One-step nucleic acid amplification assay is an accurate technique for sentinel lymph node biopsy of breast cancer patients: a meta-analysis.

abstract：:The activity of ZD 1839 on brain metastases (BM) from Non-Small-Cell Lung Cancer (NSCLC) is unknown. We report four cases of BM responding to ZD 1839 theraphy. ...

journal_title：British journal of cancer

authors： Cappuzzo F,Calandri C,Bartolini S,Crinò L

更新日期：2003-07-21 00:00:00

abstract：BACKGROUND:A frequent mechanism of acquired multidrug resistance in human cancers is overexpression of ATP-binding cassette transporters such as the Multi-Drug Resistance Protein 1 (MDR-1). Nutlin-3, an MDM2-p53 antagonist, has previously been reported to be a competitive MDR-1 inhibitor. METHODS:This study assessed w...

journal_title：British journal of cancer

authors： Chen L,Zhao Y,Halliday GC,Berry P,Rousseau RF,Middleton SA,Nichols GL,Del Bello F,Piergentili A,Newell DR,Lunec J,Tweddle DA

更新日期：2014-08-12 00:00:00

abstract：:Androgen receptor (AR) signalling drives neoplastic growth and therapy resistance in prostate cancer. Recent clinical data show that docetaxel combined with androgen deprivation therapy improves outcome in hormone-sensitive disease. We studied whether testosterone and AR signalling interferes with docetaxel treatment ...

journal_title：British journal of cancer

authors： Mout L,Moll JM,Chen M,de Morrée ES,de Ridder CMA,Gibson A,Stuurman D,Aghai A,Erkens-Schulze S,Mathijssen RHJ,Sparreboom A,de Wit R,Lolkema MP,van Weerden WM

更新日期：2020-12-01 00:00:00

abstract：:Interactions between immune and malignant cells have been known to have clinical relevance for decades. The potential for immune control is now being therapeutically enhanced with checkpoint inhibitors and other novel agents to improve outcomes in cancer. The importance of the immune infiltrate as a prognostic marker ...

journal_title：British journal of cancer

authors： Barnes TA,Amir E

更新日期：2017-08-08 00:00:00

abstract：BACKGROUND:We performed a retrospective nationwide study to explore age as a prognostic factor in synovial sarcoma patients. METHODS:Data on 613 synovial sarcoma patients were obtained from the Netherlands Cancer Registry. The prognostic relevance of age groups (children, adolescent and young adults (AYAs), adults, an...

journal_title：British journal of cancer

authors： Vlenterie M,Ho VK,Kaal SE,Vlenterie R,Haas R,van der Graaf WT

更新日期：2015-12-01 00:00:00

abstract：:The aim of this study was to determine the concentration of PDGF in vivo in neoplastic and non-neoplastic brain lesions. Fluid from cystic lesions and cerebrospinal fluid was tested in a radioreceptor assay that detects all described PDGF isoforms. High concentration of PDGF were found in cyst fluids from several astr...

journal_title：British journal of cancer

authors： Nistér M,Enblad P,Bäckström G,Söderman T,Persson L,Heldin CH,Westermark B

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:Stathmin mediates cell migration and invasion in vitro, and metastasis in vivo. To investigate stathmin's role on the metastatic process, we performed integrated mRNA-miRNA expression analysis to identify pathways regulated by stathmin. METHODS:MiRNA and gene arrays followed by miRNA-target-gene integration...

journal_title：British journal of cancer

authors： Po'uha ST,Le Grand M,Brandl MB,Gifford AJ,Goodall GJ,Khew-Goodall Y,Kavallaris M

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:The vascular disrupting agent combretastatin A4 phosphate (CA4P) causes major regression of animal tumours when given as combination therapy. METHODS:Patients with advanced cancer refractory to standard therapy were treated with CA4P as a 10-min infusion, 20 h before carboplatin, paclitaxel, or paclitaxel, ...

journal_title：British journal of cancer

authors： Rustin GJ,Shreeves G,Nathan PD,Gaya A,Ganesan TS,Wang D,Boxall J,Poupard L,Chaplin DJ,Stratford MR,Balkissoon J,Zweifel M

更新日期：2010-04-27 00:00:00

abstract：:Estimation of FGF-3 oncogene amplification in DNA samples extracted from paraffin embedded sections of 136 ovarian cancer samples was carried out by a quantitative PCR method. The aim of this study was to elucidate a possible association of FGF-3 copy numbers with established prognostic factors such as age, histology,...

journal_title：British journal of cancer

authors： Rosen A,Sevelda P,Klein M,Dobianer K,Hruza C,Czerwenka K,Hanak H,Vavra N,Salzer H,Leodolter S

更新日期：1993-05-01 00:00:00

abstract：BACKGROUND:Low cancer awareness may contribute to delayed diagnosis and poor cancer survival. We aimed to quantify socio-demographic differences in cancer symptom awareness and barriers to symptomatic presentation in the English population. METHODS:Using a uniquely large data set (n=49 270), we examined the associatio...

