The presence of intraepithelial CD45RO+ cells in resected lymph nodes with metastases from NSCLC patients is an independent predictor of disease-specific survival.

abstract：:It has been suggested that tamoxifen may improve the efficacy of medical castration with luteinising hormone-releasing hormone analogues, but very few data have so far been published concerning the clinical and endocrinological activity of this therapeutic modality. In this phase II multicentre trial conducted by the ...

journal_title：British journal of cancer

authors： Buzzoni R,Biganzoli L,Bajetta E,Celio L,Fornasiero A,Mariani L,Zilembo N,Di Bartolomeo M,Di Leo A,Arcangeli G

更新日期：1995-05-01 00:00:00

abstract：:Hypoxic cells in KHT sarcomas were characterized using fluorescence activated cell sorting based on the diffusion properties of the fluorochrome Hoechst 33342. Tumour-bearing female C3H/HeJ mice were injected i.v. with 10 micrograms g-1 Hoechst 33342 and the cells derived from the tumours sorted on the basis of their ...

journal_title：British journal of cancer

authors： Siemann DW,Keng PC

更新日期：1988-09-01 00:00:00

abstract：:Do family history clinics offering counselling, surveillance and preventative programmes alleviate or exacerbate anxiety in women at a high risk of developing breast cancer? In this study risk perceptions and anxiety of 99 'at risk' women participating in the Tamoxifen Prevention Trial were compared with those of 87 '...

journal_title：British journal of cancer

authors： Thirlaway K,Fallowfield L,Nunnerley H,Powles T

更新日期：1996-06-01 00:00:00

abstract：BACKGROUND:This study is to investigate the effects of geserelin+tamoxifen (TAM) on estradiol level, breast density (BD), endometrial thickness (ET), and blood lipids in premenopausal and perimenopausal women with hormone receptor-positive early-stage breast cancer. METHODS:This study recruited 110 premenopausal and p...

journal_title：British journal of cancer

authors： Yang H,Zong X,Yu Y,Shao G,Zhang L,Qian C,Bian Y,Xu X,Sun W,Meng X,Ding X,Chen D,Zou D,Xie S,Zheng Y,Zhang J,He X,Sun C,Yu X,Ni J

更新日期：2013-08-06 00:00:00

abstract：BACKGROUND:Sequence variations in coding and non-coding regions of the genome can affect gene expression and signalling pathways, which in turn may influence disease outcome. METHODS:In this study, we integrated somatic mutations, gene expression and clinical data from 930 breast cancer patients included in the TCGA d...

journal_title：British journal of cancer

authors： Győrffy B,Pongor L,Bottai G,Li X,Budczies J,Szabó A,Hatzis C,Pusztai L,Santarpia L

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Breast cancer, a heterogeneous disease has been broadly classified into oestrogen receptor positive (ER+) or oestrogen receptor negative (ER-) tumour types. Each of these tumours is dependent on specific signalling pathways for their progression. While high levels of survivin, an anti-apoptotic protein, incr...

journal_title：British journal of cancer

authors： Pervin S,Tran L,Urman R,Braga M,Parveen M,Li SA,Chaudhuri G,Singh R

更新日期：2013-03-05 00:00:00

abstract：:The purpose of the study is to test the hypothesis that expression of cell cycle regulatory proteins p16(INK4a) and pRb is significantly associated with prognosis in ovarian carcinomas. We performed immunohistochemical analysis of p16(INK4a) and pRb expression and correlated with survival in a series of 300 patients w...

journal_title：British journal of cancer

authors： Kommoss S,du Bois A,Ridder R,Trunk MJ,Schmidt D,Pfisterer J,Kommoss F,AGO-OVAR.

