当前位置： SCI文献检索 > BRITISH JOURNAL OF CANCER期刊下所有文献 > A small molecule inhibitor of XIAP induces apoptosis and synergises with vinorelbine and cisplatin in NSCLC.

A small molecule inhibitor of XIAP induces apoptosis and synergises with vinorelbine and cisplatin in NSCLC.

Abstract：

BACKGROUND:Evasion of apoptosis contributes to the pathogenesis of solid tumours including non-small cell lung cancer (NSCLC). Malignant cells resist apoptosis through over-expression of inhibitor of apoptosis proteins (IAPs), such as X-linked IAP (XIAP). METHODS:A phenylurea-based small molecule inhibitor of XIAP, XIAP antagonist compound (XAC) 1396-11, was investigated preclincally to determine its ability to sensitise to clinically relevant cytotoxics, potentially allowing dose reduction while maintaining therapeutic efficacy. RESULTS:XIAP protein expression was detected in six NSCLC cell lines examined. The cytotoxicity of XAC 1396-11 against cultured NSCLC cell lines in vitro was concentration- and time-dependent in both short-term and clonogenic assays. XAC 1396-11-induced apoptosis was confirmed by PARP cleavage and characteristic nuclear morphology. XAC 1396-11 synergised with vinorelbine+/-cisplatin in H460 and A549 NSCLC cells. The mechanism of synergy was enhanced apoptosis, shown by increased cleavage of caspase-3 and PARP and by the reversal of synergy by a pan-caspase inhibitor. Synergy between XAC 1396-11 and vinorelbine was augmented by optimising drug scheduling with superior effects when XAC 1396-11 was administered before vinorelbine. CONCLUSION:These preclinical data suggest that XIAP inhibition in combination with vinorelbine holds potential as a therapeutic strategy in NSCLC.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Dean EJ,Ward T,Pinilla C,Houghten R,Welsh K,Makin G,Ranson M,Dive C

doi

10.1038/sj.bjc.6605418

subject

Has Abstract

pub_date

2010-01-05 00:00:00

pages

97-103

issue

1

eissn

0007-0920

issn

1532-1827

pii

6605418

journal_volume

102

pub_type

杂志文章

相关文献

BRITISH JOURNAL OF CANCER文献大全
  • A retrospective study of the cancer patterns among hospital in-patients in Botswana 1960-72.

    abstract：:Records of approximately 310,000 patients admitted to the 10 hospitals in Botswana between 1960 and 1972 have been studied and details of 1445 patients with malignant tumours abstracted. For the 894 tumours for which there was some supporting evidence--at best histological proof and minimally a clinical description of...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1975.138

    authors： Macrae SM,Cook BV

    更新日期：1975-07-01 00:00:00

  • Chromosome 9p21 gene copy number and prognostic significance of p16 in ESFT.

    abstract：:Chromosome 9p21 gene copy number in Ewing's sarcoma family of tumour (ESFT) cell lines and primary ESFT has been evaluated using Multiplex Ligation-dependent probe amplification, and the clinical significance of CDKN2A loss and p16/p14(ARF) expression investigated. Homozygous deletion of CDKN2A was identified in 4/9 (...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6603819

    authors： Brownhill SC,Taylor C,Burchill SA

    更新日期：2007-06-18 00:00:00

  • Survival of mice with NC carcinoma is unchanged by drugs that are thought to inhibit thromboxane synthesis or increase prostacyclin formation.

    abstract：:Mice transplanted with NC carcinoma were treated with the thromboxane synthetase inhibitor dazmegrel (UK38485) or with nafazatrom (BAY G 6575), a compound that is reported to increase prostacyclin formation. Some experiments included the cytotoxic drugs methotrexate and melphalan. The tumours were excised under anaest...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1986.171

    authors： Stamford IF,Melhuish PB,Carroll MA,Corrigan CJ,Patel S,Bennett A

    更新日期：1986-08-01 00:00:00

  • Expression of eEF1A2 is associated with clear cell histology in ovarian carcinomas: overexpression of the gene is not dependent on modifications at the EEF1A2 locus.

