Identification of a common oncofoetal protein in x-ray and chemically induced rat gastrointestinal tumours.

abstract：BACKGROUND:The TP53 tumor suppressor gene is the most frequently altered gene in tumors and mutant p53 gain-of-function isoforms actively promote cancer malignancy. METHODS:A panel of wild-type and mutant p53 cancer cell lines of different tissues, including pancreas, breast, skin, and lung were used, as well as chron...

journal_title：British journal of cancer

authors： Cordani M,Butera G,Dando I,Torrens-Mas M,Butturini E,Pacchiana R,Oppici E,Cavallini C,Gasperini S,Tamassia N,Nadal-Serrano M,Coan M,Rossi D,Gaidano G,Caraglia M,Mariotto S,Spizzo R,Roca P,Oliver J,Scupoli MT,Donad

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Bevacizumab has broad anti-tumour activity, but substantial risk of hypertension. No reliable markers are available for predicting bevacizumab-induced hypertension. METHODS:A genome-wide association study (GWAS) was performed in the phase III bevacizumab-based adjuvant breast cancer trial, ECOG-5103, to eva...

journal_title：British journal of cancer

authors： Schneider BP,Li L,Shen F,Miller KD,Radovich M,O'Neill A,Gray RJ,Lane D,Flockhart DA,Jiang G,Wang Z,Lai D,Koller D,Pratt JH,Dang CT,Northfelt D,Perez EA,Shenkier T,Cobleigh M,Smith ML,Railey E,Partridge A,Gralo

更新日期：2014-09-09 00:00:00

abstract：:Several diseases are known or suspected to be associated with altered levels of hormones and growth factors that may influence breast cancer risk. To elucidate this possibility, we studied the relationship between 23 medical conditions or procedures and breast cancer risk by means of data from a multicentric case-cont...

journal_title：British journal of cancer

authors： Talamini R,Franceschi S,Favero A,Negri E,Parazzini F,La Vecchia C

更新日期：1997-01-01 00:00:00

abstract：:The purpose of this study was to address the prognostic significance of circulating melanoma cells by reverse transcriptase-polymerase chain reaction in the peripheral blood of stage IIB and III melanoma patients on high-dose adjuvant interferon at multiple sequential time points from initiation of treatment. Tyrosina...

journal_title：British journal of cancer

authors： Gogas H,Kefala G,Bafaloukos D,Frangia K,Polyzos A,Pectasides D,Tsoutsos D,Panagiotou P,Ioannovich J,Loukopoulos D

更新日期：2002-07-15 00:00:00

abstract：BACKGROUND:Several recent studies have demonstrated that microRNAs (miRNAs) are stably detectable in the plasma/serum. We hypothesised that miR-18a in the plasma is a potential biomarker in patients with pancreatic cancer. METHODS:miR-18a is located in the miR-17-92 cluster and reported to be highly expressed in pancr...

journal_title：British journal of cancer

authors： Morimura R,Komatsu S,Ichikawa D,Takeshita H,Tsujiura M,Nagata H,Konishi H,Shiozaki A,Ikoma H,Okamoto K,Ochiai T,Taniguchi H,Otsuji E

更新日期：2011-11-22 00:00:00

abstract：:We evaluated the interaction between hepatitis C virus (HCV) and cigarette smoking on death from hepatocellular cancer in The Japan Collaborative Cohort Study. The odds ratio of death from HCC for smoking was 9.60 (1.50-61.35) and 1.71(0.58-5.08) among anti-HCV positive and negative individuals, respectively. ...

journal_title：British journal of cancer

authors： Fujita Y,Shibata A,Ogimoto I,Kurozawa Y,Nose T,Yoshimura T,Suzuki H,Iwai N,Sakata R,Ichikawa S,Tamakoshi A

更新日期：2006-03-13 00:00:00

abstract：:The registered incidence rate of childhood central nervous system (CNS) tumours has increased in several countries. It is uncertain whether these increases are biologically real or owing to improved diagnostic methods. We explored the medical records of 626 CNS tumours diagnosed in Danish children between 1980 and 199...

