The androgen-regulated gene human kallikrein 15 (KLK15) is an independent and favourable prognostic marker for breast cancer.

abstract：:Twenty patients with non-Hodgkin's lymphoma were treated with a combination of cyclophosphamide (750 mg m(-2), day 1), epidoxorubicin (60 mg m(-2), day 1), vincristine (1.4 mg m(-2), day 1) and prednisone (100 mg m(-2), days 1-5) every 14 days. Shortening of intervals was associated with the prophylactic employment of...

journal_title：British journal of cancer

authors： Pronzato P,Lionetto R,Botto F,Pensa F,Tognoni A

更新日期：1998-09-01 00:00:00

abstract：:Mechanisms of resistance to Tomudex include increased thymidylate synthase activity, as well as reduced intracellular drug uptake and polyglutamation. However, little is known about other mechanisms of resistance, such as a possible protection against Tomudex-induced apoptosis mediated by bcl-2. We transfected the MDA...

journal_title：British journal of cancer

authors： Orlandi L,Bearzatto A,Abolafio G,De Marco C,Daidone MG,Zaffaroni N

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND:Most oestrogen receptor (ER)-positive early breast cancer diagnosed today is highly curable with multimodality treatment. Systemic adjuvant treatments including endocrine therapy and chemotherapy have made a significant contribution to the increasing cure rates over the past three decades. However not all wo...

journal_title：British journal of cancer

authors： Yeo B,Zabaglo L,Hills M,Dodson A,Smith I,Dowsett M

更新日期：2015-07-28 00:00:00

abstract：:Thirty-four patients with progressive low grade non-Hodgkin's lymphoma were treated with 1 microgram oral alfacalcidol daily. Complete response was seen in four patients and a partial response in four patients with an overall response rate of 24%. Median duration of response was 14 months. Disease stabilised in ten ot...

journal_title：British journal of cancer

authors： Raina V,Cunningham D,Gilchrist N,Soukop M

更新日期：1991-03-01 00:00:00

abstract：:Dendritic cells (DC) are professional antigen-presenting cells (APC) of the immune system, uniquely able to prime naive T-cell responses. They are the focus of a range of novel strategies for the immunotherapy of cancer, a proportion of which include treating DC with ionising radiation to high dose. The effects of rad...

journal_title：British journal of cancer

authors： Merrick A,Errington F,Milward K,O'Donnell D,Harrington K,Bateman A,Pandha H,Vile R,Morrison E,Selby P,Melcher A

更新日期：2005-04-25 00:00:00

abstract：:Expression of the tumour suppressor gene p53 was examined in squamous cell carcinoma of the head and neck using two p53 antibodies, PAb 421 and PAb 1801. Elevated p53 expression was found in 67% of the 73 patients investigated. P53 expression was not found to correlate with whether the patient had been previously trea...

journal_title：British journal of cancer

authors： Field JK,Spandidos DA,Malliri A,Gosney JR,Yiagnisis M,Stell PM

更新日期：1991-09-01 00:00:00

abstract：:Solid tumours are often highly acidic compared to normal tissue, and tumour extracellular acidosis contributes to multiple aspects of cancer progression. Now, Anemone et al. in this issue of the British Journal of Cancer provide in vivo evidence that the degree to which various breast cancer cell lines acidify their e...

journal_title：British journal of cancer

authors： Rolver MG,Pedersen SF

更新日期：2021-01-01 00:00:00

abstract：:The prognostic weight of histological and biological factors was compared with that of known clinical prognostic factors in a population of 108 consecutive previously untreated patients with head and neck squamous cell carcinoma. Parameters studied were: tumour vascularisation, mitotic index, histological differentiat...

journal_title：British journal of cancer

authors： Janot F,Klijanienko J,Russo A,Mamet JP,de Braud F,El-Naggar AK,Pignon JP,Luboinski B,Cvitkovic E

更新日期：1996-02-01 00:00:00

abstract：:P450 reductase (NADPH:cytochrome P450 reductase, EC 1.6.2.4) is known to be important in the reductive activation of the benzotriazene-di-N-oxide tirapazamine (SR 4233). Using a panel of six human breast adenocarcinoma cell lines we have examined the relationship between P450 reductase activity and sensitivity to tira...

journal_title：British journal of cancer

authors： Patterson AV,Barham HM,Chinje EC,Adams GE,Harris AL,Stratford IJ

更新日期：1995-11-01 00:00:00

abstract：:The National Registry of Childhood Tumours contains over 51000 records of children born in Great Britain who developed cancer under the age of 15 years. Patterns of childhood cancer among families containing more than one child with cancer have been studied. A total of 225 "sib pair' families have been ascertained fro...

journal_title：British journal of cancer

authors： Draper GJ,Sanders BM,Lennox EL,Brownbill PA

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND:It has been a challenge to determine breast cancer clonality accurately. The aim of the present study was to assess methods using formalin-fixed paraffin-embedded (FFPE) tissue to differentiate new primary tumours from true recurrences that are associated with poorer prognoses and often require more aggressi...

