Abstract：
:It has been suggested that tamoxifen may improve the efficacy of medical castration with luteinising hormone-releasing hormone analogues, but very few data have so far been published concerning the clinical and endocrinological activity of this therapeutic modality. In this phase II multicentre trial conducted by the Italian Trials in Medical Oncology group (ITMO), 64 premenopausal patients with hormone receptor-positive or unknown breast cancer were treated with monthly s.c. injections of goserelin 3.6 mg, in association with a tamoxifen daily dose of 20 mg, as first-line therapy for their advanced disease. All of the patients were evaluable for efficacy and there was an overall response rate of 41% (95% confidence interval 28-52%), with 7 of the 26 responders achieving complete remission. The median time to response was 4 months (range 2-17), and the median response duration was 13 months (range 6-37 +). Better responses were observed in soft tissues (51%); the response in visceral and bone metastases was respectively 19% and 37%. Serum concentrations of gonadotrophins and oestradiol were significantly decreased by the treatment, oestrogen levels being constantly suppressed to within the range observed in post-menopausal women. No significant change was detected in serum testosterone levels. In our experience, although it was not associated with any increased clinical efficacy, the concurrent use of goserelin and tamoxifen proved to be a feasible approach in the management of premenopausal advanced breast cancer.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Buzzoni R,Biganzoli L,Bajetta E,Celio L,Fornasiero A,Mariani L,Zilembo N,Di Bartolomeo M,Di Leo A,Arcangeli Gdoi
10.1038/bjc.1995.215subject
Has Abstract,Author List Incompletepub_date
1995-05-01 00:00:00pages
1111-4issue
5eissn
0007-0920issn
1532-1827journal_volume
71pub_type
临床试验,杂志文章,多中心研究abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide. We tested megestrol acetate (MA) against placebo in the treatment of advanced HCC. METHODS:From 2002 through 2007, this randomised double-blind trial enrolled 204 patients with treatment-naive advanced HCC (Eastern Coopera...
journal_title：British journal of cancer
pub_type： 杂志文章,随机对照试验
doi：10.1038/bjc.2011.333
更新日期：2011-09-27 00:00:00
abstract：:Studies in animal tumour models of colorectal cancer suggest that F(ab')2 antibody fragments to carcinoembryonic antigen (CEA) labelled with iodine-131 give superior therapy compared with intact anti-CEA antibody. The purpose of this study was to investigate this hypothesis in patients. Ten patients received intact A5...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/bjc.1994.338
更新日期：1994-09-01 00:00:00
abstract：:Carcinoembryonic antigen-like substances in the urine of patients with bladder carcinoma and of healthy male subjects occur in a wide range of average molecular sizes. Some of these substances are glycoproteins giving reactions of antigenic identity with carcinoembryonic antigen (CEA) derived from colorectal carcinoma...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1974.93
更新日期：1974-06-01 00:00:00
abstract：BACKGROUND:Nonsteroidal anti-inflammatory drugs (NSAIDs) have been associated with improved survival in some cancers, but evidence for ovarian cancer is limited. METHODS:Pooling individual-level data from 12 Ovarian Cancer Association Consortium studies, we evaluated the association between self-reported, pre-diagnosi...