journal_title：British journal of cancer

authors： Raaschou-Nielsen O,Sørensen M,Carstensen H,Jensen T,Bernhardtsen T,Gjerris F,Schmiegelow K

更新日期：2006-08-07 00:00:00

abstract：:Transforming growth factor alpha (TGF alpha) and Transforming growth factor beta-1 (TGF-beta 1) are growth regulatory for breast cancer cell lines in vitro and several studies have suggested that levels of the receptor for TGF alpha, the epidermal growth factor (EGFR) in tumour biopsies predict relapse and survival. W...

journal_title：British journal of cancer

authors： Murray PA,Barrett-Lee P,Travers M,Luqmani Y,Powles T,Coombes RC

更新日期：1993-06-01 00:00:00

abstract：:Fibroblast growth factors (FGFs) and fibroblast growth factor receptors (FGFRs) have been increasingly recognized to play an important role in the pathobiology of pancreatic malignancy. We have investigated the effects of FGF-1 and FGF-2 on the behaviour and adhesion properties of human pancreatic adenocarcinoma cell ...

journal_title：British journal of cancer

authors： El-Hariry I,Pignatelli M,Lemoine NR

更新日期：2001-06-15 00:00:00

abstract：BACKGROUND:High amplification of epiregulin (EREG) and amphireglin (AREG) in tumour tissues has been previously reported to be associated with better outcome in metastatic colorectal cancer (mCRC) patients who were treated with anti-EGFR antibodies. Here we investigated associations between the expression of other cand...

journal_title：British journal of cancer

authors： Takahashi N,Iwasa S,Taniguchi H,Sasaki Y,Shoji H,Honma Y,Takashima A,Okita N,Kato K,Hamaguchi T,Shimada Y,Yamada Y

更新日期：2016-04-26 00:00:00

abstract：:Ovulation is believed to contribute to the development of ovarian cancers that derive from the ovarian surface epithelium (OSE). The process of ovulation is synonymous with inflammation and inflammatory cytokines such as interleukin-1alpha (IL-1alpha) have recently been shown to induce both inflammatory and anti-infla...

journal_title：British journal of cancer

authors： Gubbay O,Guo W,Rae MT,Niven D,Langdon SP,Hillier SG

更新日期：2005-05-23 00:00:00

abstract：:The antitumour activities of N-methylformamide, N-ethylformamide and formamide against a number of murine tumours in vivo (Sarcoma 180, M5076 ovarian sarcoma and TLX5 lymphoma) have been estimated. In all cases N-methyl-formamide had significant activity, formamide had marginal or no activity and N-ethylformamide had ...

journal_title：British journal of cancer

authors： Gescher A,Gibson NW,Hickman JA,Langdon SP,Ross D,Atassi G

更新日期：1982-06-01 00:00:00

abstract：:Imaging has an essential role in the planning and delivery of radiotherapy. Recent advances in imaging have led to the development of advanced radiotherapy techniques-including image-guided radiotherapy, intensity-modulated radiotherapy, stereotactic body radiotherapy and proton beam therapy. The optimal use of imagin...

journal_title：British journal of cancer

authors： Beaton L,Bandula S,Gaze MN,Sharma RA

更新日期：2019-04-01 00:00:00

abstract：:A recent study showed an association between a single base substitution, T-->C, in the promotor region of the CYP17 gene, the risk of breast cancer and age at menarche in Asian, African-American and Latino women from California and Hawaii. The C allele was associated with increased risk of breast cancer, significantly...

journal_title：British journal of cancer

authors： Dunning AM,Healey CS,Pharoah PD,Foster NA,Lipscombe JM,Redman KL,Easton DF,Day NE,Ponder BA

更新日期：1998-06-01 00:00:00

abstract：BACKGROUND:The germline BRCA2 mutation is associated with increased prostate cancer (PrCa) risk. We have assessed survival in young PrCa cases with a germline mutation in BRCA2 and investigated loss of heterozygosity at BRCA2 in their tumours. METHODS:Two cohorts were compared: one was a group with young-onset PrCa, t...

