Abstract：
BACKGROUND:Chemerin, a known chemoattractant, participates in multiple biological events. However, its role in cancer remains largely unknown. METHODS:Chemerin expression was evaluated by real-time PCR, western blot and immunohistochemistry. Forced expression, RNAi, immunoprecipitation, etc. were used in function and mechanism study. Mouse models of extrahepatic and intrahepatic metastasis were employed to evaluate the therapeutic potential of chemerin. RESULTS:Chemerin expression was significantly downregulated in hepatocellular carcinoma, and associated with poor prognosis of HCC patients. Forced expression of chemerin inhibited in vitro migration, invasion and in vivo metastasis of HCC cells. Administration of chemerin effectively suppressed extrahepatic and intrahepatic metastases of HCC cells, resulting in prolonged survival of tumour-bearing nude mice. Chemerin upregulated expression and phosphatase activity of PTEN by interfering with PTEN-CMKLR1 interaction, leading to weakened ubiquitination of PTEN and decreased p-Akt (Ser473) level, which was responsible for suppressed migration, invasion and metastasis of HCC cells. Positive correlation between chemerin and PTEN, and reverse correlation between chemerin and p-Akt (Ser473) were also observed in HCC clinical samples and intrahepatic mouse model in vivo. CONCLUSIONS:Our study has revealed the suppressive role and therapeutic potential of chemerin in HCC metastasis, providing both a prognostic marker and drug candidate for HCC.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Li JJ,Yin HK,Guan DX,Zhao JS,Feng YX,Deng YZ,Wang X,Li N,Wang XF,Cheng SQ,Bao Y,Xie Ddoi
10.1038/s41416-018-0077-ysubject
Has Abstractpub_date
2018-05-01 00:00:00pages
1337-1348issue
10eissn
0007-0920issn
1532-1827pii
10.1038/s41416-018-0077-yjournal_volume
118pub_type
杂志文章abstract：:At baseline, weight-losing pancreatic cancer patients (n=7) had lower leptin (P<0.05) but higher cortisol, interleukin-6, resting energy expenditure and fat oxidation than healthy subjects (n=6, P<0.05). Over a 4 h feeding period, the areas under the curve for glucose, cortisol and interleukin-6 were greater (P<0.05),...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601712
更新日期：2004-03-22 00:00:00
abstract：BACKGROUND:Dyskeratosis congenita 1 (DKC1) is dysregulated in several cancers. However, the expression and function of DKC1 in colorectal cancer (CRC) is rarely reported. METHODS:Tissue microarrays (TAMs) including 411 cases of CRC tissues and corresponding paracancerous tissues were used to examine the DKC1 expressio...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-019-0695-z
更新日期：2020-03-01 00:00:00
abstract：:The relationship between skin tumours in man and exposure to polyaromatic hydrocarbons has been studied in lathe operators exposed to cutting oils. Seven cases of scrotal cancer and 13 cases of senile keratosis and keratoacanthoma were observed. The risk varied as the 1.6th power of duration of exposure for cancer on ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1990.435
更新日期：1990-12-01 00:00:00
abstract：:Multidrug resistance is often associated with the (over)expression of drug efflux transporters of the ATP-binding cassette (ABC) protein family. This minireview discusses the role of one selected ABC-transporter family member, the breast cancer resistance protein (BCRP/ABCG2), in the (pre)clinical efficacy of novel ex...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/sj.bjc.6604213
更新日期：2008-03-11 00:00:00
abstract：:Molecular and immunohistochemical studies of genetic events on chromosome 17p were prospectively compared with conventional clinical and pathological parameters and disease behaviour at a minimum of 72 months follow-up. In a series of 91 patients with primary operable breast cancer, 37 out of 91 (41%) patients had dis...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.129
更新日期：1998-03-01 00:00:00
abstract：:In rats a maximal tolerated dose of carboplatin (60 mg kg-1, i.v.) caused severe anaemia, leucopenia and thrombocytopenia. These indices of haematological toxicity were also observed with a maximal tolerated dose of cis-platin (6.5 mg kg-1, i.v.), but reductions in blood cell counts were less than those observed with ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1987.75
更新日期：1987-04-01 00:00:00
