MDA435/LCC6 and MDA435/LCC6MDR1: ascites models of human breast cancer.

abstract：:We previously demonstrated a characteristically high sensitivity of pancreatic cancer cells to interferon alpha (IFN-alpha) gene transfer, which induced a more prominent growth suppression and cell death in pancreatic cancer cells than in other types of cancers and normal cells. The IFN-alpha protein can exhibit both ...

journal_title：British journal of cancer

authors： Ohashi M,Yoshida K,Kushida M,Miura Y,Ohnami S,Ikarashi Y,Kitade Y,Yoshida T,Aoki K

更新日期：2005-08-22 00:00:00

abstract：:Based on observations that for certain cancers, mortality varies according to sun exposure, vitamin D has been proposed to influence on disease progression. This study aims to investigate whether serum levels of 25(OH)D are associated with prognosis in patients with prostate cancer. In total, 160 patients with a serum...

journal_title：British journal of cancer

authors： Tretli S,Hernes E,Berg JP,Hestvik UE,Robsahm TE

更新日期：2009-02-10 00:00:00

abstract：BACKGROUND:To evaluate the possible association between paediatric head computed tomography (CT) examination and increased subsequent risk of malignancy and benign brain tumour. METHODS:In the exposed cohort, 24 418 participants under 18 years of age, who underwent head CT examination between 1998 and 2006, were ident...

journal_title：British journal of cancer

authors： Huang WY,Muo CH,Lin CY,Jen YM,Yang MH,Lin JC,Sung FC,Kao CH

更新日期：2014-04-29 00:00:00

abstract：BACKGROUND:A major molecular pathway of genetic instability in cancer is DNA mismatch repair deficiency. High-level microsatellite instability (MSI-H) is currently the best predictor of responsiveness towards immune checkpoint blockade. Data about the prevalence of high-level microsatellite instability in cholangiocarc...

journal_title：British journal of cancer

authors： Goeppert B,Roessler S,Renner M,Singer S,Mehrabi A,Vogel MN,Pathil A,Czink E,Köhler B,Springfeld C,Pfeiffenberger J,Rupp C,Weiss KH,Schirmacher P,von Knebel Doeberitz M,Kloor M

更新日期：2019-01-01 00:00:00

abstract：:Helicobacter has been suggested to play a possible role in hepatitis, gallstones, and hepatobiliary tumours. We assessed whether seropositivity to 15 H. pylori proteins was associated with subsequent incidence of 74 biliary tract and 105 liver cancer cases vs. 357 matched controls in the Prostate, Lung, Colorectal, an...

journal_title：British journal of cancer

authors： Makkar R,Butt J,Huang WY,McGlynn KA,Koshiol J,Pawlita M,Waterboer T,Freedman ND,Murphy G

更新日期：2020-09-01 00:00:00

abstract：:A brief review is presented of the evidence linking the development of certain types of neoplasms, and of the malignant lymphomas in particular, to chronic immunosuppression in animals and man and to the naturally occurring human immunologic deficiency states. The discussion then focuses on Hodgkin's disease and consi...

journal_title：British journal of cancer

authors： Kaplan HS

更新日期：1971-12-01 00:00:00

abstract：:One hundred resected cases of squamous cell carcinomas of the oesophagus were reviewed and a series of histological criteria related to the survival time. Two histological features were important in the assessment of survival. Good prognostic factors were a marked lymphocytic response to the tumour and a lack of intra...

journal_title：British journal of cancer

authors： Edwards JM,Hillier VF,Lawson RA,Moussalli H,Hasleton PS

更新日期：1989-03-01 00:00:00

abstract：:Many kallikrein genes were found to be differentially expressed in various malignancies, and prostate specific antigen (encoded by the KLK3 gene) is the best tumour marker for prostate cancer. Prostate specific antigen has recently been shown to be an independent favourable prognostic marker for breast cancer. KLK15 i...

journal_title：British journal of cancer

authors： Yousef GM,Scorilas A,Magklara A,Memari N,Ponzone R,Sismondi P,Biglia N,Abd Ellatif M,Diamandis EP

更新日期：2002-11-18 00:00:00

abstract：:We examined a panel of 25 small cell lung cancer (SCLC) cell lines and nude mouse xenografts for expression of the proto-oncogenes c-met and c-kit, and for expression of the corresponding ligands, hepatocyte growth factor (HGF) (also known as scatter factor (SF)), and stem cell factor (SCF), respectively. Expression o...

journal_title：British journal of cancer

authors： Rygaard K,Nakamura T,Spang-Thomsen M

更新日期：1993-01-01 00:00:00

abstract：:A monoclonal antibody recognizing the blood group H type 2 antigen has been obtained from a BALB/c mouse immunized with MCF-7 (human mammary carcinoma) cells. The specificity of this antibody (A46-B/B10, IgM, kappa) has been identified by haemagglutination tests, immunohistochemistry, binding inhibition studies, and a...

journal_title：British journal of cancer

authors： Karsten U,Pilgrim G,Hanisch FG,Uhlenbruck G,Kasper M,Stosiek P,Papsdorf G,Pasternak G

