Expression of different conformations of p53 in the blast cells of acute myeloblastic leukaemia is related to in vitro growth characteristics.

abstract：:Hypomethylation has been reported to be responsible for the activation of several oncogenes. The possibility that hypomethylation is involved in the regulation of MET transcription was investigated through the analysis of the methylation status of one CpG island containing 43 CpGs in six cases of papillary carcinoma, ...

journal_title：British journal of cancer

authors： Scarpino S,Di Napoli A,Rapazzotti-Onelli M,Pilozzi E,Ruco L

更新日期：2004-08-16 00:00:00

abstract：:In vivo DNA damage and repair was induced by nicotinamide (NAM) in adenotype 12 virus-induced mouse sarcoma A12B3 and sarcoma F inoculated into CBA mice. DNA damage, NAM and NAD concentrations were measured after in vivo exposure to NAM, in tumours and spleens by alkaline elution and by HPLC analysis. Our results indi...

journal_title：British journal of cancer

authors： Olsson AR,Sheng Y,Pero RW,Chaplin DJ,Horsman MR

更新日期：1996-08-01 00:00:00

abstract：:There is increasing evidence that the presence of a systemic inflammatory response plays an important role in survival following curative resection for colorectal cancer. The present study evaluated the relationship between C-reactive protein concentrations and survival in a cohort of patients receiving adjuvant 5-flu...

journal_title：British journal of cancer

authors： Crozier JE,McKee RF,McArdle CS,Angerson WJ,Anderson JH,Horgan PG,McMillan DC

更新日期：2006-06-19 00:00:00

abstract：:The aim of this paper was to provide epidemiological evidence to support the notion that cervical intraepithelial neoplasia (CIN) without human papillomavirus (HPV) is a true entity. If a diagnosis of HPV-negative cervical neoplasia is erroneous, one would not expect there to be any differences in risk factors between...

journal_title：British journal of cancer

authors： Burger MP,Hollema H,Pieters WJ,Schröder FP,Quint WG

更新日期：1996-03-01 00:00:00

abstract：:Following an i.p. dose of 150 mg x kg(-1) 5-fluorouracil (5-FU), drug uptake and metabolism over a 2-h period were studied by in vivo (19)F magnetic resonance spectroscopy (MRS) for the murine colon carcinoma lines C26-B (5-FU-insensitive; n=11) and C26-10 (5-FU-sensitive; n=15) implanted s.c. in Balb/C mice. Time cou...

journal_title：British journal of cancer

authors： Kamm YJ,Peters GJ,Hull WE,Punt CJ,Heerschap A

更新日期：2003-08-18 00:00:00

abstract：:The conventional diffusion chamber (CDC) as described by Benestad (1970) had been modified to assay the colony forming capacity of RFM bone marrow and spleen cells in agar diffusion chambers (ADCs). The colonies are morphologically identical to those formed by the CFUc in agar culture in vitro and have an incidence of...

journal_title：British journal of cancer

authors： Gordon MY

更新日期：1974-11-01 00:00:00

abstract：BACKGROUND:Immunoscore have shown a promising prognostic value in many cancers. We aimed to establish and validate an immune classifier to predict survival after curative resection of hepatocellular carcinoma (HCC) patients who have undergone curative resection. METHODS:The immunohistochemistry (IHC) classifier assay ...

journal_title：British journal of cancer

authors： Liu WR,Tian MX,Tang Z,Fang Y,Zhou YF,Song SS,Jiang XF,Wang H,Tao CY,Zhou PY,Qu WF,Ding ZB,Peng YF,Zhou J,Fan J,Shi YH

更新日期：2020-07-01 00:00:00

abstract：:This is the first study to investigate the associations of IGF-1, IGF-2 and IGFBP-3 concentrations with the risk of colorectal cancer in prospectively collected blood samples from an Oriental population. Between 1986 and 1989 serum samples were collected at baseline from 18 244 men, aged 45-65 years, without a history...