journal_title：British journal of cancer

authors： Masuda S,Kadowaki T,Kumaki N,Tang X,Tokuda Y,Yoshimura S,Takekoshi S,Osamura RY

更新日期：2012-12-04 00:00:00

abstract：:Many cancers express Fas ligand (FasL/CD95L) in vivo, and can kill lymphoid cells by Fas-mediated apoptosis in vitro. However, overexpression of recombinant FasL in murine tumour allografts revealed a potential antitumour effect of FasL, via recruitment of neutrophils. Transforming growth factor-beta1 (TGF-beta1) coul...

journal_title：British journal of cancer

authors： Houston A,Bennett MW,O'Sullivan GC,Shanahan F,O'Connell J

更新日期：2003-10-06 00:00:00

abstract：:Pancreatic tumours are scirrhous, avascular tumours, suggesting that they may produce angiogenesis inhibitors that suppress the growth of the vasculature to the tumour and metastases. We have sought evidence for the angiogenesis inhibitor, endostatin, in normal and cancerous pancreatic tissue. Using Western blotting, ...

journal_title：British journal of cancer

authors： Brammer RD,Bramhall SR,Eggo MC

更新日期：2005-01-17 00:00:00

abstract：:Adriamycin and cyclophosphamide are active agents in human and experimental tumours. Using the L1210 murine leukaemia, their effectiveness alone and in combination was studied. The combination is highly synergistic in this tumour, resulting in a greater than 50% survival rate when the agents used alone at optimal dose...

journal_title：British journal of cancer

authors： Tobias JS,Parker LM,Tattersall MH,Frei E 3rd

更新日期：1975-08-01 00:00:00

abstract：:To estimate the prevalence of TP53 mutations in familial breast cancer, constant denaturant gel electrophoresis (CDGE) was used to screen exons 5-8 of the TP53 gene for germline mutations. Genomic DNA from 128 breast cancer patients belonging to 109 families with familial cancer were screened. No germline mutations we...

journal_title：British journal of cancer

authors： Zelada-Hedman M,Børresen-Dale AL,Claro A,Chen J,Skoog L,Lindblom A

更新日期：1997-01-01 00:00:00

abstract：:Laminin promotes the malignant phenotype, and the expression of certain laminin receptors is increased in malignancy. Previously, we demonstrated that a laminin-adhesive subclone of a human colon cancer cell line showed increased tumorigenicity in nude mice and increased affinity of the beta1 integrin for laminin rela...

journal_title：British journal of cancer

authors： Kim WH,Lee BL,Jun SH,Song SY,Kleinman HK

更新日期：1998-01-01 00:00:00

abstract：:A brief review is presented of the evidence linking the development of certain types of neoplasms, and of the malignant lymphomas in particular, to chronic immunosuppression in animals and man and to the naturally occurring human immunologic deficiency states. The discussion then focuses on Hodgkin's disease and consi...

journal_title：British journal of cancer

authors： Kaplan HS

更新日期：1971-12-01 00:00:00

abstract：:This report presents the results of a study into the effect of breast self-examination (BSE) in a large defined population within the City of Nottingham since 1979. We have examined the effect of breast self-examination in a group of patients invited to attend for education in BSE compared with a group of historical c...

journal_title：British journal of cancer

authors： Locker AP,Caseldine J,Mitchell AK,Blamey RW,Roebuck EJ,Elston CW

更新日期：1989-09-01 00:00:00

abstract：:Protracted venous infusion 5-fluorouracil (5FU) combined with mitomycin C (MMC) has demonstrated significant activity against metastatic colorectal cancer. Owing to potential synergy based upon upregulation of thymidine phosphorylase by MMC, the combination of capecitabine and MMC may improve outcomes in irinotecan-re...

journal_title：British journal of cancer

authors： Chong G,Dickson JL,Cunningham D,Norman AR,Rao S,Hill ME,Price TJ,Oates J,Tebbutt N

更新日期：2005-09-05 00:00:00

abstract：:Alcohol consumption has been inconsistently associated with breast cancer risk. Recent studies suggest that genetic polymorphisms of glutathione S-transferases (GSTs) may modify this relation. To determine if breast cancer risk is associated with GSTM1 and GSTT1 genetic polymorphisms, and to evaluate the effect modifi...

journal_title：British journal of cancer

authors： Zheng T,Holford TR,Zahm SH,Owens PH,Boyle P,Zhang Y,Zhang B,Wise JP Sr,Stephenson LP,Ali-Osman F

更新日期：2003-01-13 00:00:00

abstract：:The relationship between skin tumours in man and exposure to polyaromatic hydrocarbons has been studied in lathe operators exposed to cutting oils. Seven cases of scrotal cancer and 13 cases of senile keratosis and keratoacanthoma were observed. The risk varied as the 1.6th power of duration of exposure for cancer on ...

