Effect of modulation of the transferrin receptor on gallium-67 uptake and cytotoxicity in lymphoma cell lines.

abstract：BACKGROUND:Temsirolimus was approved in Europe as first-line treatment of poor-prognosis advanced renal cell carcinoma (advRCC) based on significant clinical benefits. METHODS:Patients with advRCC and multiple poor-prognostic factors were randomly assigned to receive 25 mg intravenous temsirolimus weekly, interferon-a...

journal_title：British journal of cancer

authors： Yang S,de Souza P,Alemao E,Purvis J

更新日期：2010-05-11 00:00:00

abstract：:A previous publication (Leith et al., 1992) showed that administration of basic fibroblast growth factor (FGF-2, 0.25 mg kg-1, q.i.d. x 7) to mice bearing xenografted DLD-2 human colon cancers would increase treated tumour growth rates as compared to control neoplasms. Additionally, at the end of the 7 day treatment p...

journal_title：British journal of cancer

authors： Leith JT,Michelson S

更新日期：1993-10-01 00:00:00

abstract：:The pathophysiology of Raynaud's phenomenon after Cisplatin-Bleomycin-Vinblastine combination chemotherapy, its relationship to polyneuropathy, and response to transcutaneous nerve stimulation (TNS), was studied in eight patients previously treated for testicular cancer. Peripheral circulation in the index finger was ...

journal_title：British journal of cancer

authors： Heier MS,Nilsen T,Graver V,Aass N,Fosså SD

更新日期：1991-04-01 00:00:00

abstract：:We carried out a comparison of three commonly used mucin markers, CA549, CA15.3 and MCA. Serum samples from 184 healthy women and 237 patients with primary breast cancer were evaluated. The markers were measured using commercially available immunometric assays. Like CA15.3 and MCA, CA549 was significantly associated w...

journal_title：British journal of cancer

authors： Gion M,Plebani M,Mione R,Penzo C,Meo S,Burlina A

更新日期：1994-04-01 00:00:00

abstract：BACKGROUND:Most oestrogen receptor (ER)-positive early breast cancer diagnosed today is highly curable with multimodality treatment. Systemic adjuvant treatments including endocrine therapy and chemotherapy have made a significant contribution to the increasing cure rates over the past three decades. However not all wo...

journal_title：British journal of cancer

authors： Yeo B,Zabaglo L,Hills M,Dodson A,Smith I,Dowsett M

更新日期：2015-07-28 00:00:00

abstract：:Chlamydia pneumoniae, Chlamydia trachomatis and Chlamydia psittaci were detected at low frequencies (<20%) among 69 pulmonary mucosa-associated lymphoid tissue (MALT) lymphomas, 30 other lymphoproliferative disorders (LPD) and 44 non-LPD. The incidence of individual Chlamydiae was generally higher in MALT lymphoma tha...

journal_title：British journal of cancer

authors： Chanudet E,Adam P,Nicholson AG,Wotherspoon AC,Ranaldi R,Goteri G,Pileri SA,Ye H,Müller-Hermelink HK,Du MQ

更新日期：2007-10-08 00:00:00

abstract：:The pharmacokinetics and pharmacodynamics of oral S-1, a dihydropyrimidine dehydrogenase (DPD) inhibitory fluoropyrimidine, were compared with those of protracted venous infusion (PVI) of 5-fluorouracil (5-FU). In all, 10 patients with gastric cancer received PVI of 5-FU at a dose of 250 mg m(-2) day(-1) for 5 days. A...

journal_title：British journal of cancer

authors： Yamada Y,Hamaguchi T,Goto M,Muro K,Matsumura Y,Shimada Y,Shirao K,Nagayama S

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND:RECORD-3 assessed non-inferiority of progression-free survival (PFS) with everolimus vs sunitinib in previously untreated patients with metastatic renal cell carcinoma. Baseline plasma sample collection and randomised design enabled correlation of circulating biomarkers with efficacy. METHODS:Samples were a...

journal_title：British journal of cancer

authors： Voss MH,Chen D,Marker M,Hakimi AA,Lee CH,Hsieh JJ,Knox JJ,Voi M,Motzer RJ

更新日期：2016-03-15 00:00:00

abstract：:There is increasing evidence that essential fatty acids (EFA) may have a role to play in the aetiology of some types of cancer although their precise mode of action is unknown. Differences in the metabolism of EFA between patients with benign or malignant prostatic disease may help to elucidate their role in the latte...

journal_title：British journal of cancer

authors： Chaudry A,McClinton S,Moffat LE,Wahle KW

更新日期：1991-12-01 00:00:00

abstract：BACKGROUND:In neuroblastoma (NB), the most powerful prognostic marker, the MYCN amplification (MNA), occasionally shows intratumoural heterogeneity (ITH), i.e. coexistence of MYCN-amplified and non-MYCN-amplified tumour cell clones, called heterogeneous MNA (hetMNA). Prognostication and therapy allocation are still uns...