journal_title：British journal of cancer

authors： Edwards SM,Evans DG,Hope Q,Norman AR,Barbachano Y,Bullock S,Kote-Jarai Z,Meitz J,Falconer A,Osin P,Fisher C,Guy M,Jhavar SG,Hall AL,O'Brien LT,Gehr-Swain BN,Wilkinson RA,Forrest MS,Dearnaley DP,Ardern-Jones AT,Pag

更新日期：2010-09-07 00:00:00

abstract：:Van Trommel et al have previously shown that serum human chorionic gonadotropin (hCG) cutoff levels can provide early prediction of resistance to first-line methotrexate (MTX) in patients with persistent trophoblastic disease (PTD). In this study, we validate this approach of prediction of resistance to single-agent c...

journal_title：British journal of cancer

authors： Kerkmeijer LG,Thomas CM,Harvey R,Sweep FC,Mitchell H,Massuger LF,Seckl MJ

更新日期：2009-03-24 00:00:00

abstract：BACKGROUND:Thymidine phosphorylase (TP) is often overexpressed in tumours and has a role in tumour aggressiveness and angiogenesis. Here, we determined whether TP increased tumour invasion and whether TP-expressing cancer cells stimulated angiogenesis. METHODS:Angiogenesis was studied by exposing endothelial cells (HU...

journal_title：British journal of cancer

authors： Bijnsdorp IV,Capriotti F,Kruyt FA,Losekoot N,Fukushima M,Griffioen AW,Thijssen VL,Peters GJ

更新日期：2011-03-29 00:00:00

abstract：BACKGROUND:CYFRA 21-1 serves as biomarker in several epithelial malignancies. However, its role in pancreatic cancer (PC) has not yet been investigated. METHODS:Within a prospective single-centre study serial blood samples were collected from patients with confirmed advanced PC. Pre-treatment values and weekly measure...

journal_title：British journal of cancer

authors： Boeck S,Wittwer C,Heinemann V,Haas M,Kern C,Stieber P,Nagel D,Holdenrieder S

更新日期：2013-04-30 00:00:00

abstract：:Decreased accumulation of the fluorescent dye BCECF [2', 7'-bis-(2-carboxyethyl)-5-(6)- carboxyfluorescein] characterized murine and human multidrug-resistant cell lines overexpressing the multidrug resistance protein (MRP). Indomethacin (10 microM), a known cyclo-oxygenase and glutathione-S-transferase inhibitor as w...

journal_title：British journal of cancer

authors： Draper MP,Martell RL,Levy SB

更新日期：1997-01-01 00:00:00

abstract：:We have analysed DNA extracted from the serum and peritoneal fluid of 20 ovarian cancer patients for the presence of tumour-specific genetic alterations. The 20 patients included six with stage Ia disease. Using six polymorphic microsatellite loci we were able to detect novel alleles or loss of heterozygosity in 17/20...

journal_title：British journal of cancer

authors： Hickey KP,Boyle KP,Jepps HM,Andrew AC,Buxton EJ,Burns PA

更新日期：1999-08-01 00:00:00

abstract：BACKGROUND:To estimate the accuracy of one-step nucleic acid amplification (OSNA) assay as an intra-operative sentinel lymph node biopsy (SLNB) for sentinel lymph node (SLN) metastasis in breast cancer. METHODS:PubMed, Cochrane Library and Web of Science databases were searched by two independent reviewers to retrieve...

journal_title：British journal of cancer

authors： Shi F,Zhang Q,Liang Z,Zhang M,Liu X

更新日期：2017-10-10 00:00:00

abstract：BACKGROUND:The accuracy of prostate-specific antigen (PSA) testing in prostate cancer detection is constrained by low sensitivity and specificity. Dysregulated expression of minichromosome maintenance (Mcm) 2-7 proteins is an early event in epithelial multistep carcinogenesis and thus MCM proteins represent powerful ca...

journal_title：British journal of cancer

authors： Dudderidge TJ,Kelly JD,Wollenschlaeger A,Okoturo O,Prevost T,Robson W,Leung HY,Williams GH,Stoeber K

更新日期：2010-08-24 00:00:00

abstract：:The serum CA125 level was determined by a one-step immunoradiometric assay method in patients with lung cancer. Increased serum CA125 levels were observed in 37.8% of patients with squamous cell cancer, in 30.0% of those with adenocarcinoma and in 60.0% of those with small call cancer. Most patients with increased ser...

