan XB

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) is the third most common cancer worldwide. Accurately identifying stage II CRC patients at risk for recurrence is an unmet clinical need. KCNQ1 was previously identified as a tumour suppressor gene and loss of expression was associated with poor survival in patients with CRC liver met...

journal_title：British journal of cancer

authors： den Uil SH,Coupé VM,Linnekamp JF,van den Broek E,Goos JA,Delis-van Diemen PM,Belt EJ,van Grieken NC,Scott PM,Vermeulen L,Medema JP,Bril H,Stockmann HB,Cormier RT,Meijer GA,Fijneman RJ

更新日期：2016-12-06 00:00:00

abstract：BACKGROUND:Whether red and processed meat consumption is a risk factor for pancreatic cancer remains unclear. We conducted a meta-analysis to summarise the evidence from prospective studies of red and processed meat consumption and pancreatic cancer risk. METHODS:Relevant studies were identified by searching PubMed an...

journal_title：British journal of cancer

authors： Larsson SC,Wolk A

更新日期：2012-01-31 00:00:00

abstract：BACKGROUND:Multiple early gastric cancers (EGCs) may develop in 6-14% of patients even after achieving curative endoscopic submucosal dissection (ESD); however, a useful biomarker for predicting recurrence is not available. The present study investigated whether the expression of CD44 variant 9 (CD44v9), a functional c...

journal_title：British journal of cancer

authors： Hirata K,Suzuki H,Imaeda H,Matsuzaki J,Tsugawa H,Nagano O,Asakura K,Saya H,Hibi T

更新日期：2013-07-23 00:00:00

abstract：:2-Amino-3,4-dihydro-6-methyl-4-oxo-5-(4-pyridylthio)-quinazoline dihydrochloride (nolatrexed dihydrochloride, Thymitaq, AG337), a specific inhibitor of thymidylate synthase, was developed using protein structure-based drug design. Intravenously administered nolatrexed is active clinically. As oral bioavailability is h...

journal_title：British journal of cancer

authors： Jodrell DI,Bowman A,Rye R,Byrne B,Boddy A,Rafi I,Taylor GA,Johnston A,Clendeninn NJ

更新日期：1999-02-01 00:00:00

abstract：:In order to elucidate the clinical significance of the erbB family, epidermal growth factor receptor (EGF-R), c-erbB-2, c-erbB-3 and c-erbB-4 in hepatocellular carcinoma (HCC), we investigated the expression of these proteins by means of immunohistochemistry for HCC as well as adjacent noncancerous lesions. EGF-R was ...

journal_title：British journal of cancer

authors： Ito Y,Takeda T,Sakon M,Tsujimoto M,Higashiyama S,Noda K,Miyoshi E,Monden M,Matsuura N

更新日期：2001-05-18 00:00:00

abstract：BACKGROUND:Gamma-glutamyltransferase (GGT) - a membrane-bound enzyme crucially involved in the cell's detoxification pathway and apoptotic balance - is involved in tumour development, progression and chemotherapy resistance. Elevated GGT serum levels are associated with increased cancer risk in women and worse prognosi...

journal_title：British journal of cancer

authors： Grimm C,Hofstetter G,Aust S,Mutz-Dehbalaie I,Bruch M,Heinze G,Rahhal-Schupp J,Reinthaller A,Concin N,Polterauer S

更新日期：2013-08-06 00:00:00

abstract：:Insulin-like growth factor-1 (IGF-1) has been described as an important factor in proliferation, cell survival and migration of multiple myeloma (MM) cells. Angiogenesis correlates with development and prognosis of the MM disease. Vascular endothelial growth factor (VEGF) is one of the prominent factors involved in th...

journal_title：British journal of cancer

authors： Menu E,Kooijman R,Van Valckenborgh E,Asosingh K,Bakkus M,Van Camp B,Vanderkerken K

更新日期：2004-03-08 00:00:00

abstract：:The survival of 64 consecutive patients with disseminated midgut carcinoid tumours was compared in a retrospective study with that of 25 consecutive patients with sporadic malignant endocrine pancreatic tumours treated according to similar surgical principles. The presence of hepatic metastases implied a worse prognos...

journal_title：British journal of cancer

authors： Johanson V,Tisell LE,Olbe L,Wängberg B,Nilsson O,Ahlman H

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND:Temsirolimus was approved in Europe as first-line treatment of poor-prognosis advanced renal cell carcinoma (advRCC) based on significant clinical benefits. METHODS:Patients with advRCC and multiple poor-prognostic factors were randomly assigned to receive 25 mg intravenous temsirolimus weekly, interferon-a...

journal_title：British journal of cancer

authors： Yang S,de Souza P,Alemao E,Purvis J

更新日期：2010-05-11 00:00:00

abstract：:Matched pair analysis relating to 3376 mothers of children who died of cancer 1972-1981 and of healthy control children from the Oxford Survey of Childhood Cancers showed no evidence of protection from breastfeeding for acute lymphocytic leukaemia (OR 1.04, 95% CI 0.86-1.26), for all cancers combined (OR 1.04, 95% CI ...

journal_title：British journal of cancer

authors： Lancashire RJ,Sorahan T,OSCC.