    abstract：:The tissue-specific translation elongation factor eEF1A2 is a potential oncogene that is overexpressed in human ovarian cancer. eEF1A2 is highly similar (98%) to the near-ubiquitously expressed eEF1A1 (formerly known as EF1-alpha) making analysis with commercial antibodies difficult. We wanted to establish the express...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6603748

    authors： Tomlinson VA,Newbery HJ,Bergmann JH,Boyd J,Scott D,Wray NR,Sellar GC,Gabra H,Graham A,Williams AR,Abbott CM

    更新日期：2007-05-21 00:00:00

  • Rare germline mutations in the BRCA2 gene are associated with early-onset prostate cancer.

    abstract：:Studies of families who segregate BRCA2 mutations have found that men who carry disease-associated mutations have an increased risk of prostate cancer, particularly early-onset disease. A study of sporadic prostate cancer in the UK reported a prevalence of 2.3% for protein-truncating BRCA2 mutations among patients dia...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6603929

    authors： Agalliu I,Karlins E,Kwon EM,Iwasaki LM,Diamond A,Ostrander EA,Stanford JL

    更新日期：2007-09-17 00:00:00

  • Analysis of the interaction of monoclonal antibodies with surface IgM on neoplastic B-cells.

    abstract：:In vitro studies identified three Burkitts lymphoma cell lines, Ramos, MUTU-I and Daudi, that were growth inhibited by anti-IgM antibody. However, only Ramos and MUTU-I were sensitive to monoclonal antibodies (mAb) recognizing the Fc region of surface IgM (anti-Fc mu). Experiments using anti-Fc mu mAb (single or non-c...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6690136

    authors： Cragg MS,Zhang L,French RR,Glennie MJ

    更新日期：1999-02-01 00:00:00

  • Loss of acetoacetate coenzyme A transferase activity in tumours of peripheral tissues.

    abstract：:The presence of succinyl-coenzyme A: acetoacetate CoA--transferase (3-oxo acid-CoA transferase), an initiator of ketone body utilization in non-hepatic tissue was examined in a number of animal and human tumours of peripheral tissues. While enzyme levels in heart, kidney, lymphocytes and bladder were high, the tumours...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1983.38

    authors： Tisdale MJ,Brennan RA

    更新日期：1983-02-01 00:00:00

  • Epidemiological evidence of cervical intraepithelial neoplasia without the presence of human papillomavirus.

    abstract：:The aim of this paper was to provide epidemiological evidence to support the notion that cervical intraepithelial neoplasia (CIN) without human papillomavirus (HPV) is a true entity. If a diagnosis of HPV-negative cervical neoplasia is erroneous, one would not expect there to be any differences in risk factors between...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1996.146

    authors： Burger MP,Hollema H,Pieters WJ,Schröder FP,Quint WG

    更新日期：1996-03-01 00:00:00

  • Cell killing by the novel imidazoacridinone antineoplastic agent, C-1311, is inhibited at high concentrations coincident with dose-differentiated cell cycle perturbation.

    abstract：:We have studied the actions of C-1311, an imidazoacridinone analogue with potent in vivo antitumour activity, against a human tumour line (HeLa S3), in an examination of the events associated with the lethality of this agent. Continuous exposures (24 h) induced complete G2 arrest, although the concentration range of t...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1996.550

    authors： Lamb J,Wheatley DN

    更新日期：1996-11-01 00:00:00

  • PROX1 is a predictor of survival for gliomas WHO grade II.

    abstract：BACKGROUND:The clinical course of World Health Organisation grade II gliomas remains variable and their time point of transformation into a more malignant phenotype is unpredictable. Identification of biological markers that can predict prognosis in individual patients is of great clinical value. PROX1 is a transcripti...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2011.162

    authors： Elsir T,Qu M,Berntsson SG,Orrego A,Olofsson T,Lindström MS,Nistér M,von Deimling A,Hartmann C,Ribom D,Smits A

    更新日期：2011-05-24 00:00:00

  • Analysis of gene alterations of mitochondrial DNA D-loop regions to determine breast cancer clonality.