journal_title：British journal of cancer

authors： Berbegall AP,Bogen D,Pötschger U,Beiske K,Bown N,Combaret V,Defferrari R,Jeison M,Mazzocco K,Varesio L,Vicha A,Ash S,Castel V,Coze C,Ladenstein R,Owens C,Papadakis V,Ruud E,Amann G,Sementa AR,Navarro S,Ambros PF

更新日期：2018-05-01 00:00:00

abstract：:Antibody-dependent cellular cytotoxicity (ADCC) is considered to be the major mechanism through which tumour cells, upon treatment with anti-tumour MAbs, are eliminated in vivo. However, the relative importance of various parameters that influence the efficacy of ADCC is unclear. Here we present in vitro data on the i...

journal_title：British journal of cancer

authors： Velders MP,van Rhijn CM,Oskam E,Fleuren GJ,Warnaar SO,Litvinov SV

更新日期：1998-08-01 00:00:00

abstract：:The depression of the immunological status of BALB/c mice treated during infancy with two different doses of urethane, alone or combined with cortisone, was evaluated by counting the number of plaque forming cells at 30 or 50 days of age. The incidence of lung adenomatous nodules was directly related to the degree of ...

journal_title：British journal of cancer

authors： Ménard S,Colnaghi MI,Cornalba G

更新日期：1973-05-01 00:00:00

abstract：:Several studies of breast tumour histology and oestrogen receptor (ER) contents report an inverse correlation between the density of the stromal lymphoid cell infiltrate and the presence or concentration of ER. Using monoclonal antibodies to lymphoid cell surface markers we have examined the immunophenotype of the inf...

journal_title：British journal of cancer

authors： Underwood JC,Giri DD,Rooney N,Lonsdale R

更新日期：1987-12-01 00:00:00

abstract：BACKGROUND:Aetiology of acute myeloid leukaemia (AML) is not well understood, perhaps because of its distinct subtypes. High-dose ionising radiation is a known risk factor, but less is known about risk from low-dose exposure such as from diagnostic radiography. METHODS:Subjects were 412 matched case-control pairs. Ten...

journal_title：British journal of cancer

authors： Pogoda JM,Nichols PW,Ross RK,Stram DO,Thomas DC,Preston-Martin S

更新日期：2011-04-26 00:00:00

abstract：:In mice given a single dose of diethylnitrosamine, a hepatonecrotic dose of carbon tetrachloride, 5 weeks after dosing with DEN and repeated 6 times at 4-weekly intervals, augmented the tumour yield in the livers. A single hepatonecrotic dose of CCl4 24 h before a single dose of DEN also increased the number of tumour...

journal_title：British journal of cancer

authors： Poound AW,McGuire LJ

更新日期：1978-04-01 00:00:00

abstract：:The mature epidermal growth factor receptor (EGFR) neither associates with nor requires the molecular chaperone heat-shock protein 90 (Hsp90). Mutations in EGFR exons 18, 19, and 21 confer Hsp90 chaperone dependence. In non-small cell lung cancer (NSCLC), these mutations are associated with enhanced sensitivity to EGF...

journal_title：British journal of cancer

authors： Xu W,Soga S,Beebe K,Lee MJ,Kim YS,Trepel J,Neckers L

更新日期：2007-09-17 00:00:00

abstract：:The cytotoxicity of three platinum complexes, cis-diamminedichloroplatinum(II) (cis-platin), cis-dichloro-trans-dihydroxy-cis-bis (isopropylamine) platinum(IV), (CHIP) and diammine (1, 1-cyclobutane-dicarboxylato) platinum(II) (carboplatin) on Chinese Hamster ovary (CHO) and mouse sarcoma RIF-1 cells cultured in vitro...

journal_title：British journal of cancer

authors： Smith E,Brock AP

更新日期：1988-06-01 00:00:00

abstract：:The diagnosis and follow-up of patients with bladder cancer rely on invasive procedures (cystoscopy with biopsy). Polymerase chain reaction (PCR)-based technologies may allow the sensitive detection of cancer-related genetic mutations in exfoliated tumour material, potentially allowing the development of less invasive...

journal_title：British journal of cancer

authors： Phillips HA,Howard GC,Miller WR

更新日期：2000-01-01 00:00:00

abstract：:Fifty-one patients with advanced non-small cell lung carcinoma were treated with a combination of mitomycin C, vinblastine and cis-platin (MVP). Most cycles were given on an out-patient basis. Major side effects were leukopenia and peripheral neurotoxicity; one patient died of sepsis while leukopenic. In 44 evaluable ...

journal_title：British journal of cancer

authors： Giaccone G,Bagatella M,Donadio M,Bonardi GM,Testore F,Ferrati P,Ciuffreda L,Calciati A

更新日期：1987-10-01 00:00:00

abstract：BACKGROUND:Gold(III) porphyrin 1a is a new class of anticancer drug, which inhibits cell proliferation of wide range of human cancer cell lines and induces apoptosis in human nasopharyngeal carcinoma cells. However, the underlying signalling mechanism by which gold(III) porphyrin 1a modifies the intracellular apoptosis...

