In vitro monocyte maturation in squamous carcinoma of the lung.

abstract：:Epidermal growth factor receptor (EGFR) gene mutations and increased copy numbers are considered as predictors of response to EGFR tyrosine kinase inhibitors (EGFR-TKI) in non-small-cell lung cancer (NSCLC). Lung cancer diagnosis is often based on cytology alone. However, almost all published data on EGFR gene analyse...

journal_title：British journal of cancer

authors： Savic S,Tapia C,Grilli B,Rufle A,Bihl MP,de Vito Barascud A,Herzog M,Terracciano L,Baty F,Bubendorf L

更新日期：2008-01-15 00:00:00

abstract：:The role of two common polymorphisms of enzymes involved in the metabolism of drugs and carcinogens was studied in relation to prostate cancer. The gene encoding one of these enzymes (NAT2) is located in an area where frequent allelic loss occurs in prostate cancer. Mutations at the genes CYP2D6 and NAT2 were analysed...

journal_title：British journal of cancer

authors： Agúndez JA,Martínez C,Olivera M,Gallardo L,Ladero JM,Rosado C,Prados J,Rodriguez-Molina J,Resel L,Benítez J

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND:Epithelial-mesenchymal transition (EMT) is characterised by the loss of cell-to-cell adhesion and gaining of mesenchymal phenotypes. Epithelial-mesenchymal transition is proposed to occur in various developmental processes and cancer progression. 'Cadherin switch', a process in which cells shift to express d...

journal_title：British journal of cancer

authors： Nitta T,Mitsuhashi T,Hatanaka Y,Miyamoto M,Oba K,Tsuchikawa T,Suzuki Y,Hatanaka KC,Hirano S,Matsuno Y

更新日期：2014-09-23 00:00:00

abstract：BACKGROUND:The lifestyle risk factors for nasopharyngeal carcinoma (NPC) in North Africa are not known. METHODS:From 2002 to 2005, we interviewed 636 patients and 615 controls from Algeria, Morocco and Tunisia, frequency-matched by centre, age, sex, and childhood household type (urban/rural). Conditional logistic regr...

journal_title：British journal of cancer

authors： Feng BJ,Khyatti M,Ben-Ayoub W,Dahmoul S,Ayad M,Maachi F,Bedadra W,Abdoun M,Mesli S,Bakkali H,Jalbout M,Hamdi-Cherif M,Boualga K,Bouaouina N,Chouchane L,Benider A,Ben-Ayed F,Goldgar DE,Corbex M

更新日期：2009-10-06 00:00:00

abstract：BACKGROUND:Little is known about the effect of participating in a colorectal cancer (CRC) screening programme on quality of life (QOL), neither for participants with a negative nor for those with a positive test result. These findings, however, are important to evaluate the impact of CRC screening. METHODS:Participant...

journal_title：British journal of cancer

authors： Kapidzic A,Korfage IJ,van Dam L,van Roon AH,Reijerink JC,Zauber AG,van Ballegooijen M,Kuipers EJ,van Leerdam ME

更新日期：2012-10-09 00:00:00

abstract：:Elevated expression of matrix metalloproteinases (MMPs), a family of secreted proteinases that degrade matrix components of basement membranes and connective tissues, is strongly correlated with malignant expression in various human epithelial cancers and epithelial cancer cell lines. We have tested whether elevated l...

journal_title：British journal of cancer

authors： Meade-Tollin LC,Boukamp P,Fusenig NE,Bowen CP,Tsang TC,Bowden GT

更新日期：1998-03-01 00:00:00

abstract：BACKGROUND:Ovarian and endometrial high-grade serous carcinomas (HGSCs) have similar clinical and pathological characteristics; however, exhaustive protein expression profiling of these cancers has yet to be reported. METHODS:We performed protein expression profiling on 14 cases of HGSCs (7 ovarian and 7 endometrial) ...

