The combination of radiotherapy, adjuvant chemotherapy (cyclophosphamide-doxorubicin-ftorafur) and tamoxifen in stage II breast cancer. Long-term follow-up results of a randomised trial.

abstract：:Four-coordinate (Pt(II)) platinum-based anticancer drugs are widely used in primary or palliative chemotherapy and produce considerable efficacy in certain clinical applications, for example testicular cancer. However, in many cancers the Pt(II) drugs are beset by poor efficacy mainly due to suboptimal pharmacokinetic...

journal_title：British journal of cancer

authors： Modok S,Scott R,Alderden RA,Hall MD,Mellor HR,Bohic S,Roose T,Hambley TW,Callaghan R

更新日期：2007-07-16 00:00:00

abstract：BACKGROUND:Tongue squamous cell carcinoma (TSCC) is increasing in incidence, especially among young patients and preferably females. Infection with human papilloma virus (HPV) has been suggested as a cause of SCC in the head and neck, and the proportion of oropharyngeal cancers caused by HPV has steadily increased. ME...

journal_title：British journal of cancer

authors： Sgaramella N,Coates PJ,Strindlund K,Loljung L,Colella G,Laurell G,Rossiello R,Muzio LL,Loizou C,Tartaro G,Olofsson K,Danielsson K,Fåhraeus R,Nylander K

更新日期：2015-07-14 00:00:00

abstract：:Delta-aminolevulinic acid (ALA) is the precursor in the biosynthesis of porphyrins. The knowledge of both the regulation of ALA entrance and efflux from the cells and the control of porphyrin biosynthesis is essential to improve ALA-mediated photodynamic therapy. In this work, we studied the regulation of ALA uptake a...

journal_title：British journal of cancer

authors： Correa García S,Casas A,Perotti C,Batlle A,Bermúdez Moretti M

更新日期：2003-07-07 00:00:00

abstract：:The blood-brain barrier is a major obstacle for the chemotherapeutic drugs to effectively reach primary or secondary brain tumours. Stealth liposomal drugs are highly accumulated in tumoural tissues. In the present study we investigated the relative accumulation of(99m)Tc-DTPA radiolabelled stealth liposomal doxorubic...

journal_title：British journal of cancer

authors： Koukourakis MI,Koukouraki S,Fezoulidis I,Kelekis N,Kyrias G,Archimandritis S,Karkavitsas N

更新日期：2000-11-01 00:00:00

abstract：:Colorectal tumours from MYH polyposis patients display an excess of somatic G : C --> T : A transversions in the adenomatous polyposis coli gene. Here, we identify k-ras mutations in nine out of 54 (16.7%) MYH polyposis tumours. Their presence was associated with increased dysplasia and tubulovillous morphology (P=0.0...

journal_title：British journal of cancer

authors： Jones S,Lambert S,Williams GT,Best JM,Sampson JR,Cheadle JP

更新日期：2004-04-19 00:00:00

abstract：:Within a population-based cohort study, 40,708 men aged 45-79 years followed from 1998 to 2004. After adjusting for potential confounders, we observed a strong inverse linear association between total daily physical activity (PA) and death from cancer (n=1153). For each increment of 4 metabolic equivalent (MET)-h day(...

journal_title：British journal of cancer

authors： Orsini N,Mantzoros CS,Wolk A

更新日期：2008-06-03 00:00:00

abstract：BACKGROUND:The human epidermal growth factor receptor (EGFR) is an important therapeutic target in oncology, and three different types of EGFR inhibitors have been approved for the treatment of cancer patients. However, there has been no clear association between the expression levels of EGFR protein in the tumours det...

journal_title：British journal of cancer

authors： Modjtahedi H,Khelwatty SA,Kirk RS,Seddon AM,Essapen S,Del Vecchio CA,Wong AJ,Eccles S

更新日期：2012-02-28 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is one of the most common types of malignant tumour and has poor prognosis. Currently, systematic chemotherapy is the only approach to prolong survival. Thus the development of new treatment regimens is urgently needed to improve the therapeutic efficacy. Our study intended to ...

