Abstract:
:The incidence of oncofoetal antigens has been reported to be increased in patients with gynaecological cancers. In this study the incidence of CEA, AFP, and hCG (beta subunit) were studied in patients with adenocarcinoma of the ovary, adenocarcinoma of the cervix, and squamous-cell carcinoma of the cervix. Using a low cut-off point (CEA 2.5 microgram/l, AFP 5 microgram/l, and hCG 3 i.u./l) there is an unacceptably high proportion of control patients having one or more positive tests (42-54%) compared to cancer-bearing patients (67%). The specificity of the tests can be increased to over 95% by increasing the cut-off point to CEA 10 microgram/l, AFP 10 microgram/l, and hCG 10 i.u./l). Although this reduces the sensitivity considerably, the incidence of false positives in the control population is reduced to nil in non-cancer patients and to 2% in cancer patients tested when free of tumour, compared to 17% of patients with cancer of the ovary, 33% with adenocarcinoma of the cervix, and 6% with squamous-cell carcinoma of the cervix. Patients with adenocarcinoma of the cervix were clearly distinguishable from those with squamous-cell carcinoma of the cervix by these tests. There was also a significant correlation between AFP and hCG levels in adenocarcinoma of the cervix (r = 0.53, P less than 0.05).
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Cauchi MN,Koh SH,Lim D,Hay DLdoi
10.1038/bjc.1981.198subject
Has Abstractpub_date
1981-09-01 00:00:00pages
403-9issue
3eissn
0007-0920issn
1532-1827journal_volume
44pub_type
杂志文章abstract::Accumulating evidence suggests that the p53 gene is a good target for molecular epidemiological studies. We previously reported an association between the presence of p53 mutations and lifetime cigarette consumption. Although over 675 p53 mutations have been reported in lung cancers in the literature thus far, very li...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1998.258
更新日期:1998-05-01 00:00:00
abstract::Cancer of the colon and rectum is one of the most frequent malignancies both in the US and Europe. Standard palliative therapy is based on 5-fluorouracil/folinic acid combinations, with or without oxaliplatin or irinotecan, given intravenously. Oral medication has the advantage of greater patient convenience and accep...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章
doi:10.1038/sj.bjc.6600781
更新日期:2003-03-10 00:00:00
abstract::Follicular-phase (Day 11) plasma prolactin, and plasma and urinary oestrogen levels of 70 nulliparous nuns were compared with those of 80 of their sisters, of whom 62 were parous. The nuns and their nulliparous sisters did not differ significantly in their prolactin and oestrogen levels. No differences in plasma oestr...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1981.121
更新日期:1981-06-01 00:00:00
abstract::To improve our understanding of the relationship and possible associations between human papillomavirus (HPV) infection and the development of cervical malignancies, the presence of multiple types of HPV DNA sequences in cervical carcinoma was determined in Chinese citizens living in two different geographical locatio...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1994.375
更新日期:1994-10-01 00:00:00
abstract:BACKGROUND:This study aimed to evaluate the safety and efficacy of dose-dense weekly chemotherapy, followed by resection and/or thoracic radiotherapy. METHODS:Patients with histologically documented thymoma with unresectable stage III disease received 9 weeks of chemotherapy: cisplatin 25 mg m(-2) on weeks 1-9; vincri...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605731
更新日期:2010-06-29 00:00:00
abstract::Throughout the world there are problems recruiting ethnic minority patients into cancer clinical trials. A major barrier to trial entry may be distrust of research and the medical system. This may be compounded by the regulatory framework governing research with an emphasis on written consent, closed questions and con...
journal_title:British journal of cancer
pub_type: 杂志文章,评审
doi:10.1038/bjc.2012.240
更新日期:2012-09-25 00:00:00
abstract::The cytotoxicity of methotrexate (MTX) on representative human tumour cell lines (two cell lines from head and neck carcinomas, two from breast carcinomas, two from osteosarcomas and one lymphoblastoid cell line) was evaluated to: (1) examine the optimal time interval between MTX and folinic acid (FA) administration; ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1991.70
更新日期:1991-02-01 00:00:00
abstract::The treatment of breast cancer patients has changed rapidly in the past decade, but empirical data at local and national level are scarce. Predicting the consequences of screening for primary treatment is consequently difficult. The aim of this analysis of records on admissions to hospital of women with breast cancer ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1994.466
更新日期:1994-12-01 00:00:00
abstract:BACKGROUND:This study is to investigate the effects of geserelin+tamoxifen (TAM) on estradiol level, breast density (BD), endometrial thickness (ET), and blood lipids in premenopausal and perimenopausal women with hormone receptor-positive early-stage breast cancer. METHODS:This study recruited 110 premenopausal and p...
