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Cytotoxic effects of tumour necrosis factor and gamma-interferon on acute myeloid leukaemia blasts.

Abstract：

:We have studied the cytotoxic effects of recombinant tumour necrosis factor and recombinant gamma interferon on primary cultures of leukaemia cells. The agents were added alone or in a combination to cells from 17 patients. Eleven had acute myeloblastic leukaemia (6 at presentation, 5 at relapse), 4 had acute lymphoblastic leukaemia, one had hairy cell leukaemia, and 2 had chronic myeloid leukaemia--one of whom was in myeloid blast transformation. Cells from patients with lymphoid malignancies or from the patient with chronic phase CML were not affected by either agent in any dose combination. In contrast, reduction of viability of myeloid blasts was weakly accelerated by TNF and gamma-interferon individually. Combination of the agents invariably produced enhanced killing and additive or synergistic effects were seen when 20-500 IU ml-1 of each cytokine was present. This sensitivity was also shown by blast cells from 5 patients with relapsed AML. We therefore suggest that trials of such combination therapy may be indicated in drug resistant or relapsed AML.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Price G,Brenner MK,Prentice HG,Hoffbrand AV,Newland AC

doi

10.1038/bjc.1987.55

subject

Has Abstract

pub_date

1987-03-01 00:00:00

pages

287-90

issue

3

eissn

0007-0920

issn

1532-1827

journal_volume

55

pub_type

杂志文章

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