    abstract：BACKGROUND:It has been a challenge to determine breast cancer clonality accurately. The aim of the present study was to assess methods using formalin-fixed paraffin-embedded (FFPE) tissue to differentiate new primary tumours from true recurrences that are associated with poorer prognoses and often require more aggressi...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2012.505

    authors： Masuda S,Kadowaki T,Kumaki N,Tang X,Tokuda Y,Yoshimura S,Takekoshi S,Osamura RY

    更新日期：2012-12-04 00:00:00

  • Short-time repeat high-risk HPV testing by self-sampling for screening of cervical cancer.

    abstract：BACKGROUND:Testing for high-risk human papillomavirus (HPV) in primary screening for cervical cancer is considered more sensitive, but less specific, in comparison with Pap-smear cytology. Women with persistent HPV infections have a higher risk of developing cervical intraepithelial neoplasia 2+ (CIN2+) lesions. This s...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2011.277

    authors： Gyllensten U,Sanner K,Gustavsson I,Lindell M,Wikström I,Wilander E

    更新日期：2011-08-23 00:00:00

  • Hormone replacement treatment and breast cancer risk: a cooperative Italian study.

    abstract：:The relationship between hormone replacement treatment (HRT) and breast cancer risk was analysed using data from a case-control study conducted between June 1991 and February 1994 in six Italian centres on 2569 patients aged below 75 with histologically confirmed breast cancer and 2588 controls admitted to hospital fo...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1995.310

    authors： La Vecchia C,Negri E,Franceschi S,Favero A,Nanni O,Filiberti R,Conti E,Montella M,Veronesi A,Ferraroni M

    更新日期：1995-07-01 00:00:00

  • Adenosine deaminase activity in peripheral blood cells of patients with haematological malignancies.

    abstract：:Adenosine deaminase (EC 3.5.4.4, ADA) has been assayed in lymphocytes, granulocytes and erythrocytes from 45 patients with haematological malignancies. Activities were uniformly low in lymphocytes from patients with chronic lymphocytic leukaemia. Variable, but abnormal activities were frequently found in multiple myel...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1976.45

    authors： Meier J,Coleman MS,Hutton JJ

    更新日期：1976-03-01 00:00:00

  • A multicenter phase II study of the combination of oxaliplatin, irinotecan and capecitabine in the first-line treatment of metastatic colorectal cancer.

    abstract：:The triple drug combination consisting of irinotecan, oxaliplatin and 5-fluorouracil (FOLFOXIRI) has demonstrated higher activity and efficacy compared to the doublet FOLFIRI. 5-Fluorouracil could be substituted in FOLFOXIRI regimen by capecitabine, an oral fluoropyrimidine with similar efficacy. Recently, a dose-find...

    journal_title：British journal of cancer

    pub_type： 杂志文章,多中心研究

    doi：10.1038/sj.bjc.6605075

    authors： Vasile E,Masi G,Fornaro L,Cupini S,Loupakis F,Bursi S,Petrini I,Di Donato S,Brunetti IM,Ricci S,Antonuzzo A,Chiara S,Amoroso D,Andreuccetti M,Falcone A

    更新日期：2009-06-02 00:00:00

  • Plasma vascular endothelial but not fibroblast growth factor levels correlate with colorectal liver mestastasis vascularity and volume.

    abstract：:The extent to which plasma levels of angiogenic factors in healthy individuals and tumour volume-related variations in colorectal cancer affect the accuracy of circulating angiogenic factors as predictors of colorectal cancer vascularity is unknown. We used enzyme-linked immunosorbant assay to measure plasma vascular ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1054/bjoc.1999.1033

    authors： Davies MM,Jonas SK,Kaur S,Allen-Mersh TG

    更新日期：2000-03-01 00:00:00

  • Cell-cell contact affects cellular sensitivity to hyperthermia.

