Abstract：
:Carcinoembryonic antigen-like substances in the urine of patients with bladder carcinoma and of healthy male subjects occur in a wide range of average molecular sizes. Some of these substances are glycoproteins giving reactions of antigenic identity with carcinoembryonic antigen (CEA) derived from colorectal carcinoma and occur in aggregation with proteins showing antigen specificities of albumin, haptoglobin and the heavy chains of immunoglobulins G, A and M. Recoveries of CEA-like activities, following Sepharose 4B chromatography of urinary materials of molecular size > 3 × 10(4), varied from 40 to 1530%. Treatment with 1 mol/1 HClO(4) caused an apparent solubilization of 85% of the CEA-like activity of such materials from the urine of a patient with bladder carcinoma and raised the specific CEA-like activity of the solubilized product to 379% of that of the untreated materials.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Nery R,James R,Barsoum AL,Bullman Hdoi
10.1038/bjc.1974.93subject
Has Abstractpub_date
1974-06-01 00:00:00pages
413-24issue
6eissn
0007-0920issn
1532-1827journal_volume
29pub_type
杂志文章abstract：:Two hundred and thirty five patients with osteosarcoma, aged less than 40 years, and treated by amputation or radiotherapy, were entered in a randomised trial of two forms of adjuvant chemotherapy. A two drug regimen, namely vincristine 2 mg m-2 (maximum 2mg) followed by methotrexate 200 mgm-2, given every three weeks...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/bjc.1986.81
更新日期：1986-04-01 00:00:00
abstract：:We investigated breast cancer incidence in migrants in the Netherlands in 1988-1998. The standardised incidence ratio for breast cancer in Northwest-Netherlands was statistically significantly reduced for women born in Surinam (0.56), Turkey (0.29) and Morocco (0.22). The proportion of women with advanced stages (III ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601821
更新日期：2004-06-01 00:00:00
abstract：BACKGROUND:Period analysis is increasingly used to compute long-term cancer survival, as it provides better prediction of survival of newly diagnosed patients than traditional cohort analysis. However, the patient population to which period survival estimates best pertain to and which should be described in a study is ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.14
更新日期：2013-02-19 00:00:00
abstract：:Even though the majority of patients with bladder malignancies initially present with low stage disease, the clinical epidemiology of these so-called superficial bladder tumours is not well known. In this paper, disease characteristics at initial presentation and during follow-up are described in 1,745 primary cases d...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究
doi：10.1038/bjc.1993.147
更新日期：1993-04-01 00:00:00
abstract：:The relationship between hepatic arterial albumin microsphere distribution and hepatic arterial blood flow and the effects of regional angiotensin II were studied in a rat liver metastases model. Hooded-Lister rats were inoculated subcapsularly with 2 x 10(6) HSN sarcoma cells. At 20 days, hepatic arterial blood flow ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.258
更新日期：1992-08-01 00:00:00
abstract：:In 1985 a second randomisation was initiated for women in the treatment arm of the Scottish Tamoxifen Trial either to stop tamoxifen at 5 years or to continue indefinitely. A preliminary analysis of outcome in 342 patients at a median follow-up of 6 years suggests that a worthwhile gain in disease control from continu...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1038/bjc.1996.356
更新日期：1996-07-01 00:00:00
abstract：:RNA tumour virus genes are contained in the chromosomal DNA of most vertebrates, and may be transmitted vertically from parent to progeny along with other cellular genes, as well as horizontally as infectious particles. Activation of these viral genes may be part of the means by which RNA tumour viruses produce cancer...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/bjc.1978.23
更新日期：1978-02-01 00:00:00
abstract：:Deletion of chromosome arm 1p and amplification of the MYCN oncogene are well-recognized genetic alterations in neuroblastoma cells. Recently, another alteration has been reported; gain of the distal part of chromosome arm 17q. In this study 48 neuroblastoma tumours were successfully analysed for 17q status in relatio...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6692231
更新日期：1999-12-01 00:00:00
