Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study.

abstract：:Matrix metalloproteinases (MMPs) have been implicated as important factors in gliomas since they may both facilitate invasion into the surrounding brain and participate in neovascularization. We have tested the hypothesis that deregulated expression of gelatinase-A or B, or an activator of gelatinase-A, MT1-MMP, may c...

journal_title：British journal of cancer

authors： Forsyth PA,Wong H,Laing TD,Rewcastle NB,Morris DG,Muzik H,Leco KJ,Johnston RN,Brasher PM,Sutherland G,Edwards DR

更新日期：1999-04-01 00:00:00

abstract：:The cisplatin analogue 1R,2R-diaminocyclohexane(trans-diacetato)(dichloro)platinum(IV) (DAP) is a DNA-damaging agent that will be entering clinical trials for its potent cytotoxic effects against cisplatin-resistant tumour cells. This cytotoxicity may reside in its ability to selectively activate G1-phase checkpoint r...

journal_title：British journal of cancer

authors： He G,Kuang J,Huang Z,Koomen J,Kobayashi R,Khokhar AR,Siddik ZH

更新日期：2006-12-04 00:00:00

abstract：:Following an i.p. dose of 150 mg x kg(-1) 5-fluorouracil (5-FU), drug uptake and metabolism over a 2-h period were studied by in vivo (19)F magnetic resonance spectroscopy (MRS) for the murine colon carcinoma lines C26-B (5-FU-insensitive; n=11) and C26-10 (5-FU-sensitive; n=15) implanted s.c. in Balb/C mice. Time cou...

journal_title：British journal of cancer

authors： Kamm YJ,Peters GJ,Hull WE,Punt CJ,Heerschap A

更新日期：2003-08-18 00:00:00

abstract：:A mini-review of the literature concerning epigenetic gene regulation in cancer. ...

journal_title：British journal of cancer

authors： Malik K,Brown KW

更新日期：2000-12-01 00:00:00

abstract：:Fibroblast growth factors (FGFs) and fibroblast growth factor receptors (FGFRs) have been increasingly recognized to play an important role in the pathobiology of pancreatic malignancy. We have investigated the effects of FGF-1 and FGF-2 on the behaviour and adhesion properties of human pancreatic adenocarcinoma cell ...

journal_title：British journal of cancer

authors： El-Hariry I,Pignatelli M,Lemoine NR

更新日期：2001-06-15 00:00:00

abstract：:Increased expression of tumour-associated trypsin inhibitor (TATI) in tumour tissue and/or serum has been associated with poor survival in various cancer forms. Moreover, a proinvasive function of TATI has been shown in colon cancer cell lines. In this study, we have examined the prognostic significance of tumour-spec...

journal_title：British journal of cancer

authors： Gaber A,Johansson M,Stenman UH,Hotakainen K,Pontén F,Glimelius B,Bjartell A,Jirström K,Birgisson H

更新日期：2009-05-19 00:00:00

abstract：:Small cell bronchial carcinoma (SCC) xenografts with differing sensitivity to cyclophosphamide (CY) were investigated using a variety of techniques. Two xenografts (HX78 and HX88) were relatively sensitive to CY, one xenograft (HX72) was inherently resistant to CY and a fourth xenograft (HX78Cy) was a CY induced resis...

journal_title：British journal of cancer

authors： Berman R,Gusterson B,Steel GG

更新日期：1985-05-01 00:00:00

abstract：:To design hybrid tumour necrosis factor-alpha (TNF-alpha) applicable to systemic anti-tumour therapeutic use, we assessed the relationships among the molecular size of hybrid TNF-alpha, in vitro bioactivity and in vivo anti-tumour potency. Natural human TNF-alpha was covalently modified with polyethylene glycol (PEG) ...

journal_title：British journal of cancer

authors： Tsutsumi Y,Tsunoda S,Kamada H,Kihira T,Nakagawa S,Kaneda Y,Kanamori T,Mayumi T

