Abstract:
:Breast cancer is the second most common cancer among women in Madras and southern India after cervix cancer. The Madras Metropolitan Tumour Registry (MMTR), a population-based cancer registry, collects data on the outcome of cancer diagnosis by both active and passive methods. A total of 2080 cases of invasive female breast cancer were registered in MMTR during 1982-89. Of these, 98 (4.7%) cases were registered on the basis of death certificate information only (DCO), and there was no follow-up information for 235 (11.3%). These were excluded, leaving 1747 (84%) for survival analysis. The mean follow-up time was 43 months. The overall Kaplan-Meier observed survival rates at 1, 3 and 5 years were 80%, 58% and 48% respectively; the corresponding figures for relative survival were 81%, 61% and 51%. A multifactorial analysis of prognostic factors using a proportional hazards model showed statistically significant differences in survival for subjects in different categories of age at diagnosis, marital status, educational level and clinical extent of disease. Increasing age at diagnosis was associated with decreased survival. Single women displayed poorer survival (37.4%) at 5 years than those married and living with spouses (50.0%). The survival rate among those who had more than 12 years of education was higher (70%) at 5 years than that of illiterate subjects (47%). An inverse relationship was seen between survival rates and clinical extent of disease. The need for research to determine feasible public health approaches, allied to coordinated treatment facilities to control breast cancer in India, is emphasized.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Gajalakshmi CK,Shanta V,Swaminathan R,Sankaranarayanan R,Black RJdoi
10.1038/bjc.1997.137subject
Has Abstractpub_date
1997-01-01 00:00:00pages
771-5issue
5eissn
0007-0920issn
1532-1827journal_volume
75pub_type
杂志文章abstract::O6-benzylguanine (O6-BG) and 3-aminobenzamide (3-AB) inhibit the DNA repair proteins O6-alkylguanine-DNA alkyltransferase (AGT) and poly(ADP-ribose) polymerase (PARP) respectively. The effect of O6-BG and/or 3-AB on temozolomide and 1,3-bis(2-chloroethyl)-nitrosourea (BCNU) cytotoxicity, was assessed in seven human tu...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1996.485
更新日期:1996-10-01 00:00:00
abstract:BACKGROUND:Treatment options for patients with metastatic gastroenteropancreatic neuroendocrine tumours (GEP NETs) are still limited. We investigated the antitumour activity and safety profile of pazopanib--a multitarget drug with anti-angiogenic activity in patients with metastatic GEP NETs. METHODS:This was a nonran...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2013.470
更新日期:2013-09-17 00:00:00
abstract::A study is presented of all cases of primary sarcoma of bone registered during the period 1946 to 1974 for a specified population resident in south-western England. Ninety-six per cent of the 365 cases were histologically and radiologically verified and are separated into 8 categories of sarcoma. The number of tumours...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1977.221
更新日期:1977-10-01 00:00:00
abstract:BACKGROUND:The lifestyle risk factors for nasopharyngeal carcinoma (NPC) in North Africa are not known. METHODS:From 2002 to 2005, we interviewed 636 patients and 615 controls from Algeria, Morocco and Tunisia, frequency-matched by centre, age, sex, and childhood household type (urban/rural). Conditional logistic regr...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605281
更新日期:2009-10-06 00:00:00
abstract::To test the hypothesis that steroid hormone receptor expression is particularly pronounced in breast tumours when compared with non-neoplastic tissue, mastectomy samples were divided into 16 sectors. Multifocal tumours, of varying receptor phenotype were found in 4 patients and in addition different regions of large t...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1987.90
更新日期:1987-04-01 00:00:00
abstract::In an Italian case-control study of oral cancer, number of missing teeth and other aspects of dental care were similar, but the general condition of the mouth, as indicated by gum bleeding, tartar deposits and mucosal irritation, was worse among oral cancer cases than controls. No differences were detected in sexual p...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2000.1398
更新日期:2000-11-01 00:00:00
abstract:BACKGROUND:We modified and evaluated an advance care planning (ACP) intervention, which had been shown to improve compliance with patient's end of life (EoL) wishes, in a different patient population. METHODS:Patients with incurable cancer, and a Family Member (FM), were randomised one-to-one to usual care or usual ca...
