Abstract：
BACKGROUND:Little has been reported on socioeconomic (SES) patterns of risk for most forms of childhood cancer. METHODS:Population-based case-control data from epidemiological studies of childhood cancer conducted in five US states were pooled and associations of maternal, paternal and household educational attainment with childhood cancers were analysed. Odds ratios (ORs) and 95% confidence intervals were estimated using logistic regression, controlling for confounders. RESULTS:Although there was no association with parental education for the majority of cancers evaluated, there was an indication of a positive association with lower education for Hodgkin's and Burkitt's lymphoma and Wilm's tumour, with the ORs ranging from 1.5 to >3.0 times that of more educated parents. A possible protective effect was seen for lower parental education and astrocytoma and hepatoblastoma, with ORs reduced by 30 to 40%. CONCLUSIONS:These study results should be viewed as exploratory because of the broad nature of the SES assessment, but they give some indication that childhood cancer studies might benefit from a more thorough assessment of SES.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Carozza SE,Puumala SE,Chow EJ,Fox EE,Horel S,Johnson KJ,McLaughlin CC,Reynolds P,Von Behren J,Mueller BA,Spector LGdoi
10.1038/sj.bjc.6605732subject
Has Abstractpub_date
2010-06-29 00:00:00pages
136-42issue
1eissn
0007-0920issn
1532-1827pii
6605732journal_volume
103pub_type
杂志文章abstract：:The relationship between fetal growth as indicated by weight and length at birth, and cancer risk in 1080 adult Swedish women was examined. Birth factors were retrieved from original midwife records for the years 1914, 1918, 1922 and 1930, and primary cancer cases were identified by matching with national and regional...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2000.1738
更新日期：2001-05-04 00:00:00
abstract：:Multicellular tumour spheroids are cellular aggregates that can be prepared from many types of tumour cells. These three-dimensional structures provide a model for analysing the effects of cell-cell contact and intercellular microenvironments on phenomena such as autocrine regulation of growth factor synthesis. Autore...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.34
更新日期：1992-02-01 00:00:00
abstract：:Age distributions of parents at birth of patients registered in the National Wilms' Tumour Study were compared to those of the general population. An increasing incidence of sporadic Wilms' tumour with increasing paternal age was found, with a relative risk of 2.1 of tumour in children of fathers over 55 compared to c...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1993.148
更新日期：1993-04-01 00:00:00
abstract：BACKGROUND:Circulating tumour cells (CTCs) can provide information on patient prognosis and treatment efficacy. However, there is no universal method to detect CTC currently available. Here, we compared the performance of two CTC detection systems based on the expression of the EpCAM antigen (CellSearch assay) or on ce...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.294
更新日期：2011-09-06 00:00:00
abstract：:In a clinical investigation of observed postoperative survival, 563 patients have been registered for primary surgical treatment of colorectal cancer since 1974. The potential prognostic factors examined within the first days of hospitalization for primary resection included age of the patients, operability, location ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1981.250
更新日期：1981-11-01 00:00:00
abstract：BACKGROUND:The integrin-binding protein osteopontin is strongly associated with tumour development, yet is an abundant dietary component as a constituent of human and bovine milk. Therefore, we tested the effect of orally administered osteopontin (o-OPN) on the development of subcutaneous tumours in mice. METHODS:Bovi...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2014.10
更新日期：2014-03-04 00:00:00
abstract：:Epidemiological, animal, and cell culture studies have identified boron as a chemopreventative agent in prostate cancer. The present objective was to identify boron-induced changes in the DU-145 human prostate cancer cell line. We show that prolonged exposure to pharmacologically-relevant levels of boric acid, the nat...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603009
更新日期：2006-03-27 00:00:00
abstract：:Angiogenesis is an essential requirement for tumour growth and metastasis and is regulated by a complex network of factors produced by both stromal cells and neoplastic cells within solid tumours. The cytokine tumour necrosis factor alpha (TNF-alpha) and the enzyme thymidine phosphorylase (TP) are two factors known to...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.373
更新日期：1998-06-01 00:00:00
abstract：:Supplementary Table 1 and the Supplementary Figure legends were not included when this manuscript was first published. The files are now available here. ...