更新日期：1988-08-01 00:00:00

abstract：:Tamoxifen is the current therapy of choice for patients with oestrogen receptor positive breast cancer, and it is currently under evaluation as a prophylactic for women at high risk of developing the disease. However, tamoxifen is also known to induce proliferative changes in the endometrium increasing the risk of dev...

journal_title：British journal of cancer

authors： Hague S,Manek S,Oehler MK,MacKenzie IZ,Bicknell R,Rees MC

更新日期：2002-03-04 00:00:00

abstract：BACKGROUND:Detection of metastatic spread of head and neck cancer to cervical lymph nodes is essential for optimal design of therapy. Undetected metastases lead to mortality, which can be prevented by better detection methods. METHODS:We analysed 41 lymph nodes from 19 patients with oral squamous cell carcinoma (OSCC)...

journal_title：British journal of cancer

authors： Häyry V,Kågedal Å,Hjalmarsson E,Neves da Silva PF,Drakskog C,Margolin G,Georén SK,Munck-Wikland E,Winqvist O,Cardell LO

更新日期：2018-02-06 00:00:00

abstract：:The aim of this work was to test in vitro and in vivo the efficacy of the derivatives of 5-aminolevulinic acid (ALA): hexyl-ALA (He-ALA), undecanoyl-ALA and R,S-2-(hydroximethyl)tetrahydropyranyl-ALA (THP-ALA) as pro-photosensitising agents. The compounds were assayed in a cell line derived from a murine mammary tumou...

journal_title：British journal of cancer

authors： Perotti C,Fukuda H,DiVenosa G,MacRobert AJ,Batlle A,Casas A

更新日期：2004-04-19 00:00:00

abstract：:In haemagglutination tests we have found that the monoclonal antibody B5 discriminates between erythrocytes from patients with malignant cancer (total 386; greater than 80% B5 positive) and individuals with no known tumour (total 247; less than 20% B5 positive). The B5 antigen detected on intact erythrocytes is a tigh...

journal_title：British journal of cancer

authors： Metcalfe S,Milner J,Svvennsen RJ

更新日期：1984-03-01 00:00:00

abstract：:Studies of underground miners occupationally exposed to radon have consistently demonstrated an increased risk of lung cancer in both smokers and non-smokers. Radon exposure also occurs elsewhere, especially in houses, and estimates based on the findings for miners suggest that residential radon is responsible for abo...

journal_title：British journal of cancer

authors： Darby S,Whitley E,Silcocks P,Thakrar B,Green M,Lomas P,Miles J,Reeves G,Fearn T,Doll R

更新日期：1998-08-01 00:00:00

abstract：:Interferon-alpha (IFN-alpha) is a clinically useful cytokine for treatment of a variety of cancers, including chronic myelocytic leukaemia (CML). Most CML cells are sensitive to IFN-alpha; however, its biological effects on leukaemic cells are incompletely characterized. Here, we provide evidence that IFN-alpha induce...

journal_title：British journal of cancer

authors： Miyachi T,Adachi M,Hinoda Y,Imai K

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:Epithelial-mesenchymal transition (EMT) is characterised by the loss of cell-to-cell adhesion and gaining of mesenchymal phenotypes. Epithelial-mesenchymal transition is proposed to occur in various developmental processes and cancer progression. 'Cadherin switch', a process in which cells shift to express d...

journal_title：British journal of cancer

authors： Nitta T,Mitsuhashi T,Hatanaka Y,Miyamoto M,Oba K,Tsuchikawa T,Suzuki Y,Hatanaka KC,Hirano S,Matsuno Y

更新日期：2014-09-23 00:00:00

abstract：:Mediastinal masses include a wide variety of tumours and remain an interesting diagnostic challenge for radiologist. We performed positron emission tomography (PET) studies of primary mediastinal tumours in order to predict the malignancy of these tumours preoperatively. Twenty-two patients with primary mediastinal tu...

journal_title：British journal of cancer

authors： Kubota K,Yamada S,Kondo T,Yamada K,Fukuda H,Fujiwara T,Ito M,Ido T

更新日期：1996-04-01 00:00:00

abstract：:The chick embryo was used to study the relationship between the onset of tumour neovascularization and tumour growth. Walker 256 carcinosarcoma was implanted on the chrioallantoic membrane (CAM) of about 600 embryos aged 5-16 days. Tumour diameter and changes in the CAM vasculature in response to the implants were rec...

journal_title：British journal of cancer

authors： Knighton D,Ausprunk D,Tapper D,Folkman J

更新日期：1977-03-01 00:00:00

abstract：BACKGROUND:Placental-site trophoblastic (PSTT) and epithelioid trophoblastic tumours (ETT) are the rarest malignant forms of gestational trophoblastic disease (GTD). Our prior work demonstrated that an interval of ≥48 months from the antecedent pregnancy was associated with 100% death rate, independent of the stage. He...

journal_title：British journal of cancer

authors： Froeling FEM,Ramaswami R,Papanastasopoulos P,Kaur B,Sebire NJ,Short D,Fisher RA,Sarwar N,Wells M,Singh K,Ellis L,Horsman JM,Winter MC,Tidy J,Hancock BW,Seckl MJ

