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Paired related homoeobox 1, a new EMT inducer, is involved in metastasis and poor prognosis in colorectal cancer.

Abstract：

BACKGROUND:Paired related homoeobox 1 (PRRX1) has been identified as a new epithelial-mesenchymal transition (EMT) inducer in breast cancer. However, the function of PRRX1 in colorectal cancer (CRC) has not been elucidated. METHODS:We utilised ectopic PRRX1-expressing cell lines to analyse the function of PRRX1 in CRC. The clinical significance of PRRX1 was also examined on three independent CRC case sets. RESULTS:PRRX1 induced EMT and the stem-like phenotype in CRC cells. In contrast to studies of breast cancer, abundant expression of PRRX1 was significantly associated with metastasis and poor prognosis in CRC. CONCLUSION:PRRX1 is an indicator of metastasis and poor prognosis in CRC cases. Further investigation is required to uncover the signalling network regulating PRRX1.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Takahashi Y,Sawada G,Kurashige J,Uchi R,Matsumura T,Ueo H,Takano Y,Akiyoshi S,Eguchi H,Sudo T,Sugimachi K,Doki Y,Mori M,Mimori K

doi

10.1038/bjc.2013.339

subject

Has Abstract

pub_date

2013-07-23 00:00:00

pages

307-11

issue

2

eissn

0007-0920

issn

1532-1827

pii

bjc2013339

journal_volume

109

pub_type

杂志文章

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