Evaluation of pharmacodynamic biomarkers in a Phase 1a trial of dulanermin (rhApo2L/TRAIL) in patients with advanced tumours.

abstract：:The structural characteristics of mesoionic compounds, which contain distinct regions of positive and negative charges associated with a poly-heteroatomic system, enable them to cross cellular membranes and interact strongly with biomolecules. Potential biological applications have been described for mesoionic compoun...

journal_title：British journal of cancer

authors： Senff-Ribeiro A,Echevarria A,Silva EF,Franco CR,Veiga SS,Oliveira MB

更新日期：2004-07-19 00:00:00

abstract：:Fifty patients affected by histologically confirmed gastrointestinal tract cancer (GTC) were treated with oral tegafur (TG) 1,000 mg m-2 p.o. on days 1-14 repeated after a 14 day interval. Out of 42 evaluable patients seven patients had a partial response (PR. 17%) with a median duration of 20.5 weeks, three had a min...

journal_title：British journal of cancer

authors： Palmeri S,Gebbia V,Russo A,Armata MG,Gebbia N,Rausa L

更新日期：1990-03-01 00:00:00

abstract：:Experiments were conducted to determine whether bladder cancer would develop in primates (Papio sp.) infected with S. haematobium and concurrently exposed to low initiating doses of the bladder carcinogen N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN). To control for the systemic effects of schistosomiasis, 5 baboons wer...

journal_title：British journal of cancer

authors： Hicks RM,James C,Webbe G

更新日期：1980-11-01 00:00:00

abstract：:It has been shown that some types of tumour cells produce activated transforming growth factor beta-1 (TGF-beta 1). However, the mechanism for the activation of TGF-beta 1 derived from tumour cells has not been fully elucidated. The present study was undertaken to characterise an activator of latent TGF-beta 1 secrete...

journal_title：British journal of cancer

authors： Horimoto M,Kato J,Takimoto R,Terui T,Mogi Y,Niitsu Y

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND:Golgi phosphoprotein 3 (GOLPH3) has been reported to be involved in the development of several human cancers. The present study was conducted to investigate the expression of GOLPH3 and its prognostic significance in renal cell carcinoma (RCC). Meanwhile, the function of GOLPH3 in human RCC was further inves...

journal_title：British journal of cancer

authors： Xue Y,Wu G,Liao Y,Xiao G,Ma X,Zou X,Zhang G,Xiao R,Wang X,Liu Q,Long D,Yang J,Xu H,Liu F,Liu M,Xie K,Huang R

更新日期：2014-04-29 00:00:00

abstract：:The accurate determination of exposure to environmental tobacco smoke is notoriously difficult. There have been to date two approaches to determining this exposure in the study of association of passive smoking and lung cancer: the biochemical approach, using cotinine in the main as a marker, and the epidemiological a...

journal_title：British journal of cancer

authors： Tweedie RL,Mengersen KL

更新日期：1992-10-01 00:00:00

abstract：:When assessing the value of a particular treatment, it is important to consider the impact it may have on the quality of life of those being treated. This is particularly so for cancer patients, whose life expectancy may be short. Patients with advanced colorectal cancer who participated in two international comparati...

journal_title：British journal of cancer

authors： Anderson H,Palmer MK

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:Immunoscore have shown a promising prognostic value in many cancers. We aimed to establish and validate an immune classifier to predict survival after curative resection of hepatocellular carcinoma (HCC) patients who have undergone curative resection. METHODS:The immunohistochemistry (IHC) classifier assay ...

journal_title：British journal of cancer

authors： Liu WR,Tian MX,Tang Z,Fang Y,Zhou YF,Song SS,Jiang XF,Wang H,Tao CY,Zhou PY,Qu WF,Ding ZB,Peng YF,Zhou J,Fan J,Shi YH

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Operable non-small cell lung cancer (NSCLC) patients whose tumours have spread to regional or central lymph nodes at the time of diagnosis have dismal prognoses compared with those who have limited disease. The current TNM staging system for NSCLC poorly distinguishes patients with lymph-node metastases who ...

journal_title：British journal of cancer

authors： Kilvaer TK,Paulsen EE,Khanehkenari MR,Al-Saad S,Johansen RM,Al-Shibli K,Bremnes RM,Busund LT,Donnem T

更新日期：2016-05-10 00:00:00

abstract：:We examined the expression of the midkine (MK) and alpha-fetoprotein (AFP) genes in 15 paired human specimens obtained from hepatocellular carcinoma (HCC) and the corresponding noncancerous regions of the same patients. A total of 14 HCC but none of the noncancerous specimens were positive for the MK mRNA. In contrast...

journal_title：British journal of cancer

authors： Tomizawa M,Yu L,Wada A,Tamaoki T,Kadomatsu K,Muramatsu T,Matsubara S,Watanabe K,Ebara M,Saisho H,Sakiyama S,Tagawa M

更新日期：2003-09-15 00:00:00

abstract：:In a prospective cohort study, a close to two-fold elevated risk of bladder cancer was found among men reporting a history of gonorrhoea (relative risk=1.92, 95% CI=1.10-3.33). Our finding warrants further examination of the role of gonorrhoea in bladder carcinogenesis. ...