abstract：:Members of the public are increasingly consulted over health care and research priorities. Patient involvement in determining cancer research priorities, however, has remained underdeveloped. This paper presents the findings of the first consultation to be conducted with UK cancer patients concerning research prioriti...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603662
更新日期：2007-03-26 00:00:00
abstract：:The role of protein kinase C (PKC) in in vitro invasiveness of four different human renal cell carcinoma (RCC) cell lines of the clear cell type was investigated. Different PKC-inhibitors markedly inhibited invasiveness of the highly invasive cell lines, suggesting an invasion-promoting role of PKC in human RCC. Analy...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.1999.1043
更新日期：2000-03-01 00:00:00
abstract：:Dormant and regressing implants of C3H mammary carcinoma MC2 were always found to be surrounded by a cellular fibrous capsule where macrophages and T cells predominated as the cellular elements. Macrophages were always closely associated with the collagen deposition, and stained with anti-collagen type I immuno-peroxi...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1991.169
更新日期：1991-05-01 00:00:00
abstract：:As regulators of malignant cell behaviour and communication with stroma, cytokines have proved useful in understanding cancer biology and developing novel therapies. In renal cell carcinoma, patients with inflammatory reactions are known to have poor prognosis. In order to elucidate the relation between renal cell car...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600257
更新日期：2002-05-06 00:00:00
abstract：:Circulating serum factors have been said to abrogate the effects of immune response in cancer, i.e. "blocking" and "antigenic inhibition". The aim of this investigation was to isolate such specific factors in a purified and native state. F(ab)2 fragments isolated from hypernephroma were insolubilized on the surfaces o...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1975.279
更新日期：1975-12-01 00:00:00
abstract：BACKGROUND:Proviral integration Moloney virus (PIM) kinases (PIM1, 2 and 3) are overexpressed in several tumour types and contribute to oncogenesis. AZD1208 is a potent ATP-competitive PIM kinase inhibitor investigated in patients with recurrent or refractory acute myeloid leukaemia (AML) or advanced solid tumours. ME...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究
doi：10.1038/s41416-018-0082-1
更新日期：2018-05-01 00:00:00
abstract：:The cardiotoxicity of 5-fluorouracil (FU) was attributed to impurities present in the injected vials. One of these impurities was identified as fluoroacetaldehyde which is metabolised by isolated perfused rabbit hearts into fluoroacetate (FAC), a highly cardiotoxic compound. FAC was also detected in the urine of patie...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.227
更新日期：1992-07-01 00:00:00
abstract：BACKGROUND:Venous thromboembolism (VTE) frequently complicates cancer. Data on tumour-specific VTE predictors are limited, but may inform strategies to prevent thrombosis. METHODS:We computed incidence rates (IRs) with 95% confidence intervals (CIs) for VTE hospitalisation in a cohort of cancer patients (n=57,591) and...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605883
更新日期：2010-09-28 00:00:00
abstract：:Peripheral blood mononuclear cells (PBMCs) were obtained from patients receiving radioactive murine monoclonal antibody (MAb) therapy for malignant epithelial tumours, as well as normal controls, and were tested for the ability of T cells to proliferate in vitro in the presence of the MAb administered for therapy (HMF...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1991.337
更新日期：1991-09-01 00:00:00
abstract：:In advanced pancreatic cancer, level one evidence has established a significant survival advantage with chemotherapy, compared to best supportive care. The treatment-associated toxicity needs to be evaluated. This study examines the secondary outcome measures for chemotherapy in advanced pancreatic cancer using meta-a...
journal_title：British journal of cancer
pub_type： 杂志文章,meta分析
doi：10.1038/sj.bjc.6604436
更新日期：2008-07-08 00:00:00
abstract：BACKGROUND:Observational studies suggest greater height is associated with increased ovarian cancer risk, but cannot exclude bias and/or confounding as explanations for this. Mendelian randomisation (MR) can provide evidence which may be less prone to bias. METHODS:We pooled data from 39 Ovarian Cancer Association Con...