journal_title:British journal of cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1038/s41416-018-0303-7
更新日期:2018-11-01 00:00:00
abstract::Fifteen human glioma cell lines were examined for their sensitivity to 1,3-bis(chloroethyl)-nitrosourea (BCNU, carmustine) and cis-dichlorodiamminoplatinum (cisplatin), the induction of DNA interstrand cross-linking (DNA-ISC) induced by the two agents and cellular O6-alkylguanine alkyltransferase (ATase) activity. Cel...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1997.87
更新日期:1997-01-01 00:00:00
abstract::Patients affected by squamous cell carcinoma of the head and neck (HNSCC) show frequent occurrence of multiple cancers and widespread precancerous lesions in the mucosa of the upper respiratory tract, a phenomenon known as field cancerization. In this study, we investigated the role of genetic instability in the devel...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1998.644
更新日期:1998-11-01 00:00:00
abstract:BACKGROUND:Four-and-a-half LIM domains protein 2 (FHL2) is a component of the focal adhesion structures and has been suggested to have a role in cancer progression. It has been shown to be overexpressed in the colorectal cancer (CRC). METHODS:Here, we examined a possible prognostic value of FHL2 in CRC. Immunohistoche...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2013.290
更新日期:2013-07-09 00:00:00
abstract:BACKGROUND:The co-chaperone protein Bcl-2-associated athanogene-1 (BAG-1) is overexpressed in breast cancer and has been incorporated in the oncotype DX and PAM50 breast cancer prognostic assays. Bcl-2-associated athanogene-1 exists as multiple protein isoforms that interact with diverse partners, including chaperones ...
journal_title:British journal of cancer
pub_type: 杂志文章,meta分析,评审
doi:10.1038/bjc.2017.130
更新日期:2017-06-06 00:00:00
abstract:BACKGROUND:Dysregulation of microRNAs (miRNAs) has been found in human epithelial ovarian cancer (EOC). However, the role and mechanism of action of miR-23a in EOC remain unclear. METHODS:The roles of miR-23a, IKKα, and ST7L in EOC were determined by MTT, colony formation, wounding healing, transwell, flow cytometry, ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2016.244
更新日期:2016-09-06 00:00:00
abstract:BACKGROUND:Clear cell renal cancer frequently harbours von Hippel-Lindau (VHL) gene mutations, leading to stabilisation of the hypoxia-inducible factors (HIFs) and expression of their target genes. We investigated HIF-1 and HIF-2 in the regulation of microRNA-210 (miR-210), and its clinical relevance in renal tumours. ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2013.56
更新日期:2013-03-19 00:00:00
abstract:BACKGROUND:Novel treatment strategies in Ewing sarcoma include targeted cellular therapies. Preclinical in vivo models are needed that reflect their activity against systemic (micro)metastatic disease. METHODS:Whole-body magnetic resonance imaging (WB-MRI) was used to monitor the engraftment and dissemination of human...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2013.356
更新日期:2013-08-06 00:00:00
abstract:BACKGROUND:Little has been reported on socioeconomic (SES) patterns of risk for most forms of childhood cancer. METHODS:Population-based case-control data from epidemiological studies of childhood cancer conducted in five US states were pooled and associations of maternal, paternal and household educational attainment...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605732
更新日期:2010-06-29 00:00:00
abstract::Alcohol consumption has been inconsistently associated with breast cancer risk. Recent studies suggest that genetic polymorphisms of glutathione S-transferases (GSTs) may modify this relation. To determine if breast cancer risk is associated with GSTM1 and GSTT1 genetic polymorphisms, and to evaluate the effect modifi...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6600708
更新日期:2003-01-13 00:00:00
abstract::Two techniques for growing colonies of human tumour cells in soft agar have been applied to cell suspensions derived from fresh tumour tissue from 48 patients. Colonies were obtained in 31 cases, with plating efficiencies between 0.01 and 15%. In 11 cases the plating efficiencies were 1% or above. There was evidence t...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1978.165
更新日期:1978-07-01 00:00:00
abstract::Detailed data were provided by the Oxford Survey of Childhood Cancer OSCC on deaths from childhood cancer in Britain after irradiation of the fetus during diagnostic radiology of the mother. In each age group at death, 0-5, 6-9 and 10-15 years, excess cancer deaths decreased suddenly for births in and after 1958. A ma...
