Changes in expression of cellular oncogenes and endogenous retrovirus-like sequences during hepatocarcinogenesis induced by a peroxisome proliferator.

abstract：:We evaluated the degree of tubular differentiation in 172 samples of invasive ductal breast cancer in order to determine numerical thresholds for histological breast cancer grading. The tubular differentiation in each sample was defined as the fraction of fields showing tubular differentiation (FTD). The analysis was ...

journal_title：British journal of cancer

authors： Kronqvist P,Kuopio T,Collan Y

更新日期：2000-05-01 00:00:00

abstract：:Records of approximately 310,000 patients admitted to the 10 hospitals in Botswana between 1960 and 1972 have been studied and details of 1445 patients with malignant tumours abstracted. For the 894 tumours for which there was some supporting evidence--at best histological proof and minimally a clinical description of...

journal_title：British journal of cancer

authors： Macrae SM,Cook BV

更新日期：1975-07-01 00:00:00

abstract：BACKGROUND:This multicentre, open-label study evaluated the efficacy and safety of SPI-1620, an analogue of endothelin-1, administered in combination with docetaxel as second-line treatment for patients with advanced biliary tract cancer (ABTC). METHODS:Eligible patients received continuous cycles of combination thera...

journal_title：British journal of cancer

authors： Kim R,Chiorean EG,Amin M,Rocha-Lima CMS,Gandhi J,Harris WP,Song T,Portnoy D

更新日期：2017-07-11 00:00:00

abstract：:Hormone concentrations in blood and total 12 h urine values were compared between 40 post-menopausal women with breast cancer and 40 control women in a study which carefully controlled for the possible confounding effects of age, weight and pregnancy history by individually matching cases and controls on these factors...

journal_title：British journal of cancer

authors： Bernstein L,Ross RK,Pike MC,Brown JB,Henderson BE

更新日期：1990-02-01 00:00:00

abstract：:Eleven patients suffering from intra-abdominal malignancy were treated with various doses of intraperitoneal mitomycin C adsorbed onto activated carbon particles. Seven of the patients underwent resection of their primary gastric tumour and all developed potentially life-threatening severe complications that proved to...

journal_title：British journal of cancer

authors： Ubhi SS,McCulloch P,Veitch PS

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Little is known about the factors that drive metastasis formation in colorectal cancer (CRC). Here, we set out to identify genes and proteins in patients with colorectal liver metastases that correlate with early disease recurrence. Such factors may predict a propensity for metastasis in earlier stages of CR...

journal_title：British journal of cancer

authors： Snoeren N,Emmink BL,Koerkamp MJ,van Hooff SR,Goos JA,van Houdt WJ,de Wit M,Prins AM,Piersma SR,Pham TV,Belt EJ,Bril H,Stockmann HB,Meijer GA,van Hillegersberg R,Holstege FC,Jimenez CR,Fijneman RJ,Kranenburg OW,Rinke

更新日期：2013-09-17 00:00:00

abstract：:The overall tumour incidence and breast cancer incidence related to hormone replacement therapy (HRT) were followed in a population-based cohort of 29 508 women, aged 25-65 when interviewed in 1990-92. By the end of the follow up in December 1999, there were 226 611 person-years of observation. A total of 1145 maligna...

journal_title：British journal of cancer

authors： Olsson H,Bladström A,Ingvar C,Möller TR

更新日期：2001-09-01 00:00:00

abstract：:Fifty-two previously untreated patients with advanced non-small-cell lung cancer (NSCLC) were treated on a 14 day cycle with cisplatin (60 mg m-2 i.v.) and vindesine (3 mg m-2 i.v.) on day 1, followed by a 3 day continuous infusion of 5-fluorouracil (800 mg m-2 day-1) starting on day 8. An overall response rate of 40....

journal_title：British journal of cancer

authors： Nakano T,Ikegami H,Nakamura S,Kawase T,Nishikawa H,Yokota S,Yoshida M,Tachibana T,Igarashi T,Komuta K,Higashino K