abstract：:A comparative study has been made of fibroblasts obtained from patients with differing susceptibilities to malignant disease, both with respect to their chromosome complements and their transformation with SV40 virus. Fibroblasts from 2 Bloom's syndrome patients were found not to have raised SV40 transformation rates ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1977.235
更新日期：1977-11-01 00:00:00
abstract：:To design hybrid tumour necrosis factor-alpha (TNF-alpha) applicable to systemic anti-tumour therapeutic use, we assessed the relationships among the molecular size of hybrid TNF-alpha, in vitro bioactivity and in vivo anti-tumour potency. Natural human TNF-alpha was covalently modified with polyethylene glycol (PEG) ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.495
更新日期：1996-10-01 00:00:00
abstract：:The influence of anthracyclines on membrane permeability functions has been investigated in HeLa cells by monitoring the efflux of fluorescein. Release of the fluorescent dye, dependent on the metabolic energy supply, occurs after the intracellular accumulation and enzymatic hydrolysis of the non-fluorescent substrate...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1986.265
更新日期：1986-12-01 00:00:00
abstract：BACKGROUND:The interaction between human prostate cancer (PCa) cells and bone marrow (BM) endothelium follows a rolling-and-adhesion cascade mediated by E-selectin ligand (ESL): E-selectin. This adhesion is enabled by elevated expression of α-1,3-fucosyltransferases (FTs), enzymes responsible for ESL-mediated bone meta...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.690
更新日期：2013-12-10 00:00:00
abstract：:To study the effect of oral supplemental calcium on colonic epithelial proliferation, 17 adenomatous polyp patients received 1.5 g Ca2+ as calcium carbonate daily during 12 weeks, while on a calcium constant diet, based on the patients' habitual diet. Seven subsequently continued calcium supplementation for 9 months w...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1993.93
更新日期：1993-03-01 00:00:00
abstract：:Primary liver cancer, predominantly consisting of hepatocellular carcinoma (HCC), is one of the most common and aggressive human malignancies worldwide. MicroRNAs (miRNAs) are a class of small non-coding RNAs that regulate gene expression post-transcriptionally. Emerging evidence indicates that miRNAs are often deregu...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/sj.bjc.6606010
更新日期：2011-01-18 00:00:00
abstract：:In the years before human immunodeficiency virus (HIV) infection, the incidence of Kaposi's sarcoma varied markedly across the African continent, and it was a disease primarily affecting men. In contrast, the evidence reviewed here shows that the causal virus-Kaposi's sarcoma associated herpesvirus (KSHV)-is prevalent...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/sj.bjc.6600745
更新日期：2003-01-13 00:00:00
abstract：BACKGROUND:Childhood cancer survivors can experience learning problems resulting in lower-than-expected attained education as adults. It is unclear whether learning problems manifest already during adolescence. METHODS:We analysed nationwide Danish registries on school grades for Danish children during 2001-2014. Appl...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2016.438
更新日期：2017-01-01 00:00:00
abstract：:Piwi proteins and their interaction with piRNAs have rapidly emerged as important contributors to gene regulation, indicating their crucial function in germline and stem cell development. However, data on the Hiwi 1 (Hiwi) gene, one of the four human Piwi homologues, are still scarce. Therefore, we investigated the Hi...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604653
更新日期：2008-10-07 00:00:00
abstract：:A Phase I study of oral daily misonidazole (MISO) with conventional pelvic irradiation, has been conducted in patients with carcinoma of the cervix Stages IB, IIB, IIIB and IVA. MISO was administered in daily dosages to sequential groups of patients at doses of 0.15 g/m2, 0.30 g/m2 or 0.45 g/m2 for 22 days over 5 week...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/bjc.1982.138
更新日期：1982-06-01 00:00:00
abstract：:Analysis of data from 1434 children with primary renal tumours revealed 57 who developed bone metastases. Of these, 54 were initially recorded as nephroblastoma. Fifty-two of the 57 cases were reviewed histologically, and only 18 were found to be Wilms' tumours. Twenty-three were classified as "Bone-Metastasizing Rena...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1980.163
更新日期：1980-06-01 00:00:00