journal_title:British journal of cancer
pub_type: 杂志文章,评审
doi:10.1038/bjc.1990.249
更新日期:1990-07-01 00:00:00
abstract:BACKGROUND:Cancer incidence is increasing in the United Kingdom, as well as on a global basis. Biochemical parameters, such as C-reactive protein and albumin (combined to form the modified Glasgow Prognostic Score, mGPS), alkaline phosphatase (Alk phos), gamma-glutamyl transferase (GGT) and serum calcium have been repo...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605855
更新日期:2010-09-07 00:00:00
abstract:BACKGROUND:Cytosolic deacetylase histone deacetylase 6 (HDAC6) is involved in the autophagy degradation pathway of malformed proteins, an important survival mechanism in cancer cells. We evaluated modulation of autophagy-related proteins and cell death by the HDAC6-selective inhibitor C1A. METHODS:Autophagy substrates...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-018-0232-5
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:This study explored the association between smoking and colorectal malignant carcinoma (CRC) in the Chinese population at the national level for the first time. METHODS:In the China Nationwide Retrospective Mortality Survey conducted during 1989-1991, 12,942 CRC cases among 1,136,336 all-cause deaths aged ≥...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2014.9
更新日期:2014-03-04 00:00:00
abstract::The nature of the invasive growth pattern and microvessel density (MVD) have been suggested to be predictors of prognosis in primary colorectal cancer (CRC) and colorectal liver metastases. The purpose of the present study was to determine whether these two histological features were interrelated and to assess their r...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6603677
更新日期:2007-04-10 00:00:00
abstract::Activation of Met by its ligand HGF has been shown to elicit both mitogenic and motogenic responses in thyrocytes in vitro. In the present study we have investigated the expression of Met in human anaplastic thyroid carcinoma cells in culture. There was a variation in expression level and size of Met in the different ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6690406
更新日期:1999-05-01 00:00:00
abstract::beta2-Microglobulin (beta2M), a component of MHC class I molecules, is believed to be associated with tumour status in various cancers. In this study, we examined the expression of beta2M at different malignant stages of oral cavity squamous cell carcinoma (OCSCC). To determine the possible correlation between beta2M ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604698
更新日期:2008-11-04 00:00:00
abstract:BACKGROUND:Heat shock protein 90 (HSP90) has a key role in the maintenance of the cellular proteostasis. However, HSP90 is also involved in stabilisation of oncogenic client proteins and facilitates oncogene addiction and cancer cell survival. The development of HSP90 inhibitors for cancer treatment is an area of growi...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2013.710
更新日期:2014-01-07 00:00:00
abstract:BACKGROUND:The risk and prognosis of ovarian cancer have not been well established in women with endometriosis. Thus, we investigated the impact of endometriosis on the risk and prognosis for ovarian cancer, and evaluated clinicopathologic characteristics of endometriosis-associated ovarian cancer (EAOC) in comparison ...
journal_title:British journal of cancer
pub_type: 杂志文章,meta分析
doi:10.1038/bjc.2014.29
更新日期:2014-04-02 00:00:00
abstract:BACKGROUND:Little is known about the effect of participating in a colorectal cancer (CRC) screening programme on quality of life (QOL), neither for participants with a negative nor for those with a positive test result. These findings, however, are important to evaluate the impact of CRC screening. METHODS:Participant...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2012.386
更新日期:2012-10-09 00:00:00
abstract::A human tamoxifen-resistant mammary carcinoma, MaCa 3366/TAM, originating from a sensitive parental xenograft 3366 was successfully established by treatment of tumour-bearing nude mice with 1-50 mg kg(-1) tamoxifen for 3 years during routine passaging. Both tumours did not differ significantly in OR- and PR-positivity...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2000.1156
更新日期:2000-06-01 00:00:00
abstract::The establishment and characterisation (morphology, ultrastructure, tumourigenicity) of six cell lines from primary human colorectal adenocarcinomas is described. These lines were established from surgical specimens, from 49 unselected patients, without the use of 'feeder' cells, 'conditioned' medium or passage of cel...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1986.132
更新日期:1986-06-01 00:00:00
abstract:BACKGROUND:It has been hypothesised that intrauterine exposures are important for subsequent prostate cancer risk. Prior epidemiological studies have used birthweight as a proxy of cumulative intrauterine exposures to test this hypothesis, but results have been inconsistent partly because of limited statistical power. ...
journal_title:British journal of cancer
pub_type: 杂志文章,meta分析,评审
doi:10.1038/bjc.2016.38
更新日期:2016-03-29 00:00:00