更新日期：1996-10-01 00:00:00

abstract：BACKGROUND:Alternative treatments are needed for elderly patients with acute myeloid leukaemia, as the disease prognosis is poor and the current treatment is unsuitable for many patients. METHODS:In this study, we investigated whether combining the nucleoside analogue sapacitabine with histone deacetylase (HDAC) inhib...

journal_title：British journal of cancer

authors： Green SR,Choudhary AK,Fleming IN

更新日期：2010-10-26 00:00:00

abstract：:The tissue-specific translation elongation factor eEF1A2 is a potential oncogene that is overexpressed in human ovarian cancer. eEF1A2 is highly similar (98%) to the near-ubiquitously expressed eEF1A1 (formerly known as EF1-alpha) making analysis with commercial antibodies difficult. We wanted to establish the express...

journal_title：British journal of cancer

authors： Tomlinson VA,Newbery HJ,Bergmann JH,Boyd J,Scott D,Wray NR,Sellar GC,Gabra H,Graham A,Williams AR,Abbott CM

更新日期：2007-05-21 00:00:00

abstract：:High-throughput microarrays are being used in expression profiling analyses with the objectives of gene and pathway discovery, functional characterization of genes, and tumor subclassification. This review summarizes bladder cancer studies dealing with both in vitro models and clinical specimens, using distinct microa...

journal_title：British journal of cancer

authors： Sánchez-Carbayo M,Cordon-Cardo C

更新日期：2003-12-15 00:00:00

abstract：:Metallothioneins (MT) are ubiquitous, intracellular small proteins with high affinity for heavy metal ions. In the last decades, it was shown that MT overexpression in a variety of cancers is associated with resistance to anticancer drugs and is combined with a poor prognosis. In this prospective study, we examined th...

journal_title：British journal of cancer

authors： Weinlich G,Eisendle K,Hassler E,Baltaci M,Fritsch PO,Zelger B

更新日期：2006-03-27 00:00:00

abstract：BACKGROUND:PI3K/Akt (PKB) pathway has been shown in several cell types to be activated by ligands to cell surface integrins, leading to the metastasis of tumour cells. The signalling pathways involved in the metastatic spread of human scirrhous gastric carcinoma cells have not been defined. METHODS:The role of the PI3...

journal_title：British journal of cancer

authors： Matsuoka T,Yashiro M,Nishioka N,Hirakawa K,Olden K,Roberts JD

更新日期：2012-04-24 00:00:00

abstract：BACKGROUND:Only a small proportion of patients respond to anti-VEGF therapy, pressing the need for a reliable biomarker that can identify patients who will benefit. We studied the biological activity of anti-VEGF antibodies in patients' blood during anti-VEGF therapy by using the Ba/F3-VEGFR2 cell line, which is depend...

journal_title：British journal of cancer

authors： Wentink MQ,Broxterman HJ,Lam SW,Boven E,Walraven M,Griffioen AW,Pili R,van der Vliet HJ,de Gruijl TD,Verheul HM

更新日期：2016-10-11 00:00:00

abstract：BACKGROUND:The current analysis was performed to evaluate the impact of PIK3CA hotspot mutations on everolimus efficacy in BOLERO-2 participants, using cell-free DNA (cfDNA) from plasma samples collected at the time of patient randomisation. METHODS:PIK3CA H1047R, E545K, and E542K mutations in plasma-derived cfDNA wer...

journal_title：British journal of cancer

authors： Moynahan ME,Chen D,He W,Sung P,Samoila A,You D,Bhatt T,Patel P,Ringeisen F,Hortobagyi GN,Baselga J,Chandarlapaty S

更新日期：2017-03-14 00:00:00

abstract：BACKGROUND:Folate receptor 1 (FOLR1) is expressed in the majority of ovarian carcinomas (OvCa), making it an attractive target for therapy. However, clinical trials testing anti-FOLR1 therapies in OvCa show mixed results and require better understanding of the prognostic relevance of FOLR1 expression. We conducted a la...

