Abstract:
BACKGROUND:Tongue squamous cell carcinoma (TSCC) is increasing in incidence, especially among young patients and preferably females. Infection with human papilloma virus (HPV) has been suggested as a cause of SCC in the head and neck, and the proportion of oropharyngeal cancers caused by HPV has steadily increased. METHODS:Samples from 109 patients with primary TSCC were analysed for the presence of HPV16 by in situ hybridisation and for expression of its surrogate marker p16 and the HPV receptor syndecan-1 by immunhistochemistry. RESULTS:No evidence of HPV16 DNA was observed in the tumours, although one-third showed p16 staining. There was no difference in the expression of the primary HPV receptor, syndecan-1, between TSCC and a group of tonsil SCC. CONCLUSION:Whereas p16 is expressed in some TSCCs, HPV16 is undetectable, therefore, p16 cannot be used as a surrogate marker for high-risk HPV-infection in this tumour. Despite presence of the HPV-receptor syndecan-1 in TSCC, HPV prefers the tonsillar environment. Lack of p16 associates with worse prognosis primarily in patients aged ⩽40 years with tongue SCC. The improved prognosis seen in p16-positive TSCC can be due to induction of a senescent phenotype or an inherent radiosensitivity due to the ability of p16 to inhibit homologous recombination repair.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Sgaramella N,Coates PJ,Strindlund K,Loljung L,Colella G,Laurell G,Rossiello R,Muzio LL,Loizou C,Tartaro G,Olofsson K,Danielsson K,Fåhraeus R,Nylander Kdoi
10.1038/bjc.2015.207subject
Has Abstractpub_date
2015-07-14 00:00:00pages
321-6issue
2eissn
0007-0920issn
1532-1827pii
bjc2015207journal_volume
113pub_type
杂志文章abstract:BACKGROUND:Cytochrome P450 2D6 (CYP2D6) has a crucial role in the metabolic conversion of tamoxifen into the active metabolite endoxifen. In this cohort study, the effect of CYP2D6-predicted phenotype, defined as the combined effect of CYP2D6 genetic variation and concomitant use of CYP2D6-inhibiting medication, on tim...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605800
更新日期:2010-09-07 00:00:00
abstract::Following an i.p. dose of 150 mg x kg(-1) 5-fluorouracil (5-FU), drug uptake and metabolism over a 2-h period were studied by in vivo (19)F magnetic resonance spectroscopy (MRS) for the murine colon carcinoma lines C26-B (5-FU-insensitive; n=11) and C26-10 (5-FU-sensitive; n=15) implanted s.c. in Balb/C mice. Time cou...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6601162
更新日期:2003-08-18 00:00:00
abstract::We have studied the cytotoxic effects of recombinant tumour necrosis factor and recombinant gamma interferon on primary cultures of leukaemia cells. The agents were added alone or in a combination to cells from 17 patients. Eleven had acute myeloblastic leukaemia (6 at presentation, 5 at relapse), 4 had acute lymphobl...
journal_title:British journal of cancer
pub_type: 杂志文章
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更新日期:1987-03-01 00:00:00
abstract:BACKGROUND:In colorectal cancer (CRC), BRAF mutations influence tumour progression. In mismatch repair-deficient (dMMR) tumours, BRAF mutations are associated with a good prognosis, whereas in MMR-competent tumours, they are detrimental. The differential expression of the downstream MAPK pathway members, which are cons...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-018-0174-y
更新日期:2018-08-01 00:00:00
abstract::We have treated 40 patients was relapsed or resistant lymphoma with the combination of Etoposide, Prednisolone, Ifosfamide and Cisplatin (EPIC). Complete response was obtained in 11 patients (28%) with an overall response of 58%. The presence of bulky disease (P < 0.005), elevated LDH serum levels (P < 0.005), respons...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章
doi:10.1038/bjc.1993.393
更新日期:1993-09-01 00:00:00
abstract::We have investigated both the effects of X-rays on angiogenesis and the possible role of nitric oxide (NO) on the observed antiangiogenic effect of X-rays, using as an in vivo model the chick embryo chorioallantoic membrane (CAM). These effects were assessed both morphologically and biochemically, by measuring vascula...