    abstract：:The influence on heat sensitivity of interactions between HT29 human colon adenocarcinoma cells grown in two- or three-dimensional contact was investigated. No evidence for intercellular cooperation affecting cellular sensitivity to hyperthermia was found. Cells grown in monolayer were found to be more heat sensitive ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1985.268

    authors： Dobrucki J,Bleehen NM

    更新日期：1985-12-01 00:00:00

  • Prevalence of human papillomavirus DNA sequences in an area with very high incidence of cervical carcinoma.

    abstract：:To improve our understanding of the relationship and possible associations between human papillomavirus (HPV) infection and the development of cervical malignancies, the presence of multiple types of HPV DNA sequences in cervical carcinoma was determined in Chinese citizens living in two different geographical locatio...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1994.375

    authors： Pao CC,Kao SM,Tang GC,Lee K,Si J,Ruan S

    更新日期：1994-10-01 00:00:00

  • Gastric cancer in Gwynedd. Possible links with bracken.

    abstract：:One hundred and one histologically confirmed gastric cancer patients in Gwynedd, North Wales, were matched by sex, age and social class to two hospital inpatients without cancer. Seventy-seven of the gastric cancer cases were also matched, using the same criteria, to a patient with a confirmed cancer of a different si...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1990.165

    authors： Galpin OP,Whitaker CJ,Whitaker R,Kassab JY

    更新日期：1990-05-01 00:00:00

  • Intrathecal chemotherapy. Selection of cytostatic agents.

    abstract：:Selection of cytostatic agents for intrathecal administration is the subject of this paper.Both the toxic side effects-destruction of blood-brain barrier and change of body weight-and the cytostatic effects on intracranially transplanted Yoshida ascites sarcoma were investigated of intrathecal administration of variou...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1970.59

    authors： Hayakawa T,Yamada R,Kanai N,Kuroda R,Ushio Y,Higashi H,Mogami H

    更新日期：1970-09-01 00:00:00

  • Detection of occult carcinomatous diffusion in lymph nodes from head and neck squamous cell carcinoma using real-time RT-PCR detection of cytokeratin 19 mRNA.

    abstract：:The aim of the present study was to evaluate the occult lymph node carcinomatous diffusion in head and neck squamous cell carcinoma (HNSCC). A total of 1328 lymph nodes from 31 patients treated between 2004 and 2005 were prospectively evaluated by routine haematoxylin-eosin-safran (HES) staining, immunohistochemistry ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6603073

    authors： Tao L,Lefèvre M,Ricci S,Saintigny P,Callard P,Périé S,Lacave R,Bernaudin JF,Lacau St Guily J

    更新日期：2006-04-24 00:00:00

  • Erythrocyte sedimentation rate and anaemia are independent predictors of survival in patients with clear cell renal cell carcinoma.

    abstract：BACKGROUND:The 1997 international consensus conference on renal cell cancer (RCC) prognosis suggested erythrocyte sedimentation rate (ESR), alkaline phosphatase (ALP), and anaemia as prognostic biomarkers, but most studies reviewed were limited by small sample sizes. METHODS:The Cox proportional hazards model was used...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2012.565

    authors： Choi Y,Park B,Kim K,Jeong BC,Seo SI,Jeon SS,Choi HY,Lee JE,Lee HM

    更新日期：2013-02-05 00:00:00

  • Examining the common aetiology of serous ovarian cancers and basal-like breast cancers using double primaries.

    abstract：BACKGROUND:The somatic molecular profiles of basal-like breast cancers and high-grade serous ovarian cancers share many similarities, leading to the hypothesis that they have similar aetiologies, in which case they should occur together in the same patient more often than expected. METHODS:We identified 545 women with...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2017.73

    authors： Begg CB,Rice MS,Zabor EC,Tworoger SS

    更新日期：2017-04-11 00:00:00

  • VEGF expression by mesenchymal stem cells contributes to angiogenesis in pancreatic carcinoma.

    abstract：:Little is known about the factors that enable the mobilisation of human mesenchymal stem cells (MSC) from the bone marrow into the blood stream and their recruitment to and retention in the tumour. We found specific migration of MSC towards growth factors present in pancreatic tumours, such as PDGF, EGF, VEGF and spec...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6604508

    authors： Beckermann BM,Kallifatidis G,Groth A,Frommhold D,Apel A,Mattern J,Salnikov AV,Moldenhauer G,Wagner W,Diehlmann A,Saffrich R,Schubert M,Ho AD,Giese N,Büchler MW,Friess H,Büchler P,Herr I