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:To prospectively examine the association between diabetes and risk of prostate cancer defined by clinical and molecular features. METHODS:A total of 49,392 men from the Health Professionals Follow-up Study (HPFS) were followed from 1986 to 2014. Data on self-reported diabetes were collected at baseline and ...

journal_title：British journal of cancer

authors： Feng X,Song M,Preston MA,Ma W,Hu Y,Pernar CH,Stopsack KH,Ebot EM,Fu BC,Zhang Y,Li N,Dai M,Liu L,Giovannucci EL,Mucci LA

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Few studies have investigated the relationship between physician and patient-assessed performance status (PS) in blood cancers. METHODS:Retrospective analysis among 1418 patients with haematologic malignancies seen at Dana-Farber Cancer Institute between 2007 and 2014. We analysed physician-patient agreemen...

journal_title：British journal of cancer

authors： Liu MA,Hshieh T,Condron N,Wadleigh M,Abel GA,Driver JA

更新日期：2016-09-27 00:00:00

abstract：:Insoluble conanavalin A and wheat germ agglutinin (WGA) were found to bind to carbohydrates on radio-labelled carcinoembryonic antigen (CEA). Binding by WGA was inhibited both by N-acetyl D-glucosamine and fragments of antibody to CEA, but was increased by intact antibody to CEA. This suggests that WGA binds to expose...

journal_title：British journal of cancer

authors： Macsween JM,Fox RA

更新日期：1975-03-01 00:00:00

abstract：:Forty-two patients with clinical stage IIIA or IIIB breast cancer were treated with neoadjuvant chemotherapy followed by mastectomy and radiotherapy. The median follow-up was 32 months (range 10-72 months) and the median time to progression was 17 months (range 10-30 months). A multivariate analysis showed that a long...

journal_title：British journal of cancer

authors： Honkoop AH,van Diest PJ,de Jong JS,Linn SC,Giaccone G,Hoekman K,Wagstaff J,Pinedo HM

更新日期：1998-02-01 00:00:00

abstract：:For the first time in a clinical study oral Ifosfamide was used: 65 elderly or unfit patients with small cell lung cancer (SCLC) were treated as outpatients with fractionated oral Ifosfamide and Etoposide. Forty patients (62%) had extensive stage (ED) disease. The median age of the patients was 66 years. In the 60 pat...

journal_title：British journal of cancer

authors： Cerny T,Lind M,Thatcher N,Swindell R,Stout R

更新日期：1989-08-01 00:00:00

abstract：:Dormant and regressing implants of C3H mammary carcinoma MC2 were always found to be surrounded by a cellular fibrous capsule where macrophages and T cells predominated as the cellular elements. Macrophages were always closely associated with the collagen deposition, and stained with anti-collagen type I immuno-peroxi...

journal_title：British journal of cancer

authors： Vaage J,Harlos JP

更新日期：1991-05-01 00:00:00

abstract：:We carried out a comparison of three commonly used mucin markers, CA549, CA15.3 and MCA. Serum samples from 184 healthy women and 237 patients with primary breast cancer were evaluated. The markers were measured using commercially available immunometric assays. Like CA15.3 and MCA, CA549 was significantly associated w...

journal_title：British journal of cancer

authors： Gion M,Plebani M,Mione R,Penzo C,Meo S,Burlina A

更新日期：1994-04-01 00:00:00

abstract：:The geographical distribution of mortality from mesothelioma of the pleura during the years 1968-78 in England and Wales has been studied using extracts from the death records held by the Office of Population Censuses and Surveys. Using the national death rate as standard, Local Authority areas with raised mortality a...

journal_title：British journal of cancer

authors： Gardner MJ,Acheson ED,Winter PD

更新日期：1982-07-01 00:00:00

abstract：:Pancreatic cancer is a highly lethal malignancy with a dismal 5-year survival of less than 5%. The scarcity of early biomarkers has considerably hindered our ability to launch preventive measures for this malignancy in a timely manner. Neutrophil gelatinase-associated lipocalin (NGAL), a 24-kDa glycoprotein, was repor...

journal_title：British journal of cancer

authors： Moniaux N,Chakraborty S,Yalniz M,Gonzalez J,Shostrom VK,Standop J,Lele SM,Ouellette M,Pour PM,Sasson AR,Brand RE,Hollingsworth MA,Jain M,Batra SK

更新日期：2008-05-06 00:00:00

abstract：BACKGROUND:Gemcitabine-based chemotherapy is the standard treatment for pancreatic cancer. However, the issue of resistance remains unresolved. The aim of this study was to identify microRNAs (miRNAs) that govern the resistance to gemcitabine in pancreatic cancer. METHODS:miRNA microarray analysis using gemcitabine-re...

journal_title：British journal of cancer

authors： Iwagami Y,Eguchi H,Nagano H,Akita H,Hama N,Wada H,Kawamoto K,Kobayashi S,Tomokuni A,Tomimaru Y,Mori M,Doki Y

更新日期：2013-07-23 00:00:00