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Use of common analgesic medications and ovarian cancer survival: results from a pooled analysis in the Ovarian Cancer Association Consortium.

Abstract：

BACKGROUND:Nonsteroidal anti-inflammatory drugs (NSAIDs) have been associated with improved survival in some cancers, but evidence for ovarian cancer is limited. METHODS:Pooling individual-level data from 12 Ovarian Cancer Association Consortium studies, we evaluated the association between self-reported, pre-diagnosis use of common analgesics and overall/progression-free/disease-specific survival among 7694 women with invasive epithelial ovarian cancer (4273 deaths). RESULTS:Regular analgesic use (at least once per week) was not associated with overall survival (pooled hazard ratios, pHRs (95% confidence intervals): aspirin 0.96 (0.88-1.04); non-aspirin NSAIDs 0.97 (0.89-1.05); acetaminophen 1.01 (0.93-1.10)), nor with progression-free/disease-specific survival. There was however a survival advantage for users of any NSAIDs in studies clearly defining non-use as less than once per week (pHR=0.89 (0.82-0.98)). CONCLUSIONS:Although this study did not show a clear association between analgesic use and ovarian cancer survival, further investigation with clearer definitions of use and information about post-diagnosis use is warranted.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Dixon SC,Nagle CM,Wentzensen N,Trabert B,Beeghly-Fadiel A,Schildkraut JM,Moysich KB,deFazio A,Australian Ovarian Cancer Study Group.,Risch HA,Rossing MA,Doherty JA,Wicklund KG,Goodman MT,Modugno F,Ness RB,Edwards RP,Jen

doi

10.1038/bjc.2017.68

subject

Has Abstract

pub_date

2017-04-25 00:00:00

pages

1223-1228

issue

9

eissn

0007-0920

issn

1532-1827

pii

bjc201768

journal_volume

116

pub_type

杂志文章,meta分析

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