journal_title：British journal of cancer

authors： Niksic M,Rachet B,Warburton FG,Wardle J,Ramirez AJ,Forbes LJ

更新日期：2015-07-28 00:00:00

abstract：:One hundred resected cases of squamous cell carcinomas of the oesophagus were reviewed and a series of histological criteria related to the survival time. Two histological features were important in the assessment of survival. Good prognostic factors were a marked lymphocytic response to the tumour and a lack of intra...

journal_title：British journal of cancer

authors： Edwards JM,Hillier VF,Lawson RA,Moussalli H,Hasleton PS

更新日期：1989-03-01 00:00:00

abstract：:The association between body height and the incidence rate of breast cancer has been examined in 236 cases of breast cancer that occurred among 23,831 Norwegian women during 11-14 years of follow-up. At the time of height measurement they were 35-51 years of age. The age-adjusted incidence rate ratio (IRR) of breast c...

journal_title：British journal of cancer

authors： Vatten LJ,Kvinnsland S

更新日期：1990-06-01 00:00:00

abstract：:The MIB-1 antibody has been raised against recombinant parts of the Ki-67 antigen and, unlike Ki-67, has wider application to routinely fixed specimens. The aim of this study was to compare the usefulness of MIB-1 with S-phase fraction (SPF) as a measure of proliferation. A total of 75 patients with operable breast ca...

journal_title：British journal of cancer

authors： Ellis PA,Makris A,Burton SA,Titley J,Ormerod MG,Salter J,Powles TJ,Smith IE,Dowsett M

更新日期：1996-03-01 00:00:00

abstract：:2-Amino-3,4-dihydro-6-methyl-4-oxo-5-(4-pyridylthio)-quinazoline dihydrochloride (nolatrexed dihydrochloride, Thymitaq, AG337), a specific inhibitor of thymidylate synthase, was developed using protein structure-based drug design. Intravenously administered nolatrexed is active clinically. As oral bioavailability is h...

journal_title：British journal of cancer

authors： Jodrell DI,Bowman A,Rye R,Byrne B,Boddy A,Rafi I,Taylor GA,Johnston A,Clendeninn NJ

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND:The addition of breast magnetic resonance imaging (MRI) to screening mammography for women with BRCA mutations significantly increases sensitivity, but there is little data on clinical outcomes. We report screening performance, cancer stage, distant recurrence rate, and breast cancer-specific mortality in ou...

journal_title：British journal of cancer

authors： Passaperuma K,Warner E,Causer PA,Hill KA,Messner S,Wong JW,Jong RA,Wright FC,Yaffe MJ,Ramsay EA,Balasingham S,Verity L,Eisen A,Curpen B,Shumak R,Plewes DB,Narod SA

更新日期：2012-06-26 00:00:00

abstract：BACKGROUND:OCT3/4 (POU5F1) is an established diagnostic immunohistochemical marker for specific histological variants of human malignant germ cell tumours (GCTs), including the seminomatous types and the stem cell component of non-seminomas, known as embryonal carcinoma. OCT3/4 is crucial for the regulation of pluripot...

journal_title：British journal of cancer

authors： Rijlaarsdam MA,van Herk HA,Gillis AJ,Stoop H,Jenster G,Martens J,van Leenders GJ,Dinjens W,Hoogland AM,Timmermans M,Looijenga LH

更新日期：2011-09-06 00:00:00

abstract：:The effect on cell-cycle progression in various phases of the cell cycle caused by an acute exposure to hypoxia in absence and presence of misonidazole (MISO) was investigated. Exponentially growing and synchronized cells of the human line NHIK 3025 were exposed to different degrees of hypoxia for a short period (1.5 ...

journal_title：British journal of cancer

authors： Pettersen EO,Lindmo T

更新日期：1983-12-01 00:00:00

abstract：:Human peripheral-blood mononuclear cells, separated by Isopaque-Ficoll flotation and E-rosette formation, were tested by the fluorescein fluorescence polarization method of Cercek & Cercek (the SCM test). The response to stimulation with PHA or cancer tissue leads to a decreased polarization value TP). The responding ...

journal_title：British journal of cancer

authors： Orjasaeter H,Jordfald G,Svendsen I

更新日期：1979-10-01 00:00:00

abstract：:Sixteen chronic myeloid leukaemia (CML) patients in remission were tested with solubilized membrane antigens from CML leukaemic cells, CML blasts, AML blasts and ALL blasts for cellular immunity in vitro by lymphocyte transformation (LT) and leucocyte migration inhibition (LMI) assays. Twelve CML patients in remission...

journal_title：British journal of cancer

authors： Gangal SG,Damle NK,Khare AG,Advani SH

更新日期：1979-09-01 00:00:00

abstract：:Eleven groups of workers submitted a total of 21 bronchial tumour-associated antigen preparations and 19 antisera for comparative studies. Many of the antisera proved to be polyspecific despite absorption procedures. Most of the antigen preparations contained some material reactive towards a reference antiserum to nor...

journal_title：British journal of cancer

authors： Gennings JN,Bagshawe KD,Axelsen NH,Sizaret P

更新日期：1981-10-01 00:00:00

abstract：:The continuous cell line UCRU BL 17CL was derived from a human invasive bladder cancer and expresses elements of transitional, squamous and glandular differentiation. Nine clones of this line were established by limit dilution and have been extensively characterised. Only six of these clones grew subcutaneously in nud...