journal_title：British journal of cancer

authors： Xu L,Zhu Y,Shao J,Chen M,Yan H,Li G,Zhu Y,Xu Z,Yang B,Luo P,He Q

更新日期：2017-04-11 00:00:00

abstract：BACKGROUND:MicroRNA (miRNA)-126 (miR-126) is an endothelial-specific miRNA located within intron 7 of epidermal growth factor-like domain 7 (EGFL7). However, the role of miR-126 in cancer is controversial. METHODS:We examined the function of miR-126 in oral squamous cell carcinoma (OSCC) cells. Furthermore, a series o...

journal_title：British journal of cancer

authors： Sasahira T,Kurihara M,Bhawal UK,Ueda N,Shimomoto T,Yamamoto K,Kirita T,Kuniyasu H

更新日期：2012-08-07 00:00:00

abstract：:Sera from breast cancer patients and from female controls were tested for inhibition of lysis of antibody-coated target cells by human leukocytes (K cells). Sera from 39% of breast cancer patients, but from only 8% of controls, inhibited lysis by more than 30%. This inhibition was unrelated to the stage of the disease...

journal_title：British journal of cancer

authors： Matthews N,Whitehead RH

更新日期：1976-12-01 00:00:00

abstract：:The possible use of liposomes (phospholipid vesicles) to direct cytotoxic drugs to tumours has led us to investigate the tissue localization of i.v. injected 99m-Tc-labelled liposomes in cancer patients. Twenty mg or 300 mg doses of liposomal lipid (7:2:1 molar ratio of phosphatidylcholine : cholesterol : phosphatidic...

journal_title：British journal of cancer

authors： Richardson VJ,Ryman BE,Jewkes RF,Jeyasingh K,Tattersall MN,Newlands ES,Kaye SB

更新日期：1979-07-01 00:00:00

abstract：:It is known that interferon-gamma (IFN-gamma) is produced by activated T and NK lymphoid cells, mononuclear cells, and macrophage and dendritic cells. Our previous studies have shown that IFN-gamma-like immunoreactivity also appears in human adrenal cortical tumour and phaeochromocytoma. To investigate whether human t...

journal_title：British journal of cancer

authors： Li Q,Zhang XQ,Nie L,Chen GS,Li H,Zhang F,Zhang LY,Hong L,Wang SF,Wang H

更新日期：2007-08-06 00:00:00

abstract：:The ability of 5-aminolaevulinic acid and some of its esterified derivatives to induce porphyrin accumulation has been examined in CaNT murine mammary carcinoma cells growing in culture and as tumours in vivo. Topical or intravenous administration of 5-aminolaevulinic acid-esters to mice bearing subcutaneous tumours p...

journal_title：British journal of cancer

authors： Tunstall RG,Barnett AA,Schofield J,Griffiths J,Vernon DI,Brown SB,Roberts DJ

更新日期：2002-07-15 00:00:00

abstract：:We examined the association of diet with insulin-like growth factors (IGF) in 344 disease-free men. Raised levels of IGF-I and/or its molar ratio with IGFBP-3 were associated with higher intakes of milk, dairy products, calcium, carbohydrate and polyunsaturated fat; lower levels with high vegetable consumption, partic...

journal_title：British journal of cancer

authors： Gunnell D,Oliver SE,Peters TJ,Donovan JL,Persad R,Maynard M,Gillatt D,Pearce A,Hamdy FC,Neal DE,Holly JM

更新日期：2003-06-02 00:00:00

abstract：:Imatinib mesilate (Glivec), Novartis Pharmaceuticals) is a novel therapy for the treatment of chronic myeloid leukaemia (CML). We evaluated the cost-effectiveness of imatinib (600 mg daily) when used for the treatment of patients in advanced stages of CML (accelerated phase and blast crisis) against conventional thera...

