Abstract:
:The registered incidence rate of childhood central nervous system (CNS) tumours has increased in several countries. It is uncertain whether these increases are biologically real or owing to improved diagnostic methods. We explored the medical records of 626 CNS tumours diagnosed in Danish children between 1980 and 1996. Population-based registers were used to extract data on mortality and background population. Temporal patterns were analysed by regression techniques. Most tumours were verified by computed tomography (78%) or magnetic resonance imaging (14%). Overall, the incidence rate increased by 2.9% per year (95% confidence interval (CI): 1.3;4.5) and the mortality rate increased by 1.4% per year (95% CI: -0.4;3.3). Among children aged 0-4 years, the survival rate after diagnosis remained almost unchanged, whereas among children aged 5-14 years, the 10-year survival rate improved from 59 to 74%. These data suggest that the incidence rate of CNS tumours among Danish children has truly increased, although alternative explanations cannot be excluded.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Raaschou-Nielsen O,Sørensen M,Carstensen H,Jensen T,Bernhardtsen T,Gjerris F,Schmiegelow Kdoi
10.1038/sj.bjc.6603278subject
Has Abstractpub_date
2006-08-07 00:00:00pages
416-22issue
3eissn
0007-0920issn
1532-1827pii
6603278journal_volume
95pub_type
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