Clonal analysis of a bladder cancer cell line: an experimental model of tumour heterogeneity.

abstract：BACKGROUND:Tumour microenvironments can differ according to intratumoural locations. We investigated the immune status at different locations in primary tumours and its clinical significance in oesophageal squamous cell carcinoma (ESCC). METHODS:The number of CD8+ tumour-infiltrating immune cells (TIICs) and PD-1+ TII...

journal_title：British journal of cancer

authors： Hatogai K,Fujii S,Kitano S,Kojima T,Daiko H,Yoshino T,Ohtsu A,Takiguchi Y,Doi T,Ochiai A

更新日期：2020-02-01 00:00:00

abstract：:In resection tissue samples of colorectal carcinomas, the concentration of urokinase-type plasminogen activator (u-Pa) was found to be significantly higher than in the normal parent mucosal tissue, while there was less tissue-type plasminogen activator (t-PA). u-PA and t-PA were also determined in endoscopic biopsies ...

journal_title：British journal of cancer

authors： de Bruin PA,Verspaget HW,Griffioen G,Verheijen JH,Dooijewaard G,Lamers CB

更新日期：1989-09-01 00:00:00

abstract：:Deletion of chromosome arm 1p and amplification of the MYCN oncogene are well-recognized genetic alterations in neuroblastoma cells. Recently, another alteration has been reported; gain of the distal part of chromosome arm 17q. In this study 48 neuroblastoma tumours were successfully analysed for 17q status in relatio...

journal_title：British journal of cancer

authors： Abel F,Ejeskär K,Kogner P,Martinsson T

更新日期：1999-12-01 00:00:00

abstract：:Disseminating disease is a predictive and prognostic indicator of poor outcome in children with neuroblastoma. Its accurate and sensitive assessment can facilitate optimal treatment decisions. The International Neuroblastoma Risk Group (INRG) Task Force has defined standardised methods for the determination of minimal...

journal_title：British journal of cancer

authors： Beiske K,Burchill SA,Cheung IY,Hiyama E,Seeger RC,Cohn SL,Pearson AD,Matthay KK,International neuroblastoma Risk Group Task Force.

更新日期：2009-05-19 00:00:00

abstract：BACKGROUND:Combined oral contraceptive (COC) use reduces epithelial ovarian cancer (EOC) risk. However, little is known about risk with COC use before the first full-term pregnancy (FFTP). METHODS:This Canadian population-based case-control study (2001-2012) included 854 invasive cases/2139 controls aged ⩾40 years who...

journal_title：British journal of cancer

authors： Cook LS,Pestak CR,Leung AC,Steed H,Nation J,Swenerton K,Gallagher R,Magliocco A,Köbel M,Brooks-Wilson A,Le N

更新日期：2017-01-17 00:00:00

abstract：BACKGROUND:defective DNA repair has a causal role in hereditary colorectal cancer (CRC). Defects in the base excision repair gene MUTYH are responsible for MUTYH-associated polyposis and CRC predisposition as an autosomal recessive trait. Numerous reports have suggested MUTYH mono-allelic variants to be low penetrance ...

journal_title：British journal of cancer

authors： Theodoratou E,Campbell H,Tenesa A,Houlston R,Webb E,Lubbe S,Broderick P,Gallinger S,Croitoru EM,Jenkins MA,Win AK,Cleary SP,Koessler T,Pharoah PD,Küry S,Bézieau S,Buecher B,Ellis NA,Peterlongo P,Offit K,Aaltonen L

更新日期：2010-12-07 00:00:00

abstract：:The limited prognosis of patients with castration-resistant prostate cancer (CRPC) on existing hormonal manipulation therapies calls out for the urgent need for new management strategies. The novel, orally available, small-molecule compound, abiraterone acetate, is undergoing evaluation in early clinical trials and em...

