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Chromosomal radiosensitivity in head and neck cancer patients: evidence for genetic predisposition?

Abstract：

:The association between chromosomal radiosensitivity and genetic predisposition to head and neck cancer was investigated in this study. In all, 101 head and neck cancer patients and 75 healthy control individuals were included in the study. The G(2) assay was used to measure chromosomal radiosensitivity. The results demonstrated that head and neck cancer patients had a statistically higher number of radiation-induced chromatid breaks than controls, with mean values of 1.23 and 1.10 breaks per cell, respectively (P<0.001). Using the 90th percentile of the G(2) scores of the healthy individuals as a cutoff value for chromosomal radiosensitivity, 26% of the cancer patients were radiosensitive compared with 9% of the healthy controls (P=0.008). The mean number of radiation-induced chromatid breaks and the proportion of radiosensitive individuals were highest for oral cavity cancer patients (1.26 breaks per cell, 38%) and pharynx cancer patients (1.27 breaks per cell, 35%). The difference between patients and controls was most pronounced in the lower age group (

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

De Ruyck K,de Gelder V,Van Eijkeren M,Boterberg T,De Neve W,Vral A,Thierens H

doi

10.1038/sj.bjc.6604345

subject

Has Abstract

pub_date

2008-05-20 00:00:00

pages

1723-38

issue

10

eissn

0007-0920

issn

1532-1827

pii

6604345

journal_volume

98

pub_type

杂志文章

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