journal_title：British journal of cancer
pub_type： 杂志文章,meta分析
doi：10.1038/bjc.2017.68
更新日期：2017-04-25 00:00:00
abstract：:Interleukin 6 (IL-6) and its soluble receptor (IL-6sR) can markedly stimulate aromatase activity in cultured fibroblasts derived from normal or malignant breast tissues. IL-6 acts by binding to a low-affinity membrane-spanning receptor (IL-6R), which must associate with a high-affinity receptor (gp130) for signal tran...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600785
更新日期：2003-02-24 00:00:00
abstract：:The aim of this study was to determine the correlation between changes in collagen metabolites (ICTP, mature cross-linked carboxy-terminal telopeptide of type I collagen; PINP, the amino-terminal propeptide of type I procollagen) and bone mineral density (BMD) in 206 pre- and post-menopausal breast cancer patients wit...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/bjc.1998.471
更新日期：1998-07-01 00:00:00
abstract：:ICI 182,780 (Fulvestrant) is the first in a new class of novel, steroidal, 'pure' antioestrogens--the oestrogen receptor (ER) down-regulators. Its unique mode of action and the absence of partial agonist activity make it a candidate for the treatment of advanced breast cancer in both pre- and postmenopausal women. Tam...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1054/bjoc.2001.1982
更新日期：2001-11-01 00:00:00
abstract：BACKGROUND:Cediranib is a highly potent inhibitor of vascular endothelial growth factor (VEGF) signalling with activity against all three VEGF receptors. Bevacizumab is an anti-VEGF-A monoclonal antibody with clinical benefit in previously treated metastatic colorectal cancer (mCRC). METHODS:Patients with mCRC who had...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1038/bjc.2012.545
更新日期：2013-02-19 00:00:00
abstract：:In a prospective study we determined the frequency and causes of delay in the diagnosis of breast cancer after suspicious screening mammography. We included all women aged 50-75 years who underwent biennial screening mammography in the southern breast cancer screening region of the Netherlands between 1 January 1996 a...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602158
更新日期：2004-11-15 00:00:00
abstract：:The response of a transplantable rat fibrosarcoma, RIB(5), to a single injection of 100 mg/kg body weight of cyclophosphamide, 0·5, 1, 2 and 3 days after treatment, has been studied by means of a morphometric analysis of tumour sections and has been compared to the changes occurring in untreated tumours. The results s...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1973.9
更新日期：1973-01-01 00:00:00
abstract：:The importance of tumour angiogenesis in the process of tumour growth and progression in solid tumours has been widely accepted. Among many angiogenic factors, vascular endothelial growth factor (VEGF) has been shown to play a major role in the development and dissemination of the malignant tumours. Nitric oxide (NO) ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690573
更新日期：1999-07-01 00:00:00
abstract：:The widely held belief that 2-naphthylamine is not carcinogenic for the rat has been re-examined. Twenty female Wistar rats were dosed by gastric intubation weekly for 57 weeks with 2-naphthylamine, 300 mg/kg body wt, in arachis oil and 20 controls were given arachis oil alone. Animals which became moribund were kille...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1982.250
更新日期：1982-10-01 00:00:00
abstract：BACKGROUND:The recognition that cancer is not a single entity, rather that different cancers have different causes and trajectories, has been a key development in the scientific understanding of cancer. However, little is known about the British public's awareness of differences between cancers. This study examined dif...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2012.185
更新日期：2012-06-05 00:00:00
abstract：:Clear cell sarcoma of tendons and aponeuroses (malignant melanoma of soft parts) and conventional malignant melanoma may demonstrate significant morphologic overlap at the light microscopic and ultrastructural level. Consequently, the clinically relevant distinction between primary clear cell sarcoma and metastatic me...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2000.1628
更新日期：2001-02-01 00:00:00
abstract：:Over the period 1966-1995, based on 11,662 patients, the incidence of squamous cell carcinoma of the skin increased three to four times in Norway mainly as a result of an increased number of localized tumours. In men, cancer of the auricle was the second most common site; in women the incidence was low. ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690725
更新日期：1999-10-01 00:00:00
abstract：:The influence of anthracyclines on membrane permeability functions has been investigated in HeLa cells by monitoring the efflux of fluorescein. Release of the fluorescent dye, dependent on the metabolic energy supply, occurs after the intracellular accumulation and enzymatic hydrolysis of the non-fluorescent substrate...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1986.265
更新日期：1986-12-01 00:00:00
abstract：BACKGROUND:Exploring variation in patients' experiences of involvement in treatment decision making can identify groups needing extra support, such as additional consultation time, when considering treatment options. METHODS:We analysed data from the 2010 English National Cancer Patient Experience Survey, a national s...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.316
