RNA-tumour-virus genes and transforming genes: patterns of transmission.

abstract：:Tumour markers are important in the diagnosis and monitoring of many tumours. This study tested the hypothesis that an oncofoetal protein, foetal haemoglobin (HbF) is a potential tumour marker in embryonic tumours, useful for management. An immunohistochemical investigation of HbF blood cell (Fc) distribution was carr...

journal_title：British journal of cancer

authors： Wolk M,Martin JE,Nowicki M

更新日期：2007-08-06 00:00:00

abstract：:Individuals with a deficiency in the enzyme dihydropyrimidine dehydrogenase (DPD) may experience severe life-threatening toxicity when treated with 5-fluorouracil (5-FU). As routine measurement of enzyme activity is not practical in many clinical centres, we have investigated the use of DNA mutation analysis to identi...

journal_title：British journal of cancer

authors： Ridge SA,Sludden J,Wei X,Sapone A,Brown O,Hardy S,Canney P,Fernandez-Salguero P,Gonzalez FJ,Cassidy J,McLeod HL

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:The percentage of tumour stroma (TSP) has recently been reported to be a novel independent predictor of outcome in patients with a variety of common solid organ tumours. The aim of this study was to examine the relationship between TSP, clinicopathological characteristics and outcome in patients with invasiv...

journal_title：British journal of cancer

authors： Gujam FJ,Edwards J,Mohammed ZM,Going JJ,McMillan DC

更新日期：2014-07-08 00:00:00

abstract：:The cisplatin analogue 1R,2R-diaminocyclohexane(trans-diacetato)(dichloro)platinum(IV) (DAP) is a DNA-damaging agent that will be entering clinical trials for its potent cytotoxic effects against cisplatin-resistant tumour cells. This cytotoxicity may reside in its ability to selectively activate G1-phase checkpoint r...

journal_title：British journal of cancer

authors： He G,Kuang J,Huang Z,Koomen J,Kobayashi R,Khokhar AR,Siddik ZH

更新日期：2006-12-04 00:00:00

abstract：BACKGROUND:Emergence of drug-resistant cancer phenotypes is a challenge for anti-cancer therapy. Cancer stem cells are identified as one of the ways by which chemoresistance develops. METHOD:We investigated the anti-inflammatory combinatorial treatment (DA) of doxorubicin and aspirin using a preclinical microfluidic m...

journal_title：British journal of cancer

authors： Khoo BL,Grenci G,Lim JSY,Lim YP,Fong J,Yeap WH,Bin Lim S,Chua SL,Wong SC,Yap YS,Lee SC,Lim CT,Han J

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:The role of different subtypes of tumour infiltrating lymphocytes (TILs) in breast ductal carcinoma in situ (DCIS) is still poorly defined. This study aimed to assess the prognostic significance of B and T lymphocytes and immune checkpoint proteins expression in DCIS. METHODS:A well characterised DCIS cohor...

journal_title：British journal of cancer

authors： Toss MS,Abidi A,Lesche D,Joseph C,Mahale S,Saunders H,Kader T,Miligy IM,Green AR,Gorringe KL,Rakha EA

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Despite recent advances in cancer therapy, the 5-year survival rate for Ewing's sarcoma is still very low, and new therapeutic approaches are necessary. It was found previously that melatonin induces cell death in the Ewing's sarcoma cell line, SK-N-MC, by activating the extrinsic apoptotic pathway. METHODS...

journal_title：British journal of cancer

authors： García-Santos G,Martin V,Rodríguez-Blanco J,Herrera F,Casado-Zapico S,Sánchez-Sánchez AM,Antolín I,Rodríguez C

更新日期：2012-03-27 00:00:00

abstract：BACKGROUND:Cancer stem cells (CSCs) are responsible for tumour initiation, metastasis and recurrence. However, the mechanism of CSC formation, maintenance and expansion in colorectal cancer (CRC) remains poorly characterised. METHODS:The role of COP9 signalosome subunit 6 (CSN6) in regulating cancer stemness was evalu...