更新日期：1996-05-01 00:00:00

abstract：:The combination of 5-fluorouracil (5-FU) and interferon-alpha (IFN-alpha) has reported activity in the treatment of advanced colorectal carcinoma. Laboratory studies of IFN-beta suggest that this agent may offer theoretical advantages over IFN-alpha in combination with 5-FU. A total of 27 patients with advanced or rec...

journal_title：British journal of cancer

authors： Joffe JK,Perren TJ,Bradley C,Primrose J,Hallam S,Ward U,Illingworth JM,Selby PJ

更新日期：1997-01-01 00:00:00

abstract：:It has been reported that the rho genes, which consist of a ras-related small GTPase protein family, regulate cytoskeletal structures and have the potential to transform cultured cells. To investigate the biological relevance of the rho genes in pancreatic carcinogenesis, we examined expressions of the rhoA, B and C g...

journal_title：British journal of cancer

authors： Suwa H,Ohshio G,Imamura T,Watanabe G,Arii S,Imamura M,Narumiya S,Hiai H,Fukumoto M

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:The incidence of oesophageal adenocarcinoma is increasing globally. Barrett's oesophagus (BO) is a pre-malignant condition with no biomarker to risk stratify those at highest risk of dysplasia and malignant transformation. METHODS:Subcellular epithelial protein (HMGB1, p53, RUNX3) expression, alongside expr...

journal_title：British journal of cancer

authors： Porter RJ,Murray GI,Brice DP,Petty RD,McLean MH

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:There is emerging evidence to suggest that the association between socioeconomic circumstances and colorectal cancer incidence has changed over recent decades. METHODS:We conducted a descriptive population-based study to describe the relationship between socioeconomic circumstances and the incidence of colo...

journal_title：British journal of cancer

authors： Oliphant R,Brewster DH,Morrison DS

更新日期：2011-05-24 00:00:00

abstract：:Based on the assumption that an accelerated proliferation process prevails in tumour cell residues after surgery, the possibility that treatment acceleration would offer a therapeutic advantage in postoperative radiotherapy of locally advanced head and neck cancer was investigated. The value of T(pot) in predicting th...

journal_title：British journal of cancer

authors： Awwad HK,Lotayef M,Shouman T,Begg AC,Wilson G,Bentzen SM,Abd El-Moneim H,Eissa S

更新日期：2002-02-12 00:00:00

abstract：:Steroid receptor was assessed immunohistochemically in 158 samples of normal breast for variation through the menstrual cycle. Patterns and intensity of reaction were used in a semi-quantitative scoring system to examine the influence of cycle phase, cycle type, parity and age. The changes in oestrogen receptor for na...

journal_title：British journal of cancer

authors： Battersby S,Robertson BJ,Anderson TJ,King RJ,McPherson K

更新日期：1992-04-01 00:00:00

abstract：BACKGROUND:Golgi phosphoprotein 3 (GOLPH3) has been reported to be involved in the development of several human cancers. The present study was conducted to investigate the expression of GOLPH3 and its prognostic significance in renal cell carcinoma (RCC). Meanwhile, the function of GOLPH3 in human RCC was further inves...

journal_title：British journal of cancer

authors： Xue Y,Wu G,Liao Y,Xiao G,Ma X,Zou X,Zhang G,Xiao R,Wang X,Liu Q,Long D,Yang J,Xu H,Liu F,Liu M,Xie K,Huang R

更新日期：2014-04-29 00:00:00

abstract：:Patients with refractory metastatic renal cell carcinoma (RCC) were enrolled in a phase II study with teniposide (VM26) and cyclosporin A (CSA) to investigate (1) the effect of CSA on the response rate to VM26; and (2) the effect of CSA on the pharmacokinetics and pharmacodynamics of VM26. Sixteen patients initially r...