journal_title：British journal of cancer

authors： Ang JE,Olmos D,de Bono JS

更新日期：2009-03-10 00:00:00

abstract：BACKGROUND:Determining the rate of breast cancer (BC) growth in vivo, which can predict prognosis, has remained elusive despite its relevance for treatment, screening recommendations and medicolegal practice. We developed a model that predicts the rate of in vivo tumour growth using a unique study cohort of BC patients...

journal_title：British journal of cancer

authors： Bhattarai S,Klimov S,Aleskandarany MA,Burrell H,Wormall A,Green AR,Rida P,Ellis IO,Osan RM,Rakha EA,Aneja R

更新日期：2019-09-01 00:00:00

abstract：:The effects of suramin, an inhibitor of growth factor mitogenic activity, were evaluated on basic fibroblast growth factor (bFGF)-induced proliferation of bovine aortic endothelial cells and on angiogenesis in the chorioallantoic membrane (CAM) of chick embryos. The role of bFGF gene expression in endothelial cell gro...

journal_title：British journal of cancer

authors： Danesi R,Del Bianchi S,Soldani P,Campagni A,La Rocca RV,Myers CE,Paparelli A,Del Tacca M

更新日期：1993-11-01 00:00:00

abstract：:The prognostic value of tissue-type plasminogen activator (tPA) measured in samples derived from 865 patients with primary breast cancer using a recently developed enzyme-linked immunosorbent assay (ELISA) was evaluated. Since the assay could easily be adapted to the assessment of the complex of tPA with its type-1 in...

journal_title：British journal of cancer

authors： de Witte JH,Sweep CG,Klijn JG,Grebenschikov N,Peters HA,Look MP,van Tienoven TH,Heuvel JJ,Bolt-De Vries J,Benraad TJ,Foekens JA

更新日期：1999-04-01 00:00:00

abstract：:A study is presented of all cases of primary sarcoma of bone registered during the period 1946 to 1974 for a specified population resident in south-western England. Ninety-six per cent of the 365 cases were histologically and radiologically verified and are separated into 8 categories of sarcoma. The number of tumours...

journal_title：British journal of cancer

authors： Price CH,Jeffree GM

更新日期：1977-10-01 00:00:00

abstract：:The 5-year relative survival rates of women diagnosed with breast cancer between 1992 and 1994 were compared among the 99 Health Authorities (1999 boundaries) of England. Substantial variation, with evidence of geographical clustering was observed. Part of this variation was explained by differences in deprivation bet...

journal_title：British journal of cancer

authors： Mullee MA,De Stavola B,Romanengo M,Coleman MP

更新日期：2004-06-01 00:00:00

abstract：:Photodynamic activation of macrophage-like cells contributes to an effective outcome of photodynamic therapy (PDT) treatment. The possibility for an enhancement of macrophage activity by photosensitization with meta-tetra(hydroxyphenyl)chlorin (mTHPC) (1 microg ml(-1)) was studied in U937, monocyte cell line different...

journal_title：British journal of cancer

authors： Coutier S,Bezdetnaya L,Marchal S,Melnikova V,Belitchenko I,Merlin JL,Guillemin F

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND:Prescribing anti-programmed death-1 (PD-1) immunotherapy for advanced melanoma is currently not restricted by any biomarker assessment. Determination of programmed death-ligand-1 (PD-L1)-expression status is technically challenging and is not mandatory, because negative tumours also achieve therapeutic respo...

journal_title：British journal of cancer

authors： Dupuis F,Lamant L,Gerard E,Torossian N,Chaltiel L,Filleron T,Beylot-Barry M,Dutriaux C,Prey S,Gros A,Jullie ML,Meyer N,Vergier B

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Upregulation of the matrix metalloproteinases MMP-2 and MMP-9 in various cancers has been associated with worse survival of the patients. METHODS:We assessed MMP-2 and MMP-9 levels in normal colorectal mucosa from colorectal cancer patients in relation to the course of the disease. RESULTS:A high protein e...

journal_title：British journal of cancer

authors： Langers AM,Verspaget HW,Hawinkels LJ,Kubben FJ,van Duijn W,van der Reijden JJ,Hardwick JC,Hommes DW,Sier CF