journal_title：British journal of cancer

authors： Köbel M,Madore J,Ramus SJ,Clarke BA,Pharoah PD,Deen S,Bowtell DD,Odunsi K,Menon U,Morrison C,Lele S,Bshara W,Sucheston L,Beckmann MW,Hein A,Thiel FC,Hartmann A,Wachter DL,Anglesio MS,Høgdall E,Jensen A,Høgdall C

更新日期：2014-12-09 00:00:00

abstract：:Insulin-like growth factor-1 (IGF-1) has been described as an important factor in proliferation, cell survival and migration of multiple myeloma (MM) cells. Angiogenesis correlates with development and prognosis of the MM disease. Vascular endothelial growth factor (VEGF) is one of the prominent factors involved in th...

journal_title：British journal of cancer

authors： Menu E,Kooijman R,Van Valckenborgh E,Asosingh K,Bakkus M,Van Camp B,Vanderkerken K

更新日期：2004-03-08 00:00:00

abstract：BACKGROUND:MYCN amplification with subsequent MYCN protein overexpression is a powerful indicator of poor prognosis of neuroblastoma patients. Little is known regarding the prognostic significance of the homologous MYC protein expression in neuroblastoma. METHODS:Immunostaining for MYCN and MYC protein was performed o...

journal_title：British journal of cancer

authors： Wang LL,Teshiba R,Ikegaki N,Tang XX,Naranjo A,London WB,Hogarty MD,Gastier-Foster JM,Look AT,Park JR,Maris JM,Cohn SL,Seeger RC,Asgharzadeh S,Shimada H

更新日期：2015-06-30 00:00:00

abstract：BACKGROUND:Epithelial ovarian cancer (EOC) cells are prone to metastasise throughout the peritoneal cavity. The epithelial-to-mesenchymal transition (EMT) is a necessary step towards metastatic tumour progression. CA125/MUC16 mucin is a high-molecular-weight glycoprotein overexpressed in the majority of serous carcinom...

journal_title：British journal of cancer

authors： Comamala M,Pinard M,Thériault C,Matte I,Albert A,Boivin M,Beaudin J,Piché A,Rancourt C

更新日期：2011-03-15 00:00:00

abstract：:The aim of this study was to evaluate serum midkine (S-MK) concentrations as a prognostic tumour marker in oral squamous cell carcinoma (OSCC). We measured S-MK concentrations in patients with OSCC and healthy volunteers. In addition, we performed real-time quantitative reverse transcription-PCR analysis and immunohis...

journal_title：British journal of cancer

authors： Ota K,Fujimori H,Ueda M,Shiniriki S,Kudo M,Jono H,Fukuyoshi Y,Yamamoto Y,Sugiuchi H,Iwase H,Shinohara M,Ando Y

更新日期：2008-08-19 00:00:00

abstract：:The purpose of this study was to investigate the effect of breast density on breast cancer (BC) mortality in a mammography screening programme. The cohort included 48 052 women participating in mammography screening in Copenhagen, Denmark, where biennial screening is offered to women aged 50-69 years. We collected inf...

journal_title：British journal of cancer

authors： Olsen AH,Bihrmann K,Jensen MB,Vejborg I,Lynge E

更新日期：2009-04-07 00:00:00

abstract：BACKGROUND:Tumour stromal cells differ from its normal counterpart. We have shown that tumour endothelial cells (TECs) isolated from tumour tissues are also abnormal. Furthermore, we found that mRNAs of vascular endothelial growth factor-A (VEGF-A) and cyclooxygenase-2 (COX-2) were upregulated in TECs. Vascular endothe...

journal_title：British journal of cancer

authors： Kurosu T,Ohga N,Hida Y,Maishi N,Akiyama K,Kakuguchi W,Kuroshima T,Kondo M,Akino T,Totsuka Y,Shindoh M,Higashino F,Hida K