journal_title:British journal of cancer
pub_type: 杂志文章,随机对照试验
doi:10.1038/bjc.2013.324
更新日期:2013-08-06 00:00:00
abstract::Tumour angiogenesis is essential for progression of solid tumours and constitutes an interesting target for therapy. However, impaired tumour blood supply may also be an important obstacle for treatment by radiotherapy and chemotherapy. Estramustine has been shown to increase tumour blood flow and potentiate the effec...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6690333
更新日期:1999-04-01 00:00:00
abstract:BACKGROUND:Epidermal growth factor receptor (EGFR) is highly expressed in adenoid cystic carcinoma (ACC). The efficacy and toxicity of cetuximab with concomitant platinum-based chemoradio- or chemotherapy in patients with locally advanced or metastatic ACC, respectively, was evaluated. METHODS:Eligible patients (9 wit...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2013.468
更新日期:2013-09-03 00:00:00
abstract:BACKGROUND:Anti-PD-1 antibodies and BRAF/MEK inhibitors are the two main groups of systemic therapy in the treatment of BRAFV600-mutant advanced melanoma. Until now, data are inconclusive on which therapy to use as first-line treatment. The aim of this study was to use propensity score matching to compare first-line an...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-01229-1
更新日期:2021-01-26 00:00:00
abstract:BACKGROUND:We previously reported that chaetocin has potent and selective anti-myeloma activity attributable to reactive oxygen species (ROS) induction imposed by inhibition of the redox enzyme thioredoxin reductase; we now detail its effects in solid tumours. METHODS:Cellular assays, transcriptional profiling and the...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2011.522
更新日期:2012-01-17 00:00:00
abstract::Human glioma usually shows intrinsic multidrug resistance because of the blood-brain barrier (BBB), in which membrane-associated P-glycoprotein (P-gp), encoded by the human multidrug resistance gene MDR1, plays a role. We studied drug sensitivity to vincristine (VCR), doxorubicin (DOX) and nimustine (ACNU) in both int...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1997.408
更新日期:1997-01-01 00:00:00
abstract::We report observations on the spread by metastasis and infiltration of a transplantable tumour in rats treated by 60Co gamma-irradiation of the primary, irradiation plus parenteral cyclophosphamide, or parenteral cyclophosphamide alone. The proportion of animals with overt disseminated disease and the extent of spread...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1977.181
更新日期:1977-08-01 00:00:00
abstract::The cytotoxicity of three platinum complexes, cis-diamminedichloroplatinum(II) (cis-platin), cis-dichloro-trans-dihydroxy-cis-bis (isopropylamine) platinum(IV), (CHIP) and diammine (1, 1-cyclobutane-dicarboxylato) platinum(II) (carboplatin) on Chinese Hamster ovary (CHO) and mouse sarcoma RIF-1 cells cultured in vitro...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1988.126
更新日期:1988-06-01 00:00:00
abstract::In the UK there are standardized surveillance procedures for gestational trophoblastic disease. However, there are differences in practice between the two treatment centres in terms of definition of persistent gestational trophoblastic disease, prognostic risk assessment and chemotherapeutic regimens. The role of prop...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6690203
更新日期:1999-03-01 00:00:00
abstract:BACKGROUND:The impact of cardiovascular disease (CVD) comorbidity on resection rates and survival for patients with early-stage non-small-cell lung cancer (NSCLC) is unclear. We explored if CVD comorbidity explained surgical resection rate variation and the impact on survival if resection rates increased. METHODS:Canc...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-0869-8
更新日期:2020-08-01 00:00:00
abstract::The influence on heat sensitivity of interactions between HT29 human colon adenocarcinoma cells grown in two- or three-dimensional contact was investigated. No evidence for intercellular cooperation affecting cellular sensitivity to hyperthermia was found. Cells grown in monolayer were found to be more heat sensitive ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1985.268
更新日期:1985-12-01 00:00:00