更新日期：2007-01-29 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) was studied in ovarian tumours with immunohistochemical (IH) and ligand-binding assay (LBA). Two different monoclonal antibodies (MoAbs: 2E9, EGFR1) with respect to detecting EGFR with different ligand-binding affinities (low, high and low) were used. When comparing the IH data ...

journal_title：British journal of cancer

authors： Henzen-Logmans SC,Berns EM,Klijn JG,van der Burg ME,Foekens JA

更新日期：1992-12-01 00:00:00

abstract：:The GER human pancreatic carcinoma cell line possesses receptors for 1,25-dihydroxyvitamin D3. We report that the vitamin D analogue EB 1089 inhibits the growth of these cells in vitro and when grown as tumour xenografts in immunodeficient mice. Tumour-bearing mice were given EB 1089 at a dose of 5 microg kg(-1) body ...

journal_title：British journal of cancer

authors： Colston KW,James SY,Ofori-Kuragu EA,Binderup L,Grant AG

更新日期：1997-01-01 00:00:00

abstract：:The traditional cancer drug development pathway is increasingly being superseded by trials that address multiple clinical questions. These are collectively termed Complex Innovative Design (CID) trials. CID trials not only assess the safety and toxicity of novel anticancer medicines but also their efficacy in biomarke...

journal_title：British journal of cancer

authors： Blagden SP,Billingham L,Brown LC,Buckland SW,Cooper AM,Ellis S,Fisher W,Hughes H,Keatley DA,Maignen FM,Morozov A,Navaie W,Pearson S,Shaaban A,Wydenbach K,Kearns PR,Experimental Cancer Medicine Centres (ECMC) CID trials wo

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:The role of further hormone therapy in castration-resistant prostate cancer (CRPC) remains unclear. We performed a multi-centre randomised phase III study comparing the use of Dexamethasone, Aspirin, and immediate addition of Diethylstilbestrol (DAiS) vs Dexamethasone, Aspirin, and deferred (until disease pr...

journal_title：British journal of cancer

authors： Shamash J,Powles T,Sarker SJ,Protheroe A,Mithal N,Mills R,Beard R,Wilson P,Tranter N,O'Brien N,McFaul S,Oliver T

更新日期：2011-02-15 00:00:00

abstract：BACKGROUND:The current analysis was performed to evaluate the impact of PIK3CA hotspot mutations on everolimus efficacy in BOLERO-2 participants, using cell-free DNA (cfDNA) from plasma samples collected at the time of patient randomisation. METHODS:PIK3CA H1047R, E545K, and E542K mutations in plasma-derived cfDNA wer...

journal_title：British journal of cancer

authors： Moynahan ME,Chen D,He W,Sung P,Samoila A,You D,Bhatt T,Patel P,Ringeisen F,Hortobagyi GN,Baselga J,Chandarlapaty S

更新日期：2017-03-14 00:00:00

abstract：:Immunoglobulins (Ig) and some complement components (C) were quantified in sera from patients with gastric carcinoma before surgery and at regular intervals during a 5-year follow-up. The preoperative concentrations of C1-INH and C4 were higher (P < 0.0005 and P < 0.005) and IgG lower (P < 0.0005) in 50 patients with ...

journal_title：British journal of cancer

authors： Janssen CW Jr,Lie RT,Bassøe CF,Maartmann-Moe H,Matre R

更新日期：1992-11-01 00:00:00

abstract：:Although it is generally accepted that proteolytic degradation is an important mechanism used by malignant cells in the process of metastasis, comparatively little is known about the regulation of molecules responsible for proteolysis and how they become de-regulated during human tumour progression. Using a geneticall...

journal_title：British journal of cancer

authors： MacDougall JR,Bani MR,Lin Y,Muschel RJ,Kerbel RS

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:Patients with malignant pleural effusions (MPEs) generally have advanced disease with poor survival and few therapeutic options. Cells within MPEs may be used to stratify patients for targeted therapy. Targeted therapy with poly(ADP ribose) polymerase inhibitors (PARPi) depends on identifying homologous reco...

journal_title：British journal of cancer

authors： Patterson MJ,Sutton RE,Forrest I,Sharrock R,Lane M,Kaufmann A,O'Donnell R,Edmondson RJ,Wilson BT,Curtin NJ

