Abstract:
BACKGROUND:We conducted a multicentre feasibility study for single agent long-term S-1 chemotherapy following docetaxel plus cisplatin in patients with curatively resected stage II-IIIA non-small cell lung cancer. METHODS:Patients received three cycles of docetaxel (60 mg m(-2)) plus cisplatin (80 mg m(-2)) and then received S-1 (40 mg m(-2) twice daily) for 14 consecutive days with a 1-week rest for >6 months (maximum, 1 year). The primary end point was feasibility, which was defined as the proportion of patients who completed eight or more cycles of S-1 chemotherapy. If the lower 95% confidence interval (CI) of this proportion was 50% or more, then the treatment was considered as feasible. The sample size was set at 125 patients. RESULTS:One hundred and thirty-one patients were enrolled, of whom 129 patients were eligible and assessable. In all, 109 patients (84.5%) completed 3 cycles of docetaxel plus cisplatin and 66 patients (51.2%, 95% CI: 42.5-59.8) completed 8 or more cycles of S-1 treatment. Grade 3/4 toxicities during the S-1 chemotherapy included anaemia (7.3%), neutropaenia (3.7%), and anorexia (3.7%). CONCLUSION:The toxicity level was acceptable, although the results did not meet our criterion for feasibility. Modification of the treatment schedule for S-1 chemotherapy might improve the treatment compliance.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Niho S,Ikeda N,Michimae H,Suzuki K,Sakai H,Kaburagi T,Minato K,Kato T,Okamoto H,Seto T,Hosomi Y,Shimizu K,Oshita F,Kunitoh H,Tsuboi M,Takeuchi M,Watanabe Kdoi
10.1038/bjc.2013.378subject
Has Abstractpub_date
2013-08-06 00:00:00pages
545-51issue
3eissn
0007-0920issn
1532-1827pii
bjc2013378journal_volume
109pub_type
临床试验,杂志文章,多中心研究abstract::We analysed 26 metastases from 25 patients with sporadic cutaneous malignant melanoma for alterations in the CDKN2 gene by a combined polymerase chain reaction/single-strand conformation polymorphism (PCR/SSCP)/nucleotide sequencing approach. Eleven alterations (one in exon 1, five in exon 2 and five in the 3' non-cod...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1996.59
更新日期:1996-02-01 00:00:00
abstract::Prolactin (PRL) has been reported to inhibit apoptosis in various cell types and to serve as a cofactor in the upregulation of CD25 on T cells during activation. We investigated a possible relation between prolactin receptor (PRL-R) or IL-2 receptor alpha (IL-2Ralpha, CD25) expression on circulating T lymphocytes and ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6600860
更新日期:2003-04-22 00:00:00
abstract::Human dialysable Transfer Factor (TFd) extracted from lymphocytes of patients with transitional cell carcinoma of bladder (TCCB) was replicated in culture by lymphoblastoid cell lines. The effectiveness of two such TFdLs produced in vitro in transferring sensitivity to TCCB was assessed in the lymphocyte migration tes...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1976.98
更新日期:1976-06-01 00:00:00
abstract:BACKGROUND:It has been a challenge to determine breast cancer clonality accurately. The aim of the present study was to assess methods using formalin-fixed paraffin-embedded (FFPE) tissue to differentiate new primary tumours from true recurrences that are associated with poorer prognoses and often require more aggressi...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2012.505
更新日期:2012-12-04 00:00:00
abstract::The use of oncolytic viruses has received considerable attention in recent years and many viruses have proved to be effective against a variety of cancer models and a few are currently being used in clinical trials. However, the possible emergence and outcome of virus-resistant tumour cells has not been addressed. We ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6603363
更新日期:2006-10-23 00:00:00
abstract::We investigated the risk of gastric cancer by subsite in relation to cigarette smoking and alcohol in a large population-based cohort of 669 570 Korean men in an insurance plan followed for an average 6.5 years, yielding 3452 new cases of gastric cancer, of which 127 were cardia and upper-third gastric cancer, 2409 we...
