Abstract：
:Cellular senescence is an established tumour-suppressive mechanism that prevents the proliferation of premalignant cells. However, several lines of evidence show that senescent cells, which often persist in vivo, can also promote tumour progression in addition to other age-related pathologies via the senescence-associated secretory phenotype (SASP). Moreover, new insights suggest the SASP can facilitate tissue repair. Here, we review the beneficial and detrimental roles of senescent cells, highlighting conditions under which the senescence response does and does not promote pathology, particularly cancer. By better understanding the context-dependent effects of cellular senescence, it may be feasible to limit its detrimental properties while preserving its beneficial effects, and develop novel therapeutic strategies to prevent or treat cancer and possibly other age-associated diseases.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Lecot P,Alimirah F,Desprez PY,Campisi J,Wiley Cdoi
10.1038/bjc.2016.115subject
Has Abstractpub_date
2016-05-24 00:00:00pages
1180-4issue
11eissn
0007-0920issn
1532-1827pii
bjc2016115journal_volume
114pub_type
杂志文章,评审abstract：:Patients with refractory metastatic renal cell carcinoma (RCC) were enrolled in a phase II study with teniposide (VM26) and cyclosporin A (CSA) to investigate (1) the effect of CSA on the response rate to VM26; and (2) the effect of CSA on the pharmacokinetics and pharmacodynamics of VM26. Sixteen patients initially r...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/bjc.1997.127
更新日期：1997-01-01 00:00:00
abstract：:Eleven patients suffering from intra-abdominal malignancy were treated with various doses of intraperitoneal mitomycin C adsorbed onto activated carbon particles. Seven of the patients underwent resection of their primary gastric tumour and all developed potentially life-threatening severe complications that proved to...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1997.615
更新日期：1997-01-01 00:00:00
abstract：:This study was undertaken to investigate the intracellular induction of reactive oxygen species (ROS) by cis-dichlorodiammineplatinum (CDDP) and the augmentation of their cytotoxicity in bladder cancer cells (KU7) by enhancement of ROS generation by the glutathione (GSH) depletors buthionine sulphoximine (BSO) and die...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1997.363
更新日期：1997-01-01 00:00:00
abstract：:To investigate the efficacy and safety of combining weekly oxaliplatin with weekly 24-h infusion of high-dose 5-fluorouracil (5-FU) and folinic acid (FA) in treatment of patients with advanced gastric cancer. Patients with histologically confirmed, locally advanced or recurrent/metastatic gastric cancer were studied. ...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1038/sj.bjc.6601985
更新日期：2004-08-02 00:00:00
abstract：:The prodrug N-[4-(daunorubicin-N-carbonyl-oxymethyl)phenyl] O-beta-glucuronyl carbamate (DNR-GA3) was synthesized for specific activation by human beta-glucuronidase, released in necrotic areas of tumour lesions. In vitro, DNR-GA3 was 18 times less toxic than daunorubicin (DNR) and the prodrug was completely activated...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.729
更新日期：1998-12-01 00:00:00
abstract：BACKGROUND:Sindbis virus (SIN) infection causes no or only mild symptoms (fever, rash, and arthralgia) in humans. However, SIN has a strong cytopathic effect (CPE) on various cancer cells. This study focuses on the oncolytic activity of SIN AR399 on oral cancer cells compared with reovirus, a well-known oncolytic virus...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605209
更新日期：2009-08-18 00:00:00
abstract：:Hypoxia is a key factor contributing to the progression of human neoplasias and to the development of resistance to chemotherapy. BNIP3 is a proapoptotic member of the Bcl-2 protein family involved in hypoxia-induced cell death. We evaluated the expression and methylation status of BNIP3 gene to better understand the ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602422
更新日期：2005-03-28 00:00:00
abstract：BACKGROUND:Proviral integration Moloney virus (PIM) kinases (PIM1, 2 and 3) are overexpressed in several tumour types and contribute to oncogenesis. AZD1208 is a potent ATP-competitive PIM kinase inhibitor investigated in patients with recurrent or refractory acute myeloid leukaemia (AML) or advanced solid tumours. ME...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究
doi：10.1038/s41416-018-0082-1
更新日期：2018-05-01 00:00:00