更新日期：2014-07-08 00:00:00

abstract：BACKGROUND:Cutaneous melanoma is the most serious skin malignancy and new therapeutic strategies are needed for advanced melanoma. TP53 mutations are rare in cutaneous melanoma and hence activation of wild-type p53 is a potential therapeutic strategy in cutaneous melanoma. Here, we investigated the WIP1 inhibitor, GSK2...

journal_title：British journal of cancer

authors： Wu CE,Esfandiari A,Ho YH,Wang N,Mahdi AK,Aptullahoglu E,Lovat P,Lunec J

更新日期：2018-02-20 00:00:00

abstract：:Several diseases are known or suspected to be associated with altered levels of hormones and growth factors that may influence breast cancer risk. To elucidate this possibility, we studied the relationship between 23 medical conditions or procedures and breast cancer risk by means of data from a multicentric case-cont...

journal_title：British journal of cancer

authors： Talamini R,Franceschi S,Favero A,Negri E,Parazzini F,La Vecchia C

更新日期：1997-01-01 00:00:00

abstract：:Elderly patients are recommended to have a reduced starting dose (300 mg m(-2) once every 3 weeks) of irinotecan monotherapy. The aims of this analysis are to compare toxicity and survival according to age, performance status (PS), gender and prior radical pelvic radiotherapy (RT). The primary end points were overall ...

journal_title：British journal of cancer

authors： Chau I,Norman AR,Cunningham D,Waters JS,Topham C,Middleton G,Hill M,Ross PJ,Katopodis R,Stewart G,Oates JR

更新日期：2004-10-18 00:00:00

abstract：BACKGROUND:Mesothelin is expressed in various types of malignant tumour, and we recently reported that expression of mesothelin was related to an unfavourable patient outcome in pancreatic ductal adenocarcinoma. In this study, we examined the clinicopathological significance of the mesothelin expression in gastric canc...

journal_title：British journal of cancer

authors： Einama T,Homma S,Kamachi H,Kawamata F,Takahashi K,Takahashi N,Taniguchi M,Kamiyama T,Furukawa H,Matsuno Y,Tanaka S,Nishihara H,Taketomi A,Todo S

更新日期：2012-06-26 00:00:00

abstract：:Neuroendocrine tumours (NETs) comprise a heterogenous group of malignancies with an often unpredictable course, and with limited treatment options. Thus, new diagnostic, prognostic, and therapeutic markers are needed. To shed new lights into the biology of NETs, we have by cDNA transcript profiling, sought to identify...

journal_title：British journal of cancer

authors： Hofsli E,Wheeler TE,Langaas M,Laegreid A,Thommesen L

更新日期：2008-10-21 00:00:00

abstract：:The pathophysiology of Raynaud's phenomenon after Cisplatin-Bleomycin-Vinblastine combination chemotherapy, its relationship to polyneuropathy, and response to transcutaneous nerve stimulation (TNS), was studied in eight patients previously treated for testicular cancer. Peripheral circulation in the index finger was ...

journal_title：British journal of cancer

authors： Heier MS,Nilsen T,Graver V,Aass N,Fosså SD

更新日期：1991-04-01 00:00:00

abstract：:We previously demonstrated a characteristically high sensitivity of pancreatic cancer cells to interferon alpha (IFN-alpha) gene transfer, which induced a more prominent growth suppression and cell death in pancreatic cancer cells than in other types of cancers and normal cells. The IFN-alpha protein can exhibit both ...

journal_title：British journal of cancer

authors： Ohashi M,Yoshida K,Kushida M,Miura Y,Ohnami S,Ikarashi Y,Kitade Y,Yoshida T,Aoki K

更新日期：2005-08-22 00:00:00

abstract：BACKGROUND:Venous thromboembolism (VTE) frequently complicates cancer. Data on tumour-specific VTE predictors are limited, but may inform strategies to prevent thrombosis. METHODS:We computed incidence rates (IRs) with 95% confidence intervals (CIs) for VTE hospitalisation in a cohort of cancer patients (n=57,591) and...