更新日期：2003-04-07 00:00:00

abstract：:Monoclonal antibody MUC 2-63 recognises neurogenic tumours and has been used successfully for radioimaging human malignant gliomas. We now show that the MUC 2-63 antigen has the same tissue distribution and molecular weight range as the CD44 antigen and confirm the identity of these two molecules in blocking studies u...

journal_title：British journal of cancer

authors： Romeijn P,Lenthall R,Stavrou D,Melcher D,Ladyman H,Ritter MA

更新日期：1994-11-01 00:00:00

abstract：:Relationships between incidence of Wilms' tumour and information recorded at birth were investigated in a prospective study of the 1,489,297 children born in Norway between 1967 and 1992. A total of 119 individuals were diagnosed with Wilms' tumour in the age interval 0-14 years. A high length at birth was significant...

journal_title：British journal of cancer

authors： Heuch JM,Heuch I,Kvåle G

更新日期：1996-10-01 00:00:00

abstract：BACKGROUND:Vismodegib has been used for the treatment of locally advanced basal cell carcinoma (laBCC) and metastatic BCC (mBCC) since 2011. Most efficacy and safety data are provided by clinical trials. This study evaluates the effectiveness of vismodegib for the treatment of laBCC, mBCC and basal cell nevus syndrome ...

journal_title：British journal of cancer

authors： Verkouteren BJA,Wakkee M,Reyners AKL,Nelemans P,Aarts MJB,Rácz E,Terra JB,Devriese LA,Alers RJ,Kapiteijn E,van Doorn R,Bekkenk MW,Reinders MGHC,Mosterd K

更新日期：2021-01-19 00:00:00

abstract：BACKGROUND:Cellular Dissociation Grade (CDG) composed of tumour budding and cell nest size has been shown to independently predict prognosis in pre-therapeutic biopsies and primary resections of oesophageal squamous cell carcinoma (ESCC). Here, we aimed to evaluate the prognostic impact of CDG in ESCC after neoadjuvant...

journal_title：British journal of cancer

authors： Jesinghaus M,Boxberg M,Wilhelm D,Münch S,Dapper H,Quante M,Schlag C,Lange S,Budczies J,Konukiewitz B,Mollenhauer M,Schlitter AM,Becker KF,Feith M,Friess H,Steiger K,Combs SE,Weichert W

更新日期：2019-12-01 00:00:00

abstract：:The 62 kDa protein product of the c-myc oncogene (p62 c-myc) is thought to be involved in the control of normal cellular proliferation and differentiation. We have measured oncoprotein levels using a flow cytometric assay in 141 operable breast cancers and have correlated levels with prognostic variables, patient surv...

journal_title：British journal of cancer

authors： Locker AP,Dowle CS,Ellis IO,Elston CW,Blamey RW,Sikora K,Evan G,Robins RA

更新日期：1989-11-01 00:00:00

abstract：:We investigated trends in first-time hospital admissions and deaths attributable to hepatocellular carcinoma (HCC) in a large population-based cohort of 22 073 individuals diagnosed with hepatitis C viral (HCV) infection through laboratory testing in Scotland in 1991-2006. We identified new cases of HCC through record...

journal_title：British journal of cancer

authors： McDonald SA,Hutchinson SJ,Bird SM,Robertson C,Mills PR,Dillon JF,Goldberg DJ

更新日期：2008-09-02 00:00:00

abstract：:The risk of ovarian epithelial neoplasia following use of hormonal contraceptives (HC) was examined in data from the Norwegian-Swedish Women's Lifestyle and Health cohort including 103551 women aged 30-49 years in 1991-92. Follow-up through 2000 produced 214 incident cases of histologically confirmed epithelial ovaria...

journal_title：British journal of cancer

authors： Kumle M,Weiderpass E,Braaten T,Adami HO,Lund E,Norwegian-Swedish Women's Lifestyle and Health Cohort Study.

更新日期：2004-04-05 00:00:00

abstract：METHODS:Maternally reported congenital abnormalities (CAs) were examined in a case-control study of 278 cases of paediatric germ cell tumours (GCTs) and 423 controls. RESULTS AND CONCLUSIONS:Germ cell tumours were significantly associated with cryptorchidism in males (OR=10.8, 95% CI: 2.1-55.1), but not with any other...

journal_title：British journal of cancer

authors： Johnson KJ,Ross JA,Poynter JN,Linabery AM,Robison LL,Shu XO

更新日期：2009-08-04 00:00:00

abstract：BACKGROUND:SCALOP, a randomised, phase II trial, tested the activity and safety of gemcitabine (GEM)-based and capecitabine (CAP)-based chemoradiation (CRT) for locally advanced pancreatic cancer (LAPC). Here we present the long-term outcomes. METHODS:Eligibility: histologically proven LAPC ⩽7 cm. Following 12 weeks o...

journal_title：British journal of cancer

authors： Hurt CN,Falk S,Crosby T,McDonald A,Ray R,Joseph G,Staffurth J,Abrams RA,Griffiths G,Maughan T,Mukherjee S

