Abstract：
:Matched pair analysis relating to 3376 mothers of children who died of cancer 1972-1981 and of healthy control children from the Oxford Survey of Childhood Cancers showed no evidence of protection from breastfeeding for acute lymphocytic leukaemia (OR 1.04, 95% CI 0.86-1.26), for all cancers combined (OR 1.04, 95% CI 0.93-1.15) or for other groupings. Analyses by duration of breastfeeding also failed to support the protective hypothesis.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Lancashire RJ,Sorahan T,OSCC.doi
10.1038/sj.bjc.6600881subject
Has Abstractpub_date
2003-04-07 00:00:00pages
1035-7issue
7eissn
0007-0920issn
1532-1827pii
6600881journal_volume
88pub_type
杂志文章abstract：:Sodium polyanethol sulphonate (SPS) when incorporated into rat erythrocyte lysate (REL) containing semi-solid agar medium at 1 mg ml-1. markedly enhanced colony formation by a number of anchorage-independent cell lines. REL usually needed to be included for the expression of SPS induced potentiation as in its absence ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1984.230
更新日期：1984-11-01 00:00:00
abstract：:Chinese hamster V79-171B spheroids implanted in the peritoneal cavity of C3H mice were characterized as a model for evaluating the toxicity of drugs requiring metabolic activation in vivo. After 24 hours in the peritoneal cavity, spheroid cellularity and plating efficiency were not significantly decreased, and host ce...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1987.196
更新日期：1987-09-01 00:00:00
abstract：:We examined the relationship between p53 levels before and after irradiation, radiation-induced cell cycle delays, apoptotic cell death and radiosensitivity in a panel of eight human tumour cell lines. The cell lines differed widely in their clonogenic survival after radiation, (surviving fraction at 2 Gy: SF2=0.18-0....
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.101
更新日期：1996-03-01 00:00:00
abstract：BACKGROUND:The addition of breast magnetic resonance imaging (MRI) to screening mammography for women with BRCA mutations significantly increases sensitivity, but there is little data on clinical outcomes. We report screening performance, cancer stage, distant recurrence rate, and breast cancer-specific mortality in ou...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2012.204
更新日期：2012-06-26 00:00:00
abstract：:Angiopoietin-1 is a promoter of physiological vasculogenesis and angiogenesis because it induces vascular branching and smooth muscle recruitment to newly formed blood vessels. However, angiopoietin-1 expression in tumours appears to be uncommon, and angiopoietin-1 overexpression in cancer cells has been reported to l...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600082
更新日期：2002-02-12 00:00:00
abstract：:We have established a novel ascites tumour model (MDA435/LCC6) from the oestrogen receptor-negative, invasive and metastatic MDA-MB-435 human breast cancer cell line. MDA435/LCC6 cells grow as both malignant ascites and solid tumours in vivo in nude mice and nude rats, with a tumour incidence of approximately 100%. Un...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.29
更新日期：1996-01-01 00:00:00
abstract：:To examine whether weight loss at presentation influences outcome in patients who received chemotherapy for lung cancer or mesothelioma. Multivariate analysis of prospectively collected data 1994-2001. Data were available for age, gender, performance status, histology, stage, response, toxicity, progression-free and o...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601781
更新日期：2004-05-17 00:00:00
abstract：:In haemagglutination tests we have found that the monoclonal antibody B5 discriminates between erythrocytes from patients with malignant cancer (total 386; greater than 80% B5 positive) and individuals with no known tumour (total 247; less than 20% B5 positive). The B5 antigen detected on intact erythrocytes is a tigh...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1984.53
更新日期：1984-03-01 00:00:00
abstract：BACKGROUND:Only a small proportion of patients respond to anti-VEGF therapy, pressing the need for a reliable biomarker that can identify patients who will benefit. We studied the biological activity of anti-VEGF antibodies in patients' blood during anti-VEGF therapy by using the Ba/F3-VEGFR2 cell line, which is depend...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2016.275