journal_title：British journal of cancer

authors： Brown JL,Russell PJ,Philips J,Wotherspoon J,Raghavan D

更新日期：1990-03-01 00:00:00

abstract：BACKGROUND:Accurate assessment of the prevalence of the human papilloma virus (HPV) in oropharyngeal tumours (OpSCC) is important because HPV-positive OpSCC are consistently associated with an improved overall survival. Recently, an algorithm has become available that reliably detects clinically relevant HPV in tumour ...

journal_title：British journal of cancer

authors： Melchers LJ,Mastik MF,Samaniego Cameron B,van Dijk BA,de Bock GH,van der Laan BF,van der Vegt B,Speel EJ,Roodenburg JL,Witjes MJ,Schuuring E

更新日期：2015-04-14 00:00:00

abstract：:Nine hundred and eighty-four breast cancer patients were interviewed regarding exogenous hormonal use. This represents a random sample of breast cancer patients in Southern Sweden referred to the Department of Oncology at Lund for treatment between 1978 and 1997 (excluding 1980 and 1981) with a 100% follow-up. Ever-us...

journal_title：British journal of cancer

authors： Jernström H,Frenander J,Fernö M,Olsson H

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:Oral squamous cell carcinoma (OSCC) has increased morbidity, and its high metastatic potential affects patient survival. Bromodomain containing 4 (BRD4) is a chromatin protein that associates with acetylated histone lysines and facilitates transcription. BRD4 has been implicated in cell proliferation, metast...

journal_title：British journal of cancer

authors： Yamamoto T,Hirosue A,Nakamoto M,Yoshida R,Sakata J,Matsuoka Y,Kawahara K,Nagao Y,Nagata M,Takahashi N,Hiraki A,Shinohara M,Nakao M,Saitoh N,Nakayama H

更新日期：2020-08-01 00:00:00

abstract：:Tamoxifen is the current therapy of choice for patients with oestrogen receptor positive breast cancer, and it is currently under evaluation as a prophylactic for women at high risk of developing the disease. However, tamoxifen is also known to induce proliferative changes in the endometrium increasing the risk of dev...

journal_title：British journal of cancer

authors： Hague S,Manek S,Oehler MK,MacKenzie IZ,Bicknell R,Rees MC

更新日期：2002-03-04 00:00:00

abstract：:With recent development in molecular biology, reverse transcriptase polymerase chain reaction (RT-PCR) has been applied to detect occult lymph node metastasis, but there have been few reports concerning oesophageal cancer. The objective of this study is to investigate the usefulness of the squamous cell carcinoma (SCC...

journal_title：British journal of cancer

authors： Kano M,Shimada Y,Kaganoi J,Sakurai T,Li Z,Sato F,Watanabe G,Imamura M

更新日期：2000-01-01 00:00:00

abstract：:The factors affecting long-term survival following oesophagectomy for oesophageal cancer are poorly understood. We examined the significance of microscopic tumour involvement at the circumferential resection margin (CRM) on postoperative survival following oesophagectomy. The case notes of 329 patients who underwent a...

journal_title：British journal of cancer

authors： Khan OA,Fitzgerald JJ,Soomro I,Beggs FD,Morgan WE,Duffy JP

更新日期：2003-05-19 00:00:00

abstract：BACKGROUND:We conducted a multicentre feasibility study for single agent long-term S-1 chemotherapy following docetaxel plus cisplatin in patients with curatively resected stage II-IIIA non-small cell lung cancer. METHODS:Patients received three cycles of docetaxel (60 mg m(-2)) plus cisplatin (80 mg m(-2)) and then r...

journal_title：British journal of cancer

authors： Niho S,Ikeda N,Michimae H,Suzuki K,Sakai H,Kaburagi T,Minato K,Kato T,Okamoto H,Seto T,Hosomi Y,Shimizu K,Oshita F,Kunitoh H,Tsuboi M,Takeuchi M,Watanabe K

更新日期：2013-08-06 00:00:00

abstract：:Dynamic contrast-enhanced MR imaging (DCE-MRI) may act as a biomarker for successful cancer therapy. Simple, reproducible techniques may widen this application. This paper demonstrates a single slice imaging technique. The image acquisition is performed in less than 500 ms making it relatively insensitive to respirato...

journal_title：British journal of cancer

authors： Morgan B,Utting JF,Higginson A,Thomas AL,Steward WP,Horsfield MA

更新日期：2006-05-22 00:00:00

abstract：BACKGROUND:Breast cancer, a heterogeneous disease has been broadly classified into oestrogen receptor positive (ER+) or oestrogen receptor negative (ER-) tumour types. Each of these tumours is dependent on specific signalling pathways for their progression. While high levels of survivin, an anti-apoptotic protein, incr...

journal_title：British journal of cancer

authors： Pervin S,Tran L,Urman R,Braga M,Parveen M,Li SA,Chaudhuri G,Singh R

更新日期：2013-03-05 00:00:00