journal_title：British journal of cancer

authors： Gordois A,Scuffham P,Warren E,Ward S

更新日期：2003-08-18 00:00:00

abstract：:The incidence of nodal metastasis in early gastric carcinoma (EGC) is 10-20%. However, the optimal nodal dissection for early gastric carcinoma has not been established. A retrospective study was conducted in 392 consecutive patients who underwent potentially curative distal gastrectomy for EGC between 1962 and 1990. ...

journal_title：British journal of cancer

authors： Miwa K,Miyazaki I,Sahara H,Fujimura T,Yonemura Y,Noguchi M,Falla R

更新日期：1995-12-01 00:00:00

abstract：:A risk model for febrile neutropenia (FN) after conventional cytotoxic chemotherapy, based on early (day 5) lymphopenia and the dose of chemotherapy, has been described. A risk index based on parameters available at day 1 would be easier in daily practice. The objectives of this work were (1) to investigate a risk mod...

journal_title：British journal of cancer

authors： Ray-Coquard I,Borg C,Bachelot T,Sebban C,Philip I,Clapisson G,Le Cesne A,Biron P,Chauvin F,Blay JY,ELYPSE study group.

更新日期：2003-01-27 00:00:00

abstract：:To investigate the usefulness of thyroglobulin mRNA (Tg-mRNA) detection in peripheral blood in the follow-up of papillary and follicular (differentiated) thyroid cancer, a literature study was performed. Both evidence for and evidence against the usefulness of Tg-mRNA detection were found. Also, evidence for the expre...

journal_title：British journal of cancer

authors： Verburg FA,Lips CJ,Lentjes EG,de Klerk JM

更新日期：2004-07-19 00:00:00

abstract：:Spontaneous and radiation-induced genetic instability of peripheral blood mononuclear cells derived from unselected breast cancer (BC) patients (n=50) was examined using the single-cell gel electrophoresis (Comet) assay and a modified G2 micronucleus (MN) test. Cells from apparently healthy donors (n=16) and from canc...

journal_title：British journal of cancer

authors： Djuzenova CS,Mühl B,Fehn M,Oppitz U,Müller B,Flentje M

更新日期：2006-04-24 00:00:00

abstract：BACKGROUND:Gram-negative bacteria mediated gemcitabine resistance in pre-clinical models. We determined if intratumoural lipopolysaccharide (LPS) detection by immunohistochemistry is associated with outcome in advanced pancreatic ductal adenocarcinoma (PDAC) treated with gemcitabine and non-gemcitabine containing 1st-l...

journal_title：British journal of cancer

authors： Guenther M,Haas M,Heinemann V,Kruger S,Westphalen CB,von Bergwelt-Baildon M,Mayerle J,Werner J,Kirchner T,Boeck S,Ormanns S

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Bevacizumab has broad anti-tumour activity, but substantial risk of hypertension. No reliable markers are available for predicting bevacizumab-induced hypertension. METHODS:A genome-wide association study (GWAS) was performed in the phase III bevacizumab-based adjuvant breast cancer trial, ECOG-5103, to eva...

journal_title：British journal of cancer

authors： Schneider BP,Li L,Shen F,Miller KD,Radovich M,O'Neill A,Gray RJ,Lane D,Flockhart DA,Jiang G,Wang Z,Lai D,Koller D,Pratt JH,Dang CT,Northfelt D,Perez EA,Shenkier T,Cobleigh M,Smith ML,Railey E,Partridge A,Gralo

更新日期：2014-09-09 00:00:00

abstract：:Human peripheral-blood mononuclear cells, separated by Isopaque-Ficoll flotation and E-rosette formation, were tested by the fluorescein fluorescence polarization method of Cercek & Cercek (the SCM test). The response to stimulation with PHA or cancer tissue leads to a decreased polarization value TP). The responding ...

journal_title：British journal of cancer

authors： Orjasaeter H,Jordfald G,Svendsen I

更新日期：1979-10-01 00:00:00

abstract：BACKGROUND:8-Oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) is the most abundant marker of DNA damage and it reflects oxidative stress. Human 8-oxoguanine glycosylase (hOGG1) is a DNA-repair enzyme that participates in 8-oxodG removal. METHODS:hOGG1 protein expression was immunohistochemically studied in 96 patients with...

