Abstract:
:Fifty-one patients with advanced non-small cell lung carcinoma were treated with a combination of mitomycin C, vinblastine and cis-platin (MVP). Most cycles were given on an out-patient basis. Major side effects were leukopenia and peripheral neurotoxicity; one patient died of sepsis while leukopenic. In 44 evaluable patients the response rate was 50%, with one complete response. Overall median survival time was 280 days and median duration of responses was 232 days. A better performance status, disease limited to one hemithorax and no prior exposure to chemotherapy positively influenced the survival. MVP is an effective chemotherapy for non-small cell lung cancer and further experience with this combination is warranted.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Giaccone G,Bagatella M,Donadio M,Bonardi GM,Testore F,Ferrati P,Ciuffreda L,Calciati Adoi
10.1038/bjc.1987.227subject
Has Abstractpub_date
1987-10-01 00:00:00pages
475-8issue
4eissn
0007-0920issn
1532-1827journal_volume
56pub_type
杂志文章abstract::The aim of this work was to test in vitro and in vivo the efficacy of the derivatives of 5-aminolevulinic acid (ALA): hexyl-ALA (He-ALA), undecanoyl-ALA and R,S-2-(hydroximethyl)tetrahydropyranyl-ALA (THP-ALA) as pro-photosensitising agents. The compounds were assayed in a cell line derived from a murine mammary tumou...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6601722
更新日期:2004-04-19 00:00:00
abstract::There is a need to evaluate cancer services and provide a baseline on current treatment success and organization. This study shows that this process may be severely hindered by case note destruction or inaccessibility and incomplete information. This is an ongoing problem that needs to be addressed now. ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1997.21
更新日期:1997-01-01 00:00:00
abstract::The Second Meeting of the British Society for Immunology Tumour Immunology Affinity Group (TIAG) took place at King's College (London, UK) on 17-18 June 1997 and brought together over 100 tumour immunologists from the UK and abroad. In contrast to previous meetings the focus of the meeting was on the role of adhesion ...
journal_title:British journal of cancer
pub_type: 杂志文章,评审
doi:10.1038/bjc.1998.300
更新日期:1998-06-01 00:00:00
abstract:BACKGROUND:Tumours consist of heterogeneous cancer cells and are likely to contain drug-tolerant cell subpopulations, causing early relapse. However, treatment strategies to eliminate these cells have not been established. METHODS:We established gastric cancer patient-derived cells (PDCs) to examine the contribution o...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-019-0600-9
更新日期:2019-11-01 00:00:00
abstract::The effect of 6 putative prognostic factors on survival was studied in patients with Stages III and IV malignant teratoma of the testis. Differences between survival curves were tested for statistical significance. A diameter greater than 5 cm in the largest tumour mass, and greater than 8 pulmonary metastases were ad...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1980.332
更新日期:1980-12-01 00:00:00
abstract::Several studies have shown that dietary lipid exerts an effect on carcinogenesis. We report here that progression to malignancy in vitro is associated with changes in the response to fatty acids (FAs). Tumorigenic (THKE) cells were more sensitive to the n-3 FAs eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1995.136
更新日期:1995-04-01 00:00:00
abstract:BACKGROUND:The randomised phase III TURANDOT trial compared first-line bevacizumab-paclitaxel (BEV-PAC) vs bevacizumab-capecitabine (BEV-CAP) in HER2-negative locally recurrent/metastatic breast cancer (LR/mBC). The interim analysis revealed no difference in overall survival (OS; primary end point) between treatment ar...