journal_title：British journal of cancer
pub_type： 杂志文章,meta分析
doi：10.1038/s41416-018-0011-3
更新日期：2018-04-01 00:00:00
abstract：BACKGROUND:Platinum-based doublet chemotherapy is the standard first-line treatment for advanced non-small cell lung cancer (NSCLC), but earlier studies have suggested that non-platinum combinations are equally effective and better tolerated. We conducted a national, randomised study to compare a non-platinum with a pl...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1038/bjc.2012.284
更新日期：2012-07-24 00:00:00
abstract：:The cytocidal properties of metronidazole against hypoxic mammalian cells are described. This chemotherapeutic action has been shown to be dependent on drug concentration and duration of exposure. The x-ray TCD50 for a murine anaplastic carcinoma was reduced from 6081 rad to 4643 rad when animals were given metronidaz...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1976.78
更新日期：1976-05-01 00:00:00
abstract：BACKGROUND:The community-based incidence of cancer treatment-related long-term consequences is uncertain. We sought to establish the burden of health outcomes that have been associated with treatment among British long-term cancer survivors. METHODS:We identified 26,213 adults from the General Practice Research Databa...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.420
更新日期：2011-11-08 00:00:00
abstract：:During the period from 1950 to 1952, three patients were studied by electrophoresis according to Tiselius on account of anticomplementary activity at WR; the presence of an M-component was demonstrated. On several later occasions it was observed that this component at first seemed to remain unchanged, later it was sli...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1971.53
更新日期：1971-09-01 00:00:00
abstract：:Two-tumour-cell-aggregation factors derived from rat ascites hepatoma cells had different antigenicity; one, with a strong potency, was not absorbed by immunoadsorbent chromatography with anti-rat serum antibody and the other, with a weak potency, was. The unabsorbed factor possessed mitogenic activity on lymphocytes ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1978.192
更新日期：1978-08-01 00:00:00
abstract：:We conducted a case-control study to investigate the role of early infections in the aetiology of childhood acute leukaemias. The study included 280 incident cases (240 acute lymphoblastic leukaemia and 40 acute non-lymphoblastic leukaemia) and 288 hospital controls, frequency matched by age, gender, hospital, catchme...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600091
更新日期：2002-04-08 00:00:00
abstract：:The inability to assess the extent of tumour damage immediately following treatment is a major clinical obstacle to improving the management of cancer patients. Normally, the effectiveness of chemotherapy or radiation therapy cannot be determined for at least several weeks after treatment. We studied the increase in m...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1994.455
更新日期：1994-12-01 00:00:00
abstract：:The trimodality approach represented by concurrent chemoradiotherapy followed by surgical resection is a highly effective, but potentially toxic therapy for locally advanced non-small-cell lung cancer (NSCLC). In this review, we discuss the current status of this therapy in patients with mediastinal node-positive (N2)...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/sj.bjc.6603751
更新日期：2007-05-21 00:00:00
abstract：:The association between soya foods and breast cancer risk was investigated in a prospective study of 34759 women in Hiroshima and Nagasaki, Japan. Women completed dietary questionnaires in 1969-1970 and/or in 1979-1981 and were followed for incident breast cancer until 1993. The analysis involved 427 cases of primary ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690837
更新日期：1999-12-01 00:00:00
abstract：:Two hundred patients with node positive stage II breast cancer were randomised to four groups after radical mastectomy and axillary evacuation: (1) Postoperative radiotherapy, (2) Adjuvant chemotherapy with eight courses of CAFt (cyclophosphamide 500 mg m-2 + doxorubicin 40 mg/m-2 + ftorafur 20 mg kg-1 orally day 1-14...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/bjc.1992.430
更新日期：1992-12-01 00:00:00
abstract：:Data obtained from multiple sources indicate that no single mechanism can explain the resistance to chemotherapy exhibited by non-small cell lung carcinomas. The multi-factorial nature of drug resistance implies that the analysis of comprising expression profiles may predict drug resistance with higher accuracy than s...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600463
更新日期：2002-07-29 00:00:00
abstract：BACKGROUND:In the phase III AVAGAST trial, the addition of bevacizumab to chemotherapy improved progression-free survival (PFS) but not overall survival (OS) in patients with advanced gastric cancer. We studied the role of Angiopoietin-2 (Ang-2), a key driver of tumour angiogenesis, metastasis and resistance to antiang...
journal_title：British journal of cancer
pub_type： 杂志文章,随机对照试验
doi：10.1038/bjc.2016.30
更新日期：2016-04-12 00:00:00
abstract：BACKGROUND:Several studies have reported discordant results regarding the impact of the CYP2D6 phenotype on both the effectiveness and the degree of endocrine symptoms associated with tamoxifen. Other studies have suggested that menopausal symptoms may be a predictive factor to tamoxifen response. METHODS:We investiga...
journal_title：British journal of cancer
pub_type： 杂志文章,随机对照试验
doi：10.1038/bjc.2012.278
更新日期：2012-07-10 00:00:00