journal_title：British journal of cancer

authors： Qin B,Zou S,Li K,Wang H,Wei W,Zhang B,Xiao L,Choi HH,Tang Q,Huang D,Liu Q,Pan Q,Meng M,Fang L,Lee MH

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:MEK is activated in ∼40% colorectal cancer (CRC) and 20-30% non-small cell lung cancer (NSCLC). Selumetinib is a selective inhibitor of MEK1/2, which is currently in clinical development. METHODS:We evaluated the effects of selumetinib in vitro and in vivo in CRC and NSCLC cell lines to identify cancer cell...

journal_title：British journal of cancer

authors： Troiani T,Vecchione L,Martinelli E,Capasso A,Costantino S,Ciuffreda LP,Morgillo F,Vitagliano D,D'Aiuto E,De Palma R,Tejpar S,Van Cutsem E,De Lorenzi M,Caraglia M,Berrino L,Ciardiello F

更新日期：2012-05-08 00:00:00

abstract：:Connective tissue growth factor (CTGF) is a major chemotactic and mitogenic factor for connective tissue cells. The amino acid sequence shares an overall 28-38% identity to IGFBPs and contains critical conserved sequences in the amino terminus. It has been demonstrated that human CTGF specifically binds IGFs with low ...

journal_title：British journal of cancer

authors： Vorwerk P,Wex H,Hohmann B,Oh Y,Rosenfeld RG,Mittler U

更新日期：2000-09-01 00:00:00

abstract：:The combination of 5-fluorouracil (5-FU) and interferon-alpha (IFN-alpha) has reported activity in the treatment of advanced colorectal carcinoma. Laboratory studies of IFN-beta suggest that this agent may offer theoretical advantages over IFN-alpha in combination with 5-FU. A total of 27 patients with advanced or rec...

journal_title：British journal of cancer

authors： Joffe JK,Perren TJ,Bradley C,Primrose J,Hallam S,Ward U,Illingworth JM,Selby PJ

更新日期：1997-01-01 00:00:00

abstract：:In the present multicentre randomized phase II trial, the activity and toxicity of three platinum-based combination regimens for the treatment of advanced non-small-cell lung cancer (NSCLC) were evaluated. The three regimens were: MVP (mitomycin-C 6 mg m(-2) on day 1, vindesine 3 mg m(-2) on days 1 and 15, and cisplat...

journal_title：British journal of cancer

authors： Baldini E,Tibaldi C,Ardizzoni A,Salvati F,Antilli A,Portalone L,Barbera S,Romano F,De Marinis F,Migliorino MR,Noseda MA,Borghini U,Crippa M,Ferrara G,Raimondi M,Fioretti M,Bandera M,Pennucci MC,Galeasso G,Cacciani G

更新日期：1998-06-01 00:00:00

abstract：:Experimental studies indicated that long-chain polyunsaturated fatty acids may increase sensitivity of mammary tumours to several cytotoxic drugs. To evaluate this hypothesis in breast cancer, we have prospectively studied the association between levels of fatty acids stored in breast adipose tissue and the response o...

journal_title：British journal of cancer

authors： Bougnoux P,Germain E,Chajès V,Hubert B,Lhuillery C,Le Floch O,Body G,Calais G

更新日期：1999-04-01 00:00:00

abstract：:We screened 145 HIV-infected non-pregnant women at a tertiary care centre in Lusaka, Zambia. Liquid-based cytology and human papillomavirus (HPV) genotyping with PGMY09/11 biotinylated primers (Roche Linear Array HPV genotyping test) maximised sensitivity of cytology and HPV assessments. Among high-risk (HR) types, HP...

journal_title：British journal of cancer

authors： Sahasrabuddhe VV,Mwanahamuntu MH,Vermund SH,Huh WK,Lyon MD,Stringer JS,Parham GP