更新日期：2011-03-01 00:00:00

abstract：:To evaluate the impact of prior adjuvant chemotherapy on response rate (RR), progression-free (PFS) and overall survival (OS) of metastatic breast cancer patients treated with epirubicin/paclitaxel (ET) regimens. In all, 291 patients enrolled in five studies in metastatic breast cancer were analysed: 101 (35%) were ch...

journal_title：British journal of cancer

authors： Gennari A,Bruzzi P,Orlandini C,Salvadori B,Donati S,Landucci E,Guarneri V,Rondini M,Ricci S,Conte P

更新日期：2004-03-08 00:00:00

abstract：:The widely held belief that 2-naphthylamine is not carcinogenic for the rat has been re-examined. Twenty female Wistar rats were dosed by gastric intubation weekly for 57 weeks with 2-naphthylamine, 300 mg/kg body wt, in arachis oil and 20 controls were given arachis oil alone. Animals which became moribund were kille...

journal_title：British journal of cancer

authors： Hicks RM,Wright R,Wakefield JS

更新日期：1982-10-01 00:00:00

abstract：:The carcinoembryonic antigen (CEA) was produced and released by human colorectal carcinomata and also the normal attached mucosa when maintained in both monolayer and organ culture. Immunoperoxidase cytochemical methods were employed for the cellular localization of CEA which was demonstrable only on the neoplastic ce...

journal_title：British journal of cancer

authors： Breborowicz J,Easty GC,Birbeck M,Robertson D,Nery R,Neville AM

更新日期：1975-05-01 00:00:00

abstract：:The objective of this study was to document the occurrence and to correlate the prevalence of different human papillomavirus (HPV) types with the cytological results on simultaneously performed thin-layer preparations in a large population of Flemish women. During 1 year, 69 290 thin-layer preparations were interprete...

journal_title：British journal of cancer

authors： Depuydt CE,Vereecken AJ,Salembier GM,Vanbrabant AS,Boels LA,van Herck E,Arbyn M,Segers K,Bogers JJ

更新日期：2003-02-24 00:00:00

abstract：:Survivin is an apoptotic inhibitor that is expressed at high levels in a variety of malignancies. Survivin has four known alternative splice forms (Survivin, Survivin-2B, Survivin-deltaEx3, and Survivin-3B), and the recent literature suggests that these splice variants have unique functions and subcellular localisatio...

journal_title：British journal of cancer

authors： Fangusaro JR,Jiang Y,Holloway MP,Caldas H,Singh V,Boué DR,Hayes J,Altura RA

更新日期：2005-01-31 00:00:00

abstract：:1-5% of cancer patients treated with cytotoxic chemotherapy die within a month after the administration of chemotherapy. Risk factors for these early deaths (ED) are not well known. The purpose of this study was to establish a risk model for ED after chemotherapy applicable to all tumour types. The model was delineate...

journal_title：British journal of cancer

authors： Ray-Coquard I,Ghesquière H,Bachelot T,Borg C,Biron P,Sebban C,LeCesne A,Chauvin F,Blay JY,ELYPSE Study Group.

更新日期：2001-09-14 00:00:00

abstract：BACKGROUND:8-Oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) is the most abundant marker of DNA damage and it reflects oxidative stress. Human 8-oxoguanine glycosylase (hOGG1) is a DNA-repair enzyme that participates in 8-oxodG removal. METHODS:hOGG1 protein expression was immunohistochemically studied in 96 patients with...

journal_title：British journal of cancer

authors： Karihtala P,Kauppila S,Puistola U,Jukkola-Vuorinen A

更新日期：2012-01-17 00:00:00

abstract：:Multidrug resistance is often associated with the (over)expression of drug efflux transporters of the ATP-binding cassette (ABC) protein family. This minireview discusses the role of one selected ABC-transporter family member, the breast cancer resistance protein (BCRP/ABCG2), in the (pre)clinical efficacy of novel ex...

journal_title：British journal of cancer

authors： Lemos C,Jansen G,Peters GJ

更新日期：2008-03-11 00:00:00