journal_title：British journal of cancer

authors： Hiramatsu K,Yoshino K,Serada S,Yoshihara K,Hori Y,Fujimoto M,Matsuzaki S,Egawa-Takata T,Kobayashi E,Ueda Y,Morii E,Enomoto T,Naka T,Kimura T

更新日期：2016-03-01 00:00:00

abstract：:Carboxypeptidase G2, a zinc metalloenzyme isolated from Pseudomonas sp. strain RS-16, which catalyses the hydrolytic cleavage of reduced and non-reduced folates to pteroates and L-glutamate, has been linked to a monoclonal antibody (W14A) raised to human chorionic gonadotrophin. The coupling efficiency and retention o...

journal_title：British journal of cancer

authors： Searle F,Bier C,Buckley RG,Newman S,Pedley RB,Bagshawe KD,Melton RG,Alwan SM,Sherwood RF

更新日期：1986-03-01 00:00:00

abstract：:BW12C (5-[2-formyl-3-hydroxypenoxyl] pentanoic acid) is an agent which stabilises oxyhaemoglobin and thus reduces oxygen delivery to tissues. It is of interest as a possible potentiator of bioreductive agents and/or hyperthermia. The increases in radiobiological hypoxic fraction of RIF-1 and KHT tumours 30 min after 7...

journal_title：British journal of cancer

authors： Honess DJ,Hu DE,Bleehen NM

更新日期：1991-10-01 00:00:00

abstract：:Protracted venous infusion 5-fluorouracil (5FU) combined with mitomycin C (MMC) has demonstrated significant activity against metastatic colorectal cancer. Owing to potential synergy based upon upregulation of thymidine phosphorylase by MMC, the combination of capecitabine and MMC may improve outcomes in irinotecan-re...

journal_title：British journal of cancer

authors： Chong G,Dickson JL,Cunningham D,Norman AR,Rao S,Hill ME,Price TJ,Oates J,Tebbutt N

更新日期：2005-09-05 00:00:00

abstract：:Karyotyping and marker analysis of G- and C-banded metaphases from a metastatic bronchial carcinoma revealed a dominant stemline with five markers and four sidelines with additional markers. One to three minute bodies were noted in the majority of cells and these were classified as markers. On the basis of this analys...

journal_title：British journal of cancer

authors： Pickthall VJ

更新日期：1976-09-01 00:00:00

abstract：INTRODUCTION:We investigated the association between socioeconomic position, stage at diagnosis, and length of period between referral and diagnosis in a nationwide cohort of lung cancer patients. METHODS:Through the Danish Lung Cancer Register, we identified 18,103 persons diagnosed with lung cancer (small cell and n...

journal_title：British journal of cancer

authors： Dalton SO,Frederiksen BL,Jacobsen E,Steding-Jessen M,Østerlind K,Schüz J,Osler M,Johansen C

更新日期：2011-09-27 00:00:00

abstract：:Bryostatin 1 is a novel macrocyclic lactone activator of protein kinase C (PKC) which has clinical potential as an anti-cancer agent. The mechanism of action of this agent is unknown, but protein kinase C has been implicated. In order to investigate this possibility, we have developed P388 sublines resistant to bryost...

journal_title：British journal of cancer

authors： Prendiville J,McGown AT,Gescher A,Dickson AJ,Courage C,Pettit GR,Crowther D,Fox BW

更新日期：1994-10-01 00:00:00

abstract：:The incidence of colorectal carcinoma is rising at an alarming pace in Asian urban societies such as Hong Kong. Detailed examination of the epidemiological pattern and genetic mutation of colorectal cancer in the Hong Kong Chinese population is overdue. We compared the reported age incidence of colorectal carcinoma in...

journal_title：British journal of cancer

authors： Yuen ST,Chung LP,Leung SY,Luk IS,Chan SY,Ho JC,Ho JW,Wyllie AH

更新日期：1997-01-01 00:00:00

abstract：:Angiopoietin-1 is a promoter of physiological vasculogenesis and angiogenesis because it induces vascular branching and smooth muscle recruitment to newly formed blood vessels. However, angiopoietin-1 expression in tumours appears to be uncommon, and angiopoietin-1 overexpression in cancer cells has been reported to l...