更新日期：2017-05-09 00:00:00

abstract：:We studied 5555 seminoma patients and 3733 patients with nonseminomatous testicular cancers diagnosed in Southeast England between 1960 and 2004. For both groups survival improved over time: 10-year relative survival increased from 78% in 1960-1969 to 99% in 1990-2004 for seminomas, and from 55 to 95% for nonseminomas...

journal_title：British journal of cancer

authors： Robinson D,Møller H,Horwich A

更新日期：2007-02-12 00:00:00

abstract：:The incidence of adenocarcinoma of the oesophagus in British women is among the highest in the world. To investigate its aetiology, we conducted a multi-centre, population based case-control study in four regions in England and Scotland. We included 74 incident cases in women with histologically confirmed diagnoses of...

journal_title：British journal of cancer

authors： Cheng KK,Sharp L,McKinney PA,Logan RF,Chilvers CE,Cook-Mozaffari P,Ahmed A,Day NE

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:Diet modulates inflammation and inflammatory markers have been associated with cancer outcomes. In the Women's Health Initiative, we investigated associations between a dietary inflammatory index (DII) and invasive breast cancer incidence and death. METHODS:The DII was calculated from a baseline food freque...

journal_title：British journal of cancer

authors： Tabung FK,Steck SE,Liese AD,Zhang J,Ma Y,Caan B,Chlebowski RT,Freudenheim JL,Hou L,Mossavar-Rahmani Y,Shivappa N,Vitolins MZ,Wactawski-Wende J,Ockene JK,Hébert JR

更新日期：2016-05-24 00:00:00

abstract：:T-lymphocyte maturation associated protein, MAL, has been described as a tumour-suppressor gene with diagnostic value in colorectal and oesophageal cancers, and can be inactivated by promoter hypermethylation. The aim of this study was to analyse the prevalence of MAL promoter hypermethylation and the association with...

journal_title：British journal of cancer

authors： Buffart TE,Overmeer RM,Steenbergen RD,Tijssen M,van Grieken NC,Snijders PJ,Grabsch HI,van de Velde CJ,Carvalho B,Meijer GA

更新日期：2008-12-02 00:00:00

abstract：:This article was originally published under a standard license to Publish, but has now been made available under a CC BY license. The PDF and HTML versions of the paper have been modified accordingly.An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：British journal of cancer

authors： Evans TRJ,Kudo M,Finn RS,Han KH,Cheng AL,Ikeda M,Kraljevic S,Ren M,Dutcus CE,Piscaglia F,Sung MW

更新日期：2019-10-01 00:00:00

abstract：:Radiographically occult bronchogenic squamous cell carcinomas are early lung cancers that localize mainly in the bronchial wall, and are thought to be a good model for investigating genetic alterations through lung cancer progression. In order to elucidate sequential genetic changes in lung cancers, we analysed the in...

journal_title：British journal of cancer

authors： Endo C,Sagawa M,Sato M,Chen Y,Sakurada A,Aikawa H,Takahashi S,Usuda K,Saito Y,Fujimura S

更新日期：1998-09-01 00:00:00

abstract：:The depression of the immunological status of BALB/c mice treated during infancy with two different doses of urethane, alone or combined with cortisone, was evaluated by counting the number of plaque forming cells at 30 or 50 days of age. The incidence of lung adenomatous nodules was directly related to the degree of ...

journal_title：British journal of cancer

authors： Ménard S,Colnaghi MI,Cornalba G

更新日期：1973-05-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) mutations are strong determinants of tumour response to EGFR tyrosine kinase inhibitors in non-small-cell lung cancer (NSCLC). Pleural effusion is a common complication of lung cancer. In this study, we assessed the feasibility of detection of EGFR mutations in samples of pleura...

journal_title：British journal of cancer

authors： Kimura H,Fujiwara Y,Sone T,Kunitoh H,Tamura T,Kasahara K,Nishio K

更新日期：2006-11-20 00:00:00

abstract：:Currently, there are no effective biomarkers for ovarian cancer prognosis or prediction of therapeutic response. The objective of this study was to examine a panel of 10 serum biochemical parameters for their ability to predict response to chemotherapy, progression and survival of ovarian cancer patients. Sera from ov...

journal_title：British journal of cancer

authors： Oikonomopoulou K,Li L,Zheng Y,Simon I,Wolfert RL,Valik D,Nekulova M,Simickova M,Frgala T,Diamandis EP

更新日期：2008-10-07 00:00:00

abstract：:In this study, we aimed to analyse human cancer cell-platelet interactions in functional cell analyses and explore the molecular mechanisms behind tumour progression. Various functional analyses of gastric cancer (GC) cells were performed after direct/indirect co-incubation with platelets derived from GC patients. Fur...

journal_title：British journal of cancer

authors： Saito R,Shoda K,Maruyama S,Yamamoto A,Takiguchi K,Furuya S,Hosomura N,Akaike H,Kawaguchi Y,Amemiya H,Kawaida H,Sudo M,Inoue S,Kono H,Suzuki-Inoue K,Ichikawa D

更新日期：2020-10-28 00:00:00