journal_title：British journal of cancer

authors： Probst-Hensch NM,Yuan JM,Stanczyk FZ,Gao YT,Ross RK,Yu MC

更新日期：2001-11-30 00:00:00

abstract：:Photodynamic activation of macrophage-like cells contributes to an effective outcome of photodynamic therapy (PDT) treatment. The possibility for an enhancement of macrophage activity by photosensitization with meta-tetra(hydroxyphenyl)chlorin (mTHPC) (1 microg ml(-1)) was studied in U937, monocyte cell line different...

journal_title：British journal of cancer

authors： Coutier S,Bezdetnaya L,Marchal S,Melnikova V,Belitchenko I,Merlin JL,Guillemin F

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND:Combined oral contraceptive (COC) use reduces epithelial ovarian cancer (EOC) risk. However, little is known about risk with COC use before the first full-term pregnancy (FFTP). METHODS:This Canadian population-based case-control study (2001-2012) included 854 invasive cases/2139 controls aged ⩾40 years who...

journal_title：British journal of cancer

authors： Cook LS,Pestak CR,Leung AC,Steed H,Nation J,Swenerton K,Gallagher R,Magliocco A,Köbel M,Brooks-Wilson A,Le N

更新日期：2017-01-17 00:00:00

abstract：BACKGROUND:Increased survival after cancer in young age has made long-term follow-up studies of high external validity important. In this national cohort study, we explored the impact of cancer in young age on reproduction and marital status in male survivors. METHODS:Hazard ratios (HRs) and relative risks (RRs) of re...

journal_title：British journal of cancer

authors： Gunnes MW,Lie RT,Bjørge T,Ghaderi S,Ruud E,Syse A,Moster D

更新日期：2016-02-02 00:00:00

abstract：:Colorectal tumours from MYH polyposis patients display an excess of somatic G : C --> T : A transversions in the adenomatous polyposis coli gene. Here, we identify k-ras mutations in nine out of 54 (16.7%) MYH polyposis tumours. Their presence was associated with increased dysplasia and tubulovillous morphology (P=0.0...

journal_title：British journal of cancer

authors： Jones S,Lambert S,Williams GT,Best JM,Sampson JR,Cheadle JP

更新日期：2004-04-19 00:00:00

abstract：:The fluorometric microculture cytotoxicity assay (FMCA) was employed for analysing the effect of different chemotherapeutic drug combinations and their single constituents in 44 cases of acute myelocytic leukaemia (AML). A large heterogeneity with respect to cell kill was observed for all combinations tested, the inte...

journal_title：British journal of cancer

authors： Larsson R,Fridborg H,Kristensen J,Sundström C,Nygren P

更新日期：1993-05-01 00:00:00

abstract：:The addition of lapatinib (Tykerb/Tyverb) to capecitabine (Xeloda) delays disease progression more effectively than capecitabine monotherapy in women with previously treated HER2+ metastatic breast cancer (MBC). The quality-adjusted time without symptoms of disease or toxicity of treatment (Q-TWiST) method was used to...

journal_title：British journal of cancer

authors： Sherrill B,Amonkar MM,Stein S,Walker M,Geyer C,Cameron D

更新日期：2008-09-02 00:00:00

abstract：:Early detection of relapse has been advocated to improve survival in children with recurrent medulloblastoma. However, the prognostic factors and the longer term outcome of these patients remains unclear. Pattern of recurrences were analysed in three consecutive protocols of the Société Française d'Oncologie Pédiatriq...

journal_title：British journal of cancer

authors： Bouffet E,Doz F,Demaille MC,Tron P,Roche H,Plantaz D,Thyss A,Stephan JL,Lejars O,Sariban E,Buclon M,Zücker JM,Brunat-Mentigny M,Bernard JL,Gentet JC