更新日期：2007-05-07 00:00:00

abstract：BACKGROUND:The target substrates of DNA mismatch recognising factors MutSalpha (MSH2+MSH6) and MutSbeta (MSH2+MSH3) have already been widely researched. However, the extent of their functional redundancy and clinical substance remains unclear. Mismatch repair (MMR)-deficient tumours are strongly associated with microsa...

journal_title：British journal of cancer

authors： Kantelinen J,Kansikas M,Korhonen MK,Ollila S,Heinimann K,Kariola R,Nyström M

更新日期：2010-03-16 00:00:00

abstract：:This single-centre phase I trial was designed to determine the maximum tolerated dose of irinotecan and the recommended dose to use in combination with a fixed dose of 5-fluorouracil (5-FU) administered as a protracted venous infusion, for the first-line treatment of metastatic colorectal cancer (CRC). Tolerability an...

journal_title：British journal of cancer

authors： Saunders MP,Hogg M,Carrington B,Sjursen AM,Allen J,Beech J,Swindell R,Valle JW

更新日期：2004-10-18 00:00:00

abstract：:Secondary bile acids produced by the action of the colonic microflora may increase risk of colorectal cancer. Serum bile acid concentrations reflect the faecal bile acid profile and may be of value as biomarkers of risk of colorectal cancer. In a pilot investigation we examined: (i) the reproducibility of measurements...

journal_title：British journal of cancer

authors： Costarelli V,Key TJ,Appleby PN,Allen DS,Fentiman IS,Sanders TA

更新日期：2002-06-05 00:00:00

abstract：:A case-control study was conducted in Italy and Switzerland between 1992 and 2000 on 527 cases of laryngeal cancer and 1,297 hospital controls. The risk of laryngeal cancer steadily decreased from 3 years after stopping smoking. Some decline in risk was observed only 20 years or more after stopping drinking. ...

journal_title：British journal of cancer

authors： Altieri A,Bosetti C,Talamini R,Gallus S,Franceschi S,Levi F,Dal Maso L,Negri E,La Vecchia C

更新日期：2002-11-18 00:00:00

abstract：:The conventional diffusion chamber (CDC) as described by Benestad (1970) had been modified to assay the colony forming capacity of RFM bone marrow and spleen cells in agar diffusion chambers (ADCs). The colonies are morphologically identical to those formed by the CFUc in agar culture in vitro and have an incidence of...

journal_title：British journal of cancer

authors： Gordon MY

更新日期：1974-11-01 00:00:00

abstract：:Ovarian cancer is the fifth leading cause of female cancer deaths in the Western world. Significant progress has been made in the treatment of patients with ovarian cancer, however, the majority of patients experience disease recurrence and new therapies are being sought for such patients. Clinical investigation of po...

journal_title：British journal of cancer

authors： Ledermann JA,El-Khouly F

更新日期：2015-12-15 00:00:00

abstract：:'de novo' carcinogenesis has been advocated besides 'adenoma carcinoma sequence' as another dominant pathway leading to colorectal carcinoma. Our recent study has demonstrated that the distribution of brain (fetal)-type glycogen phosphorylase (BGP) positive foci (BGP foci) has a close relationship with the location of...

journal_title：British journal of cancer

authors： Shimada S,Shiomori K,Tashima S,Tsuruta J,Ogawa M

更新日期：2001-06-01 00:00:00

abstract：:DBA/2J mice bearing a clonal isolate of the transplantable murine lymphocytic leukaemia line P388 were used to examine the effects of L-histidinol on the antitumour activity of three alkalyating agents (bis-chloroethylnitrosourea (BCNU), cis-diamminedichloroplatinum (II) (cisDDP) and cyclophosphamide) and the antitumo...

journal_title：British journal of cancer

authors： Warrington RC,Fang WD

更新日期：1989-11-01 00:00:00

abstract：:A case-control study of lung cancer involving interviews with 965 female patients and 959 controls in Shenyang and Harbin, two industrial cities which have among the highest rates of lung cancer in China, revealed that cigarette smoking is the main causal factor and accounted for about 35% of the tumours among women. ...