journal_title：British journal of cancer

authors： Karihtala P,Kauppila S,Puistola U,Jukkola-Vuorinen A

更新日期：2012-01-17 00:00:00

abstract：:We used the nationwide Swedish Family-Cancer Database with 2060 childhood brain tumours diagnosed in the period 1958-1996 to analyse the risk of this tumour by parental cancers and in siblings of childhood brain tumour probands. Groups of patients were compared by calculating standardized incidence ratios (SIRs) for b...

journal_title：British journal of cancer

authors： Hemminki K,Li X,Vaittinen P,Dong C

更新日期：2000-08-01 00:00:00

abstract：:Ductal carcinoma in situ (DCIS) now represents 20-25% of all 'breast cancers' consequent upon detection by population-based breast cancer screening programmes. Currently, all DCIS lesions are treated, and treatment comprises either mastectomy or breast-conserving surgery supplemented with radiotherapy. However, most D...

journal_title：British journal of cancer

authors： van Seijen M,Lips EH,Thompson AM,Nik-Zainal S,Futreal A,Hwang ES,Verschuur E,Lane J,Jonkers J,Rea DW,Wesseling J,PRECISION team.

更新日期：2019-08-01 00:00:00

abstract：:Intermittent use of chemotherapy for androgen-independent prostate cancer (AIPC) instead of treatment until disease progression may reduce toxicity. We prospectively tested this approach in eight AIPC patients responding to calcitriol plus docetaxel who reached a serum prostate-specific antigen (PSA) <4 ng ml(-1). Che...

journal_title：British journal of cancer

authors： Beer TM,Garzotto M,Henner WD,Eilers KM,Wersinger EM

更新日期：2003-09-15 00:00:00

abstract：BACKGROUND:Four-and-a-half LIM domains protein 2 (FHL2) is a component of the focal adhesion structures and has been suggested to have a role in cancer progression. It has been shown to be overexpressed in the colorectal cancer (CRC). METHODS:Here, we examined a possible prognostic value of FHL2 in CRC. Immunohistoche...

journal_title：British journal of cancer

authors： Verset L,Tommelein J,Moles Lopez X,Decaestecker C,Mareel M,Bracke M,Salmon I,De Wever O,Demetter P

更新日期：2013-07-09 00:00:00

abstract：BACKGROUND:Diet modulates inflammation and inflammatory markers have been associated with cancer outcomes. In the Women's Health Initiative, we investigated associations between a dietary inflammatory index (DII) and invasive breast cancer incidence and death. METHODS:The DII was calculated from a baseline food freque...

journal_title：British journal of cancer

authors： Tabung FK,Steck SE,Liese AD,Zhang J,Ma Y,Caan B,Chlebowski RT,Freudenheim JL,Hou L,Mossavar-Rahmani Y,Shivappa N,Vitolins MZ,Wactawski-Wende J,Ockene JK,Hébert JR

更新日期：2016-05-24 00:00:00

abstract：:The secosteroid hormones, all-trans- and 9-cis-retinoic acid and vitamin D3, have demonstrated significant capacity to control proliferation in vitro of many solid tumour cell lines. Cooperative synergistic effects by these two ligands have been reported, and it is, therefore, possible that greater therapeutic effects...

journal_title：British journal of cancer

authors： Campbell MJ,Park S,Uskokovic MR,Dawson MI,Jong L,Koeffler HP

更新日期：1999-01-01 00:00:00

abstract：:There is evidence that patients living in outlying areas have poorer survival from cancer. This study set out to investigate whether they have more advanced disease at diagnosis. Case notes of 1323 patients in north and northeast Scotland who were diagnosed with lung or colorectal cancer in 1995 or 1996 were reviewed....

journal_title：British journal of cancer

authors： Campbell NC,Elliott AM,Sharp L,Ritchie LD,Cassidy J,Little J

更新日期：2001-04-06 00:00:00