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Prevalence of human papillomavirus DNA sequences in an area with very high incidence of cervical carcinoma.

Abstract：

:To improve our understanding of the relationship and possible associations between human papillomavirus (HPV) infection and the development of cervical malignancies, the presence of multiple types of HPV DNA sequences in cervical carcinoma was determined in Chinese citizens living in two different geographical locations where the incidences of cervical carcinoma are either relatively low or extremely high. HPV DNA sequences were found in 88.5% (54 of 61) of Chinese cervical carcinoma patients living in Taiwan, where the prevalence of cervical carcinoma is 23.7 per 100,000 women. In contrast, in LueYang in Shanxi province, an area with a very high prevalence of cervical carcinoma (1,026 per 100,000 women), only 57.1% (28 of 49) of Chinese cervical carcinoma patients were found to be infected with genital HPV. This result seems to suggest that either the presence of HPV may have different implications in different populations or HPV infection may not be the only factor that determines the development of cervical carcinoma, at least in certain geographical areas. Recently acquired transient or chronic persistent HPV infection may have a different outcome with regard to cervical carcinogenesis. Alternatively, other factors, such as host determinants, may play a role in the development of cervical carcinoma.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Pao CC,Kao SM,Tang GC,Lee K,Si J,Ruan S

doi

10.1038/bjc.1994.375

subject

Has Abstract

pub_date

1994-10-01 00:00:00

pages

694-6

issue

4

eissn

0007-0920

issn

1532-1827

journal_volume

70

pub_type

杂志文章

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