journal_title：British journal of cancer

authors： Cronin-Fenton DP,Søndergaard F,Pedersen LA,Fryzek JP,Cetin K,Acquavella J,Baron JA,Sørensen HT

更新日期：2010-09-28 00:00:00

abstract：:We evaluated the interaction between hepatitis C virus (HCV) and cigarette smoking on death from hepatocellular cancer in The Japan Collaborative Cohort Study. The odds ratio of death from HCC for smoking was 9.60 (1.50-61.35) and 1.71(0.58-5.08) among anti-HCV positive and negative individuals, respectively. ...

journal_title：British journal of cancer

authors： Fujita Y,Shibata A,Ogimoto I,Kurozawa Y,Nose T,Yoshimura T,Suzuki H,Iwai N,Sakata R,Ichikawa S,Tamakoshi A

更新日期：2006-03-13 00:00:00

abstract：:Pulmonary metastasectomy is widely and increasingly practiced in the belief that this intervention can cure patients with colorectal cancer, and that without it few survive 5 years. No good evidence exists supporting such convictions, indeed recent trial results challenge them. What evidence underpins this acceptance ...

journal_title：British journal of cancer

authors： Macbeth F,Fallowfield L

更新日期：2020-08-01 00:00:00

abstract：:The family history of cancer in children treated for a solid malignant tumour in the Paediatric Oncology Department at Institute Gustave-Roussy, has been investigated. In order to determine the role of germline p53 mutations in genetic predisposition to childhood cancer, germline p53 mutations were sought in individua...

journal_title：British journal of cancer

authors： Chompret A,Brugières L,Ronsin M,Gardes M,Dessarps-Freichey F,Abel A,Hua D,Ligot L,Dondon MG,Bressac-de Paillerets B,Frébourg T,Lemerle J,Bonaïti-Pellié C,Feunteun J

更新日期：2000-06-01 00:00:00

abstract：:In addition to the direct targeting effects on HER2-positive cells, trastuzumab may have a therapeutic role modulating the activity of the cellular immune system in patients with breast cancer. To investigate this further, the balance of T-regulatory (T(reg)), Th17, natural killer (NK) and NK T (NKT) cells before, dur...

journal_title：British journal of cancer

authors： Horlock C,Stott B,Dyson PJ,Morishita M,Coombes RC,Savage P,Stebbing J

更新日期：2009-04-07 00:00:00

abstract：:Limb-sparing surgeries have been performed more frequently than amputation based on the belief that limb-sparing surgeries provide improved function and quality-of-life (QOL). However, this has not been extensively studied in the paediatric population, which has unique characteristics that have implications for functi...

journal_title：British journal of cancer

authors： Nagarajan R,Clohisy DR,Neglia JP,Yasui Y,Mitby PA,Sklar C,Finklestein JZ,Greenberg M,Reaman GH,Zeltzer L,Robison LL

更新日期：2004-11-29 00:00:00

abstract：:The relationship between mammalian facilitative glucose transport proteins (GLUT) and multidrug resistance was examined in two vincristine (VCR)-selected murine erythroleukaemia (MEL) PC4 cell lines. GLUT proteins, GLUT1 and GLUT3, were constitutively coexpressed in the parental cell line and also in the VCR-selected ...

journal_title：British journal of cancer

authors： Martell RL,Slapak CA,Levy SB

更新日期：1997-01-01 00:00:00

abstract：:In the present study we have used flow cytometric DNA measurements on synchronised human NHIK 3025 cells to measure cell cycle progression under various conditions of reduced oxygenation. Our data indicate that addition of 0.1 mM deoxycytidine or uridine has no effect on the oxygen-dependent arrest in late G1 or on th...

journal_title：British journal of cancer

authors： Amellem O,Löffler M,Pettersen EO

更新日期：1994-11-01 00:00:00