journal_title:British journal of cancer
pub_type: 杂志文章,随机对照试验
doi:10.1038/bjc.2014.504
更新日期:2014-11-25 00:00:00
abstract::The continuous cell line UCRU BL 17CL was derived from a human invasive bladder cancer and expresses elements of transitional, squamous and glandular differentiation. Nine clones of this line were established by limit dilution and have been extensively characterised. Only six of these clones grew subcutaneously in nud...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1990.81
更新日期:1990-03-01 00:00:00
abstract::Eleven human bladder carcinomata of different degrees of differentiation were implanted in mice immunosuppressed by thymectomy, anti-thymocyte serum and x-rays. Seven carcinomata grew well and one poorly and 3 produced mainly fibrous nodules in the mice. Normal human bladder tissues were grown from 4 other patients. T...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1975.30
更新日期:1975-02-01 00:00:00
abstract:BACKGROUND:Emerging studies have shown the potential benefit of arming oncolytic viruses with therapeutic genes. However, most of these therapeutic genes are placed under the regulation of ubiquitous viral promoters. Our goal is to generate a safer yet potent oncolytic herpes simplex virus type-1 (HSV-1) for cancer the...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2013.692
更新日期:2014-01-07 00:00:00
abstract:BACKGROUND:The role of melanoma inhibitory activity 2 (MIA2) was examined in human oral squamous cell carcinoma (OSCC). METHODS:MIA2 role was examined by immunohistochemistry of human OSCCs and knockdown studies using human 3 OSCC cell lines with MIA2 expression. RESULTS:MIA2 expression was observed in 62 (66.7%) of ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2013.27
更新日期:2013-04-16 00:00:00
abstract::Exploring the fundamental mechanisms behind the low tumour uptake of labelled monoclonal antibodies (MoAbs) during in vivo immunotargeting, experiments were performed to estimate the in vivo value of the association constant (Ka) in an experimental targeting reaction. An artificial tumour model was utilised, based on ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1992.219
更新日期:1992-07-01 00:00:00
abstract::The discoidin domain receptors, (DDR)1 and DDR2, have been linked to numerous human cancers. We sought to determine expression levels of DDRs in human lung cancer, investigate prognostic determinates, and determine the prevalence of recently reported mutations in these receptor tyrosine kinases. Tumour samples from 14...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6603614
更新日期:2007-03-12 00:00:00
abstract:BACKGROUND:The lipogenic transcription factor carbohydrate response element-binding protein (ChREBP) may play a key role in malignant progression of breast cancer by allowing metabolic adaptations to take place in response to changes in oxygenation. METHODS:Immunohistochemical analysis of ChREBP was carried out in hum...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2013.765
更新日期:2014-02-04 00:00:00
abstract:BACKGROUND:This study aimed to evaluate the prognostic value of pre-treatment NLR in patients with oropharyngeal cancer. METHODS:Patients who completed definitive radiotherapy (RT) for oropharyngeal cancer and had blood counts taken pre-RT from 2002 to 2013 were included. NLR was calculated as total neutrophil/lymphoc...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-01106-x
更新日期:2020-10-14 00:00:00
abstract::The aim of this study was to evaluate the expression of CC chemokine receptor 7 (CCR7) in squamous cell cancer of the tonsil with respect to patterns of spread, relapse-free, overall and disease-specific survival. Eighty-four patients with squamous cell cancer of the tonsil were identified. There was a male predominan...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6603907
更新日期:2007-09-03 00:00:00
abstract::Malignant melanoma (MM) is thought to arise by sequential accumulation of genetic alterations in normal melanocytes. Previous cytogenetic and molecular studies indicated the 9p21 as the chromosomal region involved in MM pathogenesis. In addition to the CDKN genes (p16/CDKN2A, p15/CDKN2B and p19(ARF), frequently inacti...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2000.1513
更新日期:2000-12-01 00:00:00
abstract::Protein kinases play a key role in intracellular signalling, participating at multiple levels along the transduction cascades that trigger mitogenic response. Because protein kinases are involved in mitogenic pathways, they are likely to play a role in the abnormal proliferation of malignant cells. In this study we co...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1998.675
更新日期:1998-11-01 00:00:00