journal_title：British journal of cancer

authors： Tian S,Hayes AJ,Metheny-Barlow LJ,Li LY

更新日期：2002-02-12 00:00:00

abstract：:In 101 breast cancer patients, measurement of oestrogen receptor status in multiple biopsies across a tumour reveals a highly significant difference in the proportion of patients remaining either disease-free (P less than 0.04) or alive (P less than 0.005), when those with uniformly receptor positive (++) primary tumo...

journal_title：British journal of cancer

authors： Castagnetta L,Traina A,Di Carlo A,Carruba G,Lo Casto M,Mesiti M,Leake R

更新日期：1989-04-01 00:00:00

abstract：BACKGROUND:Cancer incidence is increasing in the United Kingdom, as well as on a global basis. Biochemical parameters, such as C-reactive protein and albumin (combined to form the modified Glasgow Prognostic Score, mGPS), alkaline phosphatase (Alk phos), gamma-glutamyl transferase (GGT) and serum calcium have been repo...

journal_title：British journal of cancer

authors： Proctor MJ,Talwar D,Balmar SM,O'Reilly DS,Foulis AK,Horgan PG,Morrison DS,McMillan DC

更新日期：2010-09-07 00:00:00

abstract：BACKGROUND:Pancreatic cancer is highly malignant and characterised by rapid and uncontrolled growth. While some of the important regulatory networks involved in pancreatic cancer have been determined, the cancer relevant genes have not been fully identified. METHODS:We screened genes that may control proliferation in ...

journal_title：British journal of cancer

authors： Wang J,Guo X,Xie C,Jiang J

更新日期：2017-07-11 00:00:00

abstract：:I have studied the effects on growth of two tumours in mice and on host toxicity, of combining Misonidazole (MISO) or Metronidazole (METRO) with Methotrexate (MTX)-5-fluorouracil (FU) or Adriamycin (ADR). The nitroimidazoles alone had no effect on the growth of either tumour, but MISO (1 mg/g) led to a small increase ...

journal_title：British journal of cancer

authors： Tannock IF

更新日期：1980-12-01 00:00:00

abstract：:The growth of s.c. Walker 256 carcinoma was found to be independent of secondary growths induced by i.v. injection. Tumour cells injected i.v. lodged mainly in the lungs, with small clusters of cells in the lymph nodes. The rate of cellular proliferation of these secondary growths of Walker carcinoma was significantly...

journal_title：British journal of cancer

authors： Bellamy D,Hinsull SM

更新日期：1978-01-01 00:00:00

abstract：:We examined bone marrow aspirates from 100 metastasis-free primary breast cancer patients. In 38/100 patients (38%), tumour cells were detected in the marrow using an immunocytochemical technique with a cocktail of two monoclonal antibodies: anti-EMA and anti-cytokeratin. Median follow-up was 34 months: 15/38 (39%) tu...

journal_title：British journal of cancer

authors： Harbeck N,Untch M,Pache L,Eiermann W

更新日期：1994-03-01 00:00:00

abstract：:The sera of 80 newly diagnosed lung-cancer patients have been examined for immune complexes and autoantibodies. Control subjects consisted of 20 bronchitic patients and 150 normal blood donors. Immune-complex measurements used 4 established and sensitive techniques (Raji cell assay, fluid and solid-phase C1q assays an...

journal_title：British journal of cancer

authors： Guy K,Di Mario U,Irvine WJ,Hunter AM,Hadley A,Horne NW

更新日期：1981-03-01 00:00:00

abstract：BACKGROUND:Although the anti-tumour effect of cyclooxygenase-2 (Cox-2) inhibitors in invasive bladder cancer has been confirmed, its mechanisms of action are unclear. Recently, the concept of an epithelial-to-mesenchymal transition (EMT) promoting carcinoma progression has been suggested, and a key feature of the EMT i...

