c-myc oncogene product expression and prognosis in operable breast cancer.

abstract：BACKGROUND:In two clinical trials of the vascular endothelial growth factor (VEGF) receptor inhibitor pazopanib in advanced renal cell carcinoma (mRCC), we found interleukin-6 as predictive of pazopanib benefit. We evaluated the prognostic significance of candidate cytokines and angiogenic factors (CAFs) identified in ...

journal_title：British journal of cancer

authors： Zurita AJ,Gagnon RC,Liu Y,Tran HT,Figlin RA,Hutson TE,D'Amelio AM Jr,Sternberg CN,Pandite LN,Heymach JV

更新日期：2017-08-08 00:00:00

abstract：BACKGROUND:Tallness has consistently been associated with an increased risk of breast cancer. We investigated the association further by decomposing height into leg length and sitting height. METHODS:From the prospective Danish cohort 'Diet, Cancer and Health', 23 864 postmenopausal women enrolled during 1993-1997 wer...

journal_title：British journal of cancer

authors： Mellemkjær L,Christensen J,Frederiksen K,Baker JL,Olsen A,Sørensen TI,Tjønneland A

更新日期：2012-06-26 00:00:00

abstract：:In the present study the putative chemopreventive effect of dietary fish oil (MaxEPA) on azaserine-induced pancreatic carcinogenesis in rats was investigated. Groups of rats were maintained on a semipurified low-fat (LF; 5 wt%) diet or on semipurified high-fat (HF; 25 wt%) diets containing 5 wt% linoleic acid (LA) and...

journal_title：British journal of cancer

authors： Appel MJ,Woutersen RA

更新日期：1996-01-01 00:00:00

abstract：:A multicentre phase 2 trial (single-stage design) was undertaken to test the efficacy and toxicity of carboplatin (AUC 6 according to Calvert) plus paclitaxel (175 mg/m(2)3-h infusion) every 4 weeks in the first line treatment of patients affected by extensive small cell lung cancer. The primary end-point of the trial...

journal_title：British journal of cancer

authors： Gridelli C,Manzione L,Perrone F,Veltri E,Cioffi R,Caprio MG,Frontini L,Rossi A,Barletta E,Barzelloni ML,Bilancia D,Gallo C

更新日期：2001-01-05 00:00:00

abstract：BACKGROUND:This first-in-human, phase I clinical trial of p28 (NSC745104), a 28-amino-acid fragment of the cupredoxin azurin, investigated the safety, tolerability, pharmacokinetics and preliminary activity of p28 in patients with p53(+) metastatic solid tumours. METHODS:A total of 15 patients were administered p28 i....

journal_title：British journal of cancer

authors： Warso MA,Richards JM,Mehta D,Christov K,Schaeffer C,Rae Bressler L,Yamada T,Majumdar D,Kennedy SA,Beattie CW,Das Gupta TK

更新日期：2013-03-19 00:00:00

abstract：BACKGROUND:Although the anti-tumour effect of cyclooxygenase-2 (Cox-2) inhibitors in invasive bladder cancer has been confirmed, its mechanisms of action are unclear. Recently, the concept of an epithelial-to-mesenchymal transition (EMT) promoting carcinoma progression has been suggested, and a key feature of the EMT i...

journal_title：British journal of cancer

authors： Adhim Z,Matsuoka T,Bito T,Shigemura K,Lee KM,Kawabata M,Fujisawa M,Nibu K,Shirakawa T

更新日期：2011-07-26 00:00:00

abstract：:The large numbers of papillary thyroid carcinomas that have occurred in those exposed to high levels of short-lived isotopes in fallout after Chernobyl provide a unique opportunity to correlate latency and tumour biology. We show that short latency is associated with tumours with a phenotype that is significantly less...

journal_title：British journal of cancer

authors： Williams ED,Abrosimov A,Bogdanova T,Demidchik EP,Ito M,LiVolsi V,Lushnikov E,Rosai J,Sidorov Y,Tronko MD,Tsyb AF,Vowler SL,Thomas GA