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pub_type: 杂志文章
doi:10.1038/sj.bjc.6603893
更新日期:2007-09-03 00:00:00
abstract:BACKGROUND:Hypoxia can activate autophagy, a self-digest adaptive process that maintains cell turnover. Mammalian target of rapamycin (mTOR) inhibitors are used to treat cancer but also stimulate autophagy. METHODS:Human mammary cancer cells and derived xenografts were used to examine whether hypoxia could exacerbate ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2013.644
更新日期:2013-11-12 00:00:00
abstract::The interaction between laminin and the oncoprotein encoded by the c-erbB-2 oncogene was studied in vitro and in vivo in human breast carcinomas. In vitro analysis of breast carcinoma cell lines overexpressing p185HER2 revealed that laminin, but not fibronectin, induced tyrosine phosphorylation and down-modulation of ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1996.560
更新日期:1996-11-01 00:00:00
abstract::Carboxypeptidase G2, a zinc metalloenzyme isolated from Pseudomonas sp. strain RS-16, which catalyses the hydrolytic cleavage of reduced and non-reduced folates to pteroates and L-glutamate, has been linked to a monoclonal antibody (W14A) raised to human chorionic gonadotrophin. The coupling efficiency and retention o...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1986.62
更新日期:1986-03-01 00:00:00
abstract:BACKGROUND:Inhibitors of the mammalian target of rapamycin (mTOR) might become a novel tool to treat advanced prostate cancer. However, chronic drug exposure may trigger resistance, limiting the utility of mTOR inhibitors. METHODS:Metastatic potential of PC3 prostate cancer cells, susceptible (PC3(par)) or resistant (...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2012.313
更新日期:2012-08-21 00:00:00
abstract:BACKGROUND:Overexpression of plasma membrane multi-drug resistance protein 1 (MRP-1) can lead to multidrug resistance. In this study, we describe for the first time the expression of mitochondrial MRP-1 in untreated human normal and cancer cells and tissues. METHODS:MRP-1 expression and subcellular localisation in nor...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2012.40
更新日期:2012-03-13 00:00:00
abstract::An apparently unique circulating common oncofoetal protein has been identified in rat small-bowel, colonic and pancreatic adenocarcinomas. The tumours were induced by ionizing radiation (small bowel), an alkyl hydrocarbon, 1,2-dimethylhydrazine (colon) and a polyaromatic hydrocarbon, 7,12-dimethylbenz[a]anthracene (pa...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1981.120
更新日期:1981-06-01 00:00:00
abstract::The effects of local tumour radiation over the dose range 7.5-30 Gy on the growth and cell kinetics of rat hepatoma H-4-II-E have been investigated. A plot of growth delays against log surviving fraction was linear below a fraction of 0.03, but failed to extrapolate to the origin. Following a single dose of 15 Gy to t...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1980.283
更新日期:1980-10-01 00:00:00
abstract:BACKGROUND:Factors related to early stimulation of the immune system (breastfeeding, proxies for exposure to infectious agents, normal delivery, and exposure to animals in early life) have been suggested to decrease the risk of childhood acute lymphoblastic leukaemia (ALL). METHODS:The national registry-based case-con...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2015.53
更新日期:2015-03-17 00:00:00
abstract:BACKGROUND:The role of chemotherapy for neuroendocrine tumours remains controversial and there is no standard regimen. METHOD:We report the outcome for a consecutive series of chemonaive patients with metastatic or locally advanced neuroendocrine tumours treated with a combination of 5-fluorouracil (500 mg m(-2)), cis...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章
doi:10.1038/sj.bjc.6605618
更新日期:2010-03-30 00:00:00
abstract::Exploring the fundamental mechanisms behind the low tumour uptake of labelled monoclonal antibodies (MoAbs) during in vivo immunotargeting, experiments were performed to estimate the in vivo value of the association constant (Ka) in an experimental targeting reaction. An artificial tumour model was utilised, based on ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1992.219
更新日期:1992-07-01 00:00:00
abstract::In resection tissue samples of colorectal carcinomas, the concentration of urokinase-type plasminogen activator (u-Pa) was found to be significantly higher than in the normal parent mucosal tissue, while there was less tissue-type plasminogen activator (t-PA). u-PA and t-PA were also determined in endoscopic biopsies ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1989.293