abstract：:Survival and proliferation of cell cultures from human anaplastic astrocytomas were shown to be enhanced by glucocorticoids with an optimal concentration of approximately 2.5 x 10(-5)M (10 micrograms/ml). The stimulation of proliferation was only observed in a clonal growth assay and was reversed as the size of indivi...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1980.161
更新日期：1980-06-01 00:00:00
abstract：BACKGROUND:Lymphovascular invasion (LVI) is associated with the development of metastasis in invasive breast cancer (BC). However, the complex molecular mechanisms of LVI, which overlap with other oncogenic pathways, remain unclear. This study, using available large transcriptomic datasets, aims to identify genes assoc...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-019-0486-6
更新日期：2019-06-01 00:00:00
abstract：:Oestrogen (RE) and progesterone (RP) cytosolic receptors have been studied in 59 clinically inflammatory tumours of the human breast. The results were compared to those obtained in a series of 496 operable tumours. A single saturating dose of oestradiol for RE and R 5020 for RP was used and the cut-off between negativ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1981.291
更新日期：1981-12-01 00:00:00
abstract：BACKGROUND:The risk and prognosis of ovarian cancer have not been well established in women with endometriosis. Thus, we investigated the impact of endometriosis on the risk and prognosis for ovarian cancer, and evaluated clinicopathologic characteristics of endometriosis-associated ovarian cancer (EAOC) in comparison ...
journal_title：British journal of cancer
pub_type： 杂志文章,meta分析
doi：10.1038/bjc.2014.29
更新日期：2014-04-02 00:00:00
abstract：:We have shown previously that the relative expression of a truncated oestrogen receptor-alpha variant mRNA (ER clone 4) is significantly increased in axillary node-positive primary breast tumours compared with node-negative tumours. In this study, we have examined the relative expression of clone 4-truncated, exon 5-d...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690156
更新日期：1999-02-01 00:00:00
abstract：:The influence of cyclooxygenase-2 (COX-2) overexpression on the development of tumours has been well documented. The underlying mechanism however has still not been completely elucidated. An escape of proliferating cells from the regulatory influence of TGF-beta for example in the intestine has been discussed as well ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604048
更新日期：2007-11-19 00:00:00
abstract：:To our knowledge, very few data about the role of Topoisomerase IIalpha (TOPO-IIalpha), an enzyme involved in critical steps of tumour cell proliferation and chemoresistance are currently available in ovarian cancer patients. The aim of this study was to investigate the prognostic value of TOPO-IIalpha expression in a...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604410
更新日期：2008-06-17 00:00:00
abstract：:The tumour suppressor gene p53 has been found to be mutated or inactivated at high frequency in several common human tumours. We have examined a series of exocrine pancreatic carcinomas for over-expression of mutant forms of p53 by immunohistochemistry with a panel of specific antibodies. We found immunodetectable p53...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1991.467
更新日期：1991-12-01 00:00:00
abstract：BACKGROUND:Immunohistological assessment of Ki 67 expression is less expensive than Oncotype Dx, which is currently used to identify patients with lymph node-negative breast cancer, who will benefit from adjuvant chemotherapy. METHODS:The relationship of immunohistologically measured Ki 67 to Oncotype DX recurrence sc...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.402
更新日期：2011-10-25 00:00:00
abstract：:Accuracy in the assessment of performance status by oncologists has not been well evaluated. We investigated possible discrepancies in the assessment of performance status among patients, nurses, and oncologists, and evaluated the prognostic importance of each assessment. Two hundred and six inpatients with inoperable...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2001.2162
更新日期：2001-11-30 00:00:00
abstract：BACKGROUND:In metastatic colorectal cancer (mCRC), KRAS is the only validated biomarker used to select patients for administration of epidermal growth factor receptor (EGFR)-targeted therapies. To identify additional predictive markers, we investigated the importance of HER2, the primary EGFR dimerisation partner, in t...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.4
更新日期：2013-02-19 00:00:00