journal_title：British journal of cancer

authors： Wu-Williams AH,Dai XD,Blot W,Xu ZY,Sun XW,Xiao HP,Stone BJ,Yu SF,Feng YP,Ershow AG

更新日期：1990-12-01 00:00:00

abstract：:Non-small-cell lung cancer (NSCLC) prognosis is strictly related to well-established clinicopathological parameters which have unfortunately become insufficient in the prognostic evaluation of this type of cancer. As p53 and bcl-2 gene deregulations are frequently involved in several types of epithelial malignancies, ...

journal_title：British journal of cancer

authors： Fontanini G,Vignati S,Bigini D,Mussi A,Lucchi M,Angeletti CA,Basolo F,Bevilacqua G

更新日期：1995-05-01 00:00:00

abstract：:Besides its cardiotoxic effect, doxorubicin also elicits inflammatory effects in vivo. 7-Monohydroxyethylrutoside (monoHER) has recently been used as a protector against doxorubicin-induced cardiotoxicity in vivo. It is not known yet whether monoHER can also protect against doxorubicin-induced inflammatory effects. Th...

journal_title：British journal of cancer

authors： Abou El Hassan MA,Verheul HM,Jorna AS,Schalkwijk C,van Bezu J,van der Vijgh WJ,Bast A

更新日期：2003-07-21 00:00:00

abstract：:No numerical aberration of chromosomes that might be specific for prostate cancer has so far been established. We used fluorescence in situ hybridisation (FISH) with centromere-specific probes for chromosomes 7, 8, 17, X and Y to establish the distribution of centromere copy numbers in frozen-stored or freshly prepare...

journal_title：British journal of cancer

authors： Matsuura H,Shiraishi T,Yatani R,Kawamura J

更新日期：1996-12-01 00:00:00

abstract：BACKGROUND:Hypoxia can activate autophagy, a self-digest adaptive process that maintains cell turnover. Mammalian target of rapamycin (mTOR) inhibitors are used to treat cancer but also stimulate autophagy. METHODS:Human mammary cancer cells and derived xenografts were used to examine whether hypoxia could exacerbate ...

journal_title：British journal of cancer

authors： Seront E,Boidot R,Bouzin C,Karroum O,Jordan BF,Gallez B,Machiels JP,Feron O

更新日期：2013-11-12 00:00:00

abstract：:A multicentric, prospective phase III study was carried out with the aim of testing the so-called 'worst drug rule' hypothesis, which suggests the use of an effective but 'less active' regimen that first eradicates tumoral cells resistant to a second effective and 'more active' regimen. With respect to this hypothesis...

journal_title：British journal of cancer

authors： Colucci G,Gebbia V,Galetta D,Riccardi F,Cariello S,Gebbia N

更新日期：1997-01-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) mutations are strong determinants of tumour response to EGFR tyrosine kinase inhibitors in non-small-cell lung cancer (NSCLC). Pleural effusion is a common complication of lung cancer. In this study, we assessed the feasibility of detection of EGFR mutations in samples of pleura...

journal_title：British journal of cancer

authors： Kimura H,Fujiwara Y,Sone T,Kunitoh H,Tamura T,Kasahara K,Nishio K

更新日期：2006-11-20 00:00:00

abstract：:Proton pump inhibitor (PPI) use leads to hypergastrinaemia, which has been associated with gastrointestinal neoplasia. We evaluated the association between PPI use and risk of gastric cancer using population-based health-care registers in North Jutland, Denmark, during 1990-2003. We compared incidence rates among new ...

journal_title：British journal of cancer

authors： Poulsen AH,Christensen S,McLaughlin JK,Thomsen RW,Sørensen HT,Olsen JH,Friis S

更新日期：2009-05-05 00:00:00