Abstract:
BACKGROUND:The accuracy of prostate-specific antigen (PSA) testing in prostate cancer detection is constrained by low sensitivity and specificity. Dysregulated expression of minichromosome maintenance (Mcm) 2-7 proteins is an early event in epithelial multistep carcinogenesis and thus MCM proteins represent powerful cancer diagnostic markers. In this study we investigate Mcm5 as a urinary biomarker for prostate cancer detection. METHODS:Urine was obtained from 88 men with prostate cancer and from two control groups negative for malignancy. A strictly normal cohort included 28 men with complete, normal investigations, no urinary calculi and serum PSA <2 ng ml(-1). An expanded control cohort comprised 331 men with a benign final diagnosis, regardless of PSA level. Urine was collected before and after prostate massage in the cancer patient cohort. An immunofluorometric assay was used to measure Mcm5 levels in urine sediments. RESULTS:The Mcm5 test detected prostate cancer with 82% sensitivity (confidence interval (CI)= 72-89%) and with a specificity ranging from 73 (CI=68-78%) to 93% (CI=76-99%). Prostate massage led to increased Mcm5 signals compared with pre-massage samples (median 3440 (interquartile range (IQR) 2280 to 5220) vs 2360 (IQR <1800 to 4360); P=0.009), and was associated with significantly increased diagnostic sensitivity (82 vs 60%; P=0.012). CONCLUSIONS:Urinary Mcm5 detection seems to be a simple, accurate and noninvasive method for identifying patients with prostate cancer. Large-scale prospective trials are now required to evaluate this test in diagnosis and screening.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Dudderidge TJ,Kelly JD,Wollenschlaeger A,Okoturo O,Prevost T,Robson W,Leung HY,Williams GH,Stoeber Kdoi
10.1038/sj.bjc.6605785subject
Has Abstractpub_date
2010-08-24 00:00:00pages
701-7issue
5eissn
0007-0920issn
1532-1827pii
6605785journal_volume
103pub_type
杂志文章abstract:BACKGROUND:This phase 1 study examined the safety, maximum-tolerated dose (MTD) and antitumour activity of E7449, a novel PARP 1/2 and tankyrase 1/2 inhibitor. METHODS:E7449 was orally administered once daily in 28-day cycles to patients with advanced solid tumours (50-800-mg doses). Archival tumour samples from conse...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-0916-5
更新日期:2020-08-01 00:00:00
abstract::Microsatellite instability is present in over 80% of the hereditary non-polyposis colorectal carcinoma and about 15-20% of the sporadic cancer. Microsatellite instability is caused by the inactivation of the mismatch repair genes, such as primarily hMLH1, hMSH2. To study the mechanisms of the inactivation of mismatch ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6600148
更新日期:2002-02-12 00:00:00
abstract:BACKGROUND:Identification of promising biomarkers that predict the prognosis of patients with breast cancer is needed. In this study, we hypothesised that the expression of the epithelial-mesenchymal transition-related biomarker plastin3 (PLS3) in peripheral blood could be a prognostic factor in breast cancer. METHODS...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2015.132
更新日期:2015-04-28 00:00:00
abstract::A number of growth factors have been implicated in the control of the proliferation of breast cancer cells and some have been reported to mediate the proliferative effects of oestradiol. MCF-7 cells were treated with growth factors in the presence and absence of oestradiol. Oestradiol increased the response of cells t...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1992.330
更新日期:1992-10-01 00:00:00
abstract:PURPOSE:To determine the feasibility of induction chemotherapy and chemo-IMRT in head and neck squamous cell cancers at risk of bilateral nodal spread (midline tumours) and to evaluate whether bilateral superficial lobe parotid-sparing IMRT can reduce the incidence of ⩾G2 subjective xerostomia. METHODS:Patients with m...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2014.553
更新日期:2015-01-06 00:00:00
abstract:BACKGROUND:Patients whose colorectal cancer is treated after an emergency admission tend to have late-stage cancer and a poor prognosis. We identified risk factors for an emergency admission by linking data from the National Bowel Cancer Audit (NBCA) and the English Hospital Episode Statistics (HES), an administrative ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2014.300
更新日期:2014-07-29 00:00:00
abstract::Cellular mechanisms that account for tumour osteolysis associated with Ewing's sarcoma are uncertain. Osteoclasts are marrow-derived multinucleated cells (MNCs) that effect tumour osteolysis. Osteoclasts are known to form from macrophages by both receptor activator for nuclear factor-kappaB (RANK) ligand (RANKL)-depen...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6603774