journal_title：British journal of cancer

authors： Michaud DS,Platz EA,Giovannucci E

更新日期：2007-01-15 00:00:00

abstract：:Induction of lipolysis in murine white adipocytes, and stimulation of adenylate cyclase in adipocyte plasma membranes, by a tumour-produced lipid mobilizing factor, was attenuated by low concentrations (10(-7)--10(-5)M) of the specific beta3-adrenoceptor antagonist SR59230A. Lipid mobilizing factor (250 nM) produced c...

journal_title：British journal of cancer

authors： Russell ST,Hirai K,Tisdale MJ

更新日期：2002-02-01 00:00:00

abstract：:A series of three dose escalating studies were conducted to investigate the ability of the 17alpha-hydroxylase/C(17,20)-lyase inhibitor abiraterone acetate, to cause maximum suppression of testosterone synthesis when delivered to castrate and noncastrate males with prostate cancer. Study A was a single dose study in c...

journal_title：British journal of cancer

authors： O'Donnell A,Judson I,Dowsett M,Raynaud F,Dearnaley D,Mason M,Harland S,Robbins A,Halbert G,Nutley B,Jarman M

更新日期：2004-06-14 00:00:00

abstract：:The relation between pretreatment night-time urinary catecholamine excretion and chemotherapy-induced nausea and vomiting was studied. The first cohort included 17 women and three men with various cancer forms receiving low or moderately emetogenic chemotherapy. The second cohort included 42 women receiving cisplatinu...

journal_title：British journal of cancer

authors： Fredrikson M,Hursti TJ,Steineck G,Fürst CJ,Börjesson S,Peterson C

更新日期：1994-10-01 00:00:00

abstract：:Although epithelial cell adhesion/activating molecule (EpCAM/CD326) is one of the first tumour-associated antigens identified, it has never received the same level of attention as other target proteins for therapy of cancer. It is also striking that ever since its discovery in the late 1970s the actual contribution of...

journal_title：British journal of cancer

authors： Baeuerle PA,Gires O

更新日期：2007-02-12 00:00:00

abstract：:Counter-irritation (CI) triggered by different non-specific irritant stimuli delayed the growth of a murine tumour of non-detected immunogenicity. The syngeneic LB tumour transplant by itself also induced CI and decreased the number of leukocytes migrating to a secondary s.c. irritant stimulus, e.g. sponge or carragee...

journal_title：British journal of cancer

authors： Sordelli DO,Fontán PA,Meiss RP,Ruggiero RA,Bustuoabad OD

更新日期：1989-11-01 00:00:00

abstract：BACKGROUND:Little is known about leukaemia risk following chronic radiation exposures at low dose rates. The Techa River Cohort of individuals residing in riverside villages between 1950 and 1961 when releases from the Mayak plutonium production complex contaminated the river allows quantification of leukaemia risks as...

journal_title：British journal of cancer

authors： Krestinina LY,Davis FG,Schonfeld S,Preston DL,Degteva M,Epifanova S,Akleyev AV

更新日期：2013-11-26 00:00:00

abstract：:DBA/2J mice bearing a clonal isolate of the transplantable murine lymphocytic leukaemia line P388 were used to examine the effects of L-histidinol on the antitumour activity of three alkalyating agents (bis-chloroethylnitrosourea (BCNU), cis-diamminedichloroplatinum (II) (cisDDP) and cyclophosphamide) and the antitumo...

journal_title：British journal of cancer

authors： Warrington RC,Fang WD

更新日期：1989-11-01 00:00:00

abstract：BACKGROUND AND AIMS:The serum/plasma proteome was explored for biomarkers to improve the diagnostic ability of CA19-9 in pancreatic adenocarcinoma (PC). METHODS:A Training Set of serum samples from 20 resectable and 18 stage IV PC patients, 54 disease controls (DCs) and 68 healthy volunteers (HVs) were analysed by sur...

journal_title：British journal of cancer

authors： Xue A,Scarlett CJ,Chung L,Butturini G,Scarpa A,Gandy R,Wilson SR,Baxter RC,Smith RC

更新日期：2010-07-27 00:00:00

abstract：BACKGROUND:Panobinostat, a pan-deacetylase inhibitor, overcomes imatinib resistance in preclinical models of gastrointestinal stromal tumours (GIST). Here we determined the maximum tolerated dose (MTD) and dose-limiting toxicities (DLT) of panobinostat in combination with imatinib (IM) for treatment of patients with re...

journal_title：British journal of cancer

authors： Bauer S,Hilger RA,Mühlenberg T,Grabellus F,Nagarajah J,Hoiczyk M,Reichardt A,Ahrens M,Reichardt P,Grunewald S,Scheulen ME,Pustowka A,Bock E,Schuler M,Pink D

更新日期：2014-03-04 00:00:00

abstract：:A human tamoxifen-resistant mammary carcinoma, MaCa 3366/TAM, originating from a sensitive parental xenograft 3366 was successfully established by treatment of tumour-bearing nude mice with 1-50 mg kg(-1) tamoxifen for 3 years during routine passaging. Both tumours did not differ significantly in OR- and PR-positivity...