journal_title：British journal of cancer
pub_type： 已发布勘误
doi：10.1038/s41416-018-0130-x
更新日期：2018-08-01 00:00:00
abstract：BACKGROUND:Aetiology of acute myeloid leukaemia (AML) is not well understood, perhaps because of its distinct subtypes. High-dose ionising radiation is a known risk factor, but less is known about risk from low-dose exposure such as from diagnostic radiography. METHODS:Subjects were 412 matched case-control pairs. Ten...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.114
更新日期：2011-04-26 00:00:00
abstract：BACKGROUND:This study aimed to evaluate the prognostic value of pre-treatment NLR in patients with oropharyngeal cancer. METHODS:Patients who completed definitive radiotherapy (RT) for oropharyngeal cancer and had blood counts taken pre-RT from 2002 to 2013 were included. NLR was calculated as total neutrophil/lymphoc...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-01106-x
更新日期：2020-10-14 00:00:00
abstract：:It is suggested that the proximate carcinogenic forms of dialkylnitrosamines are their oxidation products, which retain the alkylnitrosamino moiety, but have acquired a carbonyl function as a result of omega or beta oxidation of an alkyl group. Such metabolites resemble the locally acting carcinogenic "nitrosamides" a...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1973.169
更新日期：1973-11-01 00:00:00
abstract：:In some clinical situations the endogenous production of glutamine may be insufficient to maintain optimal tissue structure and function such that glutamine becomes a conditionally essential amino acid. Studies in laboratory animals have demonstrated that glutamine supplementation can reduce the incidence and severity...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/bjc.1994.385
更新日期：1994-10-01 00:00:00
abstract：:We evaluated animal food intake and cooking methods in relation to endometrial cancer risk in a population-based case-control study in Shanghai, China. A validated food frequency questionnaire was used to collect the usual dietary habits of 1204 cases and 1212 controls aged 30-69 years between 1997 and 2003. Statistic...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603458
更新日期：2006-12-04 00:00:00
abstract：BACKGROUND:The immune system has a central role in controlling cancer, and factors that influence protective antitumour immunity could therefore have a significant impact on the course of malignant disease. Opioids are essential for the management of cancer pain, and preclinical studies indicate that opioids have the p...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/bjc.2014.384
更新日期：2014-08-26 00:00:00
abstract：BACKGROUND:The Dutch guidelines advise to start radiation therapy (RT) within 5 weeks following breast-conserving surgery (BCS). However, much controversy exists regarding timing of RT. This study investigated its effect on 10-year disease-free survival (DFS) in a Dutch population-based cohort. METHODS:All women diagn...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2017.159
更新日期：2017-07-11 00:00:00
abstract：:We cytogenetically investigated six osteoid osteomas, one osteoblastoma and one aggressive osteoblastoma, and observed clonal structural changes in one osteoid osteoma and in the aggressive osteoblastoma. Clonal chromosome changes had not been reported previously in osteoid osteoma, whereas the only reported chromosom...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.496
更新日期：1998-08-01 00:00:00
abstract：:Although the presence of axillary node metastases in breast cancer is a key prognostic indicator and may influence treatment decisions, a significant proportion of patients diagnosed as axillary node negative (ANN) using standard histopathological techniques may have occult nodal metastases (OMs). A combination of lim...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.16
更新日期：1996-01-01 00:00:00
abstract：:At baseline, weight-losing pancreatic cancer patients (n=7) had lower leptin (P<0.05) but higher cortisol, interleukin-6, resting energy expenditure and fat oxidation than healthy subjects (n=6, P<0.05). Over a 4 h feeding period, the areas under the curve for glucose, cortisol and interleukin-6 were greater (P<0.05),...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601712
更新日期：2004-03-22 00:00:00