journal_title：British journal of cancer

authors： Adhim Z,Matsuoka T,Bito T,Shigemura K,Lee KM,Kawabata M,Fujisawa M,Nibu K,Shirakawa T

更新日期：2011-07-26 00:00:00

abstract：:Mutation of c-K-ras oncogene is an important step in progression of colon cancer. We used a hammerhead ribozyme (KrasRz) against mutated K-ras gene transcripts (codon 12, GTT) to inactivate mutant K-ras function in the colon cancer cell line SW480, harbouring a mutant K-ras gene. The beta-actin promoter-driven KrasRz ...

journal_title：British journal of cancer

authors： Tokunaga T,Tsuchida T,Kijima H,Okamoto K,Oshika Y,Sawa N,Ohnishi Y,Yamazaki H,Miura S,Ueyama Y,Nakamura M

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:We conducted a multicentre feasibility study for single agent long-term S-1 chemotherapy following docetaxel plus cisplatin in patients with curatively resected stage II-IIIA non-small cell lung cancer. METHODS:Patients received three cycles of docetaxel (60 mg m(-2)) plus cisplatin (80 mg m(-2)) and then r...

journal_title：British journal of cancer

authors： Niho S,Ikeda N,Michimae H,Suzuki K,Sakai H,Kaburagi T,Minato K,Kato T,Okamoto H,Seto T,Hosomi Y,Shimizu K,Oshita F,Kunitoh H,Tsuboi M,Takeuchi M,Watanabe K

更新日期：2013-08-06 00:00:00

abstract：:Mutations of the p53 tumour suppressor gene are infrequent at presentation of both acute myeloblastic leukaemia (AML) and acute lymphoblastic leukaemia (ALL), being found in between 5-10% of AML and 2-3% of ALL. Here we have studied the frequency of detection of p53 mutations at relapse of both AML and B-precursor ALL...

journal_title：British journal of cancer

authors： Zhu YM,Foroni L,McQuaker IG,Papaioannou M,Haynes A,Russell HH

更新日期：1999-03-01 00:00:00

abstract：:Associations between work in the electrical and electronic industry and cancer incidence were assessed using data for 371 890 cancers registered in England between 1981 and 1987, of which 7981 were in electrical workers. Proportional registration ratios (PRRs) were calculated, both with and without the commonest cance...

journal_title：British journal of cancer

authors： Fear NT,Roman E,Carpenter LM,Newton R,Bull D

更新日期：1996-04-01 00:00:00

abstract：:To examine whether weight loss at presentation influences outcome in patients who received chemotherapy for lung cancer or mesothelioma. Multivariate analysis of prospectively collected data 1994-2001. Data were available for age, gender, performance status, histology, stage, response, toxicity, progression-free and o...

journal_title：British journal of cancer

authors： Ross PJ,Ashley S,Norton A,Priest K,Waters JS,Eisen T,Smith IE,O'Brien ME

更新日期：2004-05-17 00:00:00

abstract：:PS2, an oestrogen-inducible protein, was measured in the cytosol of 230 primary tumours from patients who were subjected to first-line tamoxifen therapy for advanced disease without prior adjuvant therapy with tamoxifen. PS2 correlated positively with oestrogen receptor (ER, P < 0.01) and progesterone receptor content...

journal_title：British journal of cancer

authors： Foekens JA,Portengen H,Look MP,van Putten WL,Thirion B,Bontenbal M,Klijn JG

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND:Inhibitors of the mammalian target of rapamycin (mTOR) might become a novel tool to treat advanced prostate cancer. However, chronic drug exposure may trigger resistance, limiting the utility of mTOR inhibitors. METHODS:Metastatic potential of PC3 prostate cancer cells, susceptible (PC3(par)) or resistant (...

journal_title：British journal of cancer

authors： Tsaur I,Makarević J,Juengel E,Gasser M,Waaga-Gasser AM,Kurosch M,Reiter M,Wedel S,Bartsch G,Haferkamp A,Wiesner C,Blaheta RA

更新日期：2012-08-21 00:00:00