journal_title：British journal of cancer

authors： Li W,Xie Y,Sun RW,Liu Q,Young J,Yu WY,Che CM,Tam PK,Ren Y

更新日期：2009-07-21 00:00:00

abstract：:A multicentre phase 2 trial (single-stage design) was undertaken to test the efficacy and toxicity of carboplatin (AUC 6 according to Calvert) plus paclitaxel (175 mg/m(2)3-h infusion) every 4 weeks in the first line treatment of patients affected by extensive small cell lung cancer. The primary end-point of the trial...

journal_title：British journal of cancer

authors： Gridelli C,Manzione L,Perrone F,Veltri E,Cioffi R,Caprio MG,Frontini L,Rossi A,Barletta E,Barzelloni ML,Bilancia D,Gallo C

更新日期：2001-01-05 00:00:00

abstract：:The MBD4 gene is involved in the repair of mutation at methyl-CpG dinucleotides. In microsatellite unstable tumours MBD4 can itself be mutated at an exonic polynucleotide tract. By analysing DNA from microdissected tumour samples we have found that both frequency and pattern of mutation are more significant than origi...

journal_title：British journal of cancer

authors： Bader S,Walker M,Harrison D

更新日期：2000-12-01 00:00:00

abstract：:The identification of peptide vaccine candidates to date has been focused on human leukocyte antigen (HLA)-A2 and -A24 alleles. In this study, we attempted to identify cytotoxic T lymphocyte (CTL)-directed Lck-derived peptides applicable to HLA-A11(+), -A31(+), or -A33(+) cancer patients, because these HLA-A alleles s...

journal_title：British journal of cancer

authors： Naito M,Komohara Y,Ishihara Y,Noguchi M,Yamashita Y,Shirakusa T,Yamada A,Itoh K,Harada M

更新日期：2007-12-17 00:00:00

abstract：:Despite encouraging results from recent studies, there is still no consensus to undertake mass screening using the Haemoccult test in the general population. The success of mass screening for colorectal cancer depends among other things on Haemoccult test properties. In on-going screening programmes, the Haemoccult te...

journal_title：British journal of cancer

authors： Launoy G,Herbert C,Reaud JM,Thezee Y,Tichet J,Maurel J,Ollivier V,Pegulu L,Caces E,Valla A

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND:Joint effects of mammographic density and other risk factors on breast cancer risk remain unclear. METHODS:From The Singapore Breast Screening Project, we selected 491 cases and 982 controls. Mammographic density was measured quantitatively. Data analysis was by conditional logistic regression. RESULTS:Den...

journal_title：British journal of cancer

authors： Wong CS,Lim GH,Gao F,Jakes RW,Offman J,Chia KS,Duffy SW

更新日期：2011-03-01 00:00:00

abstract：:The cytochrome P450 CYP1B1 is consistently overexpressed in tumour cells as compared to their normal counterparts, but its precise role in drug resistance is yet to be defined. It has been reported that transfection of CYP1B1 results in increased resistance to docetaxel in V79 cells (McFadyen et al, 2001). In this stu...

journal_title：British journal of cancer

authors： Martinez VG,O'Connor R,Liang Y,Clynes M

更新日期：2008-02-12 00:00:00

abstract：:Aberrations within Bcl10, a gene involved in execution of apoptosis, has most recently been found in a variety of cancers, including cell lines of testicular germ cell tumours of adolescents and adults (TGCTs). To study this in more detail, we screened exons 2 and 3 of this gene for mutations in a larger series of cel...

journal_title：British journal of cancer

authors： van Schothorst EM,Mohkamsing S,van Gurp RJ,Oosterhuis JW,van der Saag PT,Looijenga LH

更新日期：1999-07-01 00:00:00

abstract：:Allele imbalance on chromosome 11 loci in ovarian cancer is a frequent event, suggesting the presence of tumour-suppressor genes for ovarian carcinogenesis on this chromosome. Ten highly polymorphic (CA) repeat microsatellites were used to determine allele imbalance in 60 primary ovarian tumours, including 47 epitheli...

journal_title：British journal of cancer

authors： Gabra H,Taylor L,Cohen BB,Lessels A,Eccles DM,Leonard RC,Smyth JF,Steel CM

更新日期：1995-08-01 00:00:00

abstract：:This paper describes the results of a study set up to investigate factors associated with the high proportions of 'death certificate only' registrations (DCOs) for all cancers registered in south-east England between 1987 and 1989 and to identify those which might be subject to registry intervention. DCOs as a proport...

journal_title：British journal of cancer

authors： Pollock AM,Vickers N

更新日期：1995-03-01 00:00:00

abstract：:Window of opportunity trials exploit the 'window' of time after cancer diagnosis, typically prior to initiation of cancer therapy. In recent years this study design has become a more regular feature of drug development, as this 'window' provides an opportunity to carry out a thorough pharmacodynamic assessment of a th...

journal_title：British journal of cancer

authors： Aroldi F,Lord SR

更新日期：2020-01-01 00:00:00