    更新日期：2008-08-19 00:00:00

  • Age of mother and grandmother in relation to a subject's breast cancer risk.

    abstract：BACKGROUND:On theoretical grounds, the age of the grandmother and the age of the mother at delivery of her daughter may affect the breast cancer risk of the granddaughter. METHODS:We used the data relating to the Diagnostic Research Mamma-carcinoma cohort (DOM (Diagnostisch Onderzoek Mammacarcinoom) 3), which comprise...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6605639

    authors： de Haan MC,Michels KB,Peeters PH,van Noord PA,Hennekam FA,van der Schouw YT

    更新日期：2010-04-27 00:00:00

  • MMP-2 and MMP-9 in normal mucosa are independently associated with outcome of colorectal cancer patients.

    abstract：BACKGROUND:Upregulation of the matrix metalloproteinases MMP-2 and MMP-9 in various cancers has been associated with worse survival of the patients. METHODS:We assessed MMP-2 and MMP-9 levels in normal colorectal mucosa from colorectal cancer patients in relation to the course of the disease. RESULTS:A high protein e...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2012.80

    authors： Langers AM,Verspaget HW,Hawinkels LJ,Kubben FJ,van Duijn W,van der Reijden JJ,Hardwick JC,Hommes DW,Sier CF

    更新日期：2012-04-24 00:00:00

  • Paediatric germ cell tumours and congenital abnormalities: a Children's Oncology Group study.

    abstract：METHODS:Maternally reported congenital abnormalities (CAs) were examined in a case-control study of 278 cases of paediatric germ cell tumours (GCTs) and 423 controls. RESULTS AND CONCLUSIONS:Germ cell tumours were significantly associated with cryptorchidism in males (OR=10.8, 95% CI: 2.1-55.1), but not with any other...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6605169

    authors： Johnson KJ,Ross JA,Poynter JN,Linabery AM,Robison LL,Shu XO

    更新日期：2009-08-04 00:00:00

  • Avoidable deaths and random variation in patients' survival.

    abstract：BACKGROUND:Random error in the numbers of avoidable deaths among cancer patients has not been considered in earlier studies. METHODS:Methods to obtain valid confidence intervals (CIs) for numbers of avoidable deaths were developed. The excess mortality rates were estimated for patients diagnosed with colon cancer in f...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2012.169

    authors： Seppä K,Hakulinen T,Läärä E

    更新日期：2012-05-22 00:00:00

  • Comparisons of vaginal and abdominal radical trachelectomy for early-stage cervical cancer: preliminary results of a multi-center research in China.

    abstract：BACKGROUND:There are limited data comparing the prognosis and fertility outcomes of the patients with early cervical cancer treated by trans-vaginal radical trachelectomy (VRT) or abdominal radical trachelectomy (ART).The objective of this study was to compare the surgical and pathologic characteristics, the prognosis ...

    journal_title：British journal of cancer

    pub_type： 杂志文章,多中心研究

    doi：10.1038/bjc.2013.656

    authors： Cao DY,Yang JX,Wu XH,Chen YL,Li L,Liu KJ,Cui MH,Xie X,Wu YM,Kong BH,Zhu GH,Xiang Y,Lang JH,Shen K,China Gynecologic Oncology Group.

    更新日期：2013-11-26 00:00:00

  • Alterations of mononuclear phagocyte function induced by Lewis lung carcinoma in C57BL mice.

    abstract：:The function of the reticulo-endothelial system in mice bearing Lewis lung carcinomas has been measured by(1) the rate of clearance of carbon particles from the circulation in vivo and calculation of the phagocytic index K; (2) chemotactic locomotion of macrophages in vitro in the presence or absence of serum or tumou...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1977.197

    authors： Otu AA,Russell RJ,Wilkinson PC,White RG

    更新日期：1977-09-01 00:00:00