更新日期：2004-06-01 00:00:00

abstract：:Recently, we have found a high frequency of p53 gene mutations in human functional adrenal tumours. As the tumorigenesis is a multigene defect, we believe that other oncogenes may also be involved in the initiation or progression of adrenal tumours. Using the single-strand conformational polymorphism (SSCP) method, we...

journal_title：British journal of cancer

authors： Lin SR,Tsai JH,Yang YC,Lee SC

更新日期：1998-04-01 00:00:00

abstract：:In the BUPA study, a prospective study of 22,000 men attending a screening centre in London, the mean serum cholesterol level of the 267 men who developed cancer was 6.66 mmol l-1, not significantly different from the mean level of 6.72 mmol l-1 among the 525 unaffected controls matched for age, smoking history and th...

journal_title：British journal of cancer

authors： Wald NJ,Thompson SG,Law MR,Densem JW,Bailey A

更新日期：1989-06-01 00:00:00

abstract：:Protein kinase C (PKC) has a critical role in several signal transduction pathways, and is involved in renal cancer pathogenesis. Bryostatin-1 modulates PKC activity and has antitumour effects in preclinical studies. We conducted a multicentre phase II clinical trial in patients with advanced renal cancer to determine...

journal_title：British journal of cancer

authors： Madhusudan S,Protheroe A,Propper D,Han C,Corrie P,Earl H,Hancock B,Vasey P,Turner A,Balkwill F,Hoare S,Harris AL

更新日期：2003-10-20 00:00:00

abstract：BACKGROUND:The aim was to evaluate whether this gastric cancer-screening programme was effective in reducing oesophageal cancer mortality. METHODS:A population-based retrospective cohort study was conducted using the Korean National Cancer Screening Programme (NCSP) database. The study cohort comprised 16,969 oesophag...

journal_title：British journal of cancer

authors： Kim JH,Han KD,Lee JK,Kim HS,Cha JM,Park S,Kim JS,Kim WH,Big Data Research Group (BDRG) of the Korean Society of Gastroenterology (KSG).

更新日期：2020-08-01 00:00:00

abstract：:The hypothesis is advanced that abnormalities of the chromosome group 17,18 play a special role in the genesis and/or evolution of some reticuloendothelial neoplasms. Aberrations of the group 17,18 chromosomes in tumour cells exceed in variety the reported anomaliesof any other chromosome. Both the frequency of these ...

journal_title：British journal of cancer

authors： Spiers AS,Baikie AG

更新日期：1970-03-01 00:00:00

abstract：:Patients with refractory metastatic renal cell carcinoma (RCC) were enrolled in a phase II study with teniposide (VM26) and cyclosporin A (CSA) to investigate (1) the effect of CSA on the response rate to VM26; and (2) the effect of CSA on the pharmacokinetics and pharmacodynamics of VM26. Sixteen patients initially r...

journal_title：British journal of cancer

authors： Toffoli G,Sorio R,Gigante M,Corona G,Galligioni E,Boiocchi M

更新日期：1997-01-01 00:00:00

abstract：:Specimens from 45 patients with previously-untreated non-small cell lung cancer (NSCLC) were tested for in vitro chemosensitivity to ten drugs utilising the DiSC assay, which measures cell kill in the total (largely non-dividing) tumour cell population. Thirty-five assays were successful and 25 patients with advanced ...

journal_title：British journal of cancer

authors： Wilbur DW,Camacho ES,Hilliard DA,Dill PL,Weisenthal LM

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:The addition of breast magnetic resonance imaging (MRI) to screening mammography for women with BRCA mutations significantly increases sensitivity, but there is little data on clinical outcomes. We report screening performance, cancer stage, distant recurrence rate, and breast cancer-specific mortality in ou...

