当前位置： SCI文献检索 > BRITISH JOURNAL OF CANCER期刊下所有文献 > Characterisation of antimitotic products from marine organisms that disorganise the microtubule network: ecteinascidin 743, isohomohalichondrin-B and LL-15.

Characterisation of antimitotic products from marine organisms that disorganise the microtubule network: ecteinascidin 743, isohomohalichondrin-B and LL-15.

Abstract：

:The effect of selected marine compounds with anti-tumoral activity on the cell microtubule network was tested by immunofluorescence analyses, or by other in vitro analyses involving competition with colchicine or with GTP for tubulin binding and tubulin polymerisation, studies that were carried out in parallel with other microtubule poisons used as controls. Three compounds were found to disorganise the microtubule network: isohomohalichondrin B, LL-15 and ecsteinascidin 743. The first two compounds prevent microtubule assembly and GTP binding to tubulin. Ecteinascidin 743 disorganises the microtubule network but it does not seem to interact directly with tubulin.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

García-Rocha M,García-Gravalos MD,Avila J

doi

10.1038/bjc.1996.176

subject

Has Abstract

pub_date

1996-04-01 00:00:00

pages

875-83

issue

8

eissn

0007-0920

issn

1532-1827

journal_volume

73

pub_type

杂志文章

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