Abstract：
:Survivin is an apoptotic inhibitor that is expressed at high levels in a variety of malignancies. Survivin has four known alternative splice forms (Survivin, Survivin-2B, Survivin-deltaEx3, and Survivin-3B), and the recent literature suggests that these splice variants have unique functions and subcellular localisation patterns. We evaluated 19 fresh-frozen paediatric medulloblastomas for the expression of three Survivin isoforms by quantitative PCR. Survivin was most highly expressed when compared with normal cerebellar tissue. We also investigated Survivin protein expression in 40 paraffin-embedded paediatric medulloblastoma tumours by immunohistochemistry. We found a statistically significant association between the percentage of Survivin-positive cells and histologic subtype, with the large-cell-anaplastic variant expressing Survivin at higher levels than the classic subtype. We also found a statistically significant relationship between the percent of Survivin-positive cells in the tumours and clinical outcome, with higher levels of Survivin correlating with a worse prognosis. In summary, our study demonstrates a role for Survivin as a marker of tumour morphology and clinical outcome in medulloblastoma. Survivin may be a promising future prognostic tool and potential biologic target in this malignancy.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Fangusaro JR,Jiang Y,Holloway MP,Caldas H,Singh V,Boué DR,Hayes J,Altura RAdoi
10.1038/sj.bjc.6602317subject
Has Abstractpub_date
2005-01-31 00:00:00pages
359-65issue
2eissn
0007-0920issn
1532-1827pii
6602317journal_volume
92pub_type
杂志文章abstract：:Cellular senescence is an established tumour-suppressive mechanism that prevents the proliferation of premalignant cells. However, several lines of evidence show that senescent cells, which often persist in vivo, can also promote tumour progression in addition to other age-related pathologies via the senescence-associ...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/bjc.2016.115
更新日期：2016-05-24 00:00:00
abstract：:A multicentric, prospective phase III study was carried out with the aim of testing the so-called 'worst drug rule' hypothesis, which suggests the use of an effective but 'less active' regimen that first eradicates tumoral cells resistant to a second effective and 'more active' regimen. With respect to this hypothesis...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1038/bjc.1997.586
更新日期：1997-01-01 00:00:00
abstract：:We report that all- trans retinoic acid (ATRA) enhanced the toxicity of docetaxel against DU145 and LNCaP prostate cancer cells, and that the nature of the interaction between ATRA and docetaxel was highly synergistic. Docetaxel-induced apoptotic cell death was associated with phosphorylation and hence inactivation of...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2001.1818
更新日期：2001-06-01 00:00:00
abstract：:The widely held belief that 2-naphthylamine is not carcinogenic for the rat has been re-examined. Twenty female Wistar rats were dosed by gastric intubation weekly for 57 weeks with 2-naphthylamine, 300 mg/kg body wt, in arachis oil and 20 controls were given arachis oil alone. Animals which became moribund were kille...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1982.250
更新日期：1982-10-01 00:00:00
abstract：BACKGROUND:Recent studies have indicated the prognostic value of tumour subtype and pathological complete response (pCR) after neoadjuvant chemotherapy (NAC). However these results were reported after a short follow-up and using a standard Cox model which could be unsatisfactory for time-dependent factors. In the prese...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2015.174
更新日期：2015-06-30 00:00:00
abstract：:The objective of this study was to document the occurrence and to correlate the prevalence of different human papillomavirus (HPV) types with the cytological results on simultaneously performed thin-layer preparations in a large population of Flemish women. During 1 year, 69 290 thin-layer preparations were interprete...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600756
更新日期：2003-02-24 00:00:00
abstract：:The relationship between fetal growth as indicated by weight and length at birth, and cancer risk in 1080 adult Swedish women was examined. Birth factors were retrieved from original midwife records for the years 1914, 1918, 1922 and 1930, and primary cancer cases were identified by matching with national and regional...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2000.1738
更新日期：2001-05-04 00:00:00
abstract：:Angiotensin II, a main effector peptide in the renin-angiotensin system, acts as a growth-promoting and angiogenic factor via type 1 angiotensin II receptors (AT(1)R). We have recently demonstrated that angiotensin II enhanced tumour cell invasion and vascular endothelial growth factor (VEGF) secretion via AT1R in ova...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602961
更新日期：2006-02-27 00:00:00
abstract：:The management of older patients with aggressive non-Hodgkin's lymphoma presents a challenge to the physician. Age is a poor prognostic indicator, due to reduced ability to tolerate and maintain dose-intensive chemotherapy. Generally, older patients demonstrate a lower response rate, reduced survival and increased tox...