更新日期：2012-04-24 00:00:00

abstract：:The abilities of chemokines in orchestrating cellular migration are utilised by different (patho-)biological networks including malignancies. However, except for CXCR4/CXCL12, little is known about the relation between tumour-related chemokine expression and the development and progression of solid tumours like breast...

journal_title：British journal of cancer

authors： Panse J,Friedrichs K,Marx A,Hildebrandt Y,Luetkens T,Barrels K,Horn C,Stahl T,Cao Y,Milde-Langosch K,Niendorf A,Kröger N,Wenzel S,Leuwer R,Bokemeyer C,Hegewisch-Becker S,Atanackovic D

更新日期：2008-09-16 00:00:00

abstract：BACKGROUND:Tissue micro-arrays (TMAs) are increasingly used to generate data of the molecular phenotype of tumours in clinical epidemiology studies, such as studies of disease prognosis. However, TMA data are particularly prone to missingness. A variety of methods to deal with missing data are available. However, the v...

journal_title：British journal of cancer

authors： Ali AM,Dawson SJ,Blows FM,Provenzano E,Ellis IO,Baglietto L,Huntsman D,Caldas C,Pharoah PD

更新日期：2011-02-15 00:00:00

abstract：:The aim of the study is to evaluate the pattern and level of expression of glucose transporter-1 (GLUT-1) in rectal carcinoma in relation to outcome as a potential surrogate marker of tumour hypoxia. Formalin-fixed tumour sections from 43 patients with rectal carcinoma, who had undergone radical resection with curativ...

journal_title：British journal of cancer

authors： Cooper R,Sarioğlu S,Sökmen S,Füzün M,Küpelioğlu A,Valentine H,Görken IB,Airley R,West C

更新日期：2003-09-01 00:00:00

abstract：:Helicobacter has been suggested to play a possible role in hepatitis, gallstones, and hepatobiliary tumours. We assessed whether seropositivity to 15 H. pylori proteins was associated with subsequent incidence of 74 biliary tract and 105 liver cancer cases vs. 357 matched controls in the Prostate, Lung, Colorectal, an...

journal_title：British journal of cancer

authors： Makkar R,Butt J,Huang WY,McGlynn KA,Koshiol J,Pawlita M,Waterboer T,Freedman ND,Murphy G

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Estimating the future incidence of cancer is important to establish sufficient service provision, however, work in this area is limited for cancer in children, adolescents, and young adults (aged 0-24). METHODS:Age-period-cohort models were applied to cancer incidence rates for the period 1971-2013 in Engla...

journal_title：British journal of cancer

authors： Pesola F,Ferlay J,Sasieni P

更新日期：2017-12-05 00:00:00

abstract：:An extensive analysis of the reliability of positron emission tomography (PET) after induction treatment in patients with Hodgkin's disease (HD) or aggressive non-Hodgkin's lymphoma (NHL). In all, 75 untreated patients with HD (n=41) or aggressive NHL (n=34) were studied with both PET and CT scans following standard c...

journal_title：British journal of cancer

authors： Zinzani PL,Fanti S,Battista G,Tani M,Castellucci P,Stefoni V,Alinari L,Farsad M,Musuraca G,Gabriele A,Marchi E,Nanni C,Canini R,Monetti N,Baccarani M

更新日期：2004-08-31 00:00:00

abstract：:The association between breast and endometrial cancer was investigated in a cohort consisting of 60,065 subjects (99% of all women in whom a first breast cancer was diagnosed in Sweden in 1960-63 and 1968-81). Complete follow-up until 1981 revealed a total of 260 endometrial cancers, as against an expected number of 1...

journal_title：British journal of cancer

authors： Adami HO,Krusemo UB,Bergkvist L,Persson I,Pettersson B

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:Cytosolic deacetylase histone deacetylase 6 (HDAC6) is involved in the autophagy degradation pathway of malformed proteins, an important survival mechanism in cancer cells. We evaluated modulation of autophagy-related proteins and cell death by the HDAC6-selective inhibitor C1A. METHODS:Autophagy substrates...