abstract：:Manganese superoxide dismutase (SOD2) is an enzyme that catalyses the dismutation of superoxide in the mitochondria, leading to reduced levels of reactive oxygen species. Reduced expression levels of SOD2 have been shown to result in increased DNA damage and sod2 heterozygous mice have increased incidences of cancer. ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604000
更新日期：2007-10-22 00:00:00
abstract：:People affected by cancer want information about their prognosis but clinicians have trouble estimating and talking about it. We sought to determine the nature and accuracy of medical oncologists' estimates of life expectancy in newly referred patients with incurable cancer. With reference to each patient, medical onc...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602908
更新日期：2006-01-30 00:00:00
abstract：:The x(c)(-) cystine transporter enhances biosynthesis of glutathione, a tripeptide thiol important in drug resistance and cellular defense against oxidative stress, by enabling cellular uptake of cystine, a rate-limiting precursor. Because it is known to regulate glutathione levels and growth of various cancer cell ty...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604485
更新日期：2008-08-05 00:00:00
abstract：BACKGROUND:This phase 1 study examined the safety, maximum-tolerated dose (MTD) and antitumour activity of E7449, a novel PARP 1/2 and tankyrase 1/2 inhibitor. METHODS:E7449 was orally administered once daily in 28-day cycles to patients with advanced solid tumours (50-800-mg doses). Archival tumour samples from conse...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-0916-5
更新日期：2020-08-01 00:00:00
abstract：:The largest single underlying cause of hepatocellular carcinoma (HCC) worldwide is hepatitis B virus (HBV) infection. Hepatitis B virus increases cellular oxidative stress and the development of HCC occurs after a long latency period. The study was carried out to determine whether mitochondrial DNA abnormalities were ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602496
更新日期：2005-04-11 00:00:00
abstract：:A screening programme designed to identify cases of Major Depressive Disorder (MDD) in patients attending a Regional Cancer Centre outpatient department was established. It comprised two stages: (1) The Hospital Anxiety and Depression Scale (HADS) self-rating questionnaire administered by a touch-screen computer; (2) ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601578
更新日期：2004-01-26 00:00:00
abstract：:Resistance of tumour cells to methylating and monochloroethylating agents in vitro and in vivo has been linked to levels of the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT). In a clinical trial of temozolomide in advanced malignant melanoma, the relationship between pretreatment MGMT levels in biop...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/bjc.1998.654
更新日期：1998-11-01 00:00:00
abstract：:Smoke condensate from two types of cigarette, dissolved in two solvents, has been applied regularly to the backs of mice at each of seven different dose levels. Treatment was continued 3 times weekly for up to 110 weeks, by which time 509 of the 1428 treated mice had developed skin tumours. The dependence of tumour in...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1974.126
更新日期：1974-08-01 00:00:00
abstract：BACKGROUND:This phase I, dose-finding study determined the safety, maximum tolerated dose (MTD)/recommended phase 2 dose (RP2D), pharmacokinetics, and antitumour activity of PX-866, a phosphatidylinositol 3-kinase inhibitor, combined with docetaxel in patients with incurable solid tumours. METHODS:PX-866 was administe...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究
doi：10.1038/bjc.2013.474
更新日期：2013-09-03 00:00:00
abstract：:We have shown that large numbers of haemopoietic progenitor cells are mobilised into the blood after filgrastim [granulocyte colony-stimulating factor (G-CSF)] alone and filgrastim following cyclophosphamide chemotherapy in previously untreated patients with ovarian cancer. These cells may be used to provide safe and ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.637
更新日期：1996-12-01 00:00:00
abstract：:Large primary breast tumours and extensive lymph node involvement are linked to a high rate of local recurrence after surgery. In 10-20% of such high-risk breast cancer patients, local relapse will occur despite postoperative radiotherapy. In the present study, we investigated whether molecular features, such as angio...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/sj.bjc.6600755
更新日期：2003-03-10 00:00:00