journal_title：British journal of cancer

authors： Naundorf H,Becker M,Lykkesfeldt AE,Elbe B,Neumann C,Büttner B,Fichtner I

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND:Docetaxel is widely used as a chemotherapeutic agent for gastric cancer treatment. A combined regimen with sunitinib demonstrated a synergistic antitumour effect in a preclinical model. The aim of this study was to evaluate the efficacy and safety of this combination in patients with unresectable or metastat...

journal_title：British journal of cancer

authors： Yi JH,Lee J,Lee J,Park SH,Park JO,Yim DS,Park YS,Lim HY,Kang WK

更新日期：2012-04-24 00:00:00

abstract：BACKGROUND:We aimed to assess the efficacy of second-line fluoropyrimidine-based chemotherapy in patients with advanced biliary tract cancer (BTC) after failure of gemcitabine plus cisplatin (GEMCIS). METHODS:We retrospectively examined patients with histologically documented advanced BTC who received first-line GEMCI...

journal_title：British journal of cancer

authors： Kim BJ,Yoo C,Kim KP,Hyung J,Park SJ,Ryoo BY,Chang HM

更新日期：2017-02-28 00:00:00

abstract：:The role of secreted frizzled-related protein (SFRP) genes in gastric cancer remains largely unknown. We determined the frequency and functional significance of SFRPs hypermethylation in human gastric cancer. The expression and methylation status of four SFRP members (SFRP1, 2, 4, and 5) in primary gastric cancer samp...

journal_title：British journal of cancer

authors： Cheng YY,Yu J,Wong YP,Man EP,To KF,Jin VX,Li J,Tao Q,Sung JJ,Chan FK,Leung WK

更新日期：2007-10-08 00:00:00

abstract：:A registry including information about nearly 1,600 cases of retinoblastoma diagnosed in Britain has been created at the Childhood Cancer Research Group. Cases have been classified as 'old germ cell mutation', 'new germ cell mutation' or 'sporadic non-hereditary'. For a population-based group of 918 cases diagnosed be...

journal_title：British journal of cancer

authors： Draper GJ,Sanders BM,Brownbill PA,Hawkins MM

更新日期：1992-07-01 00:00:00

abstract：:The goal of the study was to identify any normal genes that may become inactivated in malignant cells, with associated modifications or loss of gene products. Consequently, attempts were made to identify such products by generating monoclonal antibodies using an immune tolerisation-immunisation procedure. Using such a...

journal_title：British journal of cancer

authors： Imam SA,Stampfer MR,Yilmaz A,Taylor CR

更新日期：1994-03-01 00:00:00

abstract：:Cancer-associated fibroblasts (CAFs) were originally presumed to represent a homogeneous population uniformly driving tumorigenesis, united by their morphology and peritumoural location. Our understanding of CAFs has since been shaped by sophisticated in vitro and in vivo experiments, pathological association and, mor...

journal_title：British journal of cancer

authors： Gieniec KA,Butler LM,Worthley DL,Woods SL

更新日期：2019-08-01 00:00:00

abstract：:In the present multicentre randomized phase II trial, the activity and toxicity of three platinum-based combination regimens for the treatment of advanced non-small-cell lung cancer (NSCLC) were evaluated. The three regimens were: MVP (mitomycin-C 6 mg m(-2) on day 1, vindesine 3 mg m(-2) on days 1 and 15, and cisplat...

journal_title：British journal of cancer

authors： Baldini E,Tibaldi C,Ardizzoni A,Salvati F,Antilli A,Portalone L,Barbera S,Romano F,De Marinis F,Migliorino MR,Noseda MA,Borghini U,Crippa M,Ferrara G,Raimondi M,Fioretti M,Bandera M,Pennucci MC,Galeasso G,Cacciani G

更新日期：1998-06-01 00:00:00

abstract：BACKGROUND:Novel prognostic biomarkers and therapeutic strategies are urgently required for malignant melanoma. Ecto-5-prime-nucleotidase (NT5E; CD73) overexpression has been reported in several human cancers. The mechanism(s) underlying deregulated expression and the clinical consequences of changes in expression are ...

journal_title：British journal of cancer

authors： Wang H,Lee S,Nigro CL,Lattanzio L,Merlano M,Monteverde M,Matin R,Purdie K,Mladkova N,Bergamaschi D,Harwood C,Syed N,Szlosarek P,Briasoulis E,McHugh A,Thompson A,Evans A,Leigh I,Fleming C,Inman GJ,Hatzimichael E,

更新日期：2012-04-10 00:00:00

abstract：:The cytotoxicity of methotrexate (MTX) on representative human tumour cell lines (two cell lines from head and neck carcinomas, two from breast carcinomas, two from osteosarcomas and one lymphoblastoid cell line) was evaluated to: (1) examine the optimal time interval between MTX and folinic acid (FA) administration; ...

journal_title：British journal of cancer

authors： Bernard S,Etienne MC,Fischel JL,Formento P,Milano G

更新日期：1991-02-01 00:00:00