更新日期:1989-09-01 00:00:00
abstract::A series of 176 archival cervical intraepithelial neoplasia (CIN) was analysed for the presence, viral load and integration status of 'high-risk' types of human papillomavirus (HR-HPV). The samples were assayed using newly developed methods based on real-time PCR. Two methods for the extraction of DNA from the paraffi...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6602648
更新日期:2005-06-20 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1993.196
更新日期:1993-05-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-019-0436-3
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:Golgi phosphoprotein 3 (GOLPH3) has been reported to be involved in the development of several human cancers. The present study was conducted to investigate the expression of GOLPH3 and its prognostic significance in renal cell carcinoma (RCC). Meanwhile, the function of GOLPH3 in human RCC was further inves...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2014.124
更新日期:2014-04-29 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.1999.0918
更新日期:2000-01-01 00:00:00
abstract::Forty-one human tumour cell lines were examined for the production of epidermal growth factor (EGF)/transforming growth factor (TGF)-alpha-like activity (EGF/TGF-alpha-LA), immunoreactive (IR-) EGF and IR-TGF-alpha. EGF/TGF-alpha-LA was determined by radioreceptor assay, in which the factors with capacity to bind to E...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1989.159
更新日期:1989-05-01 00:00:00
abstract::The oestrogen receptor (RE) status of the primary tumour has been assessed in 466 of a consecutive series of 550 patients with primary operable breast cancer. All patients were followed up (without treatment) until the development of recurrence or metastases. Distant metastases have so far occurred in 124 patients and...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1981.205
更新日期:1981-09-01 00:00:00
abstract::The ESR spectrum, attributed to the ascorbic acid (ascorbyl) radical and obtained by exposing freeze dried material to air, can not be used as proof for the occurrence of in vivo free radical reactions. Depending on the method of freeze drying, the content of blood or hemolyzed blood is the dominant factor in creating...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1986.63
更新日期:1986-03-01 00:00:00
abstract:BACKGROUND:We previously reported that chaetocin has potent and selective anti-myeloma activity attributable to reactive oxygen species (ROS) induction imposed by inhibition of the redox enzyme thioredoxin reductase; we now detail its effects in solid tumours. METHODS:Cellular assays, transcriptional profiling and the...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2011.522
更新日期:2012-01-17 00:00:00
abstract::Expression of the wild-type p53 gene has an important role in cell differentiation, maturation and apoptosis. Mutation of the p53 gene is associated with tumour development and mutant p53 can promote cell proliferation. Recently wild-type p53 has been demonstrated to exist in two conformational variants: one acting as...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1993.444
更新日期:1993-11-01 00:00:00
abstract::Ovarian cancer is the fifth leading cause of female cancer deaths in the Western world. Significant progress has been made in the treatment of patients with ovarian cancer, however, the majority of patients experience disease recurrence and new therapies are being sought for such patients. Clinical investigation of po...
journal_title:British journal of cancer
pub_type: 杂志文章,评审
doi:10.1038/bjc.2015.395
更新日期:2015-12-15 00:00:00
abstract:BACKGROUND:We aimed to assess the efficacy of second-line fluoropyrimidine-based chemotherapy in patients with advanced biliary tract cancer (BTC) after failure of gemcitabine plus cisplatin (GEMCIS). METHODS:We retrospectively examined patients with histologically documented advanced BTC who received first-line GEMCI...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2016.446
更新日期:2017-02-28 00:00:00
abstract::The mechanisms underlying sperm protein 17 (Sp17) gene expression in myeloma cells remained unclear. Using reverse transcription-polymerase chain reaction (RT-PCR), Sp17 transcripts were detected in ARK-B, ARP-1, RPMI-8226 and KMS-11 but not in H929, IM-9, MM1-R and U266 cells. Using a panel of primer pairs in methyla...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6602160
更新日期:2004-10-18 00:00:00