journal_title：British journal of cancer
pub_type： 杂志文章,随机对照试验
doi：10.1038/sj.bjc.6602975
更新日期：2006-03-27 00:00:00
abstract：:Besides its cardiotoxic effect, doxorubicin also elicits inflammatory effects in vivo. 7-Monohydroxyethylrutoside (monoHER) has recently been used as a protector against doxorubicin-induced cardiotoxicity in vivo. It is not known yet whether monoHER can also protect against doxorubicin-induced inflammatory effects. Th...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601022
更新日期：2003-07-21 00:00:00
abstract：:Primary liver cancer (PLC) incidence trends from Africa are unknown. Using Kampala Cancer Registry data from 1960 to 1980 and 1991 to 2005, we identified 771 PLCs. Although rates were stable among men, PLC incidence among women increased >50%. Investigations of viral hepatitis, aflatoxin, obesity, and human immunodefi...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604893
更新日期：2009-03-10 00:00:00
abstract：:The effects of X-radiation on the Nembutal-induced redistribution of the cardiac output in two types of transplanted mouse tumours and some normal mouse tissues have been investigated, using rubidium-86 and 125I-human serum albumin. Irradiation causes an increase in 86Rb uptake (relative blood perfusion) by the tumour...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1976.186
更新日期：1976-10-01 00:00:00
abstract：:Karyotyping and marker analysis of G- and C-banded metaphases from a metastatic bronchial carcinoma revealed a dominant stemline with five markers and four sidelines with additional markers. One to three minute bodies were noted in the majority of cells and these were classified as markers. On the basis of this analys...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1976.162
更新日期：1976-09-01 00:00:00
abstract：:Hepatocyte growth factor (HGF), through Met receptor binding, fulfils numerous functions in invasive tumour growth (survival/proliferation, motility, apoptosis), but epigenetic control of gene expression in this process is poorly understood. In HGF-treated breast cancer cells we studied (a) the chemoinvasion towards C...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604726
更新日期：2008-11-18 00:00:00
abstract：BACKGROUND:Placental-site trophoblastic (PSTT) and epithelioid trophoblastic tumours (ETT) are the rarest malignant forms of gestational trophoblastic disease (GTD). Our prior work demonstrated that an interval of ≥48 months from the antecedent pregnancy was associated with 100% death rate, independent of the stage. He...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-019-0402-0
更新日期：2019-03-01 00:00:00
abstract：:5-fluorouracil (5FU) is activated intracellularly to cytotoxic 5-fluoronucleotides (FNuct). These were detected non-invasively in rats bearing the Walker carcinosarcoma by 19F-magnetic resonance spectroscopy (MRS) following an i.v. bolus dose of 5FU (50 mg kg-1). Pre-treatment of the rats (3 to 24 h earlier) by methot...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.75
更新日期：1992-03-01 00:00:00
abstract：BACKGROUND:First Spanish trial of Ewing sarcoma (ES) including adults and children with the aim to test the efficacy of Gemcitabine and Docetaxel (G/D) in newly diagnosed high-risk (HR) patients. METHODS:This was a prospective, multicentric, non-randomised, open study for patients ⩽40 years with newly diagnosed ES. HR...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究
doi：10.1038/bjc.2017.252
更新日期：2017-09-05 00:00:00
abstract：:In vivo models of acquired resistance to the platinum-based agents cisplatin (CDDP), carboplatin (CBDCA), iproplatin (CHIP) and tetraplatin have been established using a panel of six parent human ovarian carcinoma lines, two (HX/110 and PXN/87) being derived from previously untreated patients. Resistance has been gene...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1993.5
更新日期：1993-01-01 00:00:00
abstract：BACKGROUND:There is clinical evidence to suggest that tumour necrosis factor-α (TNF-α) may be a therapeutic target in renal cell carcinoma (RCC). Multi-targeted kinase inhibitors, such as sorafenib and sunitinib, have become standard of care in advanced RCC. The anti-TNF-α monoclonal antibody infliximab and sorafenib h...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605889
更新日期：2010-10-12 00:00:00