更新日期：2016-10-11 00:00:00
abstract：:The ribosome-inactivating proteins, bryodin, from Bryonia dioica, and momordin, from Momordica charantia, were coupled by a disulphide bond to a monoclonal anti-Thy 1.1 antibody (OX7). Both immunotoxins were specifically cytotoxic to the Thy 1.1-expressing mouse lymphoma cell line AKR-A in vitro. The OX7-bryodin immun...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1988.258
更新日期：1988-11-01 00:00:00
abstract：BACKGROUND:We performed a cross-sectional study in Indonesia to evaluate the performance of a single-visit approach of cervical cancer screening, using visual inspection with acetic acid (VIA), histology and cryotherapy in low-resource settings. METHODS:Women having limited access to health-care facilities were screen...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2012.334
更新日期：2012-08-21 00:00:00
abstract：:The 5T4 oncofetal antigen is a 72 kDa glycoprotein defined by a monoclonal antibody raised against human placental trophoblast and is expressed in many different carcinomas but detected only at low levels in some normal epithelia. Immunohistochemical analysis of the patterns of expression in colorectal carcinomas has ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1994.173
更新日期：1994-05-01 00:00:00
abstract：:Immunohistochemical localization of chondroitin sulphate and dermatan sulphate proteoglycans (PGs) was observed in 70 tumour tissues, using monoclonal antibodies 9A-2 and 3B-3 raised against core molecules obtained from chondroitin sulphate PG by chondroitinase ABC-treatment. They recognize a stub of delta Di-4S and d...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1988.12
更新日期：1988-01-01 00:00:00
abstract：:The bioreductive antitumour agent, mitomycin C (MMC), requires activation by reductive enzymes like NAD(P)H:quinone oxidoreductase 1 (NQO1). We used a novel approach to increase MMC efficacy by selectively inducing NQO1 in tumour cells in vivo. CD-1 nude mice were implanted with HCT116 cells, and fed control diet or d...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602171
更新日期：2004-10-18 00:00:00
abstract：BACKGROUND:The poor prognosis of patients with colorectal-cancer liver metastases (CRLM) and the insufficiency of available treatments have raised the need for alternative curative strategies. We aimed to assess the therapeutic potential of TL-118, a new anti-angiogenic drug combination, for CRLM treatment, in a mouse ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2012.322
更新日期：2012-08-07 00:00:00
abstract：BACKGROUND:Epidemiological studies evaluating the association of vitamin B6, vitamin B12 and methionine with breast cancer risk have produced inconsistent results. METHODS:Pertinent studies were identified by a search in PubMed and Web of Knowledge. Random-effect model was used. Dose-response relationship was assessed...
journal_title：British journal of cancer
pub_type： 杂志文章,meta分析
doi：10.1038/bjc.2013.438
更新日期：2013-10-01 00:00:00
abstract：:Tumour cells from 7 patients with ovarian carcinoma and from 22 different human tumour xenografts representing a wide range of histological sub-types have been examined for multicellular spheroid forming ability. Spheroid formation was limited to cells derived from xenografts. Of the 22 lines tested, 5 formed spheroid...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1982.296
更新日期：1982-12-01 00:00:00
abstract：:We compared the long-term impact of 1- and 2-year screening mammography intervals using prognostic, screening, and outcome information for women aged 50-74 years obtained from the Screening Mammography Program of British Columbia in two time periods, prior to 1997 (policy of annual mammography) and after 1997 (biennia...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602393
更新日期：2005-03-14 00:00:00
abstract：:In a meta-analysis of testicular cancer in twins, twins had a 30% increased risk (estimate 1.31, 95% CI 1.1-1.6), providing indirect support for the hypothesis that in utero hormone variations influence risk of testicular cancer. The summary-estimate for dizygotic twins was 1.3 (1.0-1.7) and for monozygotic or same se...