更新日期:2007-06-04 00:00:00
abstract::Question prompt lists (QPLs) have been shown to be an inexpensive and effective communication tool for patients in oncology consultations. We aimed to develop and pilot a QPL for palliative care (PC) patients. In order to identify suitable questions for inclusion in the QPL, we conducted focus groups and individual in...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6601380
更新日期:2003-12-01 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate the safety of neoadjuvant chemoradiation using radiotherapy (RT) combined with concurrent capecitabine and irinotecan for locally advanced rectal cancer before surgery. METHODS:Forty-six patients were recruited and treated on the basis that MRI scanning had shown poo...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605258
更新日期:2009-09-15 00:00:00
abstract::In mice given a single dose of diethylnitrosamine, a hepatonecrotic dose of carbon tetrachloride, 5 weeks after dosing with DEN and repeated 6 times at 4-weekly intervals, augmented the tumour yield in the livers. A single hepatonecrotic dose of CCl4 24 h before a single dose of DEN also increased the number of tumour...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1978.89
更新日期:1978-04-01 00:00:00
abstract::The interaction between laminin and the oncoprotein encoded by the c-erbB-2 oncogene was studied in vitro and in vivo in human breast carcinomas. In vitro analysis of breast carcinoma cell lines overexpressing p185HER2 revealed that laminin, but not fibronectin, induced tyrosine phosphorylation and down-modulation of ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1996.560
更新日期:1996-11-01 00:00:00
abstract::Measurements of methotrexate have been made in the liver and plasma of 4 patients and in the bile and plasma of 1 patient receiving [(3)H]methotrexate. Projections from a theoretical model of concentration of methotrexate in liver are confirmed but projections of biliary excretion are not. ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1973.190
更新日期:1973-12-01 00:00:00
abstract::BW12C (5-[2-formyl-3-hydroxypenoxyl] pentanoic acid) is an agent which stabilises oxyhaemoglobin and thus reduces oxygen delivery to tissues. It is of interest as a possible potentiator of bioreductive agents and/or hyperthermia. The increases in radiobiological hypoxic fraction of RIF-1 and KHT tumours 30 min after 7...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1991.387
更新日期:1991-10-01 00:00:00
abstract::BALB/c mice born to and nursed by females immunized against MSV-M showed a reduced tumour incidence and a high tumour regression rate following MSV-M injection at 7-14 days of age. Females immunized long before mating could also confer protection to their offspring whereas females immunized after parturition could not...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1973.143
更新日期:1973-09-01 00:00:00
abstract:BACKGROUND:The pathogenesis of lymph node metastases in preinvasive breast cancer – ductal carcinoma in situ (DCIS) – remains controversial. The one-step nucleic acid amplification (OSNA) assay is a novel molecular method that can assess a whole node and detect clinically relevant metastases. In this retrospective coho...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2012.168
更新日期:2012-05-08 00:00:00
abstract::The antiapoptotic Livin/ML-IAP gene has recently gained much attention as a potential new target for cancer therapy. Reports indicating that livin is expressed almost exclusively in tumours, but not in the corresponding normal tissue, suggested that the targeted inhibition of livin may present a novel tumour-specific ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604028
更新日期:2007-11-05 00:00:00
abstract:BACKGROUND:This study aimed to evaluate the safety and efficacy of dose-dense weekly chemotherapy, followed by resection and/or thoracic radiotherapy. METHODS:Patients with histologically documented thymoma with unresectable stage III disease received 9 weeks of chemotherapy: cisplatin 25 mg m(-2) on weeks 1-9; vincri...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605731
更新日期:2010-06-29 00:00:00
abstract::The idea that chemotherapy can be used in combination with immunotherapy may seem somewhat counterproductive, as it can theoretically eliminate the immune cells needed for antitumour immunity. However, much preclinical work has now demonstrated that in addition to direct cytotoxic effects on cancer cells, a proportion...