journal_title:British journal of cancer
pub_type: 杂志文章
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更新日期:1996-12-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2012.330
更新日期:2012-08-07 00:00:00
abstract::In a variety of adult and childhood leukaemia cell samples collected at different states of the disease, we analysed in a series of sequentially performed slot-blot or Northern-blot hybridisation experiments the expression of genes possibly involved in multiple drug resistance (MDR) (mdr1/P-glycoprotein, DNA topoisome...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1992.304
更新日期:1992-09-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6690725
更新日期:1999-10-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6603171
更新日期:2006-06-05 00:00:00
abstract::Nerve growth factor (NGF) administration to athymic mice with transplanted human bromocriptine-resistant prolactinoma, results in the expression of dopamine D-2 receptors in the tumour and restores sensitivity to subsequent treatment with bromocriptine, which then produces normalisation of plasma prolactin and tumour ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1995.520
更新日期:1995-12-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1038/sj.bjc.6603717
更新日期:2007-05-07 00:00:00
abstract::Serum levels of cell-free interleukin-2 receptors were elevated above normal in mice bearing the IL-2R positive T-cell lymphoma Eb or its highly metastatic variant ESb. Although ESb cells expressed less IL-2R molecules than Eb cells on their cell surface, serum receptor levels were raised more quickly in ESb than in E...
journal_title:British journal of cancer
pub_type: 杂志文章
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更新日期:1987-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1038/bjc.2013.27
更新日期:2013-04-16 00:00:00
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journal_title:British journal of cancer
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1038/sj.bjc.6600273
更新日期:2002-06-05 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2012.7
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abstract::Follicular-phase (Day 11) plasma prolactin, and plasma and urinary oestrogen levels of 70 nulliparous nuns were compared with those of 80 of their sisters, of whom 62 were parous. The nuns and their nulliparous sisters did not differ significantly in their prolactin and oestrogen levels. No differences in plasma oestr...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1981.121
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pub_type: 杂志文章,评审
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更新日期:1987-08-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6602271
更新日期:2005-01-17 00:00:00
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更新日期:2016-09-27 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1997.501
更新日期:1997-01-01 00:00:00
abstract::Transforming growth factor alpha (TGF alpha) and Transforming growth factor beta-1 (TGF-beta 1) are growth regulatory for breast cancer cell lines in vitro and several studies have suggested that levels of the receptor for TGF alpha, the epidermal growth factor (EGFR) in tumour biopsies predict relapse and survival. W...
journal_title:British journal of cancer
pub_type: 杂志文章
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更新日期:1993-06-01 00:00:00
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journal_title:British journal of cancer
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更新日期:1997-01-01 00:00:00
abstract::Four-coordinate (Pt(II)) platinum-based anticancer drugs are widely used in primary or palliative chemotherapy and produce considerable efficacy in certain clinical applications, for example testicular cancer. However, in many cancers the Pt(II) drugs are beset by poor efficacy mainly due to suboptimal pharmacokinetic...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6603854
更新日期:2007-07-16 00:00:00
abstract::Altered expression and activity of proteases is a key event in cancer, particularly in relation to invasion, modification of the extracellular matrix and metastasis. The transmembrane protease, serine 4 (TMPRSS4) is closely related to other cancer-associated proteases, such as hepsin, TMPRSS2 and matriptase. We review...
journal_title:British journal of cancer
pub_type: 杂志文章,评审
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更新日期:2015-01-06 00:00:00
abstract::In the UK there are standardized surveillance procedures for gestational trophoblastic disease. However, there are differences in practice between the two treatment centres in terms of definition of persistent gestational trophoblastic disease, prognostic risk assessment and chemotherapeutic regimens. The role of prop...
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doi:10.1038/sj.bjc.6690203
更新日期:1999-03-01 00:00:00