abstract::The toxicity produced by two courses of methotrexate separated by different intervals has been studied in matched groups of rats. The maximum degree of neutropenia reached when courses were separated by 8 days or more was no greater than that seen after a single course of methotrexate. However, when courses of neutrop...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1977.2
更新日期:1977-01-01 00:00:00
abstract::HER-2/neu is a tumour antigen that is overexpressed in human breast tumours. Among the vaccine strategies developed to overcome immune tolerance to self-proteins, vaccination with anti-idiotypic (anti-Id) antibodies has been described as a promising approach for treatment of several malignant diseases. To develop an a...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6601825
更新日期:2004-05-17 00:00:00
abstract::The study was originally set up to measure accurate cell kinetic parameters in two murine squamous cell carcinomas (scc) for comparison with radiobiological data on proliferation during radiotherapy. The tumours, AT84 and AT478, were both moderately well differentiated aneuploid scc. In the course of the study, severa...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1993.487
更新日期:1993-12-01 00:00:00
abstract:BACKGROUND:Immune checkpoint blockade (ICB) therapy improved the prognosis of cancer patients, but general administration of ICBs occasionally induces side effects that include immune-related adverse events and tumour hyper-progression. Here, we established a protein-based system, by which endogenous expression of IC m...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-019-0708-y
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:There are limited data comparing the prognosis and fertility outcomes of the patients with early cervical cancer treated by trans-vaginal radical trachelectomy (VRT) or abdominal radical trachelectomy (ART).The objective of this study was to compare the surgical and pathologic characteristics, the prognosis ...
journal_title:British journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1038/bjc.2013.656
更新日期:2013-11-26 00:00:00
abstract::The family history of cancer in children treated for a solid malignant tumour in the Paediatric Oncology Department at Institute Gustave-Roussy, has been investigated. In order to determine the role of germline p53 mutations in genetic predisposition to childhood cancer, germline p53 mutations were sought in individua...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2000.1167
更新日期:2000-06-01 00:00:00
abstract::Astrocytomas develop intense vascular proliferation, essential for tumour growth and invasiveness. Angiotensin II (ANGII) was initially described as a vasoconstrictor; recent studies have shown its participation in cellular proliferation, vascularisation, and apoptosis. We conducted a prospective study to evaluate the...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604431
更新日期:2008-07-08 00:00:00
abstract:BACKGROUND:Accurate assessment of the prevalence of the human papilloma virus (HPV) in oropharyngeal tumours (OpSCC) is important because HPV-positive OpSCC are consistently associated with an improved overall survival. Recently, an algorithm has become available that reliably detects clinically relevant HPV in tumour ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2015.99
更新日期:2015-04-14 00:00:00
abstract:BACKGROUND:Paired related homoeobox 1 (PRRX1) has been identified as a new epithelial-mesenchymal transition (EMT) inducer in breast cancer. However, the function of PRRX1 in colorectal cancer (CRC) has not been elucidated. METHODS:We utilised ectopic PRRX1-expressing cell lines to analyse the function of PRRX1 in CRC...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2013.339
更新日期:2013-07-23 00:00:00
abstract::The pharmacokinetics and pharmacodynamics of oral S-1, a dihydropyrimidine dehydrogenase (DPD) inhibitory fluoropyrimidine, were compared with those of protracted venous infusion (PVI) of 5-fluorouracil (5-FU). In all, 10 patients with gastric cancer received PVI of 5-FU at a dose of 250 mg m(-2) day(-1) for 5 days. A...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6601224
更新日期:2003-09-01 00:00:00
abstract:BACKGROUND:Recent studies have indicated the prognostic value of tumour subtype and pathological complete response (pCR) after neoadjuvant chemotherapy (NAC). However these results were reported after a short follow-up and using a standard Cox model which could be unsatisfactory for time-dependent factors. In the prese...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2015.174
更新日期:2015-06-30 00:00:00