journal_title：British journal of cancer

authors： Passaperuma K,Warner E,Causer PA,Hill KA,Messner S,Wong JW,Jong RA,Wright FC,Yaffe MJ,Ramsay EA,Balasingham S,Verity L,Eisen A,Curpen B,Shumak R,Plewes DB,Narod SA

更新日期：2012-06-26 00:00:00

abstract：:We evaluated the degree of tubular differentiation in 172 samples of invasive ductal breast cancer in order to determine numerical thresholds for histological breast cancer grading. The tubular differentiation in each sample was defined as the fraction of fields showing tubular differentiation (FTD). The analysis was ...

journal_title：British journal of cancer

authors： Kronqvist P,Kuopio T,Collan Y

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:Efficacy and safety are the two considerations when characterising the effects of a new therapy. We sought to apply an innovative method of assessing the benefit-risk balance using data from a completed randomised controlled trial that compared erlotinib vs placebo added to gemcitabine in patients with advan...

journal_title：British journal of cancer

authors： Péron J,Roy P,Ding K,Parulekar WR,Roche L,Buyse M

更新日期：2015-03-17 00:00:00

abstract：:A registry including information about nearly 1,600 cases of retinoblastoma diagnosed in Britain has been created at the Childhood Cancer Research Group. Cases have been classified as 'old germ cell mutation', 'new germ cell mutation' or 'sporadic non-hereditary'. For a population-based group of 918 cases diagnosed be...

journal_title：British journal of cancer

authors： Draper GJ,Sanders BM,Brownbill PA,Hawkins MM

更新日期：1992-07-01 00:00:00

abstract：:Although osteosclerotic bone metastases are characteristic of prostate cancer, mixed metastases with a lytic component are not uncommon. Type I collagen is synthesised by osteoblasts and accounts for about 90% of the organic matrix of bone. We have used new specific immunoassays for PICP (carboxy-terminal propeptide o...

journal_title：British journal of cancer

authors： Kylmälä T,Tammela TL,Risteli L,Risteli J,Kontturi M,Elomaa I

更新日期：1995-05-01 00:00:00

abstract：:Arginase activity was found to be increased in precancerous nodules and mammary tumour when compared with the mammary gland. Proline inhibited the mammary tumour arginase and up to 30 mmo1 concentration the inhibition follows first order kinetics. Hill analysis of the inhibition of arginase by proline showed that prol...

journal_title：British journal of cancer

authors： Rao KV,Pai SR,Bapat CV

更新日期：1974-08-01 00:00:00

abstract：:The clinical formulation of the anti-tumour agent Taxol involves the use of a mixture of ethanol and Cremophor EL. Gel electrophoresis and density-gradient ultracentrifugation were used to detect effects of Taxol infusions on serum lipoproteins. Use of the Cremophor vehicle results in a decrease in the electrophoretic...

journal_title：British journal of cancer

authors： Sykes E,Woodburn K,Decker D,Kessel D

更新日期：1994-09-01 00:00:00

abstract：:The retinoblastoma gene product (RB) contributes to normal cell growth control. One of its functions is manifest as a block to exit from G1, which is carried out by an RB subspecies which is un- or underphosphorylated. After RB phosphorylation, a process which occurs towards the end of G1 in cycling cells, the block i...

journal_title：British journal of cancer

authors： Livingston DM,Kaelin W,Chittenden T,Qin X

更新日期：1993-08-01 00:00:00

abstract：:I.p. administration at several dose levels over periods of up to 12 weeks, or continuous i.v. infusion of high doses of misonidazole (MISO) for 15 h, produced no significant change in peripheral nerve conduction velocity (NCV) and did not prevent the normal increase in NCV as the animals matured from 12 to 24 weeks of...

journal_title：British journal of cancer

authors： Conroy PJ,Von Burg R,Penney DP,Passalacqua W,Sutherland RM

更新日期：1980-04-01 00:00:00

abstract：:Collagen breakdown, and thus bone resorption, can now be assessed by measuring the urinary excretion of the collagen crosslinks, pyridinoline (Pyd) and deoxypyridinoline (Dpd). In a pilot study we measured Pyd and Dpd in 20 patients with breast cancer, ten with known bone metastases and ten with no recognised metastas...

