Abstract:
:Age distributions of parents at birth of patients registered in the National Wilms' Tumour Study were compared to those of the general population. An increasing incidence of sporadic Wilms' tumour with increasing paternal age was found, with a relative risk of 2.1 of tumour in children of fathers over 55 compared to children of fathers younger than 20. A similar effect for maternal age was found, with a relative risk of 1.4 in children of mothers over 40 compared to children of mothers younger than 20. The maternal age effect was much weaker among patients registered later in the study; in the later, more completely ascertained cohort, paternal age appears to be the major contributor to the parental age effect. Little difference in paternal age distribution was found between patients with bilateral and unilateral tumour and between male and female patients. In contrast, patients with reported associated congenital anomalies, patients with evidence of nephrogenic rests, and patients with early or late age-of-onset of tumour had parents who were, on average, substantially older than the remainder. These findings lend support to the idea that many Wilms' tumours result from new germline mutations. Further, the histologic composition of such tumours may be sufficiently distinct as to provide a valuable diagnostic indicator of the etiology of these tumours.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Olson JM,Breslow NE,Beckwith JBdoi
10.1038/bjc.1993.148subject
Has Abstractpub_date
1993-04-01 00:00:00pages
813-8issue
4eissn
0007-0920issn
1532-1827journal_volume
67pub_type
杂志文章abstract::Squamous carcinoma of the oropharynx presents with symptoms common to many benign diseases, and this can cause delay in referral to secondary care. We investigate delay in referral, defining this as the time from symptom-onset to date of general practitioners referral letter to secondary care, and the effect of that d...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6603044
更新日期:2006-04-10 00:00:00
abstract::The expression of heat shock proteins (HSP) of the 65 kD family (groEL) has been observed by flow cytometry using murine monoclonal antibody (MoAb) anti-HSP 65 kD (ML30) on the surface of B (Daudi) or T (H9) lymphoma cells, on a monocyte cell line (U937) and also on a primary culture of a human pancreatic carcinoma (H...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1992.291
更新日期:1992-09-01 00:00:00
abstract:BACKGROUND:Sequence variations in coding and non-coding regions of the genome can affect gene expression and signalling pathways, which in turn may influence disease outcome. METHODS:In this study, we integrated somatic mutations, gene expression and clinical data from 930 breast cancer patients included in the TCGA d...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-018-0030-0
更新日期:2018-04-01 00:00:00
abstract::KRN 8602 (MX2) is a novel morpholino anthracycline derivative having the chemical structure 3'-deamino-3'-morpholino-13-deoxo-10-hydroxycarminomycin hydrochloride. To investigate the mechanisms of resistance to MX2, we established an MX2-resistant phenotype (K562/MX2) of the human myelogeneous leukaemia cell line (K56...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6602498
更新日期:2005-04-25 00:00:00
abstract::Soluble and nuclear oestrogen receptor status was determined in both the central and peripheral portions of tumour for 37 cases of adenocarcinoma of the endometrium. Of these, 29 had functional receptor in the peripheral biopsy, but only 19 retained functional receptor in the centre. Six of the 10 patients whose tumou...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1983.34
更新日期:1983-02-01 00:00:00
abstract:BACKGROUND:The characterisation of desmoplastic reaction (DR) has emerged as a new, independent prognostic determinant in colorectal cancer. Herein, we report the validation of its prognostic value in a randomised controlled study (SACURA trial). METHODS:The study included 991 stage II colon cancer patients. DR was cl...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-01222-8
更新日期:2021-01-07 00:00:00
abstract::Estimation of FGF-3 oncogene amplification in DNA samples extracted from paraffin embedded sections of 136 ovarian cancer samples was carried out by a quantitative PCR method. The aim of this study was to elucidate a possible association of FGF-3 copy numbers with established prognostic factors such as age, histology,...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1993.206
更新日期:1993-05-01 00:00:00
abstract::Limb-sparing surgeries have been performed more frequently than amputation based on the belief that limb-sparing surgeries provide improved function and quality-of-life (QOL). However, this has not been extensively studied in the paediatric population, which has unique characteristics that have implications for functi...