journal_title：British journal of cancer
pub_type： 杂志文章,meta分析
doi：10.1038/sj.bjc.6604136
更新日期：2008-01-15 00:00:00
abstract：:Bacteriochlorin a (BCA) is a second-generation photosensitizer that is effective in tumour destruction upon illumination with light of a wavelength of 760 nm. Tissue penetration by light at this wavelength is greater compared with wavelengths at which commonly used photosensitizers are illuminated, making it possible ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.353
更新日期：1998-06-01 00:00:00
abstract：BACKGROUND:Bortezomib is a proteasome inhibitor with minimal clinical activity as a monotherapy in solid tumours, but its combination with other targeted therapies is being actively investigated as a way to increase its anticarcinogenic properties. Here, we evaluate the therapeutic potential of co-treatment with bortez...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.546
更新日期：2012-01-17 00:00:00
abstract：:We examined polymorphisms in exons 3 and 4 of microsomal epoxide hydrolase in 101 patients with colon cancer and compared the results with 203 control samples. The frequency of the exon 3 T to C mutation was higher in cancer patients than in controls (odds ratio 3.8; 95% confidence intervals 1.8-8.0). This sequence al...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690028
更新日期：1999-01-01 00:00:00
abstract：:Multidrug resistance (MDR) is the major confounding factor in adjuvant solid tumour chemotherapy. Increasing intracellular amounts of chemotherapeutics to circumvent MDR may be achieved by a novel delivery method, photochemical internalisation (PCI). PCI consists of the co-administration of drug and photosensitiser; u...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603895
更新日期：2007-08-20 00:00:00
abstract：:Tumour angiogenesis is a complex multistep process regulated by a number of angiogenic factors. One such factor, platelet-derived endothelial cell growth factor has recently been shown to be thymidine phosphorylase (TP). TP catalyses the reversible phosphorylation of thymidine to deoxyribose-1-phosphate and thymine. A...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.49
更新日期：1996-02-01 00:00:00
abstract：:This study provides an analysis of the structure of the initial cancer consultation, the consultation styles of medical and radiation oncologists, and their effect on patient outcomes. One hundred and fifty-five cancer patients attending their first consultation with either a medical or radiation oncologist were audio...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604348
更新日期：2008-05-06 00:00:00
abstract：:Expression of CDX2, a caudal-related homeobox gene, was found to be decreased in colorectal carcinomas. Heterozygous null mutant mice as to Cdx2 develop multiple intestinal adenomatous polyps. To clarify the role of CDX2 in colorectal carcinogenesis, we determined its genomic structure, and searched for mutations of C...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690068
更新日期：1999-02-01 00:00:00
abstract：:Nerve growth factor (NGF) administration to athymic mice with transplanted human bromocriptine-resistant prolactinoma, results in the expression of dopamine D-2 receptors in the tumour and restores sensitivity to subsequent treatment with bromocriptine, which then produces normalisation of plasma prolactin and tumour ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1995.520
更新日期：1995-12-01 00:00:00
abstract：:The sera from patients with advanced cancer were tested for their specific inhibitory effects on the cytotoxicity of autologous lymphocytes on tumour cells in a microculture assay. By adding a standard volume of the sera to suspensions of well-washed lymphocytes the inhibitory effect was quantitated by comparison with...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1973.67
更新日期：1973-07-01 00:00:00
abstract：:In advanced pancreatic cancer, level one evidence has established a significant survival advantage with chemotherapy, compared to best supportive care. The treatment-associated toxicity needs to be evaluated. This study examines the secondary outcome measures for chemotherapy in advanced pancreatic cancer using meta-a...
journal_title：British journal of cancer
pub_type： 杂志文章,meta分析
doi：10.1038/sj.bjc.6604436
更新日期：2008-07-08 00:00:00
abstract：:Angiogenesis is an essential requirement for tumour growth and metastasis and is regulated by a complex network of factors produced by both stromal cells and neoplastic cells within solid tumours. The cytokine tumour necrosis factor alpha (TNF-alpha) and the enzyme thymidine phosphorylase (TP) are two factors known to...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.373
更新日期：1998-06-01 00:00:00