abstract：BACKGROUND:Circulating tumour cells (CTCs) can be assessed through a minimally invasive blood sample with potential utility as a predictive, prognostic and pharmacodynamic biomarker. The large heterogeneity of melanoma CTCs has hindered their detection and clinical application. METHODS:Here we compared two microfluidi...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-0750-9
更新日期：2020-03-01 00:00:00
abstract：:Expression of the tumour suppressor gene p53 was examined in squamous cell carcinoma of the head and neck using two p53 antibodies, PAb 421 and PAb 1801. Elevated p53 expression was found in 67% of the 73 patients investigated. P53 expression was not found to correlate with whether the patient had been previously trea...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1991.352
更新日期：1991-09-01 00:00:00
abstract：:Loss of the short arm of chromosome 1 is a hallmark of oligodendroglial tumours (OTs). Deletion mapping studies in OTs have revealed multiple commonly deleted regions on chromosome 1p, suggesting that there are more than one tumour suppressor gene. To map critical deletion regions on 1p, a series of 25 OTs were examin...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602093
更新日期：2004-09-13 00:00:00
abstract：:Disseminating disease is a predictive and prognostic indicator of poor outcome in children with neuroblastoma. Its accurate and sensitive assessment can facilitate optimal treatment decisions. The International Neuroblastoma Risk Group (INRG) Task Force has defined standardised methods for the determination of minimal...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究,实务指引
doi：10.1038/sj.bjc.6605029
更新日期：2009-05-19 00:00:00
abstract：:Elevated expression of matrix metalloproteinases (MMPs), a family of secreted proteinases that degrade matrix components of basement membranes and connective tissues, is strongly correlated with malignant expression in various human epithelial cancers and epithelial cancer cell lines. We have tested whether elevated l...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.119
更新日期：1998-03-01 00:00:00
abstract：BACKGROUND:This study aimed to evaluate the safety and efficacy of dose-dense weekly chemotherapy, followed by resection and/or thoracic radiotherapy. METHODS:Patients with histologically documented thymoma with unresectable stage III disease received 9 weeks of chemotherapy: cisplatin 25 mg m(-2) on weeks 1-9; vincri...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605731
更新日期：2010-06-29 00:00:00
abstract：:Perforin (PFP) is a cytotoxic protein released from killer cells. PFP immunoreactivity in human peripheral blood lymphocytes (PBL) and tumour infiltrating lymphocytes (TIL) was investigated immunocytochemically with the aid of an anti-PFP monoclonal antibody. PFP was detected in the cytoplasm of 10% of PBL. We perform...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1991.283
更新日期：1991-08-01 00:00:00
abstract：:The carcinoembryonic antigen (CEA) was produced and released by human colorectal carcinomata and also the normal attached mucosa when maintained in both monolayer and organ culture. Immunoperoxidase cytochemical methods were employed for the cellular localization of CEA which was demonstrable only on the neoplastic ce...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1975.97
更新日期：1975-05-01 00:00:00
abstract：BACKGROUND:The urokinase plasminogen activator (uPA) system is one of the best-investigated protease systems, both under physiological and pathological conditions, including various types of cancer. However, effects of co-expression of members of the uPA system in soft-tissue sarcoma (STS) patients at the protein level...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605520
更新日期：2010-02-16 00:00:00
abstract：:RNA tumour virus genes are contained in the chromosomal DNA of most vertebrates, and may be transmitted vertically from parent to progeny along with other cellular genes, as well as horizontally as infectious particles. Activation of these viral genes may be part of the means by which RNA tumour viruses produce cancer...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/bjc.1978.23
更新日期：1978-02-01 00:00:00
abstract：:The death certificate only (DCO) index, which quantifies the proportion of patients for whom the death certificate provides the only notification to the registry, is a widely used measure of incompleteness of population-based cancer registration. This paper provides an algebraic assessment and a quantitative illustrat...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1995.363
更新日期：1995-08-01 00:00:00