更新日期：1998-04-01 00:00:00

abstract：BACKGROUND:Gender-associated epigenetic alterations are poorly investigated in male and female familial breast cancer (fBC). MicroRNAs may contribute to the different biology in men and women particularly related to RASSF1A pathways. METHODS:Microarray technology was used to evaluate miRNA profile in 24 male and 43 fe...

journal_title：British journal of cancer

authors： Pinto R,De Summa S,Danza K,Popescu O,Paradiso A,Micale L,Merla G,Palumbo O,Carella M,Tommasi S

更新日期：2014-12-09 00:00:00

abstract：BACKGROUND:Metastatic clear cell renal cell carcinoma (ccRCC) patients have <9% 5-year survival rate, do not respond well to targeted therapy and eventually develop resistance. A better understanding of molecular pathways of RCC metastasis is the basis for the discovery of novel prognostic markers and targeted therapie...

journal_title：British journal of cancer

authors： White NM,Masui O,Newsted D,Scorilas A,Romaschin AD,Bjarnason GA,Siu KW,Yousef GM

更新日期：2014-03-04 00:00:00

abstract：:The management of older patients with aggressive non-Hodgkin's lymphoma presents a challenge to the physician. Age is a poor prognostic indicator, due to reduced ability to tolerate and maintain dose-intensive chemotherapy. Generally, older patients demonstrate a lower response rate, reduced survival and increased tox...

journal_title：British journal of cancer

authors： Burton C,Linch D,Hoskin P,Milligan D,Dyer MJ,Hancock B,Mouncey P,Smith P,Qian W,MacLennan K,Jack A,Webb A,Cunningham D

更新日期：2006-03-27 00:00:00

abstract：:The geographical distribution of mortality from mesothelioma of the pleura during the years 1968-78 in England and Wales has been studied using extracts from the death records held by the Office of Population Censuses and Surveys. Using the national death rate as standard, Local Authority areas with raised mortality a...

journal_title：British journal of cancer

authors： Gardner MJ,Acheson ED,Winter PD

更新日期：1982-07-01 00:00:00

abstract：:We analysed two case-control studies of women from Italy and Switzerland, including 195 cases of oral and pharyngeal cancers and 1113 controls. The multivariate odds ratio was 4.6 for heavy smokers and 2.7 for high alcohol intake. Vegetables, fruit, beta-carotene and wholegrain foods were inversely, butter and retinol...

journal_title：British journal of cancer

authors： Bosetti C,Negri E,Franceschi S,Conti E,Levi F,Tomei F,La Vecchia C

更新日期：2000-01-01 00:00:00

abstract：:Pancreatic cancer is characterised by a hallmark desmoplastic response that includes upregulated expression of the extracellular matrix, and type I collagen in particular. Recent studies indicate that pancreatic cancer cells stimulate type I collagen synthesis in adjacent stellate cells, and that this upregulated type...

journal_title：British journal of cancer

authors： Grzesiak JJ,Bouvet M

更新日期：2006-05-08 00:00:00

abstract：:Metastatic variant sublines of the murine large-cell lymphoma cell line RAW117 were tested for their growth and migration properties in vitro in medium conditioned by soluble factors released from syngeneic mouse liver-, lung-, and brain-derived microvessel endothelial cells. Medium conditioned with hepatic sinusoidal...

journal_title：British journal of cancer

authors： Hamada J,Cavanaugh PG,Lotan O,Nicolson GL

更新日期：1992-08-01 00:00:00

abstract：:Between 1971 and 1988, 20 patients with previously undiagnosed non-Hodgkin's lymphoma (NHL), of intermediate or high grade histology presented with extradural spinal cord compression. All had decompressive surgery. The first treatment after surgery was chemotherapy in nine and radiotherapy in 11 patients. At presentat...

