Abstract：
BACKGROUND:Cediranib is a highly potent inhibitor of vascular endothelial growth factor (VEGF) signalling with activity against all three VEGF receptors. Bevacizumab is an anti-VEGF-A monoclonal antibody with clinical benefit in previously treated metastatic colorectal cancer (mCRC). METHODS:Patients with mCRC who had progressed following first-line therapy were randomised 1:1:1 to modified (m)FOLFOX6 plus cediranib (20 or 30 mg day(-1)) or bevacizumab (10 mg kg(-1) every 2 weeks). The primary objective was to compare progression-free survival (PFS) between treatment arms. RESULTS:A total of 210 patients were included in the intent-to-treat (ITT) analysis (cediranib 20 mg, n=71; cediranib 30 mg, n=73; bevacizumab, n=66). Median PFS in the cediranib 20 mg, cediranib 30 mg and bevacizumab groups was 5.8, 7.2 and 7.8 months, respectively. There were no statistically significant differences between treatment arms for PFS (cediranib 20 mg vs bevacizumab: HR=1.28 (95% CI, 0.85-1.95; P=0.29); cediranib 30 mg vs bevacizumab: HR=1.17 (95% CI, 0.77-1.76; P=0.79)) or overall survival (OS). Grade ≥ 3 adverse events were more common with cediranib 30 mg (91.8%) vs cediranib 20 mg (81.4%) or bevacizumab (84.8%). CONCLUSION:There were no statistically significant differences between treatment arms for PFS or OS. When combined with mFOLFOX6, the 20 mg day(-1) dose of cediranib was better tolerated than the 30 mg day(-1) dose.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Cunningham D,Wong RP,D'Haens G,Douillard JY,Robertson J,Stone AM,Van Cutsem E,HORIZON I study group.doi
10.1038/bjc.2012.545subject
Has Abstractpub_date
2013-02-19 00:00:00pages
493-502issue
3eissn
0007-0920issn
1532-1827pii
bjc2012545journal_volume
108pub_type
杂志文章,多中心研究,随机对照试验abstract：BACKGROUND:The co-chaperone protein Bcl-2-associated athanogene-1 (BAG-1) is overexpressed in breast cancer and has been incorporated in the oncotype DX and PAM50 breast cancer prognostic assays. Bcl-2-associated athanogene-1 exists as multiple protein isoforms that interact with diverse partners, including chaperones ...
journal_title：British journal of cancer
pub_type： 杂志文章,meta分析,评审
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abstract：BACKGROUND:Emerging studies have shown the potential benefit of arming oncolytic viruses with therapeutic genes. However, most of these therapeutic genes are placed under the regulation of ubiquitous viral promoters. Our goal is to generate a safer yet potent oncolytic herpes simplex virus type-1 (HSV-1) for cancer the...
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pub_type： 杂志文章,评审
doi：10.1038/sj.bjc.6601575
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pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1038/bjc.1994.173
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pub_type： 杂志文章
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1970.15
更新日期：1970-03-01 00:00:00
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abstract：:In the UK there are standardized surveillance procedures for gestational trophoblastic disease. However, there are differences in practice between the two treatment centres in terms of definition of persistent gestational trophoblastic disease, prognostic risk assessment and chemotherapeutic regimens. The role of prop...
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pub_type： 杂志文章
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pub_type： 杂志文章
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doi：10.1038/bjc.1985.151
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pub_type： 杂志文章
doi：10.1038/bjc.1993.5
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