journal_title：British journal of cancer

authors： Kimura Y,Fujii T,Hamamoto K,Miyagawa N,Kataoka M,Iio A

更新日期：1990-10-01 00:00:00

abstract：:Selection of patients for randomised clinical trials may have a large impact on the applicability of the study results to the general population presenting the same disorder. However, clinical characteristics and outcome data on non-entered patients are usually not available. The effects of patient selection for the E...

journal_title：British journal of cancer

authors： Bijker N,Peterse JL,Fentiman IS,Julien JP,Hart AA,Avril A,Cataliotti L,Rutgers EJ

更新日期：2002-09-09 00:00:00

abstract：:Between 1971 and 1988, 20 patients with previously undiagnosed non-Hodgkin's lymphoma (NHL), of intermediate or high grade histology presented with extradural spinal cord compression. All had decompressive surgery. The first treatment after surgery was chemotherapy in nine and radiotherapy in 11 patients. At presentat...

journal_title：British journal of cancer

authors： Eeles RA,O'Brien P,Horwich A,Brada M

更新日期：1991-01-01 00:00:00

abstract：:In this study, we aimed to analyse human cancer cell-platelet interactions in functional cell analyses and explore the molecular mechanisms behind tumour progression. Various functional analyses of gastric cancer (GC) cells were performed after direct/indirect co-incubation with platelets derived from GC patients. Fur...

journal_title：British journal of cancer

authors： Saito R,Shoda K,Maruyama S,Yamamoto A,Takiguchi K,Furuya S,Hosomura N,Akaike H,Kawaguchi Y,Amemiya H,Kawaida H,Sudo M,Inoue S,Kono H,Suzuki-Inoue K,Ichikawa D

更新日期：2020-10-28 00:00:00

abstract：BACKGROUND:Bortezomib is a proteasome inhibitor with minimal clinical activity as a monotherapy in solid tumours, but its combination with other targeted therapies is being actively investigated as a way to increase its anticarcinogenic properties. Here, we evaluate the therapeutic potential of co-treatment with bortez...

journal_title：British journal of cancer

authors： Taylor-Harding B,Agadjanian H,Nassanian H,Kwon S,Guo X,Miller C,Karlan BY,Orsulic S,Walsh CS

更新日期：2012-01-17 00:00:00

abstract：BACKGROUND:Despite recent advances in cancer therapy, the 5-year survival rate for Ewing's sarcoma is still very low, and new therapeutic approaches are necessary. It was found previously that melatonin induces cell death in the Ewing's sarcoma cell line, SK-N-MC, by activating the extrinsic apoptotic pathway. METHODS...

journal_title：British journal of cancer

authors： García-Santos G,Martin V,Rodríguez-Blanco J,Herrera F,Casado-Zapico S,Sánchez-Sánchez AM,Antolín I,Rodríguez C

更新日期：2012-03-27 00:00:00

abstract：:The purpose of this study was to evaluate the occurrence of lymphatic drainage to non-axillary sentinel nodes and to determine the implications of this phenomenon. A total of 549 breast cancer patients underwent lymphoscintigraphy after intratumoural injection of (99m)Tc-nanocolloid. The sentinel node was intraoperati...

journal_title：British journal of cancer

authors： Tanis PJ,Nieweg OE,Valdés Olmos RA,Peterse JL,Rutgers EJ,Hoefnagel CA,Kroon BB

更新日期：2002-09-23 00:00:00

abstract：:We assessed the association of postmenopausal serum levels of oestrogens and sex hormone-binding globulin (SHBG) with endometrial cancer risk in a case-control study nested within the NYU Women's Health Study cohort. Among 7054 women postmenopausal at enrolment, 57 cases of endometrial cancer were diagnosed a median o...

journal_title：British journal of cancer

authors： Zeleniuch-Jacquotte A,Akhmedkhanov A,Kato I,Koenig KL,Shore RE,Kim MY,Levitz M,Mittal KR,Raju U,Banerjee S,Toniolo P

更新日期：2001-04-06 00:00:00