journal_title:British journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1038/sj.bjc.6602220
更新日期:2004-11-29 00:00:00
abstract:BACKGROUND:Lignans - oestrogenic substances present in various foods - are associated with postmenopausal breast cancer risk, but not much is known regarding their effects on survival. METHODS:In a follow-up study of 2653 postmenopausal breast cancer patients diagnosed between 2001 and 2005, vital status and causes of...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2011.374
更新日期:2011-10-11 00:00:00
abstract::The relationship between melanoma incidence and latitude was investigated in North American and Europe, using the data collected by 43 population-based cancer registries. In North America melanoma incidence increased with decreasing latitude, supporting the role of UV light in the induction of melanoma. Within England...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1979.260
更新日期:1979-11-01 00:00:00
abstract::Although osteosclerotic bone metastases are characteristic of prostate cancer, mixed metastases with a lytic component are not uncommon. Type I collagen is synthesised by osteoblasts and accounts for about 90% of the organic matrix of bone. We have used new specific immunoassays for PICP (carboxy-terminal propeptide o...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1995.204
更新日期:1995-05-01 00:00:00
abstract::The purpose of this study was to investigate the effect of breast density on breast cancer (BC) mortality in a mammography screening programme. The cohort included 48 052 women participating in mammography screening in Copenhagen, Denmark, where biennial screening is offered to women aged 50-69 years. We collected inf...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604989
更新日期:2009-04-07 00:00:00
abstract:BACKGROUND:Chemerin, a known chemoattractant, participates in multiple biological events. However, its role in cancer remains largely unknown. METHODS:Chemerin expression was evaluated by real-time PCR, western blot and immunohistochemistry. Forced expression, RNAi, immunoprecipitation, etc. were used in function and ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-018-0077-y
更新日期:2018-05-01 00:00:00
abstract::Manganese superoxide dismutase (SOD2) is an enzyme that catalyses the dismutation of superoxide in the mitochondria, leading to reduced levels of reactive oxygen species. Reduced expression levels of SOD2 have been shown to result in increased DNA damage and sod2 heterozygous mice have increased incidences of cancer. ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604000
更新日期:2007-10-22 00:00:00
abstract::Cytotoxic antibodies to antigens specific for leukaemic myeloblasts have been sought in the serum of patients with acute myeloblastic leukaemia treated by immunotherapy with irradiated allogeneic myeloblasts and BCG. Assays of complement- and K-cell-mediated activity were used. Cytotoxicity to allogeneic myeloblasts w...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1977.40
更新日期:1977-03-01 00:00:00
abstract::Increases of individual beta tubulin isotypes in antimicrotubule drug resistant cell lines have been reported by several laboratories. We have previously described elevations in beta(III)and beta(IVa)isotypes in estramustine and paclitaxel resistant human prostate carcinoma cells. To investigate further the function o...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2001.1956
更新日期:2001-09-01 00:00:00
abstract:BACKGROUND:Novel treatment strategies in Ewing sarcoma include targeted cellular therapies. Preclinical in vivo models are needed that reflect their activity against systemic (micro)metastatic disease. METHODS:Whole-body magnetic resonance imaging (WB-MRI) was used to monitor the engraftment and dissemination of human...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2013.356
更新日期:2013-08-06 00:00:00
abstract::To investigate the usefulness of thyroglobulin mRNA (Tg-mRNA) detection in peripheral blood in the follow-up of papillary and follicular (differentiated) thyroid cancer, a literature study was performed. Both evidence for and evidence against the usefulness of Tg-mRNA detection were found. Also, evidence for the expre...