journal_title：British journal of cancer

authors： Järvholm B,Easton D

更新日期：1990-12-01 00:00:00

abstract：:Relationships between incidence of Wilms' tumour and information recorded at birth were investigated in a prospective study of the 1,489,297 children born in Norway between 1967 and 1992. A total of 119 individuals were diagnosed with Wilms' tumour in the age interval 0-14 years. A high length at birth was significant...

journal_title：British journal of cancer

authors： Heuch JM,Heuch I,Kvåle G

更新日期：1996-10-01 00:00:00

abstract：:We previously demonstrated a characteristically high sensitivity of pancreatic cancer cells to interferon alpha (IFN-alpha) gene transfer, which induced a more prominent growth suppression and cell death in pancreatic cancer cells than in other types of cancers and normal cells. The IFN-alpha protein can exhibit both ...

journal_title：British journal of cancer

authors： Ohashi M,Yoshida K,Kushida M,Miura Y,Ohnami S,Ikarashi Y,Kitade Y,Yoshida T,Aoki K

更新日期：2005-08-22 00:00:00

abstract：:Two subtypes of thrombospondin (TSP-1 and TSP-2) have inhibitory roles in angiogenesis in vitro, although the biological significance of these TSP isoforms has not been determined in vivo. We examined TSP-1 and TSP-2 gene expression by reverse transcription polymerase chain reaction (RT-PCR) analysis in 61 colon cance...

journal_title：British journal of cancer

authors： Tokunaga T,Nakamura M,Oshika Y,Abe Y,Ozeki Y,Fukushima Y,Hatanaka H,Sadahiro S,Kijima H,Tsuchida T,Yamazaki H,Tamaoki N,Ueyama Y

更新日期：1999-01-01 00:00:00

abstract：:The effect of selected marine compounds with anti-tumoral activity on the cell microtubule network was tested by immunofluorescence analyses, or by other in vitro analyses involving competition with colchicine or with GTP for tubulin binding and tubulin polymerisation, studies that were carried out in parallel with ot...

journal_title：British journal of cancer

authors： García-Rocha M,García-Gravalos MD,Avila J

更新日期：1996-04-01 00:00:00

abstract：:The degree of lymphocyte infiltration is a prognostic factor in liver cancer, but to date the mechanisms by which lymphocytes infiltrate into and are retained in hepatic tumours are poorly understood. We hypothesised that the extracellular matrix glycoprotein vitronectin, a major component of the stroma of hepatic tum...

journal_title：British journal of cancer

authors： Edwards S,Lalor PF,Tuncer C,Adams DH

更新日期：2006-12-04 00:00:00

abstract：:Hypoxia is a key factor contributing to the progression of human neoplasias and to the development of resistance to chemotherapy. BNIP3 is a proapoptotic member of the Bcl-2 protein family involved in hypoxia-induced cell death. We evaluated the expression and methylation status of BNIP3 gene to better understand the ...

journal_title：British journal of cancer

authors： Murai M,Toyota M,Satoh A,Suzuki H,Akino K,Mita H,Sasaki Y,Ishida T,Shen L,Garcia-Manero G,Issa JP,Hinoda Y,Tokino T,Imai K

更新日期：2005-03-28 00:00:00

abstract：BACKGROUND:The most significant problem of intra-arterial chemotherapy for advanced paranasal sinus carcinomas and residual cancers supplied by internal carotid artery (ICA) and involving the skull base is the lack of salvage therapies. OBJECTIVE:The objective of the study was to evaluate the usefulness of intra-arter...

journal_title：British journal of cancer

authors： Yokoyama J,Ohba S,Fujimaki M,Anzai T,Kojima M,Ikeda K,Suzuki M,Yoshimoto H,Inoue K

更新日期：2014-12-09 00:00:00

abstract：:Progression of colorectal cancer may follow either of two main genetic routes: the chromosome- or microsatellite-instability pathways. Association between the patients' prognosis and microsatellite instability has been questioned. Improved survival has previously been found in patients with expression of HLA-DR antige...

journal_title：British journal of cancer

authors： Løvig T,Andersen SN,Thorstensen L,Diep CB,Meling GI,Lothe RA,Rognum TO

更新日期：2002-09-23 00:00:00

abstract：:To assist in the description of the cellular heterogeneity present in normal and neoplastic urothelium, a panel of monoclonal antibodies (MoAbs) was raised against human transitional cell carcinoma (TCC) of the urinary bladder. All immunizations were carried out using whole cells and membrane preparations from well di...

journal_title：British journal of cancer

authors： Dotsikas G,Konowalchuk T,Major PP,Kovac PE,Ward GK,Stewart SS,Price GB,Elhilali MM,Mackillop WJ

更新日期：1987-10-01 00:00:00