journal_title：British journal of cancer

authors： Paterson CR,Robins SP,Horobin JM,Preece PE,Cuschieri A

更新日期：1991-11-01 00:00:00

abstract：BACKGROUND:In the coBRIM study, cobimetinib plus vemurafenib (C+V) significantly improved survival outcomes vs placebo and vemurafenib (P+V) in patients with advanced/metastatic BRAFV600-mutated melanoma. An analysis of health-related quality of life (HRQOL) from coBRIM is reported. METHODS:Patients completing the Eur...

journal_title：British journal of cancer

authors： Dréno B,Ascierto PA,Atkinson V,Liszkay G,Maio M,Mandalà M,Demidov L,Stroyakovskiy D,Thomas L,de la Cruz-Merino L,Dutriaux C,Garbe C,Bartley K,Karagiannis T,Chang I,Rooney I,Koralek DO,Larkin J,McArthur GA,Ribas A

更新日期：2018-03-20 00:00:00

abstract：BACKGROUND:High amplification of epiregulin (EREG) and amphireglin (AREG) in tumour tissues has been previously reported to be associated with better outcome in metastatic colorectal cancer (mCRC) patients who were treated with anti-EGFR antibodies. Here we investigated associations between the expression of other cand...

journal_title：British journal of cancer

authors： Takahashi N,Iwasa S,Taniguchi H,Sasaki Y,Shoji H,Honma Y,Takashima A,Okita N,Kato K,Hamaguchi T,Shimada Y,Yamada Y

更新日期：2016-04-26 00:00:00

abstract：:The p53 tumour suppressor protein inhibits malignant progression by mediating cell cycle arrest, apoptosis or repair following cellular stress. One of the major regulators of p53 function is the MDM2 protein, and multiple forms of cellular stress activate p53 by inhibiting the MDM2-mediated degradation of p53. Mutatio...

journal_title：British journal of cancer

authors： Bálint E E,Vousden KH

更新日期：2001-12-14 00:00:00

abstract：:It has been suggested that tamoxifen may improve the efficacy of medical castration with luteinising hormone-releasing hormone analogues, but very few data have so far been published concerning the clinical and endocrinological activity of this therapeutic modality. In this phase II multicentre trial conducted by the ...

journal_title：British journal of cancer

authors： Buzzoni R,Biganzoli L,Bajetta E,Celio L,Fornasiero A,Mariani L,Zilembo N,Di Bartolomeo M,Di Leo A,Arcangeli G

更新日期：1995-05-01 00:00:00

abstract：:This cross-sectional survey aimed to evaluate the prevalence of burnout and estimated psychiatric disorders among haemato-oncology healthcare professionals in Italy. The aspects of work that respondents perceive as stressful and satisfying have also been examined. The assessments were made using the Maslach Burnout In...

journal_title：British journal of cancer

authors： Bressi C,Manenti S,Porcellana M,Cevales D,Farina L,Felicioni I,Meloni G,Milone G,Miccolis IR,Pavanetto M,Pescador L,Poddigue M,Scotti L,Zambon A,Corrao G,Lambertenghi-Deliliers G,Invernizzi G

更新日期：2008-03-25 00:00:00

abstract：:High-level microsatellite instability (MSI-H) in colorectal cancer accounts for about 12% of colorectal cancers and is typically associated with a dense infiltration with cytotoxic CD8-positive lymphocytes. The role of regulatory T cells that may interfere with the host's antitumoural immune response in MSI-H colorect...

journal_title：British journal of cancer

authors： Michel S,Benner A,Tariverdian M,Wentzensen N,Hoefler P,Pommerencke T,Grabe N,von Knebel Doeberitz M,Kloor M

更新日期：2008-12-02 00:00:00