abstract：BACKGROUND:Doxorubicin and cyclophosphamide (AC) therapy is an effective treatment for early-stage breast cancer. Doxorubicin is a substrate for ABCB1 and SLC22A16 transporters. Cyclophosphamide is a prodrug that requires oxidation to 4-hydroxycyclophosphamide, which yields a cytotoxic alkylating agent. The initial oxi...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605587
更新日期：2010-03-16 00:00:00
abstract：:Besides its cardiotoxic effect, doxorubicin also elicits inflammatory effects in vivo. 7-Monohydroxyethylrutoside (monoHER) has recently been used as a protector against doxorubicin-induced cardiotoxicity in vivo. It is not known yet whether monoHER can also protect against doxorubicin-induced inflammatory effects. Th...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601022
更新日期：2003-07-21 00:00:00
abstract：:It remains unclear whether any aspect of quality of life has a role in predicting survival in an unselected cohort of patients with gastro-oesophageal cancer. Therefore the aim of the present study was to examine the relationship between quality of life (EORTC QLQ-C30), clinico-pathological characteristics and surviva...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604248
更新日期：2008-03-11 00:00:00
abstract：:The therapeutic efficacy of gemcitabine, a new nucleoside analogue, was assessed in a variety of well-established human soft tissue sarcoma and ovarian cancer xenografts grown s.c. in nude mice. Tumour lines selected had different histological subtypes, growth rates and sensitivities to conventional cytostatic agents....
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1993.285
更新日期：1993-07-01 00:00:00
abstract：:To investigate whether lung cancer clusters in families in a high incidence county of China, an analysis was conducted using data on domestic fuel history and tobacco use for family members of 740 deceased lung cancer probands and 740 controls (probands' spouses). Lung cancer prevalence was compared among first-degree...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602465
更新日期：2005-04-11 00:00:00
abstract：:Alveolar macrophage (AM) phagocytic activity and glucose metabolism were evaluated during lung tumour growth in adult rats challenged i.v. with 10(5) viable Walker 256 tumour cells. Phagocytosis was estimated by the in vitro uptake of (14)C-labelled Pseudomonas aeruginosa and glucose oxidation was evaluated by (14)CO(...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1977.249
更新日期：1977-12-01 00:00:00
abstract：BACKGROUND:Lithium accumulates in the colon and inhibits the enzyme GSK-3β that possesses anti-carcinogenic effects. We therefore examined the association between lithium use and colorectal cancer risk in a nationwide study. METHODS:We used the Danish Cancer Registry to identify all patients diagnosed with incident co...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2016.10
更新日期：2016-03-01 00:00:00
abstract：:A bispecific monoclonal antibody recognising both carcinoembryonic antigen (CEA) and ricin toxin A chain (RTA) was tested for its ability to target recombinant RTA (r-RTA) to CEA-expressing tumour cells, alone and in combination with ricin B chain (RTB). The antibody, 636 (Robins et al., 1990), induced significant RTA...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1991.153
更新日期：1991-05-01 00:00:00
abstract：:The presence of a mononuclear cell reaction to 41 gestational choriocarcinomata, 10 invasive moles and 13 malignant trophoblastic teratomata has been investigated. The intensity of the reaction was graded; there was a significantly better response to therapy and survival rate in those with a "severe" cellular reaction...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1973.144
更新日期：1973-09-01 00:00:00
abstract：BACKGROUND:Geriatric oncology guidelines state that fit older men with prostate cancer should receive curative treatment. In a population-based study, we investigated associations between age and non-receipt of curative treatment in men with localised prostate cancer, and the effect of clinical variables on this in dif...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.268
更新日期：2013-07-09 00:00:00
abstract：:An antigen common to human sarcomas, S3, has been further characterized. It is antigenically distinct from human blood-group substances A and B and from heterophile antigens such as Forssman, infectious mononucleosis and serum sickness antigens. Whilst S3 antigen preparations may contain small amounts of CEA and AFP t...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1981.43
更新日期：1981-03-01 00:00:00