abstract：:Flow cytometric (FCM) estimation of DNA content has been performed on tumour tissue from 197 patients with high and intermediate grade non-Hodgkin's lymphoma (NHL) to investigate the clinicopathological correlations and prognostic significance of DNA ploidy and proliferative activity. Fifty-one per cent of tumours wer...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1989.388
更新日期：1989-12-01 00:00:00
abstract：:Natural human interferon beta (beta-IFN) was tested during the early phase of in vitro infection with HTLV-I virus of human cord blood mononuclear cells (CBL), to evaluate whether its antiviral and immunomodulating effects might prevent spreading of infection in the host. beta-IFN was found to reduce HTLV-I transmissi...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1988.111
更新日期：1988-05-01 00:00:00
abstract：:The relationship between melanoma incidence and latitude was investigated in North American and Europe, using the data collected by 43 population-based cancer registries. In North America melanoma incidence increased with decreasing latitude, supporting the role of UV light in the induction of melanoma. Within England...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1979.260
更新日期：1979-11-01 00:00:00
abstract：:Serum samples taken between 6 and 20 weeks of gestation were obtained from 28 mothers who gave birth to cryptorchid sons (cases) and from 108 control mothers. In comparison with controls the cases had 10% higher geometric mean oestradiol (95% CI -13% to +39%: P=0.42) and 10% lower geometric mean testosterone (95% CI -...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.121
更新日期：1996-03-01 00:00:00
abstract：:Tumorigenic mouse lung-derived type 2 cell lines have large reductions in both beta-adrenergic-stimulated cAMP production and ligand binding to beta-adrenergic receptors. These tumorigenic cells are also relatively insensitive to glucocorticoids. Because glucocorticoids regulate both beta-adrenergic receptor expressio...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.377
更新日期：1996-08-01 00:00:00
abstract：BACKGROUND:Systemic failure remains a challenge in rectal cancer. We investigated the possible systemic anti-tumour immune activity invoked within oxaliplatin-based neoadjuvant therapy. METHODS:In two high-risk patient cohorts, we assessed the circulating levels of the fms-like tyrosine kinase 3 ligand (Flt3L), a fact...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-018-0085-y
更新日期：2018-05-01 00:00:00
abstract：:When purified fibre and hexon proteins of adenovirus 12 were given intramuscularly to 4-week-old BALB/c mice (250-300 mug/mouse) 2 h prior to inoculation with mouse sarcoma virus (0.05 ml of 10(4) FFU/ml) at the same site, significant suppression of tumour growth (P less than 0.001), and rapid regression in tumour siz...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1976.63
更新日期：1976-04-01 00:00:00
abstract：:Sera from breast cancer patients and from female controls were tested for inhibition of lysis of antibody-coated target cells by human leukocytes (K cells). Sera from 39% of breast cancer patients, but from only 8% of controls, inhibited lysis by more than 30%. This inhibition was unrelated to the stage of the disease...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1976.224
更新日期：1976-12-01 00:00:00
abstract：:Bryostatin 1 is a novel macrocyclic lactone activator of protein kinase C (PKC) which has clinical potential as an anti-cancer agent. The mechanism of action of this agent is unknown, but protein kinase C has been implicated. In order to investigate this possibility, we have developed P388 sublines resistant to bryost...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1994.353
更新日期：1994-10-01 00:00:00
abstract：:The objective of the study was to investigate the predictive value of various clinical, biochemical, and histopathological parameters, with special emphasis on the expression of the retinoblastoma protein (pRB), on the radiation response in bladder cancer. In order to obtain a truly objective response measure, patient...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/sj.bjc.6601063
更新日期：2003-07-21 00:00:00
abstract：:Studies of families who segregate BRCA2 mutations have found that men who carry disease-associated mutations have an increased risk of prostate cancer, particularly early-onset disease. A study of sporadic prostate cancer in the UK reported a prevalence of 2.3% for protein-truncating BRCA2 mutations among patients dia...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603929
更新日期：2007-09-17 00:00:00