journal_title：British journal of cancer

authors： Eeles RA,O'Brien P,Horwich A,Brada M

更新日期：1991-01-01 00:00:00

abstract：:To evaluate whether green tea consumption provides protection against stomach cancer, the relative risks (RRs) were calculated in the Japan Collaborative Study for Evaluation of Cancer Risk, sponsored by the Ministry of Health and Welfare (JACC Study). The study was based on 157 incident cases and 285 controls aged 40...

journal_title：British journal of cancer

authors： Hoshiyama Y,Kawaguchi T,Miura Y,Mizoue T,Tokui N,Yatsuya H,Sakata K,Kondo T,Kikuchi S,Toyoshima H,Hayakawa N,Tamakoshi A,Ohno Y,Yoshimura T,Japan Collaborative Cohort Study Group.

更新日期：2004-01-12 00:00:00

abstract：:Two subtypes of thrombospondin (TSP-1 and TSP-2) have inhibitory roles in angiogenesis in vitro, although the biological significance of these TSP isoforms has not been determined in vivo. We examined TSP-1 and TSP-2 gene expression by reverse transcription polymerase chain reaction (RT-PCR) analysis in 61 colon cance...

journal_title：British journal of cancer

authors： Tokunaga T,Nakamura M,Oshika Y,Abe Y,Ozeki Y,Fukushima Y,Hatanaka H,Sadahiro S,Kijima H,Tsuchida T,Yamazaki H,Tamaoki N,Ueyama Y

更新日期：1999-01-01 00:00:00

abstract：:We investigated the relation between head and neck cancer risk and alcohol consumption in the NIH-AARP Diet and Health Study. During 2,203,500 person-years of follow-up, 611 men and 183 women developed head and neck cancer. With moderate drinking (up to one alcoholic drink per day) as the referent group, non-drinkers ...

journal_title：British journal of cancer

authors： Freedman ND,Schatzkin A,Leitzmann MF,Hollenbeck AR,Abnet CC

更新日期：2007-05-07 00:00:00

abstract：:Antibody drug conjugates (ADCs) employ the exquisite specificity of tumour-specific monoclonal antibodies (mAb) for the targeted delivery of highly potent cytotoxic drugs to the tumour site. The chemistry of the linker, which connects the drug to the mAb, determines how and when the drug is released from the mAb. This...

journal_title：British journal of cancer

authors： Staudacher AH,Brown MP

更新日期：2017-12-05 00:00:00

abstract：:The met proto-oncogene is the tyrosine kinase growth factor receptor for hepatocyte growth factor. In the present study, we investigated the role of met expression on the modulation of apoptosis in colorectal tumours. The gene expressions of c-met and the anti-apoptotic bcl-2 family, including bcl-2, bcl-x(L)and bcl-w...

journal_title：British journal of cancer

authors： Kitamura S,Kondo S,Shinomura Y,Kanayama S,Miyazaki Y,Kiyohara T,Hiraoka S,Matsuzawa Y

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:Genome-wide association studies (GWASs) have enriched the fields of genomics and drug development. Adrenocortical carcinoma (ACC) is a rare cancer with a bimodal age distribution and inadequate treatment options. Paediatric ACC is frequently associated with TP53 mutations, with particularly high incidence in...

journal_title：British journal of cancer

authors： Surakhy M,Wallace M,Bond E,Grochola LF,Perez H,Di Giovannantonio M,Zhang P,Malkin D,Carter H,Parise IZS,Zambetti G,Komechen H,Paraizo MM,Pagadala MS,Pinto EM,Lalli E,Figueiredo BC,Bond GL

更新日期：2020-04-01 00:00:00

abstract：:The modulating effect of 43 degrees C hyperthermia on the induction of oncogenic transformation by the antineoplastic agents, actinomycin D, mitomycin C, and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) was examined using the C3H 10T1/2 cell line. For any given level of cytotoxicity, cells exposed to the three chemothe...

journal_title：British journal of cancer

authors： Komatsu K,Miller RC,Hall EJ

更新日期：1988-01-01 00:00:00