journal_title：British journal of cancer

authors： Kaliszczak M,van Hechanova E,Li Y,Alsadah H,Parzych K,Auner HW,Aboagye EO

更新日期：2018-11-01 00:00:00

abstract：:Imaging has an essential role in the planning and delivery of radiotherapy. Recent advances in imaging have led to the development of advanced radiotherapy techniques-including image-guided radiotherapy, intensity-modulated radiotherapy, stereotactic body radiotherapy and proton beam therapy. The optimal use of imagin...

journal_title：British journal of cancer

authors： Beaton L,Bandula S,Gaze MN,Sharma RA

更新日期：2019-04-01 00:00:00

abstract：:We investigated the effects of interleukin-2 (IL-2) exposure on T-cell signal transduction molecules and apoptosis markers in tumour-infiltrating lymphocytes (TIL) isolated from 20 melanoma and 16 colorectal carcinoma metastases and expanded in vitro for therapeutic reinfusion. Before IL-2 culture, TIL showed undetect...

journal_title：British journal of cancer

authors： De Paola F,Ridolfi R,Riccobon A,Flamini E,Barzanti F,Granato AM,Mordenti GL,Medri L,Vitali P,Amadori D

更新日期：2003-01-27 00:00:00

abstract：:Protein kinase C (PKC) has a critical role in several signal transduction pathways, and is involved in renal cancer pathogenesis. Bryostatin-1 modulates PKC activity and has antitumour effects in preclinical studies. We conducted a multicentre phase II clinical trial in patients with advanced renal cancer to determine...

journal_title：British journal of cancer

authors： Madhusudan S,Protheroe A,Propper D,Han C,Corrie P,Earl H,Hancock B,Vasey P,Turner A,Balkwill F,Hoare S,Harris AL

更新日期：2003-10-20 00:00:00

abstract：BACKGROUND:Epigenetic silencing by promoter methylation and chromatin remodelling affects hundreds of genes and is a causal event for lung cancer. Treatment of patients with low doses of the demethylating agent 5-azacytidine in combination with the histone deacetylase inhibitor entinostat has yielded clinical responses...

journal_title：British journal of cancer

authors： Reed MD,Tellez CS,Grimes MJ,Picchi MA,Tessema M,Cheng YS,March TH,Kuehl PJ,Belinsky SA

更新日期：2013-10-01 00:00:00

abstract：:Follicular-phase (Day 11) plasma prolactin, and plasma and urinary oestrogen levels of 70 nulliparous nuns were compared with those of 80 of their sisters, of whom 62 were parous. The nuns and their nulliparous sisters did not differ significantly in their prolactin and oestrogen levels. No differences in plasma oestr...

journal_title：British journal of cancer

authors： Yu MC,Gerkins VR,Henderson BE,Brown JB,Pike MC

更新日期：1981-06-01 00:00:00

abstract：:Fifteen human glioma cell lines were examined for their sensitivity to 1,3-bis(chloroethyl)-nitrosourea (BCNU, carmustine) and cis-dichlorodiamminoplatinum (cisplatin), the induction of DNA interstrand cross-linking (DNA-ISC) induced by the two agents and cellular O6-alkylguanine alkyltransferase (ATase) activity. Cel...

journal_title：British journal of cancer

authors： Beith J,Hartley J,Darling J,Souhami R

更新日期：1997-01-01 00:00:00

abstract：:Previous studies have demonstrated that BR-931, a hepatic peroxisome proliferator, can induce liver tumours in mice and rats. Since alterations in gene expression may play a critical role in multistage hepatocarcinogenesis, the present studies examined the expression of the c-myc, c-H-ras, epidermal growth factor (EGF...

journal_title：British journal of cancer

authors： Hsieh LL,Shinozuka H,Weinstein IB

更新日期：1991-11-01 00:00:00