更新日期：2013-08-06 00:00:00
abstract：:Tumour-associated cell-surface glycoprotein is associated with tumour progression in gastric cancer. We investigated the biological significance of tumour-associated cell-surface glycoprotein, determined by the binding of Helix pomatia agglutinin (HPA), with regard to survival time and to the malignant potential of ca...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1995.192
更新日期：1995-05-01 00:00:00
abstract：:Gallium-67 is a radionuclide that accumulates in haematological malignancies and is used for diagnostic purposes. Uptake of 67Ga into the cell occurs via the transferrin receptor, which is differentially expressed during the various cell cycle phases. With the aim of selectively increasing 67Ga uptake, we studied whet...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.411
更新日期：1996-08-01 00:00:00
abstract：:Tamoxifen is currently established as the endocrine treatment of choice in breast cancer. In advanced breast cancer, response rates of up to 60% in women with oestrogen receptor (ER)-positive tumours have been reported. In early breast cancer, tamoxifen can produce significant benefits, both statistically and clinical...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.753
更新日期：1998-09-01 00:00:00
abstract：:As regulators of malignant cell behaviour and communication with stroma, cytokines have proved useful in understanding cancer biology and developing novel therapies. In renal cell carcinoma, patients with inflammatory reactions are known to have poor prognosis. In order to elucidate the relation between renal cell car...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600257
更新日期：2002-05-06 00:00:00
abstract：:For the presentation of peptide antigens to cytotoxic CD8+ T lymphocytes of the immune system, the expression of human leukocyte antigen (HLA) class I molecules on the cell surface is necessary. There is increasing evidence that surface HLA class I antigen expression is altered in a variety of human tumours by either ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1997.472
更新日期：1997-01-01 00:00:00
abstract：:Dynamic contrast-enhanced MR imaging (DCE-MRI) may act as a biomarker for successful cancer therapy. Simple, reproducible techniques may widen this application. This paper demonstrates a single slice imaging technique. The image acquisition is performed in less than 500 ms making it relatively insensitive to respirato...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603140
更新日期：2006-05-22 00:00:00
abstract：:We have purified epithelial cells from human colonic tumours by velocity sedimentation in an isokinetic density gradient of Ficoll in tissue culture medium. In frozen sections of colonic carcinoma, histochemically demonstrable N-acetyl-beta-D-glucosaminidase (HDAG) was observed primarily in epithelial cells. We used t...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1977.128
更新日期：1977-06-01 00:00:00
abstract：:The ability of 5-aminolaevulinic acid and some of its esterified derivatives to induce porphyrin accumulation has been examined in CaNT murine mammary carcinoma cells growing in culture and as tumours in vivo. Topical or intravenous administration of 5-aminolaevulinic acid-esters to mice bearing subcutaneous tumours p...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600460
更新日期：2002-07-15 00:00:00
abstract：BACKGROUND:The target substrates of DNA mismatch recognising factors MutSalpha (MSH2+MSH6) and MutSbeta (MSH2+MSH3) have already been widely researched. However, the extent of their functional redundancy and clinical substance remains unclear. Mismatch repair (MMR)-deficient tumours are strongly associated with microsa...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605531
更新日期：2010-03-16 00:00:00
abstract：:Monoclonal antibodies 19-9 and C-50 were used to assay the cancer associated tumour antigens CA 19-9 and CA-50 in plasma from patients with confirmed pancreatic cancer, and related to the blood group and Lewis blood cell status. The plasma expressions of CA 19-9 or CA-50 were similar, including cases where the patient...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1990.241
更新日期：1990-07-01 00:00:00
abstract：:Growth factor-induced migration is a rate-limiting step in tumour invasiveness. The molecules that regulate this cellular behaviour would represent novel targets for limiting tumour cell progression. Epidermal growth factor (EGF) receptor (EGFR)-mediated motility, present in both autocrine and paracrine modes in prost...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603234
更新日期：2006-07-17 00:00:00
abstract：BACKGROUND:The characterisation of desmoplastic reaction (DR) has emerged as a new, independent prognostic determinant in colorectal cancer. Herein, we report the validation of its prognostic value in a randomised controlled study (SACURA trial). METHODS:The study included 991 stage II colon cancer patients. DR was cl...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-01222-8
更新日期：2021-01-07 00:00:00
abstract：BACKGROUND:Focal adhesion kinase (FAK) is overexpressed in a variety of cancers, such as breast, colon, prostate, ovary, and lung cancers. However, the mechanism by which extracellular matrix fibronectin stimulates lung cancer cell migration and invasion through FAK remains to be investigated. METHODS:The signalling p...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605154
更新日期：2009-07-21 00:00:00