journal_title：British journal of cancer

authors： Toffoli G,Sorio R,Gigante M,Corona G,Galligioni E,Boiocchi M

更新日期：1997-01-01 00:00:00

abstract：:Carboxypeptidase G2, a zinc metalloenzyme isolated from Pseudomonas sp. strain RS-16, which catalyses the hydrolytic cleavage of reduced and non-reduced folates to pteroates and L-glutamate, has been linked to a monoclonal antibody (W14A) raised to human chorionic gonadotrophin. The coupling efficiency and retention o...

journal_title：British journal of cancer

authors： Searle F,Bier C,Buckley RG,Newman S,Pedley RB,Bagshawe KD,Melton RG,Alwan SM,Sherwood RF

更新日期：1986-03-01 00:00:00

abstract：:To identify tumour and tumour-associated antigens in patients with hepatocellular carcinoma (HCC) one may find potential diagnostic markers and immunotherapeutic targets. In the current study, 30 distinct antigens reactive with serum IgG from HCC patients were identified by serological analysis of cDNA expression libr...

journal_title：British journal of cancer

authors： Shi YY,Wang HC,Yin YH,Sun WS,Li Y,Zhang CQ,Wang Y,Wang S,Chen WF

更新日期：2005-03-14 00:00:00

abstract：:The effect of the combined administration of doxorubicin (DX) and verapamil (VRP) on the induction of DX resistance of B16 melanoma cells, was investigated both in vitro and in vivo. Cells grown in the presence of increasing concentrations of DX and of 1 microM VRP, tested at several passages, were more resistant than...

journal_title：British journal of cancer

authors： Formelli F,Supino R,Cleris L,Mariani M

更新日期：1988-04-01 00:00:00

abstract：:A human tamoxifen-resistant mammary carcinoma, MaCa 3366/TAM, originating from a sensitive parental xenograft 3366 was successfully established by treatment of tumour-bearing nude mice with 1-50 mg kg(-1) tamoxifen for 3 years during routine passaging. Both tumours did not differ significantly in OR- and PR-positivity...

journal_title：British journal of cancer

authors： Naundorf H,Becker M,Lykkesfeldt AE,Elbe B,Neumann C,Büttner B,Fichtner I

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND:Pancreaticoduodenectomy remains a major undertaking. A preoperative blood test, which could confidently predict the benefits of surgery would improve the selection of pancreatic cancer patients for surgery. This study aimed to identify protein biomarkers prognostic for long-term survival and to validate them...

journal_title：British journal of cancer

authors： Xue A,Chang JW,Chung L,Samra J,Hugh T,Gill A,Butturini G,Baxter RC,Smith RC

更新日期：2012-11-20 00:00:00

abstract：BACKGROUND:Vascular endothelial growth factor receptor-3 (VEGFR-3) signalling mediates lymphangiogenesis and lymphatic invasion; however, the effect of VEGFR-3 inhibition on the lymph node (LN) metastasis remains unclear. The aim of this study is to clarify the benefit of a VEGFR-3 inhibitor Ki23057 for LN metastasis. ...

journal_title：British journal of cancer

authors： Yashiro M,Shinto O,Nakamura K,Tendo M,Matsuoka T,Matsuzaki T,Kaizaki R,Ohira M,Miwa A,Hirakawa K

更新日期：2009-10-06 00:00:00

abstract：BACKGROUND:Dulanermin (rhApo2L/TRAIL) induces apoptosis by binding to death receptors DR4 and DR5, leading to caspase activation and subsequent cell death. A Phase1a trial evaluated the safety and tolerability of dulanermin in patients with advanced tumours. One aim was to develop and validate pharmacodynamic biomarker...

journal_title：British journal of cancer

authors： Pan Y,Xu R,Peach M,Huang CP,Branstetter D,Novotny W,Herbst RS,Eckhardt SG,Holland PM