journal_title:British journal of cancer
pub_type: 杂志文章,评审
doi:10.1038/bjc.2017.376
更新日期:2018-02-06 00:00:00
abstract::Two hundred patients with node positive stage II breast cancer were randomised to four groups after radical mastectomy and axillary evacuation: (1) Postoperative radiotherapy, (2) Adjuvant chemotherapy with eight courses of CAFt (cyclophosphamide 500 mg m-2 + doxorubicin 40 mg/m-2 + ftorafur 20 mg kg-1 orally day 1-14...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/bjc.1992.430
更新日期:1992-12-01 00:00:00
abstract:BACKGROUND:Body mass index (BMI) has been associated with the risk of oesophageal cancer. But the influence of BMI on postoperative complication and prognosis has always been controversial. METHODS:In total, 2031 consecutive patients who underwent oesophagectomy between 1998 and 2008 were classified according to Asian...
journal_title:British journal of cancer
pub_type: 杂志文章,meta分析
doi:10.1038/bjc.2013.666
更新日期:2013-11-26 00:00:00
abstract::Intermittent use of chemotherapy for androgen-independent prostate cancer (AIPC) instead of treatment until disease progression may reduce toxicity. We prospectively tested this approach in eight AIPC patients responding to calcitriol plus docetaxel who reached a serum prostate-specific antigen (PSA) <4 ng ml(-1). Che...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章
doi:10.1038/sj.bjc.6601232
更新日期:2003-09-15 00:00:00
abstract:BACKGROUND:The role of different subtypes of tumour infiltrating lymphocytes (TILs) in breast ductal carcinoma in situ (DCIS) is still poorly defined. This study aimed to assess the prognostic significance of B and T lymphocytes and immune checkpoint proteins expression in DCIS. METHODS:A well characterised DCIS cohor...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-0797-7
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:Increased survival after cancer in young age has made long-term follow-up studies of high external validity important. In this national cohort study, we explored the impact of cancer in young age on reproduction and marital status in male survivors. METHODS:Hazard ratios (HRs) and relative risks (RRs) of re...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2015.455
更新日期:2016-02-02 00:00:00
abstract::The Second Meeting of the British Society for Immunology Tumour Immunology Affinity Group (TIAG) took place at King's College (London, UK) on 17-18 June 1997 and brought together over 100 tumour immunologists from the UK and abroad. In contrast to previous meetings the focus of the meeting was on the role of adhesion ...
journal_title:British journal of cancer
pub_type: 杂志文章,评审
doi:10.1038/bjc.1998.300
更新日期:1998-06-01 00:00:00
abstract::The feasibility of combination irinotecan, carboplatin and docetaxel chemotherapy as first-line treatment for advanced epithelial ovarian carcinoma was assessed. One hundred patients were randomised to receive four 3-weekly cycles of carboplatin (area under the curve (AUC) 7) followed by four 3-weekly cycles of doceta...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/sj.bjc.6602910
更新日期:2006-01-16 00:00:00
abstract::The accurate determination of exposure to environmental tobacco smoke is notoriously difficult. There have been to date two approaches to determining this exposure in the study of association of passive smoking and lung cancer: the biochemical approach, using cotinine in the main as a marker, and the epidemiological a...
journal_title:British journal of cancer
pub_type: 杂志文章,meta分析
doi:10.1038/bjc.1992.341
更新日期:1992-10-01 00:00:00
abstract::Adenosine deaminase (EC 3.5.4.4, ADA) has been assayed in lymphocytes, granulocytes and erythrocytes from 45 patients with haematological malignancies. Activities were uniformly low in lymphocytes from patients with chronic lymphocytic leukaemia. Variable, but abnormal activities were frequently found in multiple myel...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1976.45
更新日期:1976-03-01 00:00:00
abstract::Secretary component (SC) is expressed basolaterally as a transmembrane protein (pIg receptor) on secretory epithelial cells. As pIg receptor it plays a central role in humoral immunity by mediating the external translocation of dimeric IgA and pentameric IgM. A few case reports have suggested that reduced or absent SC...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1996.284
更新日期:1996-06-01 00:00:00
abstract::The records of 194 patients with thyroid carcinoma treated with (131)I, representing all cases thus treated in Denmark from 1948 to 1972, were reviewed. Two cases of myeloid leukaemia were found compared with 0·097 expected cases of non-lymphocytic leukaemia (0·05 > P > 0·01). In 5 series of (131)I treated thyroid car...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1973.142
更新日期:1973-09-01 00:00:00
abstract::This corrects the article DOI: 10.1038/bjc.2017.85. ...
journal_title:British journal of cancer
pub_type: 杂志文章,已发布勘误
doi:10.1038/bjc.2018.3
更新日期:2018-03-20 00:00:00