abstract::This study provides an analysis of the structure of the initial cancer consultation, the consultation styles of medical and radiation oncologists, and their effect on patient outcomes. One hundred and fifty-five cancer patients attending their first consultation with either a medical or radiation oncologist were audio...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604348
更新日期:2008-05-06 00:00:00
abstract::Teratomas have been induced in Japanese quail (Coturnix coturnix Japonica) by intra-testicular injections of 3% zinc chloride solution during a period of testicular growth artificially stimulated by increased photoperiod. These tumours resemble those previously induced by similar methods in domestic fow1 and have hist...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1971.40
更新日期:1971-06-01 00:00:00
abstract:BACKGROUND:CXC chemokine receptor 4 (CXCR4) and its ligand stromal cell-derived factor-1α (SDF-1α, also known as CXCL12) have important roles in promoting tumour growth and metastasis. Therefore, targeting CXCR4 could be a promising strategy for treatment of human cancer. METHODS:To achieve this goal, we developed a h...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2014.1
更新日期:2014-03-04 00:00:00
abstract::Growth of the transplantable EMR-86 rat mammary carcinoma depends on elevated prolactin levels which are induced by oestrogenic stimulation of the pituitary. We investigated histological and cell kinetic changes during tumour regression after removal of implanted oestrogen pellets (EP), and we especially focused on th...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1996.232
更新日期:1996-05-01 00:00:00
abstract::We used the nationwide Swedish Family-Cancer Database with 2060 childhood brain tumours diagnosed in the period 1958-1996 to analyse the risk of this tumour by parental cancers and in siblings of childhood brain tumour probands. Groups of patients were compared by calculating standardized incidence ratios (SIRs) for b...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2000.1252
更新日期:2000-08-01 00:00:00
abstract::The influence of anthracyclines on membrane permeability functions has been investigated in HeLa cells by monitoring the efflux of fluorescein. Release of the fluorescent dye, dependent on the metabolic energy supply, occurs after the intracellular accumulation and enzymatic hydrolysis of the non-fluorescent substrate...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1986.265
更新日期:1986-12-01 00:00:00
abstract::Smoking, nutrition, parity and oral contraceptive use have been reported as major environmental risk factors for cervical cancer. After the discovery of the very strong link between human papillomavirus (HPV) infection and cervical cancer, it is unclear whether the association of these environmental factors with cervi...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.1999.1100
更新日期:2000-04-01 00:00:00
abstract:BACKGROUND:Little is known about the effect of participating in a colorectal cancer (CRC) screening programme on quality of life (QOL), neither for participants with a negative nor for those with a positive test result. These findings, however, are important to evaluate the impact of CRC screening. METHODS:Participant...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2012.386
更新日期:2012-10-09 00:00:00
abstract:BACKGROUND:MiR-125b has critical role in non-small-cell lung cancer (NSCLC) cell migration, and its target genes have not been elucidated. Kinesin-1 light chain (KLC)-2 was predicted as one of miR-125b's targets by bioinformatics analysis. This study is to identify the function of KLC2 and its interaction with miR-125b...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2015.3
更新日期:2015-03-03 00:00:00
abstract::Flunarizine is a class IV calcium channel blocker which increases oxygen delivery to hypoxic regions in solid tumours, exerting a radiosensitising effect in vivo in animal tumour models. Precisely how the drug improves oxygenation is not well understood. We hypothesised that metabolic conditions present within solid t...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1993.134
更新日期:1993-04-01 00:00:00
abstract::The aim of this paper was to provide epidemiological evidence to support the notion that cervical intraepithelial neoplasia (CIN) without human papillomavirus (HPV) is a true entity. If a diagnosis of HPV-negative cervical neoplasia is erroneous, one would not expect there to be any differences in risk factors between...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1996.146
更新日期:1996-03-01 00:00:00
abstract::Cellular mechanisms that account for tumour osteolysis associated with Ewing's sarcoma are uncertain. Osteoclasts are marrow-derived multinucleated cells (MNCs) that effect tumour osteolysis. Osteoclasts are known to form from macrophages by both receptor activator for nuclear factor-kappaB (RANK) ligand (RANKL)-depen...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6603774
更新日期:2007-06-04 00:00:00