更新日期：2011-12-06 00:00:00

abstract：BACKGROUND:Non-epithelial gonadal tumours largely comprise sex cord-stromal tumours (SCSTs) and germ cell tumours (GCTs). Specific somatic mutations in DICER1, a microRNA maturation pathway gene, have been identified in these tumours. We conducted a study that aimed to confirm, refine and extend the previous observatio...

journal_title：British journal of cancer

authors： Witkowski L,Mattina J,Schönberger S,Murray MJ,Choong CS,Huntsman DG,Reis-Filho JS,McCluggage WG,Nicholson JC,Coleman N,Calaminus G,Schneider DT,Arseneau J,Stewart CJ,Foulkes WD

更新日期：2013-11-12 00:00:00

abstract：:The aetiologic fractions due to smoking and chewing tobacco have been quantified for the first time, for cancers of the oral cavity, oropharynx, hypopharynx, larynx and oesophagus. The overall aetiologic fractions due to smoking and/or chewing tobacco have been found to be 70% for cancer of the oral cavity, 84% for th...

journal_title：British journal of cancer

authors： Jayant K,Balakrishnan V,Sanghvi LD,Jussawalla DJ

更新日期：1977-02-01 00:00:00

abstract：:The purpose of this study was to determine the maximum-tolerated dose of gemcitabine plus mitoxantrone in women with metastatic breast cancer (MBC) and to evaluate activity and toxicity of this combination in a phase II trial. Sixty-three patients with MBC, previously treated with chemotherapy including anthracycline ...

journal_title：British journal of cancer

authors： Lorusso V,Crucitta E,Silvestris N,Catino A,Caporusso L,Mazzei A,Guida M,Latorre A,Sambiasi D,D'Amico C,Schittulli F,Calabrese P,De Lena M

更新日期：2003-02-24 00:00:00

abstract：:Intermittent use of chemotherapy for androgen-independent prostate cancer (AIPC) instead of treatment until disease progression may reduce toxicity. We prospectively tested this approach in eight AIPC patients responding to calcitriol plus docetaxel who reached a serum prostate-specific antigen (PSA) <4 ng ml(-1). Che...

journal_title：British journal of cancer

authors： Beer TM,Garzotto M,Henner WD,Eilers KM,Wersinger EM

更新日期：2003-09-15 00:00:00

abstract：:HER2/neu-derived peptides inducing MHC class II-restricted CD4+ T helper lymphocyte (Th) responses, although critical for tumour rejection, are not thoroughly characterized. Here, we report the generation and characterization of CD4+ T cell clones specifically recognizing a HER-2/neu-derived peptide (776-788) [designa...

journal_title：British journal of cancer

authors： Sotiriadou R,Perez SA,Gritzapis AD,Sotiropoulou PA,Echner H,Heinzel S,Mamalaki A,Pawelec G,Voelter W,Baxevanis CN,Papamichail M

更新日期：2001-11-16 00:00:00

abstract：BACKGROUND:Circulating tumour cells (CTCs) can be assessed through a minimally invasive blood sample with potential utility as a predictive, prognostic and pharmacodynamic biomarker. The large heterogeneity of melanoma CTCs has hindered their detection and clinical application. METHODS:Here we compared two microfluidi...

journal_title：British journal of cancer

authors： Aya-Bonilla CA,Morici M,Hong X,McEvoy AC,Sullivan RJ,Freeman J,Calapre L,Khattak MA,Meniawy T,Millward M,Ziman M,Gray ES

更新日期：2020-03-01 00:00:00

abstract：:Defects in the apoptotic system are likely to play a role in tumorigenesis. Pancreatic carcinoma cells are extremely resistant to apoptosis induction by chemotherapy suggesting that the apoptosis machinery is faulty. We investigated the integrity of the cytochrome c-dependent apoptotic apparatus in 10 human pancreatic...

journal_title：British journal of cancer

authors： Gerhard MC,Schmid RM,Häcker G

更新日期：2002-03-18 00:00:00