journal_title:British journal of cancer
pub_type: 杂志文章,评审
doi:10.1038/sj.bjc.6601991
更新日期:2004-07-19 00:00:00
abstract::We conducted a case-control study to investigate the role of early infections in the aetiology of childhood acute leukaemias. The study included 280 incident cases (240 acute lymphoblastic leukaemia and 40 acute non-lymphoblastic leukaemia) and 288 hospital controls, frequency matched by age, gender, hospital, catchme...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6600091
更新日期:2002-04-08 00:00:00
abstract::The goal of the study was to identify any normal genes that may become inactivated in malignant cells, with associated modifications or loss of gene products. Consequently, attempts were made to identify such products by generating monoclonal antibodies using an immune tolerisation-immunisation procedure. Using such a...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1994.80
更新日期:1994-03-01 00:00:00
abstract::The malignant epithelial cells of nasopharyngeal carcinoma (NPC) and cells of lines derived form the lymphoid cells which infiltrate this tumour have been investigated cytogenetically. Chromosome spreads of lymphoblastoid cells of lines established from 7 different NPC biopsy specimens were examined after banding stai...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1978.31
更新日期:1978-02-01 00:00:00
abstract::The vaso-active drug hydralazine causes a considerable increase in the cytotoxic effect of melphalan towards the KHT tumour in mice. The enhancement in response, measured as the concentration of melphalan required to achieve a given tumour response, is 3.0 and 2.35 when determined using the regrowth delay assay and th...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1988.177
更新日期:1988-08-01 00:00:00
abstract::The murine dose of i.v. C. parvum (466 microgram) was compared with a single, low, human-equivalent dose of 70 microgram and with repeated weekly low doses. All treatments increased the antibody titre against C. parvum (CP). However, repeated doses stimulated a much higher titre than single doses. In all treated anima...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1980.64
更新日期:1980-03-01 00:00:00
abstract:BACKGROUND:Enzastaurin, an oral serine-threonine kinase inhibitor, was initially developed as an ATP-competitive selective inhibitor against protein kinase Cβ. However, the mechanism by which enzastaurin contributes to tumourigenesis remains unclear. METHODS:We analysed the anti-tumour effects of enzastaurin in 22 lun...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2012.7
更新日期:2012-02-28 00:00:00
abstract::Serum levels of the soluble epidermal growth factor receptor (sEGFR) and its ligands epidermal growth factor (EGF), transforming growth factor-alpha (TGF-alpha) and amphiregulin (AR) were measured in healthy donors and patients with non-small cell lung cancer (NSCLC) and head and neck carcinoma (HNC). In NSCLC, we fou...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6603770
更新日期:2007-05-21 00:00:00
abstract::Thyroid carcinomas of an additional series of 34 children exposed to radioactive fall-out after the Chernobyl reactor accident were analysed for mutations in the H-, K- and N-RAS and the p53 gene. Allele-specific oligonucleotide hybridization, single-strand conformation polymorphism (SSCP) and direct sequencing did no...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1998.157
更新日期:1998-03-01 00:00:00
abstract::The use of oncolytic viruses has received considerable attention in recent years and many viruses have proved to be effective against a variety of cancer models and a few are currently being used in clinical trials. However, the possible emergence and outcome of virus-resistant tumour cells has not been addressed. We ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6603363
更新日期:2006-10-23 00:00:00
abstract::Cancer survival rates decrease in the presence of disseminated disease. However, there are few therapies that are effective at eliminating the primary tumour while providing control of distant stage disease. Photodynamic therapy (PDT) is an FDA-approved modality that rapidly eliminates local tumours, resulting in cure...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6603792
更新日期:2007-06-18 00:00:00
abstract::With the recent approval of the combinations of axitinib with the immune checkpoint inhibitor (ICI) pembrolizumab or avelumab for first-line treatment of advanced renal cell carcinoma, guidance on how to distinguish between immune-related adverse events (AEs) caused by ICI versus axitinib-related AEs is necessary to o...
journal_title:British journal of cancer
pub_type: 杂志文章,评审
doi:10.1038/s41416-020-0949-9
更新日期:2020-09-01 00:00:00
abstract::To evaluate whether green tea consumption provides protection against stomach cancer, the relative risks (RRs) were calculated in the Japan Collaborative Study for Evaluation of Cancer Risk, sponsored by the Ministry of Health and Welfare (JACC Study). The study was based on 157 incident cases and 285 controls aged